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Mark Oldham

Professor of Radiation Oncology
Radiation Oncology
Box 3295 Med Ctr, Durham, NC
04214 Duke South Clinics, Duke South Clinics, Durham, NC 27710


Dr Oldham is the Director of the Duke Medical Physics MS/PhD Graduate Program, and Professor in the Department of Radiation Oncology, with a secondary appointment in the Physics Department at Duke. 

Main current research interests include: FLASH radiation therapy, exploring FLASH mechanisms utilizing the Duke High Intensity Gamma Source (HIGS), a nuclear research accelerator on the Duke campus.  Recent work selected for best in Physics at the annual AAPM meeting.  Radiation and Immunotherapy utilizing mini-grids. Radiation Therapy Enhanced by Cherenkov photo-Activation (RECA) and Comprehensive 3D dosimetry.

Dr Oldham has patented and published on several novel radiation treatment techniques (including XPACT and RECA - Radiotherapy Enhanced by Cherenkov photo-Activation) with exiting potential to invoke systemic anti-cancer immunogenic response.  A phase I clinical trial of XPACT is underway.  The lab has pioneered novel pre-clinical treatment capabilities including mini-beam grids, and ultra-high-resolution IMRT.  The lab has also developed novel optical imaging techniques for high-resolution 3D imaging of vascular networks and fluorescent gene expression in un-sectioned tissue samples.

Current Appointments & Affiliations

Professor of Radiation Oncology · 2021 - Present Radiation Oncology, Clinical Science Departments
Professor of Physics · 2024 - Present Physics, Trinity College of Arts & Sciences
Member of the Duke Cancer Institute · 2016 - Present Duke Cancer Institute, Institutes and Centers

Education, Training & Certifications

Newcastle University (United Kingdom) · 1991 Ph.D.