Notch signalling in B cells.

Published

Journal Article (Review)

Notch signalling is likely to regulate multiple aspects of lymphoid development and function. During T cell development, Notch signalling is required for commitment of the earliest progenitor, and may also function during other developmental stages. T cell commitment from a common lymphoid progenitor occurs at the expense of B cell development, suggesting that Notch signalling inhibits the earliest stage of B lymphopoiesis. In contrast, recent evidence suggests that Notch promotes the development of marginal zone lymphocytes. Not only is Notch required for later stages of B cell development, but several viral proteins appear to utilize Notch signalling in B cells to mediate their functions. In this review, we will focus on potential roles of Notch signalling in B lymphopoiesis and also consider how viral proteins may utilize Notch signalling in B cells.

Full Text

Duke Authors

Cited Authors

  • He, Y; Pear, WS

Published Date

  • April 2003

Published In

Volume / Issue

  • 14 / 2

Start / End Page

  • 135 - 142

PubMed ID

  • 12651097

Pubmed Central ID

  • 12651097

Electronic International Standard Serial Number (EISSN)

  • 1096-3634

International Standard Serial Number (ISSN)

  • 1084-9521

Digital Object Identifier (DOI)

  • 10.1016/s1084-9521(02)00182-9

Language

  • eng