Endocytosis proteins and cancer: a potential link?

Journal Article (Journal Article;Review)

Recent studies have shown that a variety of proteins participate with clathrin and clathrin adaptors in receptor-mediated endocytosis. The genes encoding some of these proteins are targets of chromosomal rearrangements in human haematopoietic malignancies. In addition, abnormal expression or mutation of some endocytosis proteins has been reported in human cancers. This article discusses these observations and elaborates the potential mechanisms by which the abnormal expression of endocytosis proteins might participate in the biology of cancer.

Full Text

Duke Authors

Cited Authors

  • Floyd, S; De Camilli, P

Published Date

  • August 1998

Published In

Volume / Issue

  • 8 / 8

Start / End Page

  • 299 - 301

PubMed ID

  • 9704404

International Standard Serial Number (ISSN)

  • 0962-8924

Digital Object Identifier (DOI)

  • 10.1016/s0962-8924(98)01316-6

Language

  • eng

Conference Location

  • England