Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Clinical Investigator, Koch Institute For Integrative Cancer Research, Massachusetts Institute of Technology 2012
  • Resident, Harvard Radiation Oncology Program, Harvard Medical School 2003 - 2007
  • Intern, Internal Medicine, Hospital of Saint Raphael 2002 - 2003
  • M.D., Yale University School of Medicine 2002
  • Ph.D., Yale University 2002
• 

  Duke Appointment History

  • Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2016 - 2018
  • Instructor, Temporary in the Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2015 - 2016
• Research
• 

  Selected Grants

  • Role of BRD4 in the cancer cell replication stress response awarded by American Cancer Society, Inc. 2019 - 2023
  • Novel Targets for Stroke Intervention - Gene Discovery for Modulators of Infarction awarded by National Institutes of Health 2017 - 2022
  • Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
  • A 3D ex vivo orthotopic xenograft screening platform to identify radiosensitization targets and druggability in glioma awarded by National Institutes of Health 2019 - 2021
  • Native and bioprinted 3D tissue array platform for predicting cancer metastasis awarded by University of North Carolina - Chapel Hill 2018 - 2020
  • BMX-001 AS A THERAPEUTIC AGENT FOR TREATMENT OF MULTIPLE BRAIN METASTASES awarded by BioMimetix JV LLC 2018 - 2020
  • Burroughs Wellcome Fund Agreement awarded by Burroughs Wellcome Fund 2015 - 2019
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Lin, Jiaxing, Jeremy Gresham, Tongrong Wang, So Young Kim, James Alvarez, Jeffrey S. Damrauer, Scott Floyd, et al. “bcSeq: an R package for fast sequence mapping in high-throughput shRNA and CRISPR screens..” Bioinformatics (Oxford, England) 34, no. 20 (October 2018): 3581–83. https://doi.org/10.1093/bioinformatics/bty402.
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    • Lam, Fred C., Stephen W. Morton, Jeffrey Wyckoff, Tu-Lan Vu Han, Mun Kyung Hwang, Amanda Maffa, Elena Balkanska-Sinclair, Michael B. Yaffe, Scott R. Floyd, and Paula T. Hammond. “Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles..” Nature Communications 9, no. 1 (May 18, 2018). https://doi.org/10.1038/s41467-018-04315-4.
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    • Limon, Dror, Frances McSherry, James Herndon, John Sampson, Peter Fecci, Justus Adamson, Zhiheng Wang, et al. “Single fraction stereotactic radiosurgery for multiple brain metastases..” Advances in Radiation Oncology 2, no. 4 (October 2017): 555–63. https://doi.org/10.1016/j.adro.2017.09.002.
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    • Jimenez, R. B., B. M. Alexander, A. Mahadevan, A. Niemierko, S. Rajakesari, N. D. Arvold, S. R. Floyd, K. S. Oh, J. S. Loeffler, and H. A. Shih. “The impact of different stereotactic radiation therapy regimens for brain metastases on local control and toxicity.” Advances in Radiation Oncology 2, no. 3 (July 1, 2017): 391–97. https://doi.org/10.1016/j.adro.2017.05.008.
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    • Kasper, E., F. Ippen, E. Wong, E. Uhlmann, S. Floyd, and A. Mahadevan. “Stereotactic radiosurgery for brain metastasis from gynecological malignancies.” Oncology Letters 13, no. 3 (March 1, 2017): 1525–28. https://doi.org/10.3892/ol.2017.5621.
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    • Rameseder, Jonathan, Konstantin Krismer, Yogesh Dayma, Tobias Ehrenberger, Mun Kyung Hwang, Edoardo M. Airoldi, Scott R. Floyd, and Michael B. Yaffe. “A Multivariate Computational Method to Analyze High-Content RNAi Screening Data..” Journal of Biomolecular Screening 20, no. 8 (September 2015): 985–97. https://doi.org/10.1177/1087057115583037.
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    • Rangachari, Deepa, Norihiro Yamaguchi, Paul A. VanderLaan, Erik Folch, Anand Mahadevan, Scott R. Floyd, Erik J. Uhlmann, et al. “Brain metastases in patients with EGFR-mutated or ALK-rearranged non-small-cell lung cancers..” Lung Cancer 88, no. 1 (April 2015): 108–11. https://doi.org/10.1016/j.lungcan.2015.01.020.
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    • Christ, Sebastian M., Anand Mahadevan, Scott R. Floyd, Fred C. Lam, Clark C. Chen, Eric T. Wong, and Ekkehard M. Kasper. “Stereotactic radiosurgery for brain metastases from malignant melanoma..” Surgical Neurology International 6, no. Suppl 12 (January 2015): S355–65. https://doi.org/10.4103/2152-7806.163315.
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    • Mahadevan, Anand, Carrie Sampson, Salvatore LaRosa, Scott R. Floyd, Eric T. Wong, Erik J. Uhlmann, Soma Sengupta, and Ekkehard M. Kasper. “Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy..” Radiation Oncology (London, England) 10 (January 2015). https://doi.org/10.1186/s13014-015-0555-9.
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    • Schoenfeld, Jonathan D., Anand Mahadevan, Scott R. Floyd, Michael A. Dyer, Paul J. Catalano, Brian M. Alexander, David F. McDermott, and Irving D. Kaplan. “Ipilmumab and cranial radiation in metastatic melanoma patients: a case series and review..” Journal for Immunotherapy of Cancer 3 (January 2015). https://doi.org/10.1186/s40425-015-0095-8.
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    • Dyer, Michael A., Nils D. Arvold, Yu-Hui Chen, Nancy E. Pinnell, Timur Mitin, Eudocia Q. Lee, F Stephen Hodi, et al. “The role of whole brain radiation therapy in the management of melanoma brain metastases..” Radiation Oncology (London, England) 9 (January 2014). https://doi.org/10.1186/1748-717X-9-143.
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    • Floyd, Scott R., Michael E. Pacold, Qiuying Huang, Scott M. Clarke, Fred C. Lam, Ian G. Cannell, Bryan D. Bryson, et al. “The bromodomain protein Brd4 insulates chromatin from DNA damage signalling..” Nature 498, no. 7453 (June 2, 2013): 246–50. https://doi.org/10.1038/nature12147.
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    • Weingeist, David M., Jing Ge, David K. Wood, James T. Mutamba, Qiuying Huang, Elizabeth A. Rowland, Michael B. Yaffe, Scott Floyd, and Bevin P. Engelward. “Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors..” Cell Cycle (Georgetown, Tex.) 12, no. 6 (March 2013): 907–15. https://doi.org/10.4161/cc.23880.
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    • Fonkem, Ekokobe, Erik J. Uhlmann, Scott R. Floyd, Anand Mahadevan, Ekkehard Kasper, Omar Eton, and Eric T. Wong. “Melanoma brain metastasis: overview of current management and emerging targeted therapies..” Expert Review of Neurotherapeutics 12, no. 10 (October 2012): 1207–15. https://doi.org/10.1586/ern.12.111.
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    • Lu, Xing-Qi, Anand Mahadevan, George Mathiowitz, Pei-Jan P. Lin, Ajith Thomas, Ekkehard M. Kasper, Scott R. Floyd, et al. “Frameless angiogram-based stereotactic radiosurgery for treatment of arteriovenous malformations..” International Journal of Radiation Oncology, Biology, Physics 84, no. 1 (September 2012): 274–82. https://doi.org/10.1016/j.ijrobp.2011.10.044.
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    • Floyd, S. R. “Outcomes of node-negative breast cancer 5 centimeters and larger treated with and without postmastectomy radiotherapy: Goulart J, Truong P, Woods R, et al (Univ of British Columbia, Vancouver, Canada; British Columbia Cancer Agency, Vancouver, Canada) Int J Radiat Oncol Biol Phys 80:758-764, 2011.” Breast Diseases 23, no. 2 (May 24, 2012): 185–87. https://doi.org/10.1016/j.breastdis.2012.03.028.
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    • Wang, Che-Chuan, Scott R. Floyd, Chin-Hong Chang, Peter C. Warnke, Chung-Ching Chio, Ekkehard M. Kasper, Anand Mahadevan, Eric T. Wong, and Clark C. Chen. “Cyberknife hypofractionated stereotactic radiosurgery (HSRS) of resection cavity after excision of large cerebral metastasis: efficacy and safety of an 800 cGy × 3 daily fractions regimen..” Journal of Neuro Oncology 106, no. 3 (February 2012): 601–10. https://doi.org/10.1007/s11060-011-0697-z.
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    • Mahadevan, Anand, Scott Floyd, Eric Wong, Suriya Jeyapalan, Michael Groff, and Ekkehard Kasper. “Stereotactic body radiotherapy reirradiation for recurrent epidural spinal metastases..” International Journal of Radiation Oncology, Biology, Physics 81, no. 5 (December 2011): 1500–1505. https://doi.org/10.1016/j.ijrobp.2010.08.012.
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    • Mahadevan, Anand, Scott Floyd, Eric Wong, Clark Chen, and Ekkehard Kasper. “Clinical outcome after hypofractionated stereotactic radiotherapy (HSRT) for benign skull base tumors..” Computer Aided Surgery : Official Journal of the International Society for Computer Aided Surgery 16, no. 3 (January 2011): 112–20. https://doi.org/10.3109/10929088.2011.565160.
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    • Floyd, Scott R., and Alphonse G. Taghian. “Post-mastectomy radiation in large node-negative breast tumors: does size really matter?.” Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology 91, no. 1 (April 2009): 33–37. https://doi.org/10.1016/j.radonc.2008.09.015.
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    • Martin, N. E., S. Floyd, R. A. Raad, and A. Taghian. “The role of postmastectomy radiation in node-negative breast tumors larger than 5 cm.” American Journal of Hematology/ Oncology 6, no. 4 (April 1, 2007): 197–99.
    • Floyd, Scott R., Thomas A. Buchholz, Bruce G. Haffty, Saveli Goldberg, Andrzej Niemierko, Rita Abi Raad, Mary J. Oswald, et al. “Low local recurrence rate without postmastectomy radiation in node-negative breast cancer patients with tumors 5 cm and larger..” International Journal of Radiation Oncology, Biology, Physics 66, no. 2 (October 2006): 358–64. https://doi.org/10.1016/j.ijrobp.2006.05.001.
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    • Taghian, Alphonse G., Sherif I. Assaad, Andrzej Niemierko, Scott R. Floyd, and Simon N. Powell. “Is a reduction in radiation lung volume and dose necessary with paclitaxel chemotherapy for node-positive breast cancer?.” International Journal of Radiation Oncology, Biology, Physics 62, no. 2 (June 2005): 386–91. https://doi.org/10.1016/j.ijrobp.2004.09.044.
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    • Floyd, Scott R., Liron Pantanowitz, David F. McDermott, Jennifer Yannucci, Jane A. Driver, Mary Ann Stevenson, Benjamin D. Smith, Lynn D. Wilson, and Paul G. Richardson. “Plasma cell problems: Case 1. Disseminated cutaneous plasmacytomas treated with total skin electron radiotherapy..” Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 23, no. 13 (May 2005): 3138–40. https://doi.org/10.1200/jco.2005.05.175.
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    • Schmierer, K., P. Grosse, P. De Camilli, M. Solimena, S. Floyd, and R. Zschenderlein. “Paraneoplastic stiff-person syndrome: no tumor progression over 5 years..” Neurology 58, no. 1 (January 2002). https://doi.org/10.1212/wnl.58.1.148.
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    • Farsad, K., N. Ringstad, K. Takei, S. R. Floyd, K. Rose, and P. De Camilli. “Generation of high curvature membranes mediated by direct endophilin bilayer interactions..” The Journal of Cell Biology 155, no. 2 (October 15, 2001): 193–200. https://doi.org/10.1083/jcb.200107075.
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    • Floyd, S. R., E. B. Porro, V. I. Slepnev, G. C. Ochoa, L. H. Tsai, and P. De Camilli. “Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2..” The Journal of Biological Chemistry 276, no. 11 (March 2001): 8104–10. https://doi.org/10.1074/jbc.m008932200.
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    • Ferracci, F., G. Fassetta, M. H. Butler, S. Floyd, M. Solimena, and P. De Camilli. “A novel antineuronal antibody in a motor neuron syndrome associated with breast cancer..” Neurology 53, no. 4 (September 11, 1999): 852–55. https://doi.org/10.1212/wnl.53.4.852.
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    • Floyd, S., and P. De Camilli. “Endocytosis proteins and cancer: a potential link?.” Trends in Cell Biology 8, no. 8 (August 1998): 299–301. https://doi.org/10.1016/s0962-8924(98)01316-6.
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    • Floyd, S., M. H. Butler, O. Cremona, C. David, Z. Freyberg, X. Zhang, M. Solimena, et al. “Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer..” Molecular Medicine (Cambridge, Mass.) 4, no. 1 (January 1998): 29–39. https://doi.org/10.1007/bf03401727.
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  • Conference Papers

    • Lam, Fred C., Stephen W. Morton, Jeffrey Wyckoff, Amanda Maffa, Elena Balkanska-Sinclair, Scott R. Floyd, Michael B. Yaffe, and Paula T. Hammond. “ENHANCED IN VIVO EFFICACY AND SAFETY OF COMBINATION TEMOZOLOMIDE AND BROMODOMAIN INHIBITOR THERAPY FOR GLIOMAS USING A TARGETED DUAL DRUG-LOADING STEALTH LIPOSOMAL CARRIER.” In Neuro Oncology, 19:273–273. OXFORD UNIV PRESS INC, 2017.
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    • Mahadevan, Anand, Loretta Barron, Scott R. Floyd, Ekkehard Kasper, and Eric T. Wong. “Survival benefit of tumor treating fields plus stereotactic radiosurgery for recurrent malignant gliomas..” In Journal of Clinical Oncology, 33:e13036–e13036. American Society of Clinical Oncology (ASCO), 2015. https://doi.org/10.1200/jco.2015.33.15_suppl.e13036.
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• Teaching & Mentoring
• 

  Recent Courses

  • PHARM 393: Research Independent Study 2019
  • PHARM 394: Research Independent Study 2019
  • PHARM 493: Research Independent Study 2019
  • COMPSCI 393: Research Independent Study 2018

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