Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators.

Published

Journal Article

The human X and Y chromosomes evolved from an ordinary pair of autosomes, but millions of years ago genetic decay ravaged the Y chromosome, and only three per cent of its ancestral genes survived. We reconstructed the evolution of the Y chromosome across eight mammals to identify biases in gene content and the selective pressures that preserved the surviving ancestral genes. Our findings indicate that survival was nonrandom, and in two cases, convergent across placental and marsupial mammals. We conclude that the gene content of the Y chromosome became specialized through selection to maintain the ancestral dosage of homologous X-Y gene pairs that function as broadly expressed regulators of transcription, translation and protein stability. We propose that beyond its roles in testis determination and spermatogenesis, the Y chromosome is essential for male viability, and has unappreciated roles in Turner's syndrome and in phenotypic differences between the sexes in health and disease.

Full Text

Duke Authors

Cited Authors

  • Bellott, DW; Hughes, JF; Skaletsky, H; Brown, LG; Pyntikova, T; Cho, T-J; Koutseva, N; Zaghlul, S; Graves, T; Rock, S; Kremitzki, C; Fulton, RS; Dugan, S; Ding, Y; Morton, D; Khan, Z; Lewis, L; Buhay, C; Wang, Q; Watt, J; Holder, M; Lee, S; Nazareth, L; Alföldi, J; Rozen, S; Muzny, DM; Warren, WC; Gibbs, RA; Wilson, RK; Page, DC

Published Date

  • April 2014

Published In

Volume / Issue

  • 508 / 7497

Start / End Page

  • 494 - 499

PubMed ID

  • 24759411

Pubmed Central ID

  • 24759411

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/nature13206

Language

  • eng