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Emmanuel Benjamin Walter Jr.

Professor of Pediatrics
Pediatrics, General Pediatrics and Adolescent Health
27 Alexandria Way, Suite 100, RTP Box 106008, Durham, NC 27713
27 Alexandria Way, Suite 100, RTP Box 106008, Durham, NC 27713

Overview


Dr. Emmanuel Walter, MD, MPH, Professor of Pediatrics, serves as the Duke Human Vaccine Institute (DHVI) Chief Medical Officer and directs the Duke Vaccine and Trials Unit. In these roles, Dr. Walter provides strategic and operational leadership for clinical research conducted at the Institute.  In addition, he provides oversight of regulatory compliance for DHVI clinical research activities.

Dr. Walter has dedicated his career to advancing research and clinical practice in vaccinology, infectious diseases, and child health. He currently serves as the principal investigator for the Duke Clinical Core of the Collaborative Influenza Vaccine Innovations Centers (CIVICs) funded by the National Institute of Allergy and Infectious Diseases (NIAID).  The goal of this work is to evaluate promising next generation influenza vaccine candidates in Phase I and Phase I/II clinical trials and human challenge studies.  He is also the Duke Principal Investigator for the CDC-funded Clinical Immunization Safety Assessment Project which conducts studies to identify risk factors and preventive strategies for adverse events following immunization, particularly in special populations. Lastly, he is the Principal Investigator for the  CDC-funded coordinating center of the influenza and other respiratory virus vaccine effectiveness network.  This work provides national estimates for influenza and other respiratory virus vaccine effectiveness in persons presenting with respiratory illness in the ambulatory setting.

Dr. Walter's focused area of interest include vaccine development, vaccine safety, vaccine effectiveness, vaccine coverage, prevention and treatment of infectious diseases.

Current Appointments & Affiliations


Professor of Pediatrics · 2009 - Present Pediatrics, General Pediatrics and Adolescent Health, Pediatrics
Member of the Duke Human Vaccine Institute · 2013 - Present Duke Human Vaccine Institute, Institutes and Centers
Affiliate, Duke Global Health Institute · 2020 - Present Duke Global Health Institute, University Institutes and Centers

In the News


Published May 18, 2023
Duke Health Leads Its First Clinical Trial Testing a New Universal Flu Vaccine
Published March 30, 2021
Duke Enrolls First-in-Nation Children for Pfizer-BioNTech U.S. Clinical Study Trial in Children Under 12
Published November 6, 2020
Years in the Making: Duke Human Vaccine Institute Researchers Attack COVID-19

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Recent Publications


Immunogenicity of mRNA COVID-19 vaccine with either simultaneous or sequentially administered inactivated influenza vaccines: a randomized clinical trial.

Journal Article Vaccine · December 10, 2025 BACKGROUND: A U.S. multisite trial was conducted and explored whether blunting of mRNA COVID-19 vaccine immunogenicity occurred when administered simultaneously with influenza vaccine. METHODS: Persons ≥5 years of age received either quadrivalent inactivat ... Full text Link to item Cite

Influenza Vaccine Effectiveness Against Medically Attended Outpatients Illness, United States, 2023-2024 Season.

Journal Article Clin Infect Dis · November 6, 2025 BACKGROUND: The 2023-2024 US influenza season was characterized by a predominance of A(H1N1)pdm09 virus circulation with cocirculation of A(H3N2) and B/Victoria viruses. We estimated vaccine effectiveness (VE) in the United States against mild-to-moderate ... Full text Link to item Cite

Clinical immunization safety assessment (CISA) project: COVID-19 vaccine consultations and case reviews.

Journal Article Vaccine · October 24, 2025 BACKGROUND: The Clinical Immunization Safety Assessment (CISA) Project is a network of vaccine safety experts from the Centers for Disease Control and Prevention (CDC) Immunization Safety Office (ISO) and seven medical research centers. CISA responds to in ... Full text Link to item Cite
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Recent Grants


Duke University Maternal-Fetal Medicine Units (MFMU) Network Clinical Center

ResearchCollaborating Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2023 - 2030

CISA 2023 Clinical Contributing Task 2

ResearchCo-Principal Investigator · Awarded by Centers for Disease Control and Prevention · 2023 - 2028

CISA 2023 Clinical Contributing Task 1

ResearchCo-Principal Investigator · Awarded by Centers for Disease Control and Prevention · 2023 - 2028

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Education, Training & Certifications


University of North Carolina, Chapel Hill · 1992 M.P.H.
University of Maryland, Baltimore · 1983 M.D.
University of Notre Dame · 1979 B.S.