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Scott Richard Floyd

Gary Hock and Lyn Proctor Associate Professor of Radiation Oncology
Radiation Oncology
Levine Science Research Center, B233, 450 Research Drive, Box 103655, Durham, NC 27710
Duke Cancer Institute, Box 3085 DUMC, Durham, NC 27710

Research Interests


The Floyd Lab focuses on studying mechanisms of DNA damage signaling and repair in brain tumor and other mammalian cells. Specifically, we focus on how chromatin changes mediated by epigenetic modifiers affect the DNA damage response. It is our hope that deeper knowledge regarding the DNA damage response will lead to improved cancer treatments, especially for brain tumor patients. 

Dr. Floyd is a radiation oncologist and brain tumor specialist with first-hand knowledge of the devastating impact of brain tumors and side effects of many current cancer therapies. His lab develops small animal irradiation techniques and mouse models of glioblastoma to test the effects of epigenetic writers and readers on the DDR in more clinically relevant model systems. In this way, we hope to identify strategies to augment tumor cell killing, and/or protect the vital normal tissues for the brain. 

Clinically, Dr. Floyd specializes in the treatment of benign, primary and metastatic tumors of the brain and spine.

Selected Grants


NEUROD1 function in SCLC fate and plasticity

ResearchCollaborator · Awarded by National Institutes of Health · 2024 - 2029

Synthetic lethality with BET bromodomain inhibition

ResearchPrincipal Investigator · Awarded by American Cancer Society, Inc. · 2025 - 2026

Elucidating Brain Tumor Biology and Response to Radiotherapy Using Cell-Free-DNA Methylation Signatures

ResearchCo-Mentor · Awarded by National Institutes of Health · 2024 - 2026

Exploring synthetic lethality with a novel very high energy electron FLASH radiation beam

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2026

Super-FLASH radiation therapy for pediatric brain tumors

ResearchPrincipal Investigator · Awarded by Ian's Friends Foundation · 2024 - 2025

Duke Radiation Oncology and Radiology Stimulating Access to Research in Residency (Year 4)

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2025

A consortium effort to translate therapies for neurological diseases via an immune-competent organotypic platform

ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2021 - 2025

A novel platform to determine RABEP2 function as a therapeutic target in human ischemic stroke

ResearchCo-Mentor · Awarded by American Heart Association · 2022 - 2025

ASPET SURF Institutional Award

Inst. Training Prgm or CMEParticipating Faculty Member · Awarded by American Society for Pharmacology and Experimental Therapeutics · 2018 - 2025

Development of MESH1 inhibitors to treat ferroptosis-associated neurodegeneration

ResearchCo Investigator · Awarded by National Institutes of Health · 2022 - 2024

Living Patient Avatars for Tumor Microenvironment Discovery

ResearchPrincipal Investigator · Awarded by Ian's Friends Foundation · 2023 - 2024

BMX-001 AS A THERAPEUTIC AGENT FOR TREATMENT OF MULTIPLE BRAIN METASTASES

Clinical TrialCo Investigator · Awarded by BioMimetix JV LLC · 2018 - 2023

Novel Targets for Stroke Intervention - Gene Discovery for Modulators of Infarction

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2017 - 2023

Role of BRD4 in the cancer cell replication stress response

ResearchPrincipal Investigator · Awarded by American Cancer Society, Inc. · 2019 - 2023

Cabinet Radiation Therapy System for Small Animals

EquipmentMajor User · Awarded by North Carolina Biotechnology Center · 2022 - 2023

Image-Guided Radiation Therapy System for Small Animals

EquipmentMajor User · Awarded by National Institutes of Health · 2021 - 2022

Medical Scientist Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022

Patient Avatars for Pediatric Brain Tumors

ResearchPrincipal Investigator · Awarded by Ian's Friends Foundation · 2020 - 2021

A 3D ex vivo orthotopic xenograft screening platform to identify radiosensitization targets and druggability in glioma

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2021

Native and bioprinted 3D tissue array platform for predicting cancer metastasis

ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2018 - 2020

Burroughs Wellcome Fund Agreement

ResearchPrincipal Investigator · Awarded by Burroughs Wellcome Fund · 2015 - 2019

External Relationships


  • Roundtable Research

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.