Scott Richard Floyd | Scholars@Duke

Scott Richard Floyd
Gary Hock and Lyn Proctor Associate Professor of Radiation Oncology

Current Appointments & Affiliations

Gary Hock and Lyn Proctor Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2019
Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2018
Assistant Research Professor in Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2016
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2015

Contact Information

Duke Cancer Institute, Box 3085 DUMC, Durham, NC 27710
Levine Science Research Center, B233, 450 Research Drive, Box 103655, Durham, NC 27710
scott.floyd@duke.edu (919) 668-7342

Background
Education, Training, & Certifications
- Clinical Investigator, Koch Institute For Integrative Cancer Research, Massachusetts Institute of Technology 2012
- Resident, Harvard Radiation Oncology Program, Harvard Medical School 2003 - 2007
- Intern, Internal Medicine, Hospital of Saint Raphael 2002 - 2003
- M.D., Yale University School of Medicine 2002
- Ph.D., Yale University 2002
Duke Appointment History
- Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2016 - 2018
- Instructor, Temporary in the Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2015 - 2016
Research
Selected Grants
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- Duke Radiation Oncology and Radiology Stimulating Access to Research in Residency (Year 2) awarded by National Institutes of Health 2020 - 2024
- Role of BRD4 in the cancer cell replication stress response awarded by American Cancer Society, Inc. 2019 - 2023
- Novel Targets for Stroke Intervention - Gene Discovery for Modulators of Infarction awarded by National Institutes of Health 2017 - 2022
- Image-Guided Radiation Therapy System for Small Animals awarded by National Institutes of Health 2021 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- BMX-001 AS A THERAPEUTIC AGENT FOR TREATMENT OF MULTIPLE BRAIN METASTASES awarded by BioMimetix JV LLC 2018 - 2021
- Patient Avatars for Pediatric Brain Tumors awarded by Ian's Friends Foundation 2020 - 2021
- A 3D ex vivo orthotopic xenograft screening platform to identify radiosensitization targets and druggability in glioma awarded by National Institutes of Health 2019 - 2021
- Native and bioprinted 3D tissue array platform for predicting cancer metastasis awarded by University of North Carolina - Chapel Hill 2018 - 2020
- Burroughs Wellcome Fund Agreement awarded by Burroughs Wellcome Fund 2015 - 2019
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Ge, Jing, Le P. Ngo, Simran Kaushal, Ian J. Tay, Elina Thadhani, Jennifer E. Kay, Patrizia Mazzucato, et al. “CometChip enables parallel analysis of multiple DNA repair activities.” Dna Repair (Amst) 106 (October 2021): 103176. https://doi.org/10.1016/j.dnarep.2021.103176.
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  - Salama, Joseph K., Scott R. Floyd, Christopher G. Willett, and David G. Kirsch. “Fostering Radiation Oncology Physician Scientist Trainees Within a Diverse Workforce: The Radiation Oncology Research Scholar Track.” Int J Radiat Oncol Biol Phys 110, no. 2 (June 1, 2021): 288–91. https://doi.org/10.1016/j.ijrobp.2020.12.050.
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  - Park, Christine, Elizabeth P. Howell, Vikram A. Mehta, Luis Ramirez, Meghan J. Price, Scott R. Floyd, John P. Kirkpatrick, et al. “Patient outcomes and tumor control in single-fraction versus hypofractionated stereotactic body radiation therapy for spinal metastases.” J Neurosurg Spine, November 6, 2020, 1–10. https://doi.org/10.3171/2020.6.SPINE20349.
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  - Tay, Ian J., James J. H. Park, Anna L. Price, Bevin P. Engelward, and Scott R. Floyd. “HTS-Compatible CometChip Enables Genetic Screening for Modulators of Apoptosis and DNA Double-Strand Break Repair.” Slas Discov 25, no. 8 (September 2020): 906–22. https://doi.org/10.1177/2472555220918367.
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  - Edwards, Drake S., Rohin Maganti, Jarred P. Tanksley, Jie Luo, James J. H. Park, Elena Balkanska-Sinclair, Jinjie Ling, and Scott R. Floyd. “BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation.” Cell Reports 32, no. 12 (September 2020): 108166. https://doi.org/10.1016/j.celrep.2020.108166.
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  - Barbour, Andrew B., Corbin D. Jacobs, Hannah Williamson, Scott R. Floyd, Gita Suneja, Jordan A. Torok, and John P. Kirkpatrick. “Radiation Therapy Practice Patterns for Brain Metastases in the United States in the Stereotactic Radiosurgery Era.” Advances in Radiation Oncology 5, no. 1 (January 2020): 43–52. https://doi.org/10.1016/j.adro.2019.07.012.
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  - Jain, Sagarika, Suk W. Yoon, Xiaofeng Zhang, Justus Adamson, Scott Floyd, and Mark Oldham. “Evaluation of UVA emission from x-ray megavoltage-irradiated tissues and phantoms.” Phys Med Biol 64, no. 22 (November 21, 2019): 225017. https://doi.org/10.1088/1361-6560/ab4333.
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  - Nehama, Dean, Natalia Di Ianni, Silvia Musio, Hongwei Du, Monica Patané, Bianca Pollo, Gaetano Finocchiaro, et al. “B7-H3-redirected chimeric antigen receptor T cells target glioblastoma and neurospheres.” Ebiomedicine 47 (September 2019): 33–43. https://doi.org/10.1016/j.ebiom.2019.08.030.
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  - Abisheva, Zhanerke, Scott R. Floyd, Joseph K. Salama, John Kirkpatrick, Fang-Fang Yin, Michael J. Moravan, William Giles, and Justus Adamson. “The effect of MLC leaf width in single-isocenter multi-target radiosurgery with volumetric modulated arc therapy.” J Radiosurg Sbrt 6, no. 2 (2019): 131–38.
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  - Lin, Jiaxing, Jeremy Gresham, Tongrong Wang, So Young Kim, James Alvarez, Jeffrey S. Damrauer, Scott Floyd, et al. “bcSeq: an R package for fast sequence mapping in high-throughput shRNA and CRISPR screens.” Bioinformatics 34, no. 20 (October 15, 2018): 3581–83. https://doi.org/10.1093/bioinformatics/bty402.
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  - Lam, Fred C., Stephen W. Morton, Jeffrey Wyckoff, Tu-Lan Vu Han, Mun Kyung Hwang, Amanda Maffa, Elena Balkanska-Sinclair, Michael B. Yaffe, Scott R. Floyd, and Paula T. Hammond. “Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles.” Nat Commun 9, no. 1 (May 18, 2018): 1991. https://doi.org/10.1038/s41467-018-04315-4.
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  - Limon, Dror, Frances McSherry, James Herndon, John Sampson, Peter Fecci, Justus Adamson, Zhiheng Wang, et al. “Single fraction stereotactic radiosurgery for multiple brain metastases.” Adv Radiat Oncol 2, no. 4 (October 2017): 555–63. https://doi.org/10.1016/j.adro.2017.09.002.
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  - Jimenez, R. B., B. M. Alexander, A. Mahadevan, A. Niemierko, S. Rajakesari, N. D. Arvold, S. R. Floyd, K. S. Oh, J. S. Loeffler, and H. A. Shih. “The impact of different stereotactic radiation therapy regimens for brain metastases on local control and toxicity.” Advances in Radiation Oncology 2, no. 3 (July 1, 2017): 391–97. https://doi.org/10.1016/j.adro.2017.05.008.
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  - Kasper, E., F. Ippen, E. Wong, E. Uhlmann, S. Floyd, and A. Mahadevan. “Stereotactic radiosurgery for brain metastasis from gynecological malignancies.” Oncology Letters 13, no. 3 (March 1, 2017): 1525–28. https://doi.org/10.3892/ol.2017.5621.
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  - Mahadevan, Anand, Carrie Sampson, Salvatore LaRosa, Scott R. Floyd, Eric T. Wong, Erik J. Uhlmann, Soma Sengupta, and Ekkehard M. Kasper. “Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy.” Radiat Oncol 10 (November 26, 2015): 245. https://doi.org/10.1186/s13014-015-0555-9.
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  - Rameseder, Jonathan, Konstantin Krismer, Yogesh Dayma, Tobias Ehrenberger, Mun Kyung Hwang, Edoardo M. Airoldi, Scott R. Floyd, and Michael B. Yaffe. “A Multivariate Computational Method to Analyze High-Content RNAi Screening Data.” J Biomol Screen 20, no. 8 (September 2015): 985–97. https://doi.org/10.1177/1087057115583037.
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  - Rangachari, Deepa, Norihiro Yamaguchi, Paul A. VanderLaan, Erik Folch, Anand Mahadevan, Scott R. Floyd, Erik J. Uhlmann, et al. “Brain metastases in patients with EGFR-mutated or ALK-rearranged non-small-cell lung cancers.” Lung Cancer 88, no. 1 (April 2015): 108–11. https://doi.org/10.1016/j.lungcan.2015.01.020.
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  - Christ, Sebastian M., Anand Mahadevan, Scott R. Floyd, Fred C. Lam, Clark C. Chen, Eric T. Wong, and Ekkehard M. Kasper. “Stereotactic radiosurgery for brain metastases from malignant melanoma.” Surg Neurol Int 6, no. Suppl 12 (2015): S355–65. https://doi.org/10.4103/2152-7806.163315.
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  - Schoenfeld, Jonathan D., Anand Mahadevan, Scott R. Floyd, Michael A. Dyer, Paul J. Catalano, Brian M. Alexander, David F. McDermott, and Irving D. Kaplan. “Ipilmumab and cranial radiation in metastatic melanoma patients: a case series and review.” J Immunother Cancer 3 (2015): 50. https://doi.org/10.1186/s40425-015-0095-8.
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  - Dyer, Michael A., Nils D. Arvold, Yu-Hui Chen, Nancy E. Pinnell, Timur Mitin, Eudocia Q. Lee, F Stephen Hodi, et al. “The role of whole brain radiation therapy in the management of melanoma brain metastases.” Radiat Oncol 9 (June 22, 2014): 143. https://doi.org/10.1186/1748-717X-9-143.
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  - Floyd, Scott R., Michael E. Pacold, Qiuying Huang, Scott M. Clarke, Fred C. Lam, Ian G. Cannell, Bryan D. Bryson, et al. “The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.” Nature 498, no. 7453 (June 13, 2013): 246–50. https://doi.org/10.1038/nature12147.
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  - Weingeist, David M., Jing Ge, David K. Wood, James T. Mutamba, Qiuying Huang, Elizabeth A. Rowland, Michael B. Yaffe, Scott Floyd, and Bevin P. Engelward. “Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors.” Cell Cycle 12, no. 6 (March 15, 2013): 907–15. https://doi.org/10.4161/cc.23880.
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  - Fonkem, Ekokobe, Erik J. Uhlmann, Scott R. Floyd, Anand Mahadevan, Ekkehard Kasper, Omar Eton, and Eric T. Wong. “Melanoma brain metastasis: overview of current management and emerging targeted therapies.” Expert Rev Neurother 12, no. 10 (October 2012): 1207–15. https://doi.org/10.1586/ern.12.111.
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  - Lu, Xing-Qi, Anand Mahadevan, George Mathiowitz, Pei-Jan P. Lin, Ajith Thomas, Ekkehard M. Kasper, Scott R. Floyd, et al. “Frameless angiogram-based stereotactic radiosurgery for treatment of arteriovenous malformations.” Int J Radiat Oncol Biol Phys 84, no. 1 (September 1, 2012): 274–82. https://doi.org/10.1016/j.ijrobp.2011.10.044.
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  - Floyd, S. R. “Outcomes of node-negative breast cancer 5 centimeters and larger treated with and without postmastectomy radiotherapy: Goulart J, Truong P, Woods R, et al (Univ of British Columbia, Vancouver, Canada; British Columbia Cancer Agency, Vancouver, Canada) Int J Radiat Oncol Biol Phys 80:758-764, 2011.” Breast Diseases 23, no. 2 (May 24, 2012): 185–87. https://doi.org/10.1016/j.breastdis.2012.03.028.
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  - Wang, Che-Chuan, Scott R. Floyd, Chin-Hong Chang, Peter C. Warnke, Chung-Ching Chio, Ekkehard M. Kasper, Anand Mahadevan, Eric T. Wong, and Clark C. Chen. “Cyberknife hypofractionated stereotactic radiosurgery (HSRS) of resection cavity after excision of large cerebral metastasis: efficacy and safety of an 800 cGy × 3 daily fractions regimen.” J Neurooncol 106, no. 3 (February 2012): 601–10. https://doi.org/10.1007/s11060-011-0697-z.
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  - Mahadevan, Anand, Scott Floyd, Eric Wong, Suriya Jeyapalan, Michael Groff, and Ekkehard Kasper. “Stereotactic body radiotherapy reirradiation for recurrent epidural spinal metastases.” Int J Radiat Oncol Biol Phys 81, no. 5 (December 1, 2011): 1500–1505. https://doi.org/10.1016/j.ijrobp.2010.08.012.
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  - Mahadevan, Anand, Scott Floyd, Eric Wong, Clark Chen, and Ekkehard Kasper. “Clinical outcome after hypofractionated stereotactic radiotherapy (HSRT) for benign skull base tumors.” Comput Aided Surg 16, no. 3 (2011): 112–20. https://doi.org/10.3109/10929088.2011.565160.
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  - Floyd, Scott R., and Alphonse G. Taghian. “Post-mastectomy radiation in large node-negative breast tumors: does size really matter?” Radiother Oncol 91, no. 1 (April 2009): 33–37. https://doi.org/10.1016/j.radonc.2008.09.015.
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  - Martin, N. E., S. Floyd, R. A. Raad, and A. Taghian. “The role of postmastectomy radiation in node-negative breast tumors larger than 5 cm.” American Journal of Hematology/ Oncology 6, no. 4 (April 1, 2007): 197–99.
  - Floyd, Scott R., Thomas A. Buchholz, Bruce G. Haffty, Saveli Goldberg, Andrzej Niemierko, Rita Abi Raad, Mary J. Oswald, et al. “Low local recurrence rate without postmastectomy radiation in node-negative breast cancer patients with tumors 5 cm and larger.” Int J Radiat Oncol Biol Phys 66, no. 2 (October 1, 2006): 358–64. https://doi.org/10.1016/j.ijrobp.2006.05.001.
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  - Taghian, Alphonse G., Sherif I. Assaad, Andrzej Niemierko, Scott R. Floyd, and Simon N. Powell. “Is a reduction in radiation lung volume and dose necessary with paclitaxel chemotherapy for node-positive breast cancer?” Int J Radiat Oncol Biol Phys 62, no. 2 (June 1, 2005): 386–91. https://doi.org/10.1016/j.ijrobp.2004.09.044.
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  - Floyd, Scott R., Liron Pantanowitz, David F. McDermott, Jennifer Yannucci, Jane A. Driver, Mary Ann Stevenson, Benjamin D. Smith, Lynn D. Wilson, and Paul G. Richardson. “Plasma cell problems: Case 1. Disseminated cutaneous plasmacytomas treated with total skin electron radiotherapy.” J Clin Oncol 23, no. 13 (May 1, 2005): 3138–40. https://doi.org/10.1200/JCO.2005.05.175.
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  - Schmierer, K., P. Grosse, P. De Camilli, M. Solimena, S. Floyd, and R. Zschenderlein. “Paraneoplastic stiff-person syndrome: no tumor progression over 5 years.” Neurology 58, no. 1 (January 8, 2002): 148. https://doi.org/10.1212/wnl.58.1.148.
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  - Farsad, K., N. Ringstad, K. Takei, S. R. Floyd, K. Rose, and P. De Camilli. “Generation of high curvature membranes mediated by direct endophilin bilayer interactions.” J Cell Biol 155, no. 2 (October 15, 2001): 193–200. https://doi.org/10.1083/jcb.200107075.
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  - Floyd, S. R., E. B. Porro, V. I. Slepnev, G. C. Ochoa, L. H. Tsai, and P. De Camilli. “Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2.” J Biol Chem 276, no. 11 (March 16, 2001): 8104–10. https://doi.org/10.1074/jbc.M008932200.
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  - Ferracci, F., G. Fassetta, M. H. Butler, S. Floyd, M. Solimena, and P. De Camilli. “A novel antineuronal antibody in a motor neuron syndrome associated with breast cancer.” Neurology 53, no. 4 (September 11, 1999): 852–55. https://doi.org/10.1212/wnl.53.4.852.
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  - Floyd, S., and P. De Camilli. “Endocytosis proteins and cancer: a potential link?” Trends Cell Biol 8, no. 8 (August 1998): 299–301. https://doi.org/10.1016/s0962-8924(98)01316-6.
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  - Floyd, S., M. H. Butler, O. Cremona, C. David, Z. Freyberg, X. Zhang, M. Solimena, et al. “Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer.” Mol Med 4, no. 1 (January 1998): 29–39.
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- Conference Papers
  - Lam, Fred C., Stephen W. Morton, Jeffrey Wyckoff, Amanda Maffa, Elena Balkanska-Sinclair, Scott R. Floyd, Michael B. Yaffe, and Paula T. Hammond. “ENHANCED IN VIVO EFFICACY AND SAFETY OF COMBINATION TEMOZOLOMIDE AND BROMODOMAIN INHIBITOR THERAPY FOR GLIOMAS USING A TARGETED DUAL DRUG-LOADING STEALTH LIPOSOMAL CARRIER.” In Neuro Oncology, 19:273–273. OXFORD UNIV PRESS INC, 2017.
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  - Mahadevan, Anand, Loretta Barron, Scott R. Floyd, Ekkehard Kasper, and Eric T. Wong. “Survival benefit of tumor treating fields plus stereotactic radiosurgery for recurrent malignant gliomas.” In Journal of Clinical Oncology, 33:e13036–e13036. American Society of Clinical Oncology (ASCO), 2015. https://doi.org/10.1200/jco.2015.33.15_suppl.e13036.
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Teaching & Mentoring
Recent Courses
- PHARM 393: Research Independent Study 2021
- PHARM 394: Research Independent Study 2021
- PHARM 493: Research Independent Study 2021
- PHARM 494: Research Independent Study 2021
- PHARM 393: Research Independent Study 2020
- PHARM 394: Research Independent Study 2020
- PHARM 493: Research Independent Study 2020
- PHARM 494: Research Independent Study 2020
- PHARM 393: Research Independent Study 2019
- PHARM 394: Research Independent Study 2019
- PHARM 493: Research Independent Study 2019

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Recent Courses