Pilot phase II trial of 13-cis-retinoic acid and interferon-alpha combination therapy for advanced pancreatic adenocarcinoma.

Published

Journal Article

The combination of interferons (IFNs) and retinoids in antineoplastic therapy is based upon preclinical, in vitro, and in vivo observations. Retinoid-IFN combinations have shown significant antitumor activity against advanced cutaneous and cervical squamous cell carcinoma (SCC), and the toxic effects do not appear to overlap. Based on in vitro evidence of synergy and observed clinical activity, we conducted a pilot phase II trial of 13-cis-retinoic acid (1 mg/kg/day) and IFN alpha (6 million units/day) in patients with advanced pancreatic adenocarcinoma. No objective responses occurred among six evaluable patients. The toxicities were mild and reversible, and grade 3 fatigue occurred in only one patient. No objective antitumor activity was noted against pancreatic adenocarcinomas at the dose and schedule utilized. Further exploration of this this purely biological approach is not warranted for pancreatic adenocarcinomas.

Full Text

Duke Authors

Cited Authors

  • Moore, DF; Pazdur, R; Sugarman, S; Jones, D; Lippman, SM; Bready, B; Abbruzzese, JL

Published Date

  • December 1995

Published In

Volume / Issue

  • 18 / 6

Start / End Page

  • 525 - 527

PubMed ID

  • 8526197

Pubmed Central ID

  • 8526197

Electronic International Standard Serial Number (EISSN)

  • 1537-453X

International Standard Serial Number (ISSN)

  • 0277-3732

Language

  • eng