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Toll-like receptors, their ligands, and atherosclerosis.

Publication ,  Journal Article
Hodgkinson, CP; Ye, S
Published in: ScientificWorldJournal
February 14, 2011

Atherosclerosis is a disease characterized by inflammation in the arterial wall. Atherogenesis is dependent on the innate immune response involving activation of Toll-like receptors (TLRs) and the expression of inflammatory proteins. TLRs, which recognize various pathogen-associated molecular patterns, are expressed in various cell types within the atherosclerotic plaque. Microbial agents are associated with an increased risk of atherosclerosis and this is, in part, due to activation of TLRs. Recently considerable evidence has been provided suggesting that endogenous proteins promote atherosclerosis by binding to TLRs. In this review, we describe the role of TLRs in atherosclerosis with particular emphasis on those atherogenic endogenous proteins that have been implicated as TLR ligands.

Duke Scholars

Published In

ScientificWorldJournal

DOI

EISSN

1537-744X

Publication Date

February 14, 2011

Volume

11

Start / End Page

437 / 453

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • Immunity, Innate
  • Humans
  • General Science & Technology
  • Atherosclerosis
  • Animals
 

Citation

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Hodgkinson, C. P., & Ye, S. (2011). Toll-like receptors, their ligands, and atherosclerosis. ScientificWorldJournal, 11, 437–453. https://doi.org/10.1100/tsw.2011.36
Hodgkinson, Conrad P., and Shu Ye. “Toll-like receptors, their ligands, and atherosclerosis.ScientificWorldJournal 11 (February 14, 2011): 437–53. https://doi.org/10.1100/tsw.2011.36.
Hodgkinson CP, Ye S. Toll-like receptors, their ligands, and atherosclerosis. ScientificWorldJournal. 2011 Feb 14;11:437–53.
Hodgkinson, Conrad P., and Shu Ye. “Toll-like receptors, their ligands, and atherosclerosis.ScientificWorldJournal, vol. 11, Feb. 2011, pp. 437–53. Pubmed, doi:10.1100/tsw.2011.36.
Hodgkinson CP, Ye S. Toll-like receptors, their ligands, and atherosclerosis. ScientificWorldJournal. 2011 Feb 14;11:437–453.

Published In

ScientificWorldJournal

DOI

EISSN

1537-744X

Publication Date

February 14, 2011

Volume

11

Start / End Page

437 / 453

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • Immunity, Innate
  • Humans
  • General Science & Technology
  • Atherosclerosis
  • Animals