Phase II study of gemcitabine in advanced colorectal adenocarcinoma.

Journal Article (Clinical Trial;Journal Article)

A phase II trial of gemcitabine (difluorodeoxycytidine) was conducted in 14 patients with advanced colorectal adenocarcinoma. Gemcitabine was administered intravenously over 30 minutes at weekly intervals for 3 consecutive weeks each month. The starting dose was 800 mg/m2, with dose escalation as tolerated. No complete or partial response were observed. Ten patients experienced progressive disease while on therapy. Toxic effects were primarily hematologic in nature. Grade 3 toxicities included leukopenia (one patient at 1000 mg/m2), granulocytopenia (two patients at 800 mg/m2), anemia (two patients at 800 mg/m2), and myalgia (one patient at 800 mg/m2). No grade 4 toxic effects or treatment-associated deaths were observed. Gemcitabine, at the doses and schedule used in this study, did not demonstrate activity against advanced colorectal adenocarcinoma.

Full Text

Duke Authors

Cited Authors

  • Moore, DF; Pazdur, R; Daugherty, K; Tarassoff, P; Abbruzzese, JL

Published Date

  • November 1992

Published In

Volume / Issue

  • 10 / 4

Start / End Page

  • 323 - 325

PubMed ID

  • 1487408

Pubmed Central ID

  • 1487408

International Standard Serial Number (ISSN)

  • 0167-6997

Digital Object Identifier (DOI)

  • 10.1007/BF00944189


  • eng

Conference Location

  • United States