Skip to main content
Journal cover image

Aberrant expression of maspin in idiopathic inflammatory bowel disease is associated with disease activity and neoplastic transformation.

Publication ,  Journal Article
Cao, D; Wilentz, RE; Abbruzzese, JL; Ho, L; Maitra, A
Published in: Int J Gastrointest Cancer
2005

BACKGROUND: Maspin is both overexpressed in tumors and inflammation, implicating a possible role in bridging inflammation and neoplasia. Idiopathic inflammatory bowel disease (IBD) and IBD-associated dysplasias and carcinomas represent a prototype for studying the relationship between chronic inflammatory states and neoplasia. AIM OF STUDY: To investigate expression of maspin in IBD and IBD-associated dysplasia and colorectal carcinoma. METHODS: Immunohistochemical labeling of maspin was examined using tissue microarrays constructed from archival biopsy and resection tissue from 90 patients with 125 histologically defined lesions including 30 with inactive chronic IBD, 51 with active chronic IBD, 4 IBD-associated foci with epithelial changes indefinite for dysplasia (IFD), 7 with IBD-associated low-grade epithelial dysplasia (LGD), 8 with IBD-associated high grade epithelial dysplasia (HGD), and 25 with IBD-associated invasive colorectal adenocarcinomas. RESULTS: Maspin was expressed in 47/51 (92%) active chronic IBD lesions, which was significantly higher than both inactive chronic IBD (13/30, 43%) and normal mucosa (1 of 9, 11%) (p < 0.01); in particular, the diffuse pattern of maspin expression was significantly higher in active IBD (41/51, 80%), compared with inactive IBD (5/30, 17%) and normal mucosa (0%) (p < 0.01). In the multistage progression model of colitis-associated neoplasia, aberrant labeling was observed at the earliest stages, with 3/4 (75%) IFD foci, 6/7 (86%) LGD, and 8/8 (100%) HGD specimens expressing maspin, virtually always in a diffuse pattern. Expectedly, 22/25 (88%) of invasive IBD-associated cancers overexpressed maspin, including 21 with diffuse labeling. CONCLUSIONS: Maspin is significantly overexpressed in both active IBD and colitis-associated dysplasia compared to either inactive IBD or normal colonic mucosa, suggesting a potential role in disease "flare" as well as neoplastic progression. Targeting maspin for control of disease activity and cancer prophylaxis may be a promising novel therapeutic strategy for IBD.

Duke Scholars

Published In

Int J Gastrointest Cancer

DOI

ISSN

1537-3649

Publication Date

2005

Volume

36

Issue

1

Start / End Page

39 / 46

Location

United States

Related Subject Headings

  • Serpins
  • Oligonucleotide Array Sequence Analysis
  • Intestinal Mucosa
  • Inflammatory Bowel Diseases
  • Immunohistochemistry
  • Humans
  • Genes, Tumor Suppressor
  • Gene Expression Profiling
  • Colorectal Neoplasms
  • Colitis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cao, D., Wilentz, R. E., Abbruzzese, J. L., Ho, L., & Maitra, A. (2005). Aberrant expression of maspin in idiopathic inflammatory bowel disease is associated with disease activity and neoplastic transformation. Int J Gastrointest Cancer, 36(1), 39–46. https://doi.org/10.1385/IJGC:36:1:039
Cao, Dengfeng, Robb E. Wilentz, James L. Abbruzzese, Linus Ho, and Anirban Maitra. “Aberrant expression of maspin in idiopathic inflammatory bowel disease is associated with disease activity and neoplastic transformation.Int J Gastrointest Cancer 36, no. 1 (2005): 39–46. https://doi.org/10.1385/IJGC:36:1:039.
Cao D, Wilentz RE, Abbruzzese JL, Ho L, Maitra A. Aberrant expression of maspin in idiopathic inflammatory bowel disease is associated with disease activity and neoplastic transformation. Int J Gastrointest Cancer. 2005;36(1):39–46.
Cao, Dengfeng, et al. “Aberrant expression of maspin in idiopathic inflammatory bowel disease is associated with disease activity and neoplastic transformation.Int J Gastrointest Cancer, vol. 36, no. 1, 2005, pp. 39–46. Pubmed, doi:10.1385/IJGC:36:1:039.
Cao D, Wilentz RE, Abbruzzese JL, Ho L, Maitra A. Aberrant expression of maspin in idiopathic inflammatory bowel disease is associated with disease activity and neoplastic transformation. Int J Gastrointest Cancer. 2005;36(1):39–46.
Journal cover image

Published In

Int J Gastrointest Cancer

DOI

ISSN

1537-3649

Publication Date

2005

Volume

36

Issue

1

Start / End Page

39 / 46

Location

United States

Related Subject Headings

  • Serpins
  • Oligonucleotide Array Sequence Analysis
  • Intestinal Mucosa
  • Inflammatory Bowel Diseases
  • Immunohistochemistry
  • Humans
  • Genes, Tumor Suppressor
  • Gene Expression Profiling
  • Colorectal Neoplasms
  • Colitis