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Mark Oldham

Professor of Radiation Oncology
Radiation Oncology
Box 3295 Med Ctr, Durham, NC
04214 Duke South Clinics, Duke South Clinics, Durham, NC 27710

Research Interests


My main current research interests include:
  1. FLASH radiation therapy.  Our recent NIH grant scored 4th percentile for exploring FLASH mechanisms utilizing the Duke High Intensity Gamma Source (HIGS), a nuclear research accelerator on the Duke campus.  This work selected for best in Physics at the annual AAPM meeting.  Description here 
  2. Radiation and Immunotherapy utilizing mini-grids:  description here
  3. Radiation Therapy Enhanced by Cherenkov photo-Activation: description here
  4. Comprehensive 3D dosimetry: description here
Please contact me for more information (mark.oldham@duke.edu)

Selected Grants


Radioprotective effect of p53 against oral mucositis

ResearchCo Investigator · Awarded by National Institutes of Health · 2023 - 2028

Exploring synthetic lethality with a novel very high energy electron FLASH radiation beam

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2024 - 2026

Super-FLASH radiation therapy for pediatric brain tumors

ResearchCo Investigator · Awarded by Ian's Friends Foundation · 2024 - 2025

Duke CTSA (TL1) Year 5

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2018 - 2024

A practical and versatile high-resolution 3D dosimetry system for clinical use

ResearchPrincipal Investigator · Awarded by Heuris, Inc. · 2017 - 2018

An investigation of the dosimetry of the ViewRay radiation therapy system

ResearchPrincipal Investigator · Awarded by Washington University in St. Louis · 2014 - 2016

Accurate, High Resolution 3D Dosimetry

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2004 - 2013

Cross-disciplinary Training in Medical Physics

Inst. Training Prgm or CMEAssociate Director · Awarded by National Institutes of Health · 2007 - 2013

Digital tomosynthesis: a new paradigm for radiation treatment verification

ResearchCollaborator · Awarded by National Institutes of Health · 2007 - 2009

External Relationships


  • Immunolight

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.