Effects of converting enzyme inhibition with captopril on renal function in normal and ACTH treated sheep.
Publication
, Journal Article
Whitworth, JA; Hammond, TG; Stewart, KW; Mason, RT; Schneider, EG; Denton, DA; Coghlan, JP; Scoggins, BA
Published in: Clin Exp Pharmacol Physiol
1982
1. The effect on renal function in sheep of inhibiting converting enzyme with captopril was examined before and after 5 days ACTH administration. 2. Glomerular filtration rate, effective renal plasma flow, effective renal blood flow, mean arterial pressure and plasma sodium were all significantly increased by ACTH treatment and plasma potassium was decreased. Captopril (20 mg i.v.) had no effect on renal function or blood pressure before or after ACTH treatment, although urinary potassium excretion decreased following captopril on day 6 of ACTH treatment. 3. The increase in glomerular filtration rate and effective renal plasma flow seen with ACTH treatment in sheep does not appear to be mediated by the reninangiotensin system.
Duke Scholars
Published In
Clin Exp Pharmacol Physiol
DOI
ISSN
0305-1870
Publication Date
1982
Volume
9
Issue
5
Start / End Page
505 / 509
Location
Australia
Related Subject Headings
- Sodium
- Sheep
- Proline
- Potassium
- Physiology
- Kidney
- Hypertension
- Glomerular Filtration Rate
- Female
- Captopril
Citation
APA
Chicago
ICMJE
MLA
NLM
Whitworth, J. A., Hammond, T. G., Stewart, K. W., Mason, R. T., Schneider, E. G., Denton, D. A., … Scoggins, B. A. (1982). Effects of converting enzyme inhibition with captopril on renal function in normal and ACTH treated sheep. Clin Exp Pharmacol Physiol, 9(5), 505–509. https://doi.org/10.1111/j.1440-1681.1982.tb00825.x
Whitworth, J. A., T. G. Hammond, K. W. Stewart, R. T. Mason, E. G. Schneider, D. A. Denton, J. P. Coghlan, and B. A. Scoggins. “Effects of converting enzyme inhibition with captopril on renal function in normal and ACTH treated sheep.” Clin Exp Pharmacol Physiol 9, no. 5 (1982): 505–9. https://doi.org/10.1111/j.1440-1681.1982.tb00825.x.
Whitworth JA, Hammond TG, Stewart KW, Mason RT, Schneider EG, Denton DA, et al. Effects of converting enzyme inhibition with captopril on renal function in normal and ACTH treated sheep. Clin Exp Pharmacol Physiol. 1982;9(5):505–9.
Whitworth, J. A., et al. “Effects of converting enzyme inhibition with captopril on renal function in normal and ACTH treated sheep.” Clin Exp Pharmacol Physiol, vol. 9, no. 5, 1982, pp. 505–09. Pubmed, doi:10.1111/j.1440-1681.1982.tb00825.x.
Whitworth JA, Hammond TG, Stewart KW, Mason RT, Schneider EG, Denton DA, Coghlan JP, Scoggins BA. Effects of converting enzyme inhibition with captopril on renal function in normal and ACTH treated sheep. Clin Exp Pharmacol Physiol. 1982;9(5):505–509.
Published In
Clin Exp Pharmacol Physiol
DOI
ISSN
0305-1870
Publication Date
1982
Volume
9
Issue
5
Start / End Page
505 / 509
Location
Australia
Related Subject Headings
- Sodium
- Sheep
- Proline
- Potassium
- Physiology
- Kidney
- Hypertension
- Glomerular Filtration Rate
- Female
- Captopril