Feasibility of a bilateral 4000-6000 Hz notch as a phenotype for genetic association analysis.
Journal Article (Journal Article)
OBJECTIVE: Noise-induced hearing loss (NIHL) is a worldwide health problem and a growing concern among young people. Although some people appear to be more susceptible to NIHL, genetic association studies lack a specific phenotype. We tested the feasibility of a bilateral 4000-6000 Hz audiometric notch as a phenotype for identifying genetic contributions to hearing loss in young adults. DESIGN: A case-control-control study was conducted to examine selected SNPs in 52 genes previously associated with hearing loss and/or expressed in the cochlea. A notch was defined as a minimum of a 15-dB drop at 4000-6000 Hz from the previous best threshold with a 5-dB 'recovery' at 8000 Hz. STUDY SAMPLE: Participants were 252 individuals of European descent taken from a population of 640 young adults who are students of classical music. Participants were grouped as No-notch (NN), Unilateral Notch (UN), or Bilateral Notch (BN). RESULTS: The strongest evidence of a genetic association with the 4000-6000 Hz notch was a nonsynonymous SNP variant in the ESRR- gene (rs61742642:C> T, P386S). Carriers of the minor allele accounted for 26% of all bilateral losses. CONCLUSION: This study indicates that the 4000-6000 Hz bilateral notch is a feasible phenotype for identifying genetic susceptibility to hearing loss.
Full Text
Duke Authors
Cited Authors
- Phillips, SL; Richter, SJ; Teglas, SL; Bhatt, IS; Morehouse, RC; Hauser, ER; Henrich, VC
Published Date
- 2015
Published In
Volume / Issue
- 54 / 10
Start / End Page
- 645 - 652
PubMed ID
- 25938503
Pubmed Central ID
- PMC4785866
Electronic International Standard Serial Number (EISSN)
- 1708-8186
Digital Object Identifier (DOI)
- 10.3109/14992027.2015.1030512
Language
- eng
Conference Location
- England