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Evaluation of UVA emission from x-ray megavoltage-irradiated tissues and phantoms.

Publication ,  Journal Article
Jain, S; Yoon, SW; Zhang, X; Adamson, J; Floyd, S; Oldham, M
Published in: Phys Med Biol
November 21, 2019

RECA (Radiotherapy enhanced with Cherenkov photo-activation) is a proposed treatment where the anti-cancer drug psoralen is photo-activated in situ by UVA (Ultraviolet A, 320-400 nm) Cherenkov light (CL) produced directly by the treatment beam itself. In this study, we develop a UVA-imaging technique to quantify relative UVA CL produced by bulk tissues and other phantoms upon clinical x-ray megavoltage irradiation. UVA CL emission (320-400 nm) was quantified in tissue samples of porcine and poultry and in two kinds of solid waters (SW): brown (Virtual Waters, Standard Imaging, WI) and white (Diagnostic Therapy, CIRS, VA), and in 1% agarose gels variously doped with absorbing dye. Quantification was achieved through cumulative imaging of the samples placed in a dark, light-blocking chamber during irradiation on a Varian 21 EX accelerator. UVA imaging required a specialized high-sensitivity cooled camera equipped with UVA lenses and a filter. At 15 MV, white SW emitted [Formula: see text], [Formula: see text] and [Formula: see text] less UVA than chicken breast, pork loin and pork belly, respectively. Similar under-response was observed at 6 MV. Brown SW had [Formula: see text] less UVA emission than white SW at 15 MV, and negligible emission at 6 MV. Agarose samples (1% by weight) doped with 250 ppm India ink exhibited equivalent UVA CL emission to chicken breast (within 8%). The results confirm that for the same absorbed dose, SW emits less UVA light than the tissue samples, indicating that prior in vitro studies utilizing SW as the CL-generating source may have underestimated the RECA therapeutic effect. Agarose doped with 250 ppm India ink is a convenient tissue-equivalent phantom for further work.

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Published In

Phys Med Biol

DOI

EISSN

1361-6560

Publication Date

November 21, 2019

Volume

64

Issue

22

Start / End Page

225017

Location

England

Related Subject Headings

  • X-Ray Therapy
  • Ultraviolet Rays
  • Physical Phenomena
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Meat
  • Lenses
  • Animals
  • 5105 Medical and biological physics
  • 1103 Clinical Sciences
 

Citation

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Jain, S., Yoon, S. W., Zhang, X., Adamson, J., Floyd, S., & Oldham, M. (2019). Evaluation of UVA emission from x-ray megavoltage-irradiated tissues and phantoms. Phys Med Biol, 64(22), 225017. https://doi.org/10.1088/1361-6560/ab4333
Jain, Sagarika, Suk W. Yoon, Xiaofeng Zhang, Justus Adamson, Scott Floyd, and Mark Oldham. “Evaluation of UVA emission from x-ray megavoltage-irradiated tissues and phantoms.Phys Med Biol 64, no. 22 (November 21, 2019): 225017. https://doi.org/10.1088/1361-6560/ab4333.
Jain S, Yoon SW, Zhang X, Adamson J, Floyd S, Oldham M. Evaluation of UVA emission from x-ray megavoltage-irradiated tissues and phantoms. Phys Med Biol. 2019 Nov 21;64(22):225017.
Jain, Sagarika, et al. “Evaluation of UVA emission from x-ray megavoltage-irradiated tissues and phantoms.Phys Med Biol, vol. 64, no. 22, Nov. 2019, p. 225017. Pubmed, doi:10.1088/1361-6560/ab4333.
Jain S, Yoon SW, Zhang X, Adamson J, Floyd S, Oldham M. Evaluation of UVA emission from x-ray megavoltage-irradiated tissues and phantoms. Phys Med Biol. 2019 Nov 21;64(22):225017.
Journal cover image

Published In

Phys Med Biol

DOI

EISSN

1361-6560

Publication Date

November 21, 2019

Volume

64

Issue

22

Start / End Page

225017

Location

England

Related Subject Headings

  • X-Ray Therapy
  • Ultraviolet Rays
  • Physical Phenomena
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Meat
  • Lenses
  • Animals
  • 5105 Medical and biological physics
  • 1103 Clinical Sciences