Scholars@Duke
Scott Richard Floyd

Scott Richard Floyd

Gary Hock and Lyn Proctor Associate Professor of Radiation Oncology
Radiation Oncology
scott.floyd@duke.edu
Levine Science Research Center, B233, 450 Research Drive, Box 103655, Durham, NC 27710
Duke Cancer Institute, Box 3085 DUMC, Durham, NC 27710

Selected Publications

Neurocognitive outcomes in patients with brain metastases: a systematic review.

Journal Article Lancet Oncol · December 2025 Multimodality therapy, including surgery, radiotherapy, and systemic therapy, has significantly improved overall survival for patients with brain metastases. However, treatment-related neurocognitive sequelae remain a major challenge in survivorship. Altho ... Full text Link to item Cite

Investigating the FLASH Effect in a Rat Brain Organotypic Model With a Novel High-Energy Electron Beam.

Journal Article Int J Radiat Oncol Biol Phys · October 10, 2025 PURPOSE: Ultrahigh dose rate (FLASH) radiation therapy is reported to reduce normal tissue toxicity while maintaining tumor control; however, mechanism(s) remain obscure. To study FLASH mechanisms in brain tissue, we developed a novel experimental platform ... Full text Link to item Cite

Management outcomes for biopsy-proven radiation necrosis in patients with brain metastases in the era of immune-checkpoint blockade.

Journal Article J Neurooncol · October 2025 PURPOSE: Immunotherapy and stereotactic radiosurgery (SRS) are frequently combined in the management of brain metastases from non-small cell lung cancer (NSCLC) and melanoma. However, concurrent SRS and dual immune-checkpoint inhibition (ICPI) elevate the ... Full text Open Access Link to item Cite

Coenzyme A protects against ferroptosis via CoAlation of mitochondrial thioredoxin reductase.

Journal Article J Clin Invest · October 1, 2025 The cystine-xCT transporter/glutathione/GPX4 axis is the canonical pathway protecting cells from ferroptosis. Whereas GPX4-targeting ferroptosis-inducing compounds (FINs) act independently of mitochondria, xCT-targeting FINs require mitochondrial lipid per ... Full text Link to item Cite

Investigating Rat-Brain Normal Tissue and Tumor FLASH Effects with a Novel Very High Energy Electron Beam.

Journal Article bioRxiv · September 10, 2025 PURPOSE: Ultra-high dose rate (FLASH) irradiation is reported to reduce normal tissue toxicity while maintaining tumor control, however mechanism(s) remain obscure. To study FLASH mechanisms in brain tissue, we developed a novel experimental platform featu ... Full text Link to item Cite

Clinical Parameters Associated With Intracranial Progression Burden Following an Initial Stereotactic Radiosurgery Course in a Multi-institutional Brain Metastases Cohort.

Journal Article Adv Radiat Oncol · September 2025 PURPOSE: Following initial stereotactic radiosurgery (SRS), risk factors for high-burden intracranial progression (ICP) necessitating whole brain radiation remain poorly characterized. We hypothesize that specific clinical parameters at initial SRS are ass ... Full text Link to item Cite

Evidence for functional regulation of the KLHL3/WNK pathway by O-GlcNAcylation.

Journal Article Glycobiology · August 11, 2025 The 42-member Kelch-like (KLHL) protein family are adaptors for ubiquitin E3 ligase complexes, governing the stability of a wide range of substrates. KLHL proteins are critical for maintaining proteostasis in a variety of tissues and are mutated in human d ... Full text Link to item Cite

A Radiogenomic Deep Ensemble Learning Model for Identifying Radionecrosis Following Brain Metastases (BM) Stereotactic Radiosurgery in Patients With Non-small Cell Lung Cancer BM.

Journal Article Adv Radiat Oncol · August 2025 PURPOSE: Stereotactic radiosurgery (SRS) is widely used for brain metastases (BM), but the risk of radionecrosis poses a challenge in post-SRS management. Given the lack of noninvasive imaging methods for distinguishing radionecrosis from recurrence, we ai ... Full text Link to item Cite

Multi-institutional Outcomes after Stereotactic Radiosurgery for Gastrointestinal Brain Metastases.

Journal Article Adv Radiat Oncol · July 2025 PURPOSE: To compare outcomes between gastrointestinal and nongastrointestinal patients with brain metastases after radiosurgery. METHODS AND MATERIALS: Retrospective cohort study identifying patients completing an initial course of radiosurgery between Jan ... Full text Link to item Cite

Seizure risk factors and management approaches in patients with brain metastases.

Journal Article Neurooncol Pract · June 2025 A significant proportion of patients with brain metastases experience a seizure event during their disease course, which can impact morbidity and long-term outcomes. A host of factors elevate the risk for seizures in patients with brain metastases, includi ... Full text Link to item Cite

Radiogenomic explainable AI with neural ordinary differential equation for identifying post-SRS brain metastasis radionecrosis.

Conference Med Phys · April 2025 BACKGROUND: Stereotactic radiosurgery (SRS) is widely used for managing brain metastases (BMs), but an adverse effect, radionecrosis, complicates post-SRS management. Differentiating radionecrosis from tumor recurrence non-invasively remains a major clinic ... Full text Link to item Cite

Radiogenomic explainable AI with neural ordinary differential equation for identifying post‐SRS brain metastasis radionecrosis

Journal Article Medical Physics · April 2025 AbstractBackgroundStereotactic radiosurgery (SRS) is widely used for managing brain metastases (BMs), but an adverse effect, radionecrosis, complicates post‐SRS management. Differentiating ... Full text Cite

Evidence for Functional Regulation of the KLHL3/WNK Pathway by O-GlcNAcylation.

Journal Article bioRxiv · February 27, 2025 The 42-member Kelch-like (KLHL) protein family are adaptors for ubiquitin E3 ligase complexes, governing the stability of a wide range of substrates. KLHL proteins are critical for maintaining proteostasis in a variety of tissues and are mutated in human d ... Full text Link to item Cite

Targeting the ferroptosis pathway: A novel compound, AZD1390, protects the brain after ischemic stroke.

Journal Article bioRxiv · February 25, 2025 BACKGROUND: Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation. This process has been implicated in various diseases, including ischemic stroke. Ischemic stroke leads to oxidative stress, iron overload, and reactive ... Full text Link to item Cite

Consortium for Intracranial Metastasis Academic Research (CIMARa): Global interdisciplinary collaborations to improve outcomes of patient with brain metastases.

Journal Article Neurooncol Adv · 2025 Brain metastases (BrM) arising from solid tumors is an ever-increasing and often devastating clinical challenge impacting hundreds of thousands of patients annually worldwide. As systemic anticancer therapies, and thus survival, improve, the risk for centr ... Full text Link to item Cite

Dose-Incorporated Deep Ensemble Learning for Improving Brain Metastasis Stereotactic Radiosurgery Outcome Prediction.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2024 PURPOSE: To develop a novel deep ensemble learning model for accurate prediction of brain metastasis (BM) local control outcomes after stereotactic radiosurgery (SRS). METHODS AND MATERIALS: A total of 114 brain metastases (BMs) from 82 patients were evalu ... Full text Link to item Cite

Selecting the Most Relevant Mouse Strains for Evaluating Radiation-Induced Multiple Tissue Injury after Leg-Shielded Partial-Body Gamma Irradiation.

Journal Article Radiat Res · September 1, 2024 Animal studies are needed that best simulate a large-scale, inhomogeneous body exposure after a radiological or nuclear incident and that provides a platform for future development of medical countermeasures. A partial-body irradiation (PBI) model using 13 ... Full text Link to item Cite

Determinants of Symptomatic Intracranial Progression After an Initial Stereotactic Radiosurgery Course.

Journal Article Adv Radiat Oncol · June 2024 PURPOSE: Clinical and imaging surveillance of patients with brain metastases is important after stereotactic radiosurgery (SRS) because many will experience intracranial progression (ITCP) requiring multidisciplinary management. The prognostic significance ... Full text Link to item Cite

A multi-institutional meningioma MRI dataset for automated multi-sequence image segmentation.

Journal Article Sci Data · May 15, 2024 Meningiomas are the most common primary intracranial tumors and can be associated with significant morbidity and mortality. Radiologists, neurosurgeons, neuro-oncologists, and radiation oncologists rely on brain MRI for diagnosis, treatment planning, and l ... Full text Link to item Cite

Long-Term Intracranial Outcomes With Combination Dual Immune-Checkpoint Blockade and Stereotactic Radiosurgery in Patients With Melanoma and Non-Small Cell Lung Cancer Brain Metastases.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2024 PURPOSE: The intracranial benefit of offering dual immune-checkpoint inhibition (D-ICPI) with ipilimumab and nivolumab to patients with melanoma or non-small cell lung cancer (NSCLC) receiving stereotactic radiosurgery (SRS) for brain metastases (BMs) is u ... Full text Link to item Cite

Incidence and imaging characteristics of difficult to detect retrospectively identified brain metastases in patients receiving repeat courses of stereotactic radiosurgery.

Journal Article J Neurooncol · March 2024 PURPOSE: During stereotactic radiosurgery (SRS) planning for brain metastases (BM), brain MRIs are reviewed to select appropriate targets based on radiographic characteristics. Some BM are difficult to detect and/or definitively identify and may go untreat ... Full text Link to item Cite

Effects of Ataxia-Telangiectasia Mutated Variants on Radionecrosis and Local Control After Stereotactic Radiation Surgery for Non-Small Cell Lung Cancer Brain Metastases.

Journal Article Adv Radiat Oncol · January 2024 PURPOSE: Genetic variants affecting the radiation response protein ataxia-telangiectasia mutated (ATM) have been associated with increased adverse effects of radiation but also with improved local control after conventional radiation therapy. However, it i ... Full text Link to item Cite

Impact of TP53 mutations on brain metastasis control in non-small cell lung cancer patients undergoing stereotactic radiosurgery.

Journal Article J Radiosurg SBRT · 2024 PURPOSE: To investigate whether TP53 variants may be correlated with overall survival and local control following stereotactic radiosurgery (SRS) for brain metastases (BMs) from non-small cell lung cancer (NSCLC). METHODS: Patients undergoing an initial co ... Link to item Cite

Single-fraction Radiation Treatment Dose Response in a Genetically Engineered Mouse Model of Medulloblastoma.

Journal Article Radiat Res · December 1, 2023 Medulloblastoma is the most common malignant brain tumor of children. Although standard of care radiotherapy for pediatric medulloblastoma (PM) can lead to long-term remission or cure in many patients, it can also cause life-long cognitive impairment and o ... Full text Link to item Cite

Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer.

Journal Article Commun Med (Lond) · August 9, 2023 BACKGROUND: Genetically engineered mouse models (GEMMs) of cancer are powerful tools to study mechanisms of disease progression and therapy response, yet little is known about how these models respond to multimodality therapy used in patients. Radiation th ... Full text Link to item Cite

A neural ordinary differential equation model for visualizing deep neural network behaviors in multi-parametric MRI-based glioma segmentation.

Journal Article Med Phys · August 2023 PURPOSE: To develop a neural ordinary differential equation (ODE) model for visualizing deep neural network behavior during multi-parametric MRI-based glioma segmentation as a method to enhance deep learning explainability. METHODS: By hypothesizing that d ... Full text Link to item Cite

A living ex vivo platform for functional, personalized brain cancer diagnosis.

Journal Article Cell Rep Med · June 20, 2023 Functional precision medicine platforms are emerging as promising strategies to improve pre-clinical drug testing and guide clinical decisions. We have developed an organotypic brain slice culture (OBSC)-based platform and multi-parametric algorithm that e ... Full text Link to item Cite

Pretreatment clinical parameters associated with intracranial progression burden following an initial stereotactic radiosurgery course in a multi-institutional brain metastases cohort.

Conference Journal of Clinical Oncology · June 1, 2023 2013 Background: While brain metastasis (BM) velocity is a valuable prognostic metric at time of intracranial progression (ICP), pre-SRS risk factors for post-SRS high-burden intracranial progression (ICP) remain poorly character ... Full text Cite

Novel Mechanisms and Future Opportunities for the Management of Radiation Necrosis in Patients Treated for Brain Metastases in the Era of Immunotherapy.

Journal Article Cancers (Basel) · April 24, 2023 Radiation necrosis, also known as treatment-induced necrosis, has emerged as an important adverse effect following stereotactic radiotherapy (SRS) for brain metastases. The improved survival of patients with brain metastases and increased use of combined s ... Full text Link to item Cite

Intracranial and Extracranial Progression and Their Correlation With Overall Survival After Stereotactic Radiosurgery in a Multi-institutional Cohort With Brain Metastases.

Journal Article JAMA Netw Open · April 3, 2023 IMPORTANCE: Clinical trials for metastatic malignant neoplasms are increasingly being extended to patients with brain metastases. Despite the preeminence of progression-free survival (PFS) as a primary oncologic end point, the correlation of intracranial p ... Full text Link to item Cite

A Deep Learning-Based Computer Aided Detection (CAD) System for Difficult-to-Detect Brain Metastases.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2023 PURPOSE: We sought to develop a computer-aided detection (CAD) system that optimally augments human performance, excelling especially at identifying small inconspicuous brain metastases (BMs), by training a convolutional neural network on a unique magnetic ... Full text Link to item Cite

Brain metastasis as the first and only metastatic relapse site portends worse survival in patients with advanced HER2 + breast cancer.

Conference Breast Cancer Res Treat · January 2023 PURPOSE: Current systemic therapy guidelines for patients with HER2 + breast cancer brain metastases (BCBrM) diverge based on the status of extracranial disease (ECD). An in-depth understanding of the impact of ECD on outcomes in HER2 + BCBrM has never bee ... Full text Link to item Cite

Outcomes in Patients with Intact and Resected Brain Metastasis Treated with 5-Fraction Stereotactic Radiosurgery.

Journal Article Adv Radiat Oncol · 2023 PURPOSE: Hypofractionated stereotactic radiosurgery (HF-SRS) with or without surgical resection is potentially a preferred treatment for larger or symptomatic brain metastases (BMs). Herein, we report clinical outcomes and predictive factors following HF-S ... Full text Link to item Cite

Clinical Factors Associated With 30-Day Mortality Among Patients Undergoing Radiation Therapy for Brain Metastases.

Journal Article Adv Radiat Oncol · 2023 PURPOSE: Existing brain metastasis prognostic models do not identify patients at risk of very poor survival after radiation therapy (RT). Identifying patient and disease risk factors for 30-day mortality (30-DM) after RT may help identify patients who woul ... Full text Link to item Cite

MAPKAP Kinase-2 phosphorylation of PABPC1 controls its interaction with 14-3-3 proteins after DNA damage: A combined kinase and protein array approach.

Journal Article Front Mol Biosci · 2023 14-3-3 proteins play critical roles in controlling multiple aspects of the cellular response to stress and DNA damage including regulation of metabolism, cell cycle progression, cell migration, and apoptotic cell death by binding to protein substrates of b ... Full text Link to item Cite

Long-term outcomes with reduced-dose whole-brain radiotherapy and a stereotactic radiosurgery boost for primary central nervous system lymphoma.

Journal Article Neurooncol Adv · 2023 BACKGROUND: Primary central nervous system lymphoma (PCNSL) is an aggressive diffuse large B-cell lymphoma. Treatment approaches are historically associated with neurotoxicity, particularly with high-dose whole-brain radiotherapy (WBRT). We hypothesized th ... Full text Link to item Cite

Prognostic Model for Intracranial Progression after Stereotactic Radiosurgery: A Multicenter Validation Study.

Journal Article Cancers (Basel) · October 22, 2022 Stereotactic radiosurgery (SRS) is a standard of care for many patients with brain metastases. To optimize post-SRS surveillance, this study aimed to validate a previously published nomogram predicting post-SRS intracranial progression (IP). We identified ... Full text Link to item Cite

Next-generation Tumor-homing Induced Neural Stem Cells as an Adjuvant to Radiation for the Treatment of Metastatic Lung Cancer.

Journal Article Stem Cell Rev Rep · October 2022 The spread of non-small cell lung cancer (NSCLC) to the leptomeninges is devastating with a median survival of only a few months. Radiation offers symptomatic relief, but new adjuvant therapies are desperately needed. Spheroidal, human induced neural stem ... Full text Link to item Cite

Spatiotemporal analysis of induced neural stem cell therapy to overcome advanced glioblastoma recurrence

Journal Article Molecular Therapy Oncolytics · September 15, 2022 Genetically engineered neural stem cells (NSCs) are a promising therapy for the highly aggressive brain cancer glioblastoma (GBM); however, treatment durability remains a major challenge. We sought to define the events that contribute to dynamic adaptation ... Full text Cite

Evaluation of a method to measure fluorescent cell burden in complex culture systems.

Journal Article Biomed Phys Eng Express · April 27, 2022 Purpose. This work introduces and evaluates a method for accurate in-vitro measurement of fluorescent cell burden in complex 3D-culture conditions.Methods.The Fluorescent Cell Burden (FCB) method was developed to analyze the burden of 4T1 mCherry-expressin ... Full text Link to item Cite

Factors Associated With New-Onset Seizures Following Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases.

Journal Article Adv Radiat Oncol · 2022 PURPOSE: Stereotactic radiosurgery (SRS) is a highly effective therapy for newly diagnosed brain metastases. Prophylactic antiepileptic drugs are no longer routinely used in current SRS practice, owing to a perceived low overall frequency of new-onset seiz ... Full text Link to item Cite

Systemic Therapy Type and Timing Effects on Radiation Necrosis Risk in HER2+ Breast Cancer Brain Metastases Patients Treated With Stereotactic Radiosurgery.

Journal Article Front Oncol · 2022 BACKGROUND: There is a concern that HER2-directed systemic therapies, when administered concurrently with stereotactic radiosurgery (SRS), may increase the risk of radiation necrosis (RN). This study explores the impact of timing and type of systemic thera ... Full text Link to item Cite

Preservation of neurocognitive function in the treatment of brain metastases.

Journal Article Neurooncol Adv · November 2021 Neurocognitive function (NCF) deficits are common in patients with brain metastases, occurring in up to 90% of cases. NCF deficits may be caused by tumor-related factors and/or treatment for the metastasis, including surgery, radiation therapy, chemotherap ... Full text Link to item Cite

Combining Laser Interstitial Thermal Therapy With SRS Improves Time to Progression for Recurrent SRS-Treated Brain Metastases.

Conference International journal of radiation oncology, biology, physics · November 2021 Purpose/objective(s)Improved survival for patients with brain metastases (BM) has been accompanied by a rise in tumor recurrence after stereotactic radiosurgery (SRS). Laser interstitial thermal therapy (LITT) has evolved as an effective treatment ... Full text Cite

CometChip enables parallel analysis of multiple DNA repair activities.

Journal Article DNA Repair (Amst) · October 2021 DNA damage can be cytotoxic and mutagenic, and it is directly linked to aging, cancer, and other diseases. To counteract the deleterious effects of DNA damage, cells have evolved highly conserved DNA repair pathways. Many commonly used DNA repair assays ar ... Full text Open Access Link to item Cite

Fostering Radiation Oncology Physician Scientist Trainees Within a Diverse Workforce: The Radiation Oncology Research Scholar Track.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2021 There is a need to foster future generations of radiation oncology physician scientists, but the number of radiation oncologists with sufficient education, training, and funding to make transformative discoveries is relatively small. A large number of MD/P ... Full text Open Access Link to item Cite

Effect of type and timing of systemic therapy on risk of radiation necrosis in patients with HER2+ breast cancer brain metastases.

Conference Journal of Clinical Oncology · May 20, 2021 e14002 Background: It is estimated that 30% of patients with metastatic human epidermal growth factor receptor 2-positive (HER2+) breast cancer will develop brain metastases. Current standard of care options for HER2+ breast canc ... Full text Cite

Impact of extracranial disease status on survival after initial central nervous system (CNS) involvement and radiation therapy in HER2+ breast cancer brain metastases (BCBM).

Conference Journal of Clinical Oncology · May 20, 2021 1041 Background: BCBMs are very common in metastatic HER2+ breast cancer. CNS-directed local therapy is the gold standard for treatment, followed by systemic HER2-targeted therapies. In patients with HER2+ BCBM and stable extracr ... Full text Cite

Patient outcomes and tumor control in single-fraction versus hypofractionated stereotactic body radiation therapy for spinal metastases.

Journal Article J Neurosurg Spine · February 1, 2021 OBJECTIVE: Stereotactic body radiation therapy (SBRT) offers efficient, noninvasive treatment of spinal neoplasms. Single-fraction (SF) high-dose SBRT has a relatively narrow therapeutic window, while hypofractionated delivery of SBRT may have an improved ... Full text Link to item Cite

Outcomes in Patients With 4 to 10 Brain Metastases Treated With Dose-Adapted Single-Isocenter Multitarget Stereotactic Radiosurgery: A Prospective Study.

Journal Article Adv Radiat Oncol · 2021 PURPOSE: To examine the effectiveness and safety of single-isocenter multitarget stereotactic radiosurgery using a volume-adapted dosing strategy in patients with 4 to 10 brain metastases. METHODS AND MATERIALS: Adult patients with 4 to 10 brain metastases ... Full text Link to item Cite

BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation.

Journal Article Cell Rep · September 22, 2020 Effective spatio-temporal control of transcription and replication during S-phase is paramount to maintaining genomic integrity and cell survival. Dysregulation of these systems can lead to conflicts between the transcription and replication machinery, cau ... Full text Open Access Link to item Cite

HTS-Compatible CometChip Enables Genetic Screening for Modulators of Apoptosis and DNA Double-Strand Break Repair.

Journal Article SLAS Discov · September 2020 Dysfunction of apoptosis and DNA damage response pathways often drive cancer, and so a better understanding of these pathways can contribute to new cancer therapeutic strategies. Diverse discovery approaches have identified many apoptosis regulators, DNA d ... Full text Link to item Cite

Current multidisciplinary management of brain metastases.

Journal Article Cancer · April 1, 2020 Brain metastasis (BM), the most common adult brain tumor, develops in 20% to 40% of patients with late-stage cancer and traditionally are associated with a poor prognosis. The management of patients with BM has become increasingly complex because of new an ... Full text Link to item Cite

Comprehensive radiation and imaging isocenter verification using NIPAM kV-CBCT dosimetry.

Journal Article Med Phys · March 2020 PURPOSE: To develop and demonstrate a comprehensive method to directly measure radiation isocenter uncertainty and coincidence with the cone-beam computed tomography (kV-CBCT) imaging coordinate system that can be carried out within a typical quality assur ... Full text Link to item Cite

Radiation Therapy Practice Patterns for Brain Metastases in the United States in the Stereotactic Radiosurgery Era.

Journal Article Adv Radiat Oncol · 2020 PURPOSE: Utilization of stereotactic radiosurgery (SRS) for brain metastases (BM) has increased, prompting reassessment of whole brain radiation therapy (WBRT). A pattern of care analysis of SRS and WBRT dose-fractionations was performed in patients presen ... Full text Link to item Cite

Hypofractionated Stereotactic Radiosurgery (HF-SRS) in the Treatment of Brain Metastases

Chapter · January 1, 2020 Single-fraction stereotactic radiosurgery (SF-SRS) is widely employed to safely and effectively treat small intracranial lesions. However, for large metastases or those in close proximity to critical structures, it can be difficult to obtain an acceptable ... Full text Cite

Evaluation of UVA emission from x-ray megavoltage-irradiated tissues and phantoms.

Journal Article Phys Med Biol · November 21, 2019 RECA (Radiotherapy enhanced with Cherenkov photo-activation) is a proposed treatment where the anti-cancer drug psoralen is photo-activated in situ by UVA (Ultraviolet A, 320-400 nm) Cherenkov light (CL) produced directly by the treatment beam itself. In t ... Full text Link to item Cite

B7-H3-redirected chimeric antigen receptor T cells target glioblastoma and neurospheres.

Journal Article EBioMedicine · September 2019 BACKGROUND: The dismal survival of glioblastoma (GBM) patients urgently calls for the development of new treatments. Chimeric antigen receptor T (CAR-T) cells are an attractive strategy, but preclinical and clinical studies in GBM have shown that heterogen ... Full text Open Access Link to item Cite

The effect of MLC leaf width in single-isocenter multi-target radiosurgery with volumetric modulated arc therapy.

Journal Article J Radiosurg SBRT · 2019 PURPOSE: Single-isocenter multi-target (SIMT) volumetric modulated arc therapy (VMAT) is primarily limited to linear accelerators utilizing 2.5 mm leaf width MLCs. We explore feasibility of applying this technique to linear accelerators utilizing MLCs with ... Open Access Link to item Cite

bcSeq: an R package for fast sequence mapping in high-throughput shRNA and CRISPR screens.

Journal Article Bioinformatics · October 15, 2018 SUMMARY: CRISPR-Cas9 and shRNA high-throughput sequencing screens have abundant applications for basic and translational research. Methods and tools for the analysis of these screens must properly account for sequencing error, resolve ambiguous mappings am ... Full text Link to item Cite

Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles.

Journal Article Nat Commun · May 18, 2018 Effective treatment for glioblastoma (GBM) is limited by the presence of the blood-brain barrier (BBB) and rapid resistance to single agent therapies. To address these issues, we developed a transferrin-functionalized nanoparticle (Tf-NP) that can deliver ... Full text Open Access Link to item Cite

Stereotactic radiosurgery for brain metastasis from gynecological malignancies.

Journal Article Oncol Lett · March 2017 Brain metastases are relatively uncommon in gynecological malignancies, and there is limited available data on their management. The present study reports the outcomes of patients with brain metastasis from gynecological malignancies who were treated with ... Full text Link to item Cite

The impact of different stereotactic radiation therapy regimens for brain metastases on local control and toxicity.

Journal Article Adv Radiat Oncol · 2017 PURPOSE: Stereotactic radiation therapy (SRT) enables focused, short course, high dose per fraction radiation delivery to brain tumors that are less ideal for single fraction treatment because of size, shape, or close proximity to sensitive structures. We ... Full text Link to item Cite

Single fraction stereotactic radiosurgery for multiple brain metastases.

Journal Article Adv Radiat Oncol · 2017 INTRODUCTION: Due to the neurocognitive side effects of whole brain radiation therapy (WBRT), stereotactic radiosurgery (SRS) is being used with increasing frequency. The use of SRS is expanding for patients with multiple (>4) brain metastases (BM). This s ... Full text Open Access Link to item Cite

Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy.

Journal Article Radiat Oncol · November 26, 2015 BACKGROUND: Whole brain radiation therapy (WBRT) is widely used for the treatment of brain metastases. Cognitive decline and alopecia are recognized adverse effects of WBRT. Recently hippocampus sparing whole brain radiation therapy (HS-WBRT) has been show ... Full text Open Access Link to item Cite

A Multivariate Computational Method to Analyze High-Content RNAi Screening Data.

Journal Article J Biomol Screen · September 2015 High-content screening (HCS) using RNA interference (RNAi) in combination with automated microscopy is a powerful investigative tool to explore complex biological processes. However, despite the plethora of data generated from these screens, little progres ... Full text Link to item Cite

Brain metastases in patients with EGFR-mutated or ALK-rearranged non-small-cell lung cancers.

Journal Article Lung Cancer · April 2015 INTRODUCTION: Brain metastases (BM) are common in non-small-cell lung cancer (NSCLC). However, the baseline incidence and evolution of BM over time in oncogene-driven NSCLCs are seldom reported. In this study, we evaluated the frequency of BM in patients w ... Full text Link to item Cite

Ipilmumab and cranial radiation in metastatic melanoma patients: a case series and review.

Journal Article J Immunother Cancer · 2015 BACKGROUND: Ipilimumab improves survival in metastatic melanoma patients. This population frequently develops brain metastases, which have been associated with poor survival and are often treated with radiation. Therefore, outcomes following ipilimumab and ... Full text Open Access Link to item Cite

Stereotactic radiosurgery for brain metastases from malignant melanoma.

Journal Article Surg Neurol Int · 2015 BACKGROUND: Surgical resection and stereotactic radiosurgery (SRS) are well-established treatment methods for patients with brain metastases, yet their respective roles in the management of brain metastases remain incompletely defined. METHODS: To report o ... Full text Link to item Cite

The role of whole brain radiation therapy in the management of melanoma brain metastases.

Journal Article Radiat Oncol · June 22, 2014 BACKGROUND: Brain metastases are common in patients with melanoma, and optimal management is not well defined. As melanoma has traditionally been thought of as "radioresistant," the role of whole brain radiation therapy (WBRT) in particular is unclear. We ... Full text Open Access Link to item Cite

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.

Journal Article Nature · June 13, 2013 DNA damage activates a signalling network that blocks cell-cycle progression, recruits DNA repair factors and/or triggers senescence or programmed cell death. Alterations in chromatin structure are implicated in the initiation and propagation of the DNA da ... Full text Open Access Link to item Cite

Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors.

Journal Article Cell Cycle · March 15, 2013 A key modality of non-surgical cancer management is DNA damaging therapy that causes DNA double-strand breaks that are preferentially toxic to rapidly dividing cancer cells. Double-strand break repair capacity is recognized as an important mechanism in dru ... Full text Open Access Link to item Cite

Melanoma brain metastasis: overview of current management and emerging targeted therapies.

Journal Article Expert Rev Neurother · October 2012 The high rate of brain metastasis in patients with advanced melanoma has been a clinical challenge for oncologists. Despite considerable progress made in the management of advanced melanoma over the past two decades, improvement in overall survival has bee ... Full text Link to item Cite

Frameless angiogram-based stereotactic radiosurgery for treatment of arteriovenous malformations.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2012 PURPOSE: Stereotactic radiosurgery (SRS) is an effective alternative to microsurgical resection or embolization for definitive treatment of arteriovenous malformations (AVMs). Digital subtraction angiography (DSA) is the gold standard for pretreatment diag ... Full text Link to item Cite

Cyberknife hypofractionated stereotactic radiosurgery (HSRS) of resection cavity after excision of large cerebral metastasis: efficacy and safety of an 800 cGy × 3 daily fractions regimen.

Journal Article J Neurooncol · February 2012 Development of hypofractionated stereotactic radiosurgery (HSRS) has expanded the size of lesion that can be safely treated by focused radiation in a limited number of treatment sessions. However, clinical data regarding the efficacy and morbidity of HSRS ... Full text Link to item Cite

Stereotactic body radiotherapy reirradiation for recurrent epidural spinal metastases.

Journal Article Int J Radiat Oncol Biol Phys · December 1, 2011 PURPOSE: When patients show progression after conventional fractionated radiation for spine metastasis, further radiation and surgery may not be options. Stereotactic body radiotherapy (SBRT) has been successfully used in treatment of the spine and may be ... Full text Link to item Cite

Clinical outcome after hypofractionated stereotactic radiotherapy (HSRT) for benign skull base tumors.

Journal Article Comput Aided Surg · 2011 OBJECTIVE: Surgical resection of skull base tumors can be associated with significant morbidity. In cases where the risks outweigh the benefits, radiation therapy can offer an alternative means to effectively control tumor growth. However, the optimal dose ... Full text Link to item Cite

Post-mastectomy radiation in large node-negative breast tumors: does size really matter?

Journal Article Radiother Oncol · April 2009 Treatment decisions regarding local control can be particularly challenging for T3N0 breast tumors because of difficulty in estimating rates of local failure after mastectomy. Reports in the literature detailing the rates of local failure vary widely, like ... Full text Link to item Cite

The role of postmastectomy radiation in node-negative breast tumors larger than 5 cm

Journal Article American Journal of Hematology Oncology · April 1, 2007 Cite

Low local recurrence rate without postmastectomy radiation in node-negative breast cancer patients with tumors 5 cm and larger.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2006 PURPOSE: To assess the need for adjuvant radiotherapy following mastectomy for patients with node-negative breast tumors 5 cm or larger. METHODS AND MATERIALS: Between 1981 and 2002, a total of 70 patients with node-negative breast cancer and tumors 5 cm o ... Full text Link to item Cite

Is a reduction in radiation lung volume and dose necessary with paclitaxel chemotherapy for node-positive breast cancer?

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2005 PURPOSE: To evaluate and quantify the effect of irradiated lung volume, radiation dose, and paclitaxel chemotherapy on the development of radiation pneumonitis (RP) in breast cancer patients with positive lymph nodes. METHODS AND MATERIALS: We previously r ... Full text Link to item Cite

Generation of high curvature membranes mediated by direct endophilin bilayer interactions.

Journal Article J Cell Biol · October 15, 2001 Endophilin 1 is a presynaptically enriched protein which binds the GTPase dynamin and the polyphosphoinositide phosphatase synptojanin. Perturbation of endophilin function in cell-free systems and in a living synapse has implicated endophilin in endocytic ... Full text Open Access Link to item Cite

Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2.

Journal Article J Biol Chem · March 16, 2001 Amphiphysin 1 is a phosphoprotein expressed at high levels in neurons, where it participates in synaptic vesicle endocytosis and neurite outgrowth. It is a substrate for cyclin-dependent kinase (cdk) 5, a member of the cyclin-dependent protein kinase famil ... Full text Link to item Cite

A novel antineuronal antibody in a motor neuron syndrome associated with breast cancer.

Journal Article Neurology · September 11, 1999 A 72-year-old woman developed a lower motor neuron syndrome (MNS) 4 months before the appearance of breast cancer. Monoparesis progressed to quadriparesis despite high-dose IV immunoglobulins, plasma exchange, and azathioprine, and high-dose IV methylpredn ... Full text Link to item Cite

Endocytosis proteins and cancer: a potential link?

Journal Article Trends Cell Biol · August 1998 Recent studies have shown that a variety of proteins participate with clathrin and clathrin adaptors in receptor-mediated endocytosis. The genes encoding some of these proteins are targets of chromosomal rearrangements in human haematopoietic malignancies. ... Full text Link to item Cite

Expression of amphiphysin I, an autoantigen of paraneoplastic neurological syndromes, in breast cancer.

Journal Article Mol Med · January 1998 Amphiphysin I is a 128 kD protein highly concentrated in nerve terminals, where it has a putative role in endocytosis. It is a dominant autoantigen in patients with stiff-man syndrome associated with breast cancer, as well as in other paraneoplastic autoim ... Link to item Cite