Molecular-Scale Tools for Studying Mechanotransduction.

Published

Journal Article (Review)

Mechanical stimuli are known to be potent regulators of the form and function of cells and organisms. Although biological regulation has classically been understood in terms of principles from solution biochemistry, advancements in many fields have led to the development of a suite of techniques that are able to reveal the interplay between mechanical loading and changes in the biochemical properties of proteins in systems ranging from single molecules to living organisms. Here, we review these techniques and highlight the emergence of a new molecular-scale understanding of the mechanisms mediating the detection and response of cells to mechanical stimuli, a process termed mechanotransduction. Specifically, we focus on the role of subcellular adhesion structures in sensing the stiffness of the surrounding environment because this process is pertinent to applications in tissue engineering as well the onset of several mechanosensitive disease states, including cancer.

Full Text

Duke Authors

Cited Authors

  • LaCroix, AS; Rothenberg, KE; Hoffman, BD

Published Date

  • January 2015

Published In

Volume / Issue

  • 17 /

Start / End Page

  • 287 - 316

PubMed ID

  • 26421895

Pubmed Central ID

  • 26421895

Electronic International Standard Serial Number (EISSN)

  • 1545-4274

International Standard Serial Number (ISSN)

  • 1523-9829

Digital Object Identifier (DOI)

  • 10.1146/annurev-bioeng-071114-040531

Language

  • eng