Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults.
Publication
, Journal Article
Callahan, ST; Wolff, M; Hill, HR; Edwards, KM; NIAID Vaccine and Treatment Evaluation Unit (VTEU) Pandemic H1N1 Vaccine Study Group,
Published in: J Infect Dis
October 15, 2014
Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from 3 trials of unadjuvanted split-virus H1N1 A/California/07/2009 influenza vaccines, we analyzed serologic responses of participants stratified by BMI grouping. A single vaccine dose produced higher hemagglutination inhibition antibody titers at day 21 in obese compared to nonobese adults, but there were no significant differences in responses to H1N1 vaccine among children or adults of various BMI following 2 doses.
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Published In
J Infect Dis
DOI
EISSN
1537-6613
Publication Date
October 15, 2014
Volume
210
Issue
8
Start / End Page
1270 / 1274
Location
United States
Related Subject Headings
- Young Adult
- Middle Aged
- Microbiology
- Influenza, Human
- Influenza Vaccines
- Influenza A Virus, H1N1 Subtype
- Infant
- Humans
- Child, Preschool
- Child
Citation
APA
Chicago
ICMJE
MLA
NLM
Callahan, S. T., Wolff, M., Hill, H. R., Edwards, K. M., & NIAID Vaccine and Treatment Evaluation Unit (VTEU) Pandemic H1N1 Vaccine Study Group, . (2014). Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults. J Infect Dis, 210(8), 1270–1274. https://doi.org/10.1093/infdis/jiu245
Callahan, S Todd, Mark Wolff, Heather R. Hill, Kathryn M. Edwards, and Kathryn M. NIAID Vaccine and Treatment Evaluation Unit (VTEU) Pandemic H1N1 Vaccine Study Group. “Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults.” J Infect Dis 210, no. 8 (October 15, 2014): 1270–74. https://doi.org/10.1093/infdis/jiu245.
Callahan ST, Wolff M, Hill HR, Edwards KM, NIAID Vaccine and Treatment Evaluation Unit (VTEU) Pandemic H1N1 Vaccine Study Group. Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults. J Infect Dis. 2014 Oct 15;210(8):1270–4.
Callahan, S. Todd, et al. “Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults.” J Infect Dis, vol. 210, no. 8, Oct. 2014, pp. 1270–74. Pubmed, doi:10.1093/infdis/jiu245.
Callahan ST, Wolff M, Hill HR, Edwards KM, NIAID Vaccine and Treatment Evaluation Unit (VTEU) Pandemic H1N1 Vaccine Study Group. Impact of body mass index on immunogenicity of pandemic H1N1 vaccine in children and adults. J Infect Dis. 2014 Oct 15;210(8):1270–1274.
Published In
J Infect Dis
DOI
EISSN
1537-6613
Publication Date
October 15, 2014
Volume
210
Issue
8
Start / End Page
1270 / 1274
Location
United States
Related Subject Headings
- Young Adult
- Middle Aged
- Microbiology
- Influenza, Human
- Influenza Vaccines
- Influenza A Virus, H1N1 Subtype
- Infant
- Humans
- Child, Preschool
- Child