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Delta-opioid-receptor activation by [D-Pen2,D-Pen5]enkephalin and morphine inhibits substance P release from trigeminal nucleus slices.

Publication ,  Journal Article
Suarez-Roca, H; Maixner, W
Published in: European journal of pharmacology
December 1992

The release of substance P (SP) from spinal dorsal horn slices is partially inhibited by micromolar concentrations of selective delta-opioid receptor agonists. In the present study, we have examined the effect of nanomolar concentrations of [D-Pen2,D-Pen5]enkephalin (DPDPE, delta-opioid receptor agonist) and low micromolar of concentrations morphine on K(+)-evoked SP release from rat trigeminal nucleus caudalis (TNC) slices. DPDPE and morphine inhibited SP release with an apparent maximal effect at 3 nM and at 3 microM, respectively. DPDPE and morphine produced U-shaped concentration-response curves that were completely autoinhibited at 100 nM DPDPE and 1 microM morphine. The inhibition of SP release produced by 3 nM DPDPE and 3 microM morphine was blocked by the opioid receptor antagonists naloxone (30 nM; non-selective) and ICI 174,864 (0.3 microM; delta-selective) but not by nor-binaltorphimine (3 nM n-BNI; kappa-selective), naloxonazine (1 nM; micro 1-selective) or beta-funaltrexamine (20 nM beta-FNA; mu-selective). These findings indicate that delta-opioid receptor-mediated inhibition of SP release from TNC can be achieved by nanomolar concentrations of selective delta-opioid receptor agonists. Activation of delta-opioid receptors by morphine might be involved in the residual analgesia observed after mu 1-opioid receptor blockade and in the analgesia produced by high doses of morphine.

Duke Scholars

Published In

European journal of pharmacology

DOI

EISSN

1879-0712

ISSN

0014-2999

Publication Date

December 1992

Volume

229

Issue

1

Start / End Page

1 / 7

Related Subject Headings

  • Trigeminal Nuclei
  • Substance P
  • Receptors, Opioid, delta
  • Rats, Sprague-Dawley
  • Rats
  • Radioimmunoassay
  • Potassium
  • Pharmacology & Pharmacy
  • Narcotic Antagonists
  • Morphine
 

Citation

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Suarez-Roca, H., & Maixner, W. (1992). Delta-opioid-receptor activation by [D-Pen2,D-Pen5]enkephalin and morphine inhibits substance P release from trigeminal nucleus slices. European Journal of Pharmacology, 229(1), 1–7. https://doi.org/10.1016/0014-2999(92)90278-c
Suarez-Roca, H., and W. Maixner. “Delta-opioid-receptor activation by [D-Pen2,D-Pen5]enkephalin and morphine inhibits substance P release from trigeminal nucleus slices.European Journal of Pharmacology 229, no. 1 (December 1992): 1–7. https://doi.org/10.1016/0014-2999(92)90278-c.
Suarez-Roca, H., and W. Maixner. “Delta-opioid-receptor activation by [D-Pen2,D-Pen5]enkephalin and morphine inhibits substance P release from trigeminal nucleus slices.European Journal of Pharmacology, vol. 229, no. 1, Dec. 1992, pp. 1–7. Epmc, doi:10.1016/0014-2999(92)90278-c.
Journal cover image

Published In

European journal of pharmacology

DOI

EISSN

1879-0712

ISSN

0014-2999

Publication Date

December 1992

Volume

229

Issue

1

Start / End Page

1 / 7

Related Subject Headings

  • Trigeminal Nuclei
  • Substance P
  • Receptors, Opioid, delta
  • Rats, Sprague-Dawley
  • Rats
  • Radioimmunoassay
  • Potassium
  • Pharmacology & Pharmacy
  • Narcotic Antagonists
  • Morphine