Skip to main content

Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma.

Publication ,  Journal Article
Kuniyasu, H; Abbruzzese, JL; Cleary, KR; Fidler, IJ
Published in: Int J Oncol
October 2001

A histopathology study of 22 pancreatic adenocarcinoma cases revealed that 13 of the patients presented with hyperplastic lesions (atypical and non-atypical hyperplasia, mucous cell hypertrophy, focal epithelial hyperplasia, and ductal papillary hyperplasia), and 9 exhibited fibrosis adjacent to the carcinoma. All lesions expressed high levels of epidermal growth factor receptor (EGF-R) (p<0.0001 and p=0.0008, respectively) as compared with normal ductal epithelium. Non-atypical and atypical hyperplastic lesions also had a higher proliferating cell nuclear antigen (PCNA) labeling index (p<0.001 and p=0.0008, respectively) than normal ductal epithelium. A gradient in PCNA+ nuclei was found in acinar cells adjacent to the tumors. In 16 cases with marked fibrosis, we observed a significant increase of PCNA+ nuclei in stromal fibroblasts (p=0.0041) and significant upregulation of basic fibroblast growth factor (bFGF) mRNA expression in adjacent tumor cells (p=0.0213). These data suggest that the production of bFGF by pancreatic cancer cells induces ductal and stromal hyperplasia of the pancreas.

Duke Scholars

Published In

Int J Oncol

DOI

ISSN

1019-6439

Publication Date

October 2001

Volume

19

Issue

4

Start / End Page

681 / 685

Location

Greece

Related Subject Headings

  • Tumor Cells, Cultured
  • Stromal Cells
  • RNA, Messenger
  • Proliferating Cell Nuclear Antigen
  • Pancreatic Neoplasms
  • Pancreatic Ducts
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Mitotic Index
  • In Situ Hybridization
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kuniyasu, H., Abbruzzese, J. L., Cleary, K. R., & Fidler, I. J. (2001). Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma. Int J Oncol, 19(4), 681–685. https://doi.org/10.3892/ijo.19.4.681
Kuniyasu, H., J. L. Abbruzzese, K. R. Cleary, and I. J. Fidler. “Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma.Int J Oncol 19, no. 4 (October 2001): 681–85. https://doi.org/10.3892/ijo.19.4.681.
Kuniyasu H, Abbruzzese JL, Cleary KR, Fidler IJ. Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma. Int J Oncol. 2001 Oct;19(4):681–5.
Kuniyasu, H., et al. “Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma.Int J Oncol, vol. 19, no. 4, Oct. 2001, pp. 681–85. Pubmed, doi:10.3892/ijo.19.4.681.
Kuniyasu H, Abbruzzese JL, Cleary KR, Fidler IJ. Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma. Int J Oncol. 2001 Oct;19(4):681–685.

Published In

Int J Oncol

DOI

ISSN

1019-6439

Publication Date

October 2001

Volume

19

Issue

4

Start / End Page

681 / 685

Location

Greece

Related Subject Headings

  • Tumor Cells, Cultured
  • Stromal Cells
  • RNA, Messenger
  • Proliferating Cell Nuclear Antigen
  • Pancreatic Neoplasms
  • Pancreatic Ducts
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Mitotic Index
  • In Situ Hybridization