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Novel therapies for pancreatic adenocarcinoma.

Publication ,  Journal Article
Pino, SM; Xiong, HQ; McConkey, D; Abbruzzese, JL
Published in: Curr Gastroenterol Rep
April 2004

Despite advances in our understanding of the molecular and genetic basis of pancreatic cancer, the disease remains a clinical challenge. Gemcitabine, the standard chemotherapy for pancreatic cancer, offers modest improvement of tumor-related symptoms and marginal advantage of survival. New approaches, alone and in combination with gemcitabine, are being developed to combat this cancer. In this article we review the current status of investigations into several classes of agents: matrix metalloproteinase inhibitors; farnesyl transferase inhibitors; epidermal growth factor receptor inhibitors, including monoclonal antibodies and tyrosine kinase inhibitors; cyclooxygenase-2 inhibitors, and others. The scientific rationale, mechanism of action, and clinical trial data for these novel agents are discussed.

Duke Scholars

Published In

Curr Gastroenterol Rep

DOI

ISSN

1522-8037

Publication Date

April 2004

Volume

6

Issue

2

Start / End Page

119 / 125

Location

United States

Related Subject Headings

  • RNA, Antisense
  • Protein-Tyrosine Kinases
  • Proteasome Endopeptidase Complex
  • Pancreatic Neoplasms
  • Multienzyme Complexes
  • Metalloendopeptidases
  • Matrix Metalloproteinase Inhibitors
  • Hydroxamic Acids
  • Humans
  • Gemcitabine
 

Citation

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MLA
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Pino, S. M., Xiong, H. Q., McConkey, D., & Abbruzzese, J. L. (2004). Novel therapies for pancreatic adenocarcinoma. Curr Gastroenterol Rep, 6(2), 119–125. https://doi.org/10.1007/s11894-004-0038-x
Pino, Simona M., Henry Q. Xiong, David McConkey, and James L. Abbruzzese. “Novel therapies for pancreatic adenocarcinoma.Curr Gastroenterol Rep 6, no. 2 (April 2004): 119–25. https://doi.org/10.1007/s11894-004-0038-x.
Pino SM, Xiong HQ, McConkey D, Abbruzzese JL. Novel therapies for pancreatic adenocarcinoma. Curr Gastroenterol Rep. 2004 Apr;6(2):119–25.
Pino, Simona M., et al. “Novel therapies for pancreatic adenocarcinoma.Curr Gastroenterol Rep, vol. 6, no. 2, Apr. 2004, pp. 119–25. Pubmed, doi:10.1007/s11894-004-0038-x.
Pino SM, Xiong HQ, McConkey D, Abbruzzese JL. Novel therapies for pancreatic adenocarcinoma. Curr Gastroenterol Rep. 2004 Apr;6(2):119–125.
Journal cover image

Published In

Curr Gastroenterol Rep

DOI

ISSN

1522-8037

Publication Date

April 2004

Volume

6

Issue

2

Start / End Page

119 / 125

Location

United States

Related Subject Headings

  • RNA, Antisense
  • Protein-Tyrosine Kinases
  • Proteasome Endopeptidase Complex
  • Pancreatic Neoplasms
  • Multienzyme Complexes
  • Metalloendopeptidases
  • Matrix Metalloproteinase Inhibitors
  • Hydroxamic Acids
  • Humans
  • Gemcitabine