Toll-like receptors, their ligands, and atherosclerosis.

Published online

Journal Article (Review)

Atherosclerosis is a disease characterized by inflammation in the arterial wall. Atherogenesis is dependent on the innate immune response involving activation of Toll-like receptors (TLRs) and the expression of inflammatory proteins. TLRs, which recognize various pathogen-associated molecular patterns, are expressed in various cell types within the atherosclerotic plaque. Microbial agents are associated with an increased risk of atherosclerosis and this is, in part, due to activation of TLRs. Recently considerable evidence has been provided suggesting that endogenous proteins promote atherosclerosis by binding to TLRs. In this review, we describe the role of TLRs in atherosclerosis with particular emphasis on those atherogenic endogenous proteins that have been implicated as TLR ligands.

Full Text

Duke Authors

Cited Authors

  • Hodgkinson, CP; Ye, S

Published Date

  • February 14, 2011

Published In

Volume / Issue

  • 11 /

Start / End Page

  • 437 - 453

PubMed ID

  • 21336459

Pubmed Central ID

  • 21336459

Electronic International Standard Serial Number (EISSN)

  • 1537-744X

Digital Object Identifier (DOI)

  • 10.1100/tsw.2011.36

Language

  • eng

Conference Location

  • United States