Scott Richard Floyd
Gary Hock and Lyn Proctor Associate Professor of Radiation Oncology
Current Appointments & Affiliations
- Gary Hock and Lyn Proctor Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2019
- Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2018
- Assistant Research Professor in Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2016
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2015
Contact Information
- Duke Cancer Institute, Box 3085 DUMC, Durham, NC 27710
- Levine Science Research Center, B233, 450 Research Drive, Box 103655, Durham, NC 27710
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scott.floyd@duke.edu
(919) 668-7342
- Background
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Education, Training, & Certifications
- Clinical Investigator, Koch Institute For Integrative Cancer Research, Massachusetts Institute of Technology 2012
- Resident, Harvard Radiation Oncology Program, Harvard Medical School 2003 - 2007
- Intern, Internal Medicine, Hospital of Saint Raphael 2002 - 2003
- M.D., Yale University School of Medicine 2002
- Ph.D., Yale University 2002
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Duke Appointment History
- Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2016 - 2018
- Instructor, Temporary in the Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2015 - 2016
- Research
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Selected Grants
- Duke Resident Physician-Scientist Program in Radiation Oncology and Radiology awarded by National Institutes of Health 2020 - 2024
- Role of BRD4 in the cancer cell replication stress response awarded by American Cancer Society, Inc. 2019 - 2023
- Novel Targets for Stroke Intervention - Gene Discovery for Modulators of Infarction awarded by National Institutes of Health 2017 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- BMX-001 AS A THERAPEUTIC AGENT FOR TREATMENT OF MULTIPLE BRAIN METASTASES awarded by BioMimetix JV LLC 2018 - 2021
- Patient Avatars for Pediatric Brain Tumors awarded by Ian's Friends Foundation 2020 - 2021
- A 3D ex vivo orthotopic xenograft screening platform to identify radiosensitization targets and druggability in glioma awarded by National Institutes of Health 2019 - 2021
- Native and bioprinted 3D tissue array platform for predicting cancer metastasis awarded by University of North Carolina - Chapel Hill 2018 - 2020
- Burroughs Wellcome Fund Agreement awarded by Burroughs Wellcome Fund 2015 - 2019
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Salama, Joseph K., Scott R. Floyd, Christopher G. Willett, and David G. Kirsch. “Fostering Radiation Oncology Physician Scientist Trainees Within a Diverse Workforce: The Radiation Oncology Research Scholar Track.” Int J Radiat Oncol Biol Phys, January 4, 2021. https://doi.org/10.1016/j.ijrobp.2020.12.050.Full Text Link to Item
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Park, Christine, Elizabeth P. Howell, Vikram A. Mehta, Luis Ramirez, Meghan J. Price, Scott R. Floyd, John P. Kirkpatrick, et al. “Patient outcomes and tumor control in single-fraction versus hypofractionated stereotactic body radiation therapy for spinal metastases.” J Neurosurg Spine, November 6, 2020, 1–10. https://doi.org/10.3171/2020.6.SPINE20349.Full Text Link to Item
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Edwards, Drake S., Rohin Maganti, Jarred P. Tanksley, Jie Luo, James J. H. Park, Elena Balkanska-Sinclair, Jinjie Ling, and Scott R. Floyd. “BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation.” Cell Rep 32, no. 12 (September 22, 2020): 108166. https://doi.org/10.1016/j.celrep.2020.108166.Full Text Link to Item
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Tay, Ian J., James J. H. Park, Anna L. Price, Bevin P. Engelward, and Scott R. Floyd. “HTS-Compatible CometChip Enables Genetic Screening for Modulators of Apoptosis and DNA Double-Strand Break Repair.” Slas Discov 25, no. 8 (September 2020): 906–22. https://doi.org/10.1177/2472555220918367.Full Text Link to Item
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Barbour, Andrew B., Corbin D. Jacobs, Hannah Williamson, Scott R. Floyd, Gita Suneja, Jordan A. Torok, and John P. Kirkpatrick. “Radiation Therapy Practice Patterns for Brain Metastases in the United States in the Stereotactic Radiosurgery Era.” Adv Radiat Oncol 5, no. 1 (January 2020): 43–52. https://doi.org/10.1016/j.adro.2019.07.012.Full Text Link to Item
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Jain, Sagarika, Suk W. Yoon, Xiaofeng Zhang, Justus Adamson, Scott Floyd, and Mark Oldham. “Evaluation of UVA emission from x-ray megavoltage-irradiated tissues and phantoms.” Phys Med Biol 64, no. 22 (November 21, 2019): 225017. https://doi.org/10.1088/1361-6560/ab4333.Full Text Link to Item
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Nehama, Dean, Natalia Di Ianni, Silvia Musio, Hongwei Du, Monica Patané, Bianca Pollo, Gaetano Finocchiaro, et al. “B7-H3-redirected chimeric antigen receptor T cells target glioblastoma and neurospheres.” Ebiomedicine 47 (September 2019): 33–43. https://doi.org/10.1016/j.ebiom.2019.08.030.Full Text Link to Item
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Abisheva, Zhanerke, Scott R. Floyd, Joseph K. Salama, John Kirkpatrick, Fang-Fang Yin, Michael J. Moravan, William Giles, and Justus Adamson. “The effect of MLC leaf width in single-isocenter multi-target radiosurgery with volumetric modulated arc therapy.” J Radiosurg Sbrt 6, no. 2 (2019): 131–38.Open Access Copy Link to Item
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Lin, Jiaxing, Jeremy Gresham, Tongrong Wang, So Young Kim, James Alvarez, Jeffrey S. Damrauer, Scott Floyd, et al. “bcSeq: an R package for fast sequence mapping in high-throughput shRNA and CRISPR screens.” Bioinformatics 34, no. 20 (October 15, 2018): 3581–83. https://doi.org/10.1093/bioinformatics/bty402.Full Text Link to Item
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Lam, Fred C., Stephen W. Morton, Jeffrey Wyckoff, Tu-Lan Vu Han, Mun Kyung Hwang, Amanda Maffa, Elena Balkanska-Sinclair, Michael B. Yaffe, Scott R. Floyd, and Paula T. Hammond. “Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles.” Nat Commun 9, no. 1 (May 18, 2018): 1991. https://doi.org/10.1038/s41467-018-04315-4.Full Text Open Access Copy Link to Item
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Limon, Dror, Frances McSherry, James Herndon, John Sampson, Peter Fecci, Justus Adamson, Zhiheng Wang, et al. “Single fraction stereotactic radiosurgery for multiple brain metastases.” Adv Radiat Oncol 2, no. 4 (October 2017): 555–63. https://doi.org/10.1016/j.adro.2017.09.002.Full Text Open Access Copy Link to Item
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Jimenez, R. B., B. M. Alexander, A. Mahadevan, A. Niemierko, S. Rajakesari, N. D. Arvold, S. R. Floyd, K. S. Oh, J. S. Loeffler, and H. A. Shih. “The impact of different stereotactic radiation therapy regimens for brain metastases on local control and toxicity.” Advances in Radiation Oncology 2, no. 3 (July 1, 2017): 391–97. https://doi.org/10.1016/j.adro.2017.05.008.Full Text
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Kasper, E., F. Ippen, E. Wong, E. Uhlmann, S. Floyd, and A. Mahadevan. “Stereotactic radiosurgery for brain metastasis from gynecological malignancies.” Oncology Letters 13, no. 3 (March 1, 2017): 1525–28. https://doi.org/10.3892/ol.2017.5621.Full Text
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Mahadevan, Anand, Carrie Sampson, Salvatore LaRosa, Scott R. Floyd, Eric T. Wong, Erik J. Uhlmann, Soma Sengupta, and Ekkehard M. Kasper. “Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy.” Radiat Oncol 10 (November 26, 2015): 245. https://doi.org/10.1186/s13014-015-0555-9.Full Text Open Access Copy Link to Item
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Rameseder, Jonathan, Konstantin Krismer, Yogesh Dayma, Tobias Ehrenberger, Mun Kyung Hwang, Edoardo M. Airoldi, Scott R. Floyd, and Michael B. Yaffe. “A Multivariate Computational Method to Analyze High-Content RNAi Screening Data.” J Biomol Screen 20, no. 8 (September 2015): 985–97. https://doi.org/10.1177/1087057115583037.Full Text Link to Item
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Rangachari, Deepa, Norihiro Yamaguchi, Paul A. VanderLaan, Erik Folch, Anand Mahadevan, Scott R. Floyd, Erik J. Uhlmann, et al. “Brain metastases in patients with EGFR-mutated or ALK-rearranged non-small-cell lung cancers.” Lung Cancer 88, no. 1 (April 2015): 108–11. https://doi.org/10.1016/j.lungcan.2015.01.020.Full Text Link to Item
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Christ, Sebastian M., Anand Mahadevan, Scott R. Floyd, Fred C. Lam, Clark C. Chen, Eric T. Wong, and Ekkehard M. Kasper. “Stereotactic radiosurgery for brain metastases from malignant melanoma.” Surg Neurol Int 6, no. Suppl 12 (2015): S355–65. https://doi.org/10.4103/2152-7806.163315.Full Text Link to Item
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Schoenfeld, Jonathan D., Anand Mahadevan, Scott R. Floyd, Michael A. Dyer, Paul J. Catalano, Brian M. Alexander, David F. McDermott, and Irving D. Kaplan. “Ipilmumab and cranial radiation in metastatic melanoma patients: a case series and review.” J Immunother Cancer 3 (2015): 50. https://doi.org/10.1186/s40425-015-0095-8.Full Text Open Access Copy Link to Item
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Dyer, Michael A., Nils D. Arvold, Yu-Hui Chen, Nancy E. Pinnell, Timur Mitin, Eudocia Q. Lee, F Stephen Hodi, et al. “The role of whole brain radiation therapy in the management of melanoma brain metastases.” Radiat Oncol 9 (June 22, 2014): 143. https://doi.org/10.1186/1748-717X-9-143.Full Text Open Access Copy Link to Item
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Floyd, Scott R., Michael E. Pacold, Qiuying Huang, Scott M. Clarke, Fred C. Lam, Ian G. Cannell, Bryan D. Bryson, et al. “The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.” Nature 498, no. 7453 (June 13, 2013): 246–50. https://doi.org/10.1038/nature12147.Full Text Open Access Copy Link to Item
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Weingeist, David M., Jing Ge, David K. Wood, James T. Mutamba, Qiuying Huang, Elizabeth A. Rowland, Michael B. Yaffe, Scott Floyd, and Bevin P. Engelward. “Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors.” Cell Cycle 12, no. 6 (March 15, 2013): 907–15. https://doi.org/10.4161/cc.23880.Full Text Open Access Copy Link to Item
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Fonkem, Ekokobe, Erik J. Uhlmann, Scott R. Floyd, Anand Mahadevan, Ekkehard Kasper, Omar Eton, and Eric T. Wong. “Melanoma brain metastasis: overview of current management and emerging targeted therapies.” Expert Rev Neurother 12, no. 10 (October 2012): 1207–15. https://doi.org/10.1586/ern.12.111.Full Text Link to Item
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Lu, Xing-Qi, Anand Mahadevan, George Mathiowitz, Pei-Jan P. Lin, Ajith Thomas, Ekkehard M. Kasper, Scott R. Floyd, et al. “Frameless angiogram-based stereotactic radiosurgery for treatment of arteriovenous malformations.” Int J Radiat Oncol Biol Phys 84, no. 1 (September 1, 2012): 274–82. https://doi.org/10.1016/j.ijrobp.2011.10.044.Full Text Link to Item
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Floyd, S. R. “Outcomes of node-negative breast cancer 5 centimeters and larger treated with and without postmastectomy radiotherapy: Goulart J, Truong P, Woods R, et al (Univ of British Columbia, Vancouver, Canada; British Columbia Cancer Agency, Vancouver, Canada) Int J Radiat Oncol Biol Phys 80:758-764, 2011.” Breast Diseases 23, no. 2 (May 24, 2012): 185–87. https://doi.org/10.1016/j.breastdis.2012.03.028.Full Text
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Wang, Che-Chuan, Scott R. Floyd, Chin-Hong Chang, Peter C. Warnke, Chung-Ching Chio, Ekkehard M. Kasper, Anand Mahadevan, Eric T. Wong, and Clark C. Chen. “Cyberknife hypofractionated stereotactic radiosurgery (HSRS) of resection cavity after excision of large cerebral metastasis: efficacy and safety of an 800 cGy × 3 daily fractions regimen.” J Neurooncol 106, no. 3 (February 2012): 601–10. https://doi.org/10.1007/s11060-011-0697-z.Full Text Link to Item
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Mahadevan, Anand, Scott Floyd, Eric Wong, Suriya Jeyapalan, Michael Groff, and Ekkehard Kasper. “Stereotactic body radiotherapy reirradiation for recurrent epidural spinal metastases.” Int J Radiat Oncol Biol Phys 81, no. 5 (December 1, 2011): 1500–1505. https://doi.org/10.1016/j.ijrobp.2010.08.012.Full Text Link to Item
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Mahadevan, Anand, Scott Floyd, Eric Wong, Clark Chen, and Ekkehard Kasper. “Clinical outcome after hypofractionated stereotactic radiotherapy (HSRT) for benign skull base tumors.” Comput Aided Surg 16, no. 3 (2011): 112–20. https://doi.org/10.3109/10929088.2011.565160.Full Text Link to Item
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Floyd, Scott R., and Alphonse G. Taghian. “Post-mastectomy radiation in large node-negative breast tumors: does size really matter?” Radiother Oncol 91, no. 1 (April 2009): 33–37. https://doi.org/10.1016/j.radonc.2008.09.015.Full Text Link to Item
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Martin, N. E., S. Floyd, R. A. Raad, and A. Taghian. “The role of postmastectomy radiation in node-negative breast tumors larger than 5 cm.” American Journal of Hematology/ Oncology 6, no. 4 (April 1, 2007): 197–99.
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Floyd, Scott R., Thomas A. Buchholz, Bruce G. Haffty, Saveli Goldberg, Andrzej Niemierko, Rita Abi Raad, Mary J. Oswald, et al. “Low local recurrence rate without postmastectomy radiation in node-negative breast cancer patients with tumors 5 cm and larger.” Int J Radiat Oncol Biol Phys 66, no. 2 (October 1, 2006): 358–64. https://doi.org/10.1016/j.ijrobp.2006.05.001.Full Text Link to Item
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Taghian, Alphonse G., Sherif I. Assaad, Andrzej Niemierko, Scott R. Floyd, and Simon N. Powell. “Is a reduction in radiation lung volume and dose necessary with paclitaxel chemotherapy for node-positive breast cancer?” Int J Radiat Oncol Biol Phys 62, no. 2 (June 1, 2005): 386–91. https://doi.org/10.1016/j.ijrobp.2004.09.044.Full Text Link to Item
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Floyd, Scott R., Liron Pantanowitz, David F. McDermott, Jennifer Yannucci, Jane A. Driver, Mary Ann Stevenson, Benjamin D. Smith, Lynn D. Wilson, and Paul G. Richardson. “Plasma cell problems: Case 1. Disseminated cutaneous plasmacytomas treated with total skin electron radiotherapy.” J Clin Oncol 23, no. 13 (May 1, 2005): 3138–40. https://doi.org/10.1200/JCO.2005.05.175.Full Text Link to Item
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Schmierer, K., P. Grosse, P. De Camilli, M. Solimena, S. Floyd, and R. Zschenderlein. “Paraneoplastic stiff-person syndrome: no tumor progression over 5 years.” Neurology 58, no. 1 (January 8, 2002): 148. https://doi.org/10.1212/wnl.58.1.148.Full Text Link to Item
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Farsad, K., N. Ringstad, K. Takei, S. R. Floyd, K. Rose, and P. De Camilli. “Generation of high curvature membranes mediated by direct endophilin bilayer interactions.” J Cell Biol 155, no. 2 (October 15, 2001): 193–200. https://doi.org/10.1083/jcb.200107075.Full Text Open Access Copy Link to Item
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Floyd, S. R., E. B. Porro, V. I. Slepnev, G. C. Ochoa, L. H. Tsai, and P. De Camilli. “Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2.” J Biol Chem 276, no. 11 (March 16, 2001): 8104–10. https://doi.org/10.1074/jbc.M008932200.Full Text Link to Item
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Ferracci, F., G. Fassetta, M. H. Butler, S. Floyd, M. Solimena, and P. De Camilli. “A novel antineuronal antibody in a motor neuron syndrome associated with breast cancer.” Neurology 53, no. 4 (September 11, 1999): 852–55. https://doi.org/10.1212/wnl.53.4.852.Full Text Link to Item
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Floyd, S., and P. De Camilli. “Endocytosis proteins and cancer: a potential link?” Trends Cell Biol 8, no. 8 (August 1998): 299–301. https://doi.org/10.1016/s0962-8924(98)01316-6.Full Text Link to Item
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Floyd, S., M. H. Butler, O. Cremona, C. David, Z. Freyberg, X. Zhang, M. Solimena, et al. “Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer.” Mol Med 4, no. 1 (January 1998): 29–39.Link to Item
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Conference Papers
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Lam, Fred C., Stephen W. Morton, Jeffrey Wyckoff, Amanda Maffa, Elena Balkanska-Sinclair, Scott R. Floyd, Michael B. Yaffe, and Paula T. Hammond. “ENHANCED IN VIVO EFFICACY AND SAFETY OF COMBINATION TEMOZOLOMIDE AND BROMODOMAIN INHIBITOR THERAPY FOR GLIOMAS USING A TARGETED DUAL DRUG-LOADING STEALTH LIPOSOMAL CARRIER.” In Neuro Oncology, 19:273–273. OXFORD UNIV PRESS INC, 2017.Link to Item
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Mahadevan, Anand, Loretta Barron, Scott R. Floyd, Ekkehard Kasper, and Eric T. Wong. “Survival benefit of tumor treating fields plus stereotactic radiosurgery for recurrent malignant gliomas.” In Journal of Clinical Oncology, 33:e13036–e13036. American Society of Clinical Oncology (ASCO), 2015. https://doi.org/10.1200/jco.2015.33.15_suppl.e13036.Full Text
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- Teaching & Mentoring
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Recent Courses
- PHARM 393: Research Independent Study 2021
- PHARM 394: Research Independent Study 2021
- PHARM 493: Research Independent Study 2021
- PHARM 494: Research Independent Study 2021
- PHARM 393: Research Independent Study 2020
- PHARM 394: Research Independent Study 2020
- PHARM 493: Research Independent Study 2020
- PHARM 494: Research Independent Study 2020
- PHARM 393: Research Independent Study 2019
- PHARM 394: Research Independent Study 2019
- PHARM 493: Research Independent Study 2019
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