Scott Richard Floyd | Scholars@Duke

Scott Richard Floyd
Associate Professor of Radiation Oncology

Current Appointments & Affiliations

Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2018
Assistant Research Professor in Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2016
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2015

Contact Information

Duke Cancer Institute, Box 3085 DUMC, Durham, NC 27710
Levine Science Research Center, B233, 450 Research Drive, Box 103655, Durham, NC 27710
scott.floyd@duke.edu (919) 668-7342

Background
Education, Training, & Certifications
- Clinical Investigator, Koch Institute For Integrative Cancer Research, Massachusetts Institute of Technology 2012
- Resident, Harvard Radiation Oncology Program, Harvard Medical School 2003 - 2007
- Intern, Internal Medicine, Hospital of Saint Raphael 2002 - 2003
- M.D., Yale University School of Medicine 2002
- Ph.D., Yale University 2002
Duke Appointment History
- Associate Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2016 - 2018
- Instructor, Temporary in the Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2015 - 2016
Research
Selected Grants
- Novel Targets for Stroke Intervention - Gene Discovery for Modulators of Infarction awarded by National Institutes of Health 2017 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Burroughs Wellcome Fund Agreement awarded by Burroughs Wellcome Fund 2015 - 2019
- BMX-001 AS A THERAPEUTIC AGENT FOR TREATMENT OF MULTIPLE BRAIN METASTASES awarded by BioMimetix JV LLC 2018 - 2019
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lin, J, Gresham, J, Wang, T, Kim, SY, Alvarez, J, Damrauer, JS, Floyd, S, Granek, J, Allen, A, Chan, C, Xie, J, and Owzar, K. "bcSeq: an R package for fast sequence mapping in high-throughput shRNA and CRISPR screens." Bioinformatics (Oxford, England) 34, no. 20 (October 2018): 3581-3583. Full Text
  - Lam, FC, Morton, SW, Wyckoff, J, Vu Han, T-L, Hwang, MK, Maffa, A, Balkanska-Sinclair, E, Yaffe, MB, Floyd, SR, and Hammond, PT. "Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles." Nature Communications 9, no. 1 (May 18, 2018): 1991-null. Full Text Open Access Copy
  - Limon, D, McSherry, F, Herndon, J, Sampson, J, Fecci, P, Adamson, J, Wang, Z, Yin, F-F, Floyd, S, Kirkpatrick, J, and Kim, GJ. "Single fraction stereotactic radiosurgery for multiple brain metastases." Advances in Radiation Oncology 2, no. 4 (October 2017): 555-563. Full Text Open Access Copy
  - Jimenez, RB, Alexander, BM, Mahadevan, A, Niemierko, A, Rajakesari, S, Arvold, ND, Floyd, SR, Oh, KS, Loeffler, JS, and Shih, HA. "The impact of different stereotactic radiation therapy regimens for brain metastases on local control and toxicity." Advances in Radiation Oncology 2, no. 3 (July 2017): 391-397. Full Text
  - Kasper, E, Ippen, F, Wong, E, Uhlmann, E, Floyd, S, and Mahadevan, A. "Stereotactic radiosurgery for brain metastasis from gynecological malignancies." Oncology Letters (January 18, 2017). Full Text
  - Rameseder, J, Krismer, K, Dayma, Y, Ehrenberger, T, Hwang, MK, Airoldi, EM, Floyd, SR, and Yaffe, MB. "A Multivariate Computational Method to Analyze High-Content RNAi Screening Data." Journal of biomolecular screening 20, no. 8 (September 2015): 985-997. Full Text
  - Rangachari, D, Yamaguchi, N, VanderLaan, PA, Folch, E, Mahadevan, A, Floyd, SR, Uhlmann, EJ, Wong, ET, Dahlberg, SE, Huberman, MS, and Costa, DB. "Brain metastases in patients with EGFR-mutated or ALK-rearranged non-small-cell lung cancers." Lung Cancer (Amsterdam, Netherlands) 88, no. 1 (April 2015): 108-111. Full Text
  - Christ, SM, Mahadevan, A, Floyd, SR, Lam, FC, Chen, CC, Wong, ET, and Kasper, EM. "Stereotactic radiosurgery for brain metastases from malignant melanoma." Surgical neurology international 6, no. Suppl 12 (January 2015): S355-S365. Full Text
  - Mahadevan, A, Sampson, C, LaRosa, S, Floyd, SR, Wong, ET, Uhlmann, EJ, Sengupta, S, and Kasper, EM. "Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy." Radiation oncology (London, England) 10 (January 2015): 245-. Full Text Open Access Copy
  - Schoenfeld, JD, Mahadevan, A, Floyd, SR, Dyer, MA, Catalano, PJ, Alexander, BM, McDermott, DF, and Kaplan, ID. "Ipilmumab and cranial radiation in metastatic melanoma patients: a case series and review." Journal for Immunotherapy of Cancer 3 (January 2015): 50-null. Full Text Open Access Copy
  - Dyer, MA, Arvold, ND, Chen, Y-H, Pinnell, NE, Mitin, T, Lee, EQ, Hodi, FS, Ibrahim, N, Weiss, SE, Kelly, PJ, Floyd, SR, Mahadevan, A, and Alexander, BM. "The role of whole brain radiation therapy in the management of melanoma brain metastases." Radiation Oncology (London, England) 9 (January 2014): 143-null. Full Text Open Access Copy
  - Floyd, SR, Pacold, ME, Huang, Q, Clarke, SM, Lam, FC, Cannell, IG, Bryson, BD, Rameseder, J, Lee, MJ, Blake, EJ, Fydrych, A, Ho, R, Greenberger, BA, Chen, GC, Maffa, A, Del Rosario, AM, Root, DE, Carpenter, AE, Hahn, WC, Sabatini, DM, Chen, CC, White, FM, Bradner, JE, and Yaffe, MB. "The bromodomain protein Brd4 insulates chromatin from DNA damage signalling." Nature 498, no. 7453 (June 2, 2013): 246-250. Full Text Open Access Copy
  - Weingeist, DM, Ge, J, Wood, DK, Mutamba, JT, Huang, Q, Rowland, EA, Yaffe, MB, Floyd, S, and Engelward, BP. "Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors." Cell cycle (Georgetown, Tex.) 12, no. 6 (March 2013): 907-915. Full Text Open Access Copy
  - Fonkem, E, Uhlmann, EJ, Floyd, SR, Mahadevan, A, Kasper, E, Eton, O, and Wong, ET. "Melanoma brain metastasis: overview of current management and emerging targeted therapies." Expert Review of Neurotherapeutics 12, no. 10 (October 2012): 1207-1215. (Review) Full Text
  - Lu, X-Q, Mahadevan, A, Mathiowitz, G, Lin, P-JP, Thomas, A, Kasper, EM, Floyd, SR, Holupka, E, La Rosa, S, Wang, F, and Stevenson, MA. "Frameless angiogram-based stereotactic radiosurgery for treatment of arteriovenous malformations." International journal of radiation oncology, biology, physics 84, no. 1 (September 2012): 274-282. Full Text
  - Floyd, SR. "Outcomes of node-negative breast cancer 5 centimeters and larger treated with and without postmastectomy radiotherapy: Goulart J, Truong P, Woods R, et al (Univ of British Columbia, Vancouver, Canada; British Columbia Cancer Agency, Vancouver, Canada) Int J Radiat Oncol Biol Phys 80:758-764, 2011." Breast Diseases 23, no. 2 (May 24, 2012): 185-187. Full Text
  - Wang, C-C, Floyd, SR, Chang, C-H, Warnke, PC, Chio, C-C, Kasper, EM, Mahadevan, A, Wong, ET, and Chen, CC. "Cyberknife hypofractionated stereotactic radiosurgery (HSRS) of resection cavity after excision of large cerebral metastasis: efficacy and safety of an 800 cGy × 3 daily fractions regimen." Journal of Neuro Oncology 106, no. 3 (February 2012): 601-610. Full Text
  - Mahadevan, A, Floyd, S, Wong, E, Jeyapalan, S, Groff, M, and Kasper, E. "Stereotactic body radiotherapy reirradiation for recurrent epidural spinal metastases." International journal of radiation oncology, biology, physics 81, no. 5 (December 2011): 1500-1505. Full Text
  - Mahadevan, A, Floyd, S, Wong, E, Chen, C, and Kasper, E. "Clinical outcome after hypofractionated stereotactic radiotherapy (HSRT) for benign skull base tumors." Computer aided surgery : official journal of the International Society for Computer Aided Surgery 16, no. 3 (January 2011): 112-120. Full Text
  - Floyd, SR, and Taghian, AG. "Post-mastectomy radiation in large node-negative breast tumors: does size really matter?." Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 91, no. 1 (April 2009): 33-37. (Review) Full Text
  - Martin, NE, Floyd, S, Raad, RA, and Taghian, A. "The role of postmastectomy radiation in node-negative breast tumors larger than 5 cm." American Journal of Hematology/ Oncology 6, no. 4 (April 1, 2007): 197-199.
  - Floyd, SR, Buchholz, TA, Haffty, BG, Goldberg, S, Niemierko, A, Raad, RA, Oswald, MJ, Sullivan, T, Strom, EA, Powell, SN, Katz, A, and Taghian, AG. "Low local recurrence rate without postmastectomy radiation in node-negative breast cancer patients with tumors 5 cm and larger." International journal of radiation oncology, biology, physics 66, no. 2 (October 2006): 358-364. Full Text
  - Taghian, AG, Assaad, SI, Niemierko, A, Floyd, SR, and Powell, SN. "Is a reduction in radiation lung volume and dose necessary with paclitaxel chemotherapy for node-positive breast cancer?." International journal of radiation oncology, biology, physics 62, no. 2 (June 2005): 386-391. Full Text
  - Floyd, SR, Pantanowitz, L, McDermott, DF, Yannucci, J, Driver, JA, Stevenson, MA, Smith, BD, Wilson, LD, and Richardson, PG. "Plasma cell problems: Case 1. Disseminated cutaneous plasmacytomas treated with total skin electron radiotherapy." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 23, no. 13 (May 2005): 3138-3140. Full Text
  - Schmierer, K, Grosse, P, De Camilli, P, Solimena, M, Floyd, S, and Zschenderlein, R. "Paraneoplastic stiff-person syndrome: no tumor progression over 5 years." Neurology 58, no. 1 (January 2002): 148-. Full Text
  - Farsad, K, Ringstad, N, Takei, K, Floyd, SR, Rose, K, and De Camilli, P. "Generation of high curvature membranes mediated by direct endophilin bilayer interactions." The Journal of cell biology 155, no. 2 (October 15, 2001): 193-200. Full Text Open Access Copy
  - Floyd, SR, Porro, EB, Slepnev, VI, Ochoa, GC, Tsai, LH, and De Camilli, P. "Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2." The Journal of biological chemistry 276, no. 11 (March 2001): 8104-8110. Full Text
  - Ferracci, F, Fassetta, G, Butler, MH, Floyd, S, Solimena, M, and De Camilli, P. "A novel antineuronal antibody in a motor neuron syndrome associated with breast cancer." Neurology 53, no. 4 (September 1999): 852-855. Full Text
  - Floyd, S, and De Camilli, P. "Endocytosis proteins and cancer: a potential link?." Trends in Cell Biology 8, no. 8 (August 1998): 299-301. (Review) Full Text
  - Floyd, S, Butler, MH, Cremona, O, David, C, Freyberg, Z, Zhang, X, Solimena, M, Tokunaga, A, Ishizu, H, Tsutsui, K, and De Camilli, P. "Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer." Molecular Medicine 4, no. 1 (January 1998): 29-39. Full Text
- Conference Papers
  - Lam, FC, Morton, SW, Wyckoff, J, Maffa, A, Balkanska-Sinclair, E, Floyd, SR, Yaffe, MB, and Hammond, PT. "ENHANCED IN VIVO EFFICACY AND SAFETY OF COMBINATION TEMOZOLOMIDE AND BROMODOMAIN INHIBITOR THERAPY FOR GLIOMAS USING A TARGETED DUAL DRUG-LOADING STEALTH LIPOSOMAL CARRIER." November 2017. Link to Item
  - Mahadevan, A, Barron, L, Floyd, SR, Kasper, E, and Wong, ET. "Survival benefit of tumor treating fields plus stereotactic radiosurgery for recurrent malignant gliomas." May 20, 2015. Link to Item
Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Recent Courses