Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Nephrology, Medicine, University of Wisconsin - Madison 1989 - 1990
  • Resident, Medicine, University of Wisconsin - Madison 1987 - 1989
  • M.B.B.S., University of Melbourne (Australia) 1981
• 

  Duke Appointment History

  • Instructor, Temporary in the Department of Medicine, Medicine, Nephrology, Medicine 2009
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Hammond, Timothy G., Patricia L. Allen, and Holly H. Birdsall. “Effects of Space Flight on Mouse Liver versus Kidney: Gene Pathway Analyses.” Int J Mol Sci 19, no. 12 (December 18, 2018). https://doi.org/10.3390/ijms19124106.
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    • Hammond, T. G., P. L. Allen, and H. H. Birdsall. “Gene Pathways Analysis of the Effects of Suspension Culture on Primary Human Renal Proximal Tubular Cells.” Microgravity Science and Technology 30, no. 6 (December 1, 2018): 951–63. https://doi.org/10.1007/s12217-018-9658-x.
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    • Hammond, Timothy G., Patricia L. Allen, Margaret A. Gunter, Jennifer Chiang, Guri Giaever, Corey Nislow, and Holly H. Birdsall. “Physical Forces Modulate Oxidative Status and Stress Defense Meditated Metabolic Adaptation of Yeast Colonies: Spaceflight and Microgravity Simulations.” Microgravity Sci Technol 30, no. 3 (2018): 195–208. https://doi.org/10.1007/s12217-017-9588-z.
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    • Hammond, Timothy G., and Holly H. Birdsall. “Hepatocyte CYP2B6 Can Be Expressed in Cell Culture Systems by Exerting Physiological Levels of Shear: Implications for ADME Testing.” J Toxicol 2017 (2017): 1907952. https://doi.org/10.1155/2017/1907952.
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    • Hammond, Timothy, Patricia Allen, and Holly Birdsall. “Is There a Space-Based Technology Solution to Problems with Preclinical Drug Toxicity Testing?” Pharm Res 33, no. 7 (July 2016): 1545–51. https://doi.org/10.1007/s11095-016-1942-0.
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    • Nislow, Corey, Anna Y. Lee, Patricia L. Allen, Guri Giaever, Andrew Smith, Marinella Gebbia, Louis S. Stodieck, Jeffrey S. Hammond, Holly H. Birdsall, and Timothy G. Hammond. “Genes required for survival in microgravity revealed by genome-wide yeast deletion collections cultured during spaceflight.” Biomed Res Int 2015 (2015): 976458. https://doi.org/10.1155/2015/976458.
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    • Hammond, T. G., H. H. Birdsall, J. S. Hammond, and P. L. Allen. “Optimizing host-pathogen in-flight assays for c. Elegans and methicillin-resistant staphylococcus aureus.” European Space Agency, (Special Publication) Esa Sp 706 SP (December 1, 2013).
    • Hammond, Timothy G., Louis Stodieck, Holly H. Birdsall, Jeanne L. Becker, Paul Koenig, Jeffrey S. Hammond, Margaret A. Gunter, and Patricia L. Allen. “Effects of microgravity on the virulence of Listeria monocytogenes, Enterococcus faecalis, Candida albicans, and methicillin-resistant Staphylococcus aureus.” Astrobiology 13, no. 11 (November 2013): 1081–90. https://doi.org/10.1089/ast.2013.0986.
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    • Hammond, T. G., L. Stodieck, H. H. Birdsall, J. Becker, P. Koenig, J. S. Hammond, M. A. Gunter, and P. L. Allen. “Effects of Microgravity on the Virulence of Salmonella Toward Caenorhabditis elegans.” New Space 1, no. 3 (January 1, 2013): 123–31. https://doi.org/10.1089/space.2013.0011.
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    • Hammond, T., and P. Allen. “The Bonn criteria: Minimal experimental parameter reporting for clinostat and random positioning machine experiments with cells and tissues.” Microgravity Science and Technology 23, no. 2 (February 1, 2011): 271–75. https://doi.org/10.1007/s12217-010-9226-5.
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    • Allen, D. L., E. R. Bandstra, B. C. Harrison, S. Thorng, L. S. Stodieck, P. J. Kostenuik, S. Morony, et al. “Erratum: Effects of spaceflight on murine skeletal muscle gene expression (Journal of Applied Physiology (2009) 106 (582-595) DOI: 10.1152/japplphysiol. 90780.2008).” Journal of Applied Physiology 110, no. 1 (January 1, 2011): 299. https://doi.org/10.1152/japplphysiol.zdg-9426-corr.2010.
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    • Allen, David L., Eric R. Bandstra, Brooke C. Harrison, Seiha Thorng, Louis S. Stodieck, Paul J. Kostenuik, Sean Morony, et al. “Effects of spaceflight on murine skeletal muscle gene expression.” J Appl Physiol (1985) 106, no. 2 (February 2009): 582–95. https://doi.org/10.1152/japplphysiol.90780.2008.
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    • Coleman, Chasity B., Patricia L. Allen, Mark Rupert, Carla Goulart, Alexander Hoehn, Louis S. Stodieck, and Timothy G. Hammond. “Novel Sfp1 transcriptional regulation of Saccharomyces cerevisiae gene expression changes during spaceflight.” Astrobiology 8, no. 6 (December 2008): 1071–78. https://doi.org/10.1089/ast.2007.0211.
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    • Coleman, Chasity B., Patricia L. Allen, James M. Valles, and Timothy G. Hammond. “Transcriptional regulation of changes in growth, cell cycle, and gene expression of Saccharomyces cerevisiae due to changes in buoyancy.” Biotechnol Bioeng 100, no. 2 (June 1, 2008): 334–43. https://doi.org/10.1002/bit.21748.
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    • Pohorille, A., T. Hammond, K. Schweighofer, P. Allen, L. Stodieck, T. Bateman, N. Szewczyk, and S. Chang. “Spaceflight-induced gene expression changes in the mouse liver and kidney.” International Astronautical Federation  58th International Astronautical Congress 2007 1 (December 1, 2007): 112–13.
    • Coleman, Chasity B., Romer A. Gonzalez-Villalobos, Patricia L. Allen, Kelly Johanson, Karine Guevorkian, James M. Valles, and Timothy G. Hammond. “Diamagnetic levitation changes growth, cell cycle, and gene expression of Saccharomyces cerevisiae.” Biotechnol Bioeng 98, no. 4 (November 1, 2007): 854–63. https://doi.org/10.1002/bit.21526.
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    • Wilson, J. W., C. M. Ott, K. Höner zu Bentrup, R. Ramamurthy, L. Quick, S. Porwollik, P. Cheng, et al. “Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq.” Proceedings of the National Academy of Sciences of the United States of America 104, no. 41 (October 2007): 16299–304. https://doi.org/10.1073/pnas.0707155104.
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    • Caplanusi, Adrian, Andrew J. Fuller, Romer A. Gonzalez-Villalobos, Timothy G. Hammond, and L. G. Navar. “Metabolic inhibition-induced transient Ca2+ increase depends on mitochondria in a human proximal renal cell line.” Am J Physiol Renal Physiol 293, no. 2 (August 2007): F533–40. https://doi.org/10.1152/ajprenal.00030.2007.
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    • Morré, D James, and Timothy Hammond. “Isolation of renal brush borders.” Curr Protoc Cell Biol Chapter 3 (March 2007): Unit-3.26. https://doi.org/10.1002/0471143030.cb0326s34.
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    • Johanson, K., P. L. Allen, R. A. Gonzalez-Villalobos, J. Nesbit, C. A. Nickerson, K. Höner zu Bentrup, J. W. Wilson, et al. “Haploid deletion strains of Saccharomyces cerevisiae that determine survival during space flight.” Acta Astronautica 60, no. 4-7 SPEC. ISS. (February 1, 2007): 460–71. https://doi.org/10.1016/j.actaastro.2006.09.011.
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    • Gonzalez-Villalobos, Romer, R Bryan Klassen, Patricia L. Allen, Kelly Johanson, Chasity B. Baker, Hiroyuki Kobori, L. G. Navar, and Timothy G. Hammond. “Megalin binds and internalizes angiotensin-(1-7).” Am J Physiol Renal Physiol 290, no. 5 (May 2006): F1270–75. https://doi.org/10.1152/ajprenal.00164.2005.
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    • Johanson, Kelly, Patricia L. Allen, Romer A. Gonzalez-Villalobos, Chasity B. Baker, Riccardo D’Elia, and Timothy G. Hammond. “Gene expression and survival changes in Saccharomyces cerevisiae during suspension culture.” Biotechnol Bioeng 93, no. 6 (April 20, 2006): 1050–59. https://doi.org/10.1002/bit.20810.
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    • D’Elia, Riccardo, Patricia L. Allen, Kelly Johanson, Cheryl A. Nickerson, and Timothy G. Hammond. “Homozygous diploid deletion strains of Saccharomyces cerevisiae that determine lag phase and dehydration tolerance.” Appl Microbiol Biotechnol 67, no. 6 (June 2005): 816–26. https://doi.org/10.1007/s00253-004-1793-1.
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    • Shivakumar, Bangalore R., Zoufei Wang, Timothy G. Hammond, and Raymond C. Harris. “EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor.” Cell Biochem Funct 23, no. 3 (May 2005): 195–204. https://doi.org/10.1002/cbf.1176.
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    • Gonzalez-Villalobos, Romer, R Bryan Klassen, Patricia L. Allen, L. G. Navar, and Timothy G. Hammond. “Megalin binds and internalizes angiotensin II.” Am J Physiol Renal Physiol 288, no. 2 (February 2005): F420–27. https://doi.org/10.1152/ajprenal.00243.2004.
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    • Klassen, R Bryan S., Patricia L. Allen, Vecihi Batuman, Kimberly Crenshaw, and Timothy G. Hammond. “Light chains are a ligand for megalin.” J Appl Physiol (1985) 98, no. 1 (January 2005): 257–63. https://doi.org/10.1152/japplphysiol.01090.2003.
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    • Klassen, R Bryan, Kimberly Crenshaw, Renata Kozyraki, Pierre J. Verroust, Laura Tio, Sílvia Atrian, Patricia L. Allen, and Timothy G. Hammond. “Megalin mediates renal uptake of heavy metal metallothionein complexes.” Am J Physiol Renal Physiol 287, no. 3 (September 2004): F393–403. https://doi.org/10.1152/ajprenal.00233.2003.
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    • Struckhoff, Amanda P., Robert Bittman, Matthew E. Burow, Sanda Clejan, Steven Elliott, Timothy Hammond, Yan Tang, and Barbara S. Beckman. “Novel ceramide analogs as potential chemotherapeutic agents in breast cancer.” J Pharmacol Exp Ther 309, no. 2 (May 2004): 523–32. https://doi.org/10.1124/jpet.103.062760.
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    • Klaus, David M., Michael R. Benoit, Emily S. Nelson, and Timmothy G. Hammond. “Extracellular mass transport considerations for space flight research concerning suspended and adherent in vitro cell cultures.” J Gravit Physiol 11, no. 1 (March 2004): 17–27.
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    • Becker, Bryan N., Hui-fang Cheng, Timothy G. Hammond, and Raymond C. Harris. “The type 1 angiotensin II receptor tail affects receptor targeting, internalization, and membrane fusion properties.” Mol Pharmacol 65, no. 2 (February 2004): 362–69. https://doi.org/10.1124/mol.65.2.362.
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    • Gambelli, Federica, Peter Di, Xiaomei Niu, Mitchell Friedman, Timothy Hammond, David W. H. Riches, and Luis A. Ortiz. “Phosphorylation of tumor necrosis factor receptor 1 (p55) protects macrophages from silica-induced apoptosis.” J Biol Chem 279, no. 3 (January 16, 2004): 2020–29. https://doi.org/10.1074/jbc.M309763200.
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    • Nickerson, Cheryl A., C Mark Ott, James W. Wilson, Rajee Ramamurthy, Carly L. LeBlanc, Kerstin Höner zu Bentrup, Timothy Hammond, and Duane L. Pierson. “Low-shear modeled microgravity: a global environmental regulatory signal affecting bacterial gene expression, physiology, and pathogenesis.” J Microbiol Methods 54, no. 1 (July 2003): 1–11. https://doi.org/10.1016/s0167-7012(03)00018-6.
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    • Puliyanda, Dechu P., Donald T. Ward, Michelle A. Baum, Timothy G. Hammond, and H William Harris. “Calpain-mediated AQP2 proteolysis in inner medullary collecting duct.” Biochem Biophys Res Commun 303, no. 1 (March 28, 2003): 52–58. https://doi.org/10.1016/s0006-291x(03)00215-8.
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    • Braam, Branko, Pat Allen, Ed Benes, Hein A. Koomans, L Gabriel Navar, and Timothy Hammond. “Human proximal tubular cell responses to angiotensin II analyzed using DNA microarray.” Eur J Pharmacol 464, no. 2–3 (March 19, 2003): 87–94. https://doi.org/10.1016/s0014-2999(03)01382-7.
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    • Johanson, Kelly, Patricia L. Allen, Fawn Lewis, Luis A. Cubano, Linda E. Hyman, and Timothy G. Hammond. “Saccharomyces cerevisiae gene expression changes during rotating wall vessel suspension culture.” J Appl Physiol (1985) 93, no. 6 (December 2002): 2171–80. https://doi.org/10.1152/japplphysiol.01087.2001.
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    • Wilson, James W., Rajee Ramamurthy, Steffen Porwollik, Michael McClelland, Timothy Hammond, Pat Allen, C Mark Ott, Duane L. Pierson, and Cheryl A. Nickerson. “Microarray analysis identifies Salmonella genes belonging to the low-shear modeled microgravity regulon.” Proc Natl Acad Sci U S A 99, no. 21 (October 15, 2002): 13807–12. https://doi.org/10.1073/pnas.212387899.
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    • Saban, Marcia R., Ngoc-Bich Nguyen, Timothy G. Hammond, and Ricardo Saban. “Gene expression profiling of mouse bladder inflammatory responses to LPS, substance P, and antigen-stimulation.” Am J Pathol 160, no. 6 (June 2002): 2095–2110. https://doi.org/10.1016/S0002-9440(10)61159-5.
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    • Cowger, Nancy L., Edmund Benes, Patricia L. Allen, and Timothy G. Hammond. “Expression of renal cell protein markers is dependent on initial mechanical culture conditions.” J Appl Physiol (1985) 92, no. 2 (February 2002): 691–700. https://doi.org/10.1152/jappl.2002.92.2.691.
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    • Saban, M. R., R. Saban, T. G. Hammond, M. Haak-Frendscho, H. Steinberg, M. W. Tengowski, and D. E. Bjorling. “LPS-sensory peptide communication in experimental cystitis.” Am J Physiol Renal Physiol 282, no. 2 (February 2002): F202–10. https://doi.org/10.1152/ajprenal.0163.2001.
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    • Saban, R., M. R. Saban, N. B. Nguyen, T. G. Hammond, and B. K. Wershil. “Mast cell regulation of inflammation and gene expression during antigen-induced bladder inflammation in mice.” Physiological Genomics 2002, no. 7 (January 1, 2002): 35–43.
    • Zhuo, Jia L., John D. Imig, Timothy G. Hammond, Sheyla Orengo, Edmund Benes, and L Gabriel Navar. “Ang II accumulation in rat renal endosomes during Ang II-induced hypertension: role of AT(1) receptor.” Hypertension 39, no. 1 (January 2002): 116–21. https://doi.org/10.1161/hy0102.100780.
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    • Hammond, T. G., L. A. Cubano, J. Love, T. Baker, T. J. Goodwin, and P. L. Alien. “Mechanical culture conditions effect gene expression.” 2001 Conference and Exhibit on International Space Station Utilization, December 1, 2001.
    • Jo, I., D. T. Ward, M. A. Baum, J. D. Scott, V. M. Coghlan, T. G. Hammond, and H. W. Harris. “AQP2 is a substrate for endogenous PP2B activity within an inner medullary AKAP-signaling complex.” Am J Physiol Renal Physiol 281, no. 5 (November 2001): F958–65. https://doi.org/10.1152/ajprenal.2001.281.5.F958.
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    • Nickerson, C. A., T. J. Goodwin, J. Terlonge, C. M. Ott, K. L. Buchanan, W. C. Uicker, K. Emami, et al. “Three-dimensional tissue assemblies: novel models for the study of Salmonella enterica serovar Typhimurium pathogenesis.” Infect Immun 69, no. 11 (November 2001): 7106–20. https://doi.org/10.1128/IAI.69.11.7106-7120.2001.
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    • Saban, R., M. R. Saban, N. B. Nguyen, T. G. Hammond, and B. K. Wershil. “Mast cell regulation of inflammation and gene expression during antigen-induced bladder inflammation in mice.” Physiol Genomics 7, no. 1 (October 10, 2001): 35–43. https://doi.org/10.1152/physiolgenomics.00044.2001.
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    • Hammond, T. G., and J. M. Hammond. “Optimized suspension culture: the rotating-wall vessel.” Am J Physiol Renal Physiol 281, no. 1 (July 2001): F12–25. https://doi.org/10.1152/ajprenal.2001.281.1.F12.
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    • Saban, M. R., N. B. Nguyen, T. G. Hammond, and R. Saban. “cDNA array of lipopolysaccharide-induced bladder gene expression.” Urology 57, no. 6 Suppl 1 (June 2001): 117. https://doi.org/10.1016/s0090-4295(01)01064-0.
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    • Wang, X. C., J. H. Kaysen, R. Saban, P. L. Allen, E. N. Benses, and T. G. Hammond. “cDNA expression arrays: the effects of lactacystin in lipopolysaccharide-induced cystitis.” Urology 57, no. 6 Suppl 1 (June 2001): 114–15. https://doi.org/10.1016/s0090-4295(01)01056-1.
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    • Saban, M. R., H. Hellmich, N. B. Nguyen, J. Winston, T. G. Hammond, and R. Saban. “Time course of LPS-induced gene expression in a mouse model of genitourinary inflammation.” Physiol Genomics 5, no. 3 (April 2, 2001): 147–60. https://doi.org/10.1152/physiolgenomics.2001.5.3.147.
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    • DeLucas, L. J., R. J. Bula, T. Hammond, and N. R. Pellis. “A review of microgravity biotechnology.” 38th Aerospace Sciences Meeting and Exhibit, December 1, 2000.
    • Goodwin, T. J., L. Coate-Li, R. M. Linnehan, and T. G. Hammond. “Selected contribution: a three-dimensional model for assessment of in vitro toxicity in balaena mysticetus renal tissue.” Journal of Applied Physiology (Bethesda, Md. : 1985) 89, no. 6 (December 2000): 2508–17. https://doi.org/10.1152/jappl.2000.89.6.2508.
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    • Hammond, T. G., E. Benes, K. C. O’Reilly, D. A. Wolf, R. M. Linnehan, A. Taher, J. H. Kaysen, P. L. Allen, and T. J. Goodwin. “Mechanical culture conditions effect gene expression: gravity-induced changes on the space shuttle.” Physiol Genomics 3, no. 3 (September 8, 2000): 163–73. https://doi.org/10.1152/physiolgenomics.2000.3.3.163.
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    • Hammond, T. G., R. Saban, K. L. Bost, H. W. Harris, J. H. Kaysen, F. O. Goda, X. C. Wang, et al. “Substance P dependence of endosomal fusion during bladder inflammation.” Am J Physiol Renal Physiol 278, no. 3 (March 2000): F440–51. https://doi.org/10.1152/ajprenal.2000.278.3.F440.
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    • Saban, R., M. R. Saban, N. B. Nguyen, B. Lu, C. Gerard, N. P. Gerard, and T. G. Hammond. “Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis.” Am J Pathol 156, no. 3 (March 2000): 775–80. https://doi.org/10.1016/S0002-9440(10)64944-9.
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    • Wang, X. C., R. Saban, J. H. Kaysen, M. R. Saban, P. L. Allen, E. N. Benes, and T. G. Hammond. “Nuclear factor kappa B mediates lipopolysaccharide-induced inflammation in the urinary bladder.” J Urol 163, no. 3 (March 2000): 993–98.
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    • Verroust, P. J., R. Kozyraki, T. G. Hammond, S. K. Moestrup, and E. I. Christensen. “Physiopathologic role of cubilin and megalin.” Adv Nephrol Necker Hosp 30 (2000): 127–45.
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    • Imig, J. D., G. L. Navar, L. X. Zou, K. C. O’Reilly, P. L. Allen, J. H. Kaysen, T. G. Hammond, and L. G. Navar. “Renal endosomes contain angiotensin peptides, converting enzyme, and AT(1A) receptors.” Am J Physiol 277, no. 2 (August 1999): F303–11. https://doi.org/10.1152/ajprenal.1999.277.2.F303.
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    • Hammond, T. G., F. C. Lewis, T. J. Goodwin, R. M. Linnehan, D. A. Wolf, K. P. Hire, W. C. Campbell, et al. “Gene expression in space.” Nat Med 5, no. 4 (April 1999): 359. https://doi.org/10.1038/7331.
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    • Marriott, I., T. G. Hammond, E. K. Thomas, and K. L. Bost. “Salmonella efficiently enter and survive within cultured CD11c+ dendritic cells initiating cytokine expression.” Eur J Immunol 29, no. 4 (April 1999): 1107–15. https://doi.org/10.1002/(SICI)1521-4141(199904)29:04<1107::AID-IMMU1107>3.0.CO;2-0.
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    • Kaysen, J. H., W. C. Campbell, R. R. Majewski, F. O. Goda, G. L. Navar, F. C. Lewis, T. J. Goodwin, and T. G. Hammond. “Select de novo gene and protein expression during renal epithelial cell culture in rotating wall vessels is shear stress dependent.” J Membr Biol 168, no. 1 (March 1, 1999): 77–89. https://doi.org/10.1007/s002329900499.
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    • Cowger, N. L., K. C. O’Connor, T. G. Hammond, D. J. Lacks, and G. L. Navar. “Characterization of bimodal cell death of insect cells in a rotating- wall vessel and shaker flask.” Biotechnology and Bioengineering 64, no. 1 (1999): 14–26. https://doi.org/10.1002/(SICI)1097-0290(19990705)64:1<14::AID-BIT2>3.0.CO;2-R.
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    • Hammond, T. G., A. Hu, J. M. Hammond, M. V. Relling, and J. L. Underwood. “Detection of point mutations on a DNA microchip.” Clinical Immunology Newsletter 19, no. 12 (January 1, 1999): 121–26. https://doi.org/10.1016/S0197-1859(00)88685-9.
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    • Ward, D. T., T. G. Hammond, and H. W. Harris. “Modulation of vasopressin-elicited water transport by trafficking of aquaporin2-containing vesicles.” Annu Rev Physiol 61 (1999): 683–97. https://doi.org/10.1146/annurev.physiol.61.1.683.
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    • Busser, B. W., T. G. Hammond, D. E. Bjorling, and R. Saban. “Lipopolysaccharide upregulates bradykinin 1 receptors in the isolated mouse bladder.” J Urol 160, no. 6 Pt 1 (December 1998): 2267–73. https://doi.org/10.1097/00005392-199812010-00098.
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    • Ortiz, L. A., K. Moroz, J. Y. Liu, G. W. Hoyle, T. Hammond, R. F. Hamilton, A. Holian, W. Banks, A. R. Brody, and M. Friedman. “Alveolar macrophage apoptosis and TNF-alpha, but not p53, expression correlate with murine response to bleomycin.” Am J Physiol 275, no. 6 (December 1998): L1208–18. https://doi.org/10.1152/ajplung.1998.275.6.L1208.
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    • Burow, M. E., C. B. Weldon, Y. Tang, G. L. Navar, S. Krajewski, J. C. Reed, T. G. Hammond, S. Clejan, and B. S. Beckman. “Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants.” Cancer Research 58, no. 21 (November 1998): 4940–46.
    • Luyckx, V. A., F. O. Goda, D. B. Mount, T. Nishio, A. Hall, S. C. Hebert, T. G. Hammond, and A. S. Yu. “Intrarenal and subcellular localization of rat CLC5.” Am J Physiol 275, no. 5 (November 1998): F761–69. https://doi.org/10.1152/ajprenal.1998.275.5.F761.
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    • Batuman, V., P. J. Verroust, G. L. Navar, J. H. Kaysen, F. O. Goda, W. C. Campbell, E. Simon, et al. “Myeloma light chains are ligands for cubilin (gp280).” The American Journal of Physiology 275, no. 2 (August 1998): F246–54. https://doi.org/10.1152/ajprenal.1998.275.2.f246.
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    • Hammond, T. G., F. O. Goda, G. L. Navar, W. C. Campbell, R. R. Majewski, D. L. Galvan, F. Pontillon, et al. “Membrane potential mediates H(+)-ATPase dependence of "degradative pathway" endosomal fusion.” J Membr Biol 162, no. 2 (March 15, 1998): 157–67. https://doi.org/10.1007/s002329900353.
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    • Moestrup, S. K., R. Kozyraki, M. Kristiansen, J. H. Kaysen, H. H. Rasmussen, D. Brault, F. Pontillon, et al. “The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins.” J Biol Chem 273, no. 9 (February 27, 1998): 5235–42. https://doi.org/10.1074/jbc.273.9.5235.
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    • Lockyer, J. M., J. S. Colladay, W. L. Alperin-Lea, T. Hammond, and A. J. Buda. “Inhibition of nuclear factor-kappaB-mediated adhesion molecule expression in human endothelial cells.” Circ Res 82, no. 3 (February 23, 1998): 314–20. https://doi.org/10.1161/01.res.82.3.314.
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    • Saban, R., T. G. Hammond, B. W. Busser, and D. E. Bjorling. “Lipopolysaccharide (LPS) Upregulates Bradykinin 1 (BK1) receptors in the isolated mouse bladder.” Faseb Journal 12, no. 4 (1998).
    • Hammond, T. G., R. R. Majewski, J. H. Kaysen, F. O. Goda, G. L. Navar, F. Pontillon, and P. J. Verroust. “Gentamicin inhibits rat renal cortical homotypic endosomal fusion: Role of megalin.” American Journal of Physiology 272, no. 1 PART 2 (December 1, 1997).
    • Seetharam, B., E. I. Christensen, S. K. Moestrup, T. G. Hammond, and P. J. Verroust. “Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor.” J Clin Invest 99, no. 10 (May 15, 1997): 2317–22. https://doi.org/10.1172/JCI119411.
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    • Hammond, T. G., R. R. Majewski, J. H. Kaysen, F. O. Goda, G. L. Navar, F. Pontillon, and P. J. Verroust. “Gentamicin inhibits rat renal cortical homotypic endosomal fusion: role of megalin.” Am J Physiol 272, no. 1 Pt 2 (January 1997): F117–23. https://doi.org/10.1152/ajprenal.1997.272.1.F117.
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    • Hammond, T. G., M. L. Zeidel, M. L. De Biorling, M. R. Saban, and R. Safaan. “Neurokinin-1 (substance p) receptor mediated inhibition of endosomal fusion in transitional epithelial cells during acute urinary bladder inflammation.” Faseb Journal 10, no. 6 (December 1, 1996).
    • Verroust, P. J., E. I. Christensen, and T. G. Hammond. “[Vesicular flow in epithelial cells: physiopathologic importance of two multiligand receptors].” Bull Acad Natl Med 180, no. 6 (June 1996): 1187–97.
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    • Siner, J., A. Paredes, C. Hosselet, T. Hammond, K. Strange, and H. W. Harris. “Cloning of an aquaporin homologue present in water channel containing endosomes of toad urinary bladder.” Am J Physiol 270, no. 1 Pt 1 (January 1996): C372–81. https://doi.org/10.1152/ajpcell.1996.270.1.C372.
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    • Verroust, P. J., E. I. Christensen, and T. G. Hammond. “[Endocytosis and receptors: molecular and physiological aspects].” Nephrologie 17, no. 7 (1996): 359–64.
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    • Bose, S., S. Seetharam, T. G. Hammond, and B. Seetharam. “Regulation of expression of transcobalamin II receptor in the rat.” Biochem J 310 ( Pt 3) (September 15, 1995): 923–29. https://doi.org/10.1042/bj3100923.
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    • Christensen, E. I., S. Nielsen, S. K. Moestrup, C. Borre, A. B. Maunsbach, E. de Heer, P. Ronco, T. G. Hammond, and P. Verroust. “Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules.” Eur J Cell Biol 66, no. 4 (April 1995): 349–64.
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    • Jo, I., H. W. Harris, A. M. Amendt-Raduege, R. R. Majewski, and T. G. Hammond. “Rat kidney papilla contains abundant synaptobrevin protein that participates in the fusion of antidiuretic hormone-regulated water channel-containing endosomes in vitro.” Proc Natl Acad Sci U S A 92, no. 6 (March 14, 1995): 1876–80. https://doi.org/10.1073/pnas.92.6.1876.
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    • Hammond, T. G., R. R. Majewski, K. E. Muse, T. D. Oberley, L. W. Morrissey, and A. M. Amendt-Raduege. “Energy transfer assays of rat renal cortical endosomal fusion: evidence for superfusion.” Am J Physiol 267, no. 6 Pt 2 (December 1994): F1021–33. https://doi.org/10.1152/ajprenal.1994.267.6.F1021.
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    • Hammond, T. G., R. R. Majewski, K. E. Muse, T. D. Oberley, L. W. Morrissey, and A. M. Amendt-Raduege. “Energy transfer assays of rat renal cortical endosomal fusion: Evidence for superfusion.” Am.J.Physiol. 267, no. 6 part 2 (December 1, 1994).
    • Chang, A., T. G. Hammond, T. T. Sun, and M. L. Zeidel. “Permeability properties of the mammalian bladder apical membrane.” The American Journal of Physiology 267, no. 5 Pt 1 (November 1994): C1483–92. https://doi.org/10.1152/ajpcell.1994.267.5.c1483.
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    • Hammond, T. G., P. J. Verroust, R. R. Majewski, K. E. Muse, and T. D. Oberley. “Heavy endosomes isolated from the rat renal cortex show attributes of intermicrovillar clefts.” Am J Physiol 267, no. 4 Pt 2 (October 1994): F516–27. https://doi.org/10.1152/ajprenal.1994.267.4.F516.
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    • Hammond, T. G., and P. J. Verroust. “Heterogeneity of endosomal populations in the rat renal cortex: light endosomes.” Am J Physiol 266, no. 6 Pt 1 (June 1994): C1783–94. https://doi.org/10.1152/ajpcell.1994.266.6.C1783.
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    • Morré, D. J., J. Lawrence, K. Safranski, T. Hammond, and D. M. Morré. “Experimental basis for separation of membrane vesicles by preparative free-flow electrophoresis.” J Chromatogr A 668, no. 1 (May 6, 1994): 201–13. https://doi.org/10.1016/0021-9673(94)80110-X.
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    • Lee, F. T., K. M. Leahy-Gross, T. G. Hammond, M. J. Wakeen, and S. W. Zimmerman. “Pneumoperitoneum in peritoneal dialysis patients: significance of diagnosis by CT.” J Comput Assist Tomogr 18, no. 3 (May 1994): 439–42. https://doi.org/10.1097/00004728-199405000-00018.
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    • Harris, H. W., M. L. Zeidel, I. Jo, and T. G. Hammond. “Characterization of purified endosomes containing the antidiuretic hormone-sensitive water channel from rat renal papilla.” J Biol Chem 269, no. 16 (April 22, 1994): 11993–0.
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    • Hammond, T. G., and P. J. Verroust. “Trafficking of apical proteins into clathrin-coated vesicles isolated from rat renal cortex.” Am J Physiol 266, no. 4 Pt 2 (April 1994): F554–62. https://doi.org/10.1152/ajprenal.1994.266.4.F554.
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    • Hammond, T. G., P. J. Verroust, R. R. Majewski, K. E. Muse, and T. D. Oberley. “Heavy endosomes isolated from the rat renal cortex show attributes of intermicrovillar clefts.” Am.J.Physiol. 267, no. 4 part 2 (January 1, 1994).
    • Hammond, T. G., and P. J. Verroust. “Heterogeneity of endosomal populations in the rat renal cortex: Light endosomes.” Am.J.Physiol. 266, no. 6 part 1 (January 1, 1994).
    • Hammond, T. G., and P. J. Verroust. “Trafficking of apical proteins into clathri-coated vesicles isolated from rat renal cortex.” Am.J.Physiol. 266, no. 4 part 2 (January 1, 1994).
    • Piqueras, A. I., M. Somers, T. G. Hammond, K. Strange, H. W. Harris Jnr, M. Gawryl, and M. L. Zeidel. “Permeability properties of rat renal lysosomes.” Am.J.Physiol. 266, no. 1 part 1 (January 1, 1994).
    • Piqueras, A. I., M. Somers, T. G. Hammond, K. Strange, H. W. Harris, M. Gawryl, and M. L. Zeidel. “Permeability properties of rat renal lysosomes.” Am J Physiol 266, no. 1 Pt 1 (January 1994): C121–33. https://doi.org/10.1152/ajpcell.1994.266.1.C121.
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    • Hammond, T. G., D. J. Morré, H. W. Harris, and M. L. Zeidel. “Isolation of highly purified, functional endosomes from toad urinary bladder.” Biochem J 295 ( Pt 2) (October 15, 1993): 471–76. https://doi.org/10.1042/bj2950471.
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    • Zeidel, M. L., T. G. Hammond, J. B. Wade, J. Tucker, and H. W. Harris. “Fate of antidiuretic hormone water channel proteins after retrieval from apical membrane.” Am J Physiol 265, no. 3 Pt 1 (September 1993): C822–33. https://doi.org/10.1152/ajpcell.1993.265.3.C822.
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    • Hammond, T. G., R. R. Majewski, J. J. Onorato, P. C. Brazy, and D. J. Morré. “Isolation and characterization of renal cortical membranes using an aqueous two-phase partition technique.” Biochem J 292 ( Pt 3) (June 15, 1993): 743–48. https://doi.org/10.1042/bj2920743.
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    • Ateshkadi, A., C. A. Johnson, L. L. Oxton, T. G. Hammond, W. S. Bohenek, and S. W. Zimmerman. “Pharmacokinetics of intraperitoneal, intravenous, and subcutaneous recombinant human erythropoietin in patients on continuous ambulatory peritoneal dialysis.” Am J Kidney Dis 21, no. 6 (June 1993): 635–42. https://doi.org/10.1016/s0272-6386(12)80037-0.
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    • Hammond, T. G., R. R. Majewski, D. J. Morré, K. Schell, and L. W. Morrissey. “Forward scatter pulse width signals resolve multiple populations of endosomes.” Cytometry 14, no. 4 (1993): 411–20. https://doi.org/10.1002/cyto.990140410.
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    • Hammond, T. G. “Analysis and isolation of renal tubular cells by flow cytometry.” Kidney Int 42, no. 4 (October 1992): 997–1005. https://doi.org/10.1038/ki.1992.379.
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    • Zeidel, M. L., T. Hammond, B. Botelho, and H. W. Harris. “Functional and structural characterization of endosomes from toad bladder epithelial cells.” Am J Physiol 263, no. 1 Pt 2 (July 1992): F62–76. https://doi.org/10.1152/ajprenal.1992.263.1.F62.
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    • Hammond, T. G. “Study of rat renal brush border membrane vesicles by flow cytometry.” Kidney Int 38, no. 1 (July 1990): 5–11. https://doi.org/10.1038/ki.1990.160.
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    • Hammond, T. G., and M. W. Mosesson. “Fatal small-bowel necrosis and pulmonary hypertension in sickle cell disease.” Arch Intern Med 149, no. 2 (February 1989): 447–48.
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    • Yusufi, A. N., T. G. Hammond, T. P. Dousa, and F. G. Knox. “Effect of atrial natriuretic factor on brush border membrane transport of phosphate in phosphate-deprived rats.” Biochem Pharmacol 37, no. 20 (October 15, 1988): 4027–29. https://doi.org/10.1016/0006-2952(88)90089-5.
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    • Ruilope, L. M., B. Miranda, R. G. Robles, T. G. Hammond, J. Sancho, J. C. Romero, and J. L. Rodicio. “Effect of exogenous angiotensin II infusion after one year of captopril therapy in essential hypertension.” Postgrad Med J 62 Suppl 1 (1986): 90–93.
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    • Hammond, T. G., A. Haramati, and F. G. Knox. “Synthetic atrial natriuretic factor decreases renal tubular phosphate reabsorption in rats.” American Journal of Physiology  Renal Fluid and Electrolyte Physiology 18, no. 2 (December 1, 1985).
    • Hammond, T. G., A. Haramati, and F. G. Knox. “Synthetic atrial natriuretic factor decreases renal tubular phosphate reabsorption in rats.” Am J Physiol 249, no. 2 Pt 2 (August 1985): F315–18. https://doi.org/10.1152/ajprenal.1985.249.2.F315.
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    • Hammond, T. G., A. N. Yusufi, F. G. Knox, and T. P. Dousa. “Administration of atrial natriuretic factor inhibits sodium-coupled transport in proximal tubules.” J Clin Invest 75, no. 6 (June 1985): 1983–89. https://doi.org/10.1172/JCI111916.
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    • Ruilope, L., C. Paya, J. M. Alcazar, J. Sancho-Rof, R. Garcia-Robles, J. Rodicio, T. G. Hammond, F. G. Knox, and J. C. Romero. “Failure of angiotensin II to reduce plasma renin activity in hypertensive pregnant women.” J Hypertens Suppl 2, no. 3 (December 1984): S251–54.
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    • Haas, J. A., T. G. Hammond, J. P. Granger, E. H. Blaine, and F. G. Knox. “Mechanism of natriuresis during intrarenal infusion of prostaglandins.” Am J Physiol 247, no. 3 Pt 2 (September 1984): F475–79. https://doi.org/10.1152/ajprenal.1984.247.3.F475.
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    • Hammond, T. G., J. A. Whitworth, D. Saines, R. Thatcher, J. Andrews, and P. Kincaid-Smith. “Renin-angiotensin-aldosterone system in nephrotic syndrome.” Am J Kidney Dis 4, no. 1 (July 1984): 18–23. https://doi.org/10.1016/s0272-6386(84)80021-9.
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    • Haas, J. A., T. G. Hammond, and J. P. Granger. “Mechanism of natriuresis during intrarenal infusion of prostaglandins.” American Journal of Physiology  Renal Fluid and Electrolyte Physiology 16, no. 3 (January 1, 1984).
    • Keiser, J. A., T. G. Hammond, and J. C. Romero. “Angiotensin II blockade during thoracic inferior vena cava (TIVC) constriction.” Federation Proceedings 43, no. 3 (January 1, 1984).
    • Hammond, T. G., J. D. Buchanan, B. A. Scoggins, R. Thatcher, and J. A. Whitworth. “Primary hyperaldosteronism in pregnancy.” Aust N Z J Med 12, no. 5 (October 1982): 537–39. https://doi.org/10.1111/j.1445-5994.1982.tb03842.x.
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    • Whitworth, J. A., T. G. Hammond, K. W. Stewart, R. T. Mason, E. G. Schneider, D. A. Denton, J. P. Coghlan, and B. A. Scoggins. “Effects of converting enzyme inhibition with captopril on renal function in normal and ACTH treated sheep.” Clinical and Experimental Pharmacology & Physiology 9, no. 5 (September 1982): 505–9. https://doi.org/10.1111/j.1440-1681.1982.tb00825.x.
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    • McDougall, J. G., J. P. Coghlan, D. A. Denton, D. T. Fei, T. G. Hammond, K. J. Hardy, S. J. Potocnik, B. A. Scoggins, and R. D. Wright. “Renal autotransplants in sheep: investigation of renal function and renovascular hypertension.” Clin Exp Pharmacol Physiol 8, no. 5 (September 1981): 497–501. https://doi.org/10.1111/j.1440-1681.1981.tb00756.x.
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    • Hammond, T. G., and J. A. Whitworth. “Adverse reactions to ginseng.” Med J Aust 1, no. 9 (May 2, 1981): 492.
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  • Conference Papers

    • DeLucas, L. J., R. J. Bula, T. Hammond, and N. R. Pellis. “A review of microgravity biotechnology.” In 38th Aerospace Sciences Meeting and Exhibit, 2000. https://doi.org/10.2514/6.2000-1056.
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