Efficacy of bevacizumab plus erlotinib for advanced hepatocellular carcinoma and predictors of outcome: final results of a phase II trial.
Published
Journal Article
OBJECTIVE: A phase II study was performed to evaluate the efficacy and tolerability of bevacizumab and erlotinib in advanced hepatocellular carcinoma (HCC) patients, and to investigate clinical and molecular predictors of outcome. METHODS: 59 patients with advanced HCC received 10 mg/kg i.v. of bevacizumab every 14 days and 150 mg p.o. of erlotinib daily. The primary endpoint was progression-free survival (PFS) at 16 weeks. Clinical characteristics and plasma biomarkers expression levels were analyzed. RESULTS: PFS at 16 weeks was 64% (95% CI 51-76): 14 patients achieved partial response (24%), 33 had stable disease (56%), 6 progressed (10%), and 6 were not evaluable (10%). Median overall survival was 13.7 months (95% CI 9.6-19.7), and median PFS was 7.2 months (95% CI 5.6-8.3). Grade 3-4 adverse events included fatigue (30%), diarrhea (17%), hypertension (14%), elevated transaminases (12%), and gastrointestinal hemorrhage (10%). High plasma angiopoietin-2, epidermal growth factor receptor, and endothelin-1, and lack of acneiform rash were associated with poor outcome. CONCLUSIONS: The combination of bevacizumab with erlotinib achieved encouraging results in patients with advanced HCC. Current correlatives may help to guide future HCC studies.
Full Text
Duke Authors
Cited Authors
- Kaseb, AO; Garrett-Mayer, E; Morris, JS; Xiao, L; Lin, E; Onicescu, G; Hassan, MM; Hassabo, HM; Iwasaki, M; Deaton, FL; Abbruzzese, JL; Thomas, MB
Published Date
- 2012
Published In
Volume / Issue
- 82 / 2
Start / End Page
- 67 - 74
PubMed ID
- 22327795
Pubmed Central ID
- 22327795
Electronic International Standard Serial Number (EISSN)
- 1423-0232
Digital Object Identifier (DOI)
- 10.1159/000335963
Language
- eng
Conference Location
- Switzerland