Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of London (United Kingdom) 1996
• 

  Previous Appointments & Affiliations

  • Assistant Professor in Medicine, Medicine, Cardiology, Medicine 2017 - 2020
  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2013 - 2017
• Research
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  Selected Grants

  • Enhancing cardiac reprogramming via TLR3 awarded by Rosenfeld Heart Foundation 2018 - 2024
  • Integrated Cellular and Tissue Engineering for Ischemic Heart Disease awarded by University of Alabama at Birmingham 2016 - 2022
  • Sfrp2 promotes cardiac regeneration via c-Kit(+) cell differentiation awarded by National Institutes of Health 2018 - 2022
  • Novel strategy for Enhancing miRNA as a Therapeutic for Cardiac Regeneration awarded by National Institutes of Health 2016 - 2020
  • Sfrp2 and Cardiac Progenitor Cells in Regenerative Response to Ischemic Injury awarded by National Institutes of Health 2005 - 2016
  • Gene Therapy for Long-Term Myocardial Protection awarded by National Institutes of Health 2003 - 2014
  • Genetically Altered Mesenchymal Stem Cell; Paracrine Effect on Neovascularization awarded by National Institutes of Health 2003 - 2014
• 

  External Relationships

  • Recardia Therapeutics
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Baksh, Syeda Samara, Richard E. Pratt, José Gomez, Victor J. Dzau, and Conrad P. Hodgkinson. “A novel Cbx1, PurB, and Sp3 complex mediates long-term silencing of tissue- and lineage-specific genes.” J Biol Chem 298, no. 6 (May 20, 2022): 102053. https://doi.org/10.1016/j.jbc.2022.102053.
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    • Gomez, José A., Alan Payne, Richard E. Pratt, Conrad P. Hodgkinson, and Victor J. Dzau. “A role for Sfrp2 in cardiomyogenesis in vivo.” Proc Natl Acad Sci U S A 118, no. 33 (August 17, 2021). https://doi.org/10.1073/pnas.2103676118.
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    • Sun, Hualing, Conrad P. Hodgkinson, Richard E. Pratt, and Victor J. Dzau. “CRISPR/Cas9 Mediated Deletion of the Angiotensinogen Gene Reduces Hypertension: A Potential for Cure?” Hypertension 77, no. 6 (June 2021): 1990–2000. https://doi.org/10.1161/HYPERTENSIONAHA.120.16870.
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    • Hu, Jiabiao, Conrad P. Hodgkinson, Richard E. Pratt, JaeWoo Lee, Bruce A. Sullenger, and Victor J. Dzau. “Enhancing cardiac reprogramming via synthetic RNA oligonucleotides.” Mol Ther Nucleic Acids 23 (March 5, 2021): 55–62. https://doi.org/10.1016/j.omtn.2020.10.034.
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    • Hsueh, Ying-Chang, Conrad P. Hodgkinson, and Jose A. Gomez. “The role of Sfrp and DKK proteins in cardiomyocyte development.” Physiol Rep 9, no. 3 (February 2021): e14678. https://doi.org/10.14814/phy2.14678.
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    • Wang, Xiaowen, Conrad P. Hodgkinson, and Victor J. Dzau. “Production of Cardiomyocytes by microRNA-Mediated Reprogramming in Optimized Reprogramming Media.” Methods Mol Biol 2239 (2021): 47–59. https://doi.org/10.1007/978-1-0716-1084-8_4.
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    • Sun, Hualing, Richard E. Pratt, Conrad P. Hodgkinson, and Victor J. Dzau. “Sequential paracrine mechanisms are necessary for the therapeutic benefits of stem cell therapy.” Am J Physiol Cell Physiol 319, no. 6 (December 1, 2020): C1141–50. https://doi.org/10.1152/ajpcell.00516.2019.
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    • Kang, Martin H., Jiabiao Hu, Richard E. Pratt, Conrad P. Hodgkinson, Aravind Asokan, and Victor J. Dzau. “Optimizing delivery for efficient cardiac reprogramming.” Biochem Biophys Res Commun 533, no. 1 (November 26, 2020): 9–16. https://doi.org/10.1016/j.bbrc.2020.08.104.
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    • Dal-Pra, Sophie, Conrad P. Hodgkinson, and Victor J. Dzau. “Induced cardiomyocyte maturation: Cardiac transcription factors are necessary but not sufficient.” Plos One 14, no. 10 (2019): e0223842. https://doi.org/10.1371/journal.pone.0223842.
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    • Hodgkinson, Conrad P., José A. Gomez, Syeda Samara Baksh, Alan Payne, Jeffrey Schmeckpeper, Richard E. Pratt, and Victor J. Dzau. “Insights from molecular signature of in vivo cardiac c-Kit(+) cells following cardiac injury and β-catenin inhibition.” J Mol Cell Cardiol 123 (October 2018): 64–74. https://doi.org/10.1016/j.yjmcc.2018.08.024.
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    • Hodgkinson, Conrad P., Richard E. Pratt, Imke Kirste, Sophie Dal-Pra, John P. Cooke, and Victor J. Dzau. “Cardiomyocyte Maturation Requires TLR3 Activated Nuclear Factor Kappa B.” Stem Cells 36, no. 8 (August 2018): 1198–1209. https://doi.org/10.1002/stem.2833.
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    • Bareja, Akshay, Shubham Patel, Conrad P. Hodgkinson, Alan Payne, and Victor J. Dzau. “Understanding the mechanism of bias signaling of the insulin-like growth factor 1 receptor: Effects of LL37 and HASF.” Cell Signal 46 (June 2018): 113–19. https://doi.org/10.1016/j.cellsig.2018.02.013.
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    • Bareja, Akshay, Conrad P. Hodgkinson, Erik Soderblom, Greg Waitt, and Victor J. Dzau. “The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway.” J Biol Chem 293, no. 17 (April 27, 2018): 6449–59. https://doi.org/10.1074/jbc.RA118.002406.
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    • Dal-Pra, Sophie, Conrad P. Hodgkinson, Maria Mirotsou, Imke Kirste, and Victor J. Dzau. “Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo.” Circ Res 120, no. 9 (April 28, 2017): 1403–13. https://doi.org/10.1161/CIRCRESAHA.116.308741.
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    • Bareja, Akshay, Conrad P. Hodgkinson, Alan J. Payne, Richard E. Pratt, and Victor J. Dzau. “HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor.” Biochem J 474, no. 5 (February 20, 2017): 771–80. https://doi.org/10.1042/BCJ20160976.
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    • Li, Yanzhen, Sophie Dal-Pra, Maria Mirotsou, Tilanthi M. Jayawardena, Conrad P. Hodgkinson, Nenad Bursac, and Victor J. Dzau. “Tissue-engineered 3-dimensional (3D) microenvironment enhances the direct reprogramming of fibroblasts into cardiomyocytes by microRNAs.” Sci Rep 6 (December 12, 2016): 38815. https://doi.org/10.1038/srep38815.
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    • Wang, Xiaowen, Conrad P. Hodgkinson, Kefeng Lu, Alan J. Payne, Richard E. Pratt, and Victor J. Dzau. “Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog.” Sci Rep 6 (March 15, 2016): 23017. https://doi.org/10.1038/srep23017.
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    • Hodgkinson, Conrad P., Akshay Bareja, José A. Gomez, and Victor J. Dzau. “Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology.” Circ Res 118, no. 1 (January 8, 2016): 95–107. https://doi.org/10.1161/CIRCRESAHA.115.305373.
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    • Hodgkinson, Conrad P., Martin H. Kang, Sophie Dal-Pra, Maria Mirotsou, and Victor J. Dzau. “MicroRNAs and Cardiac Regeneration.” Circ Res 116, no. 10 (May 8, 2015): 1700–1711. https://doi.org/10.1161/CIRCRESAHA.116.304377.
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    • Hodgkinson, Conrad P., and Victor J. Dzau. “Conserved microRNA program as key to mammalian cardiac regeneration: insights from zebrafish.” Circ Res 116, no. 7 (March 27, 2015): 1109–11. https://doi.org/10.1161/CIRCRESAHA.115.305852.
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    • Jayawardena, Tilanthi M., Elizabeth A. Finch, Lunan Zhang, Hengtao Zhang, Conrad P. Hodgkinson, Richard E. Pratt, Paul B. Rosenberg, Maria Mirotsou, and Victor J. Dzau. “MicroRNA induced cardiac reprogramming in vivo: evidence for mature cardiac myocytes and improved cardiac function.” Circ Res 116, no. 3 (January 30, 2015): 418–24. https://doi.org/10.1161/CIRCRESAHA.116.304510.
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    • Hodgkinson, Conrad P., Jose A. Gomez, Alan J. Payne, Lunan Zhang, Xiaowen Wang, Sophie Dal-Pra, Richard E. Pratt, and Victor J. Dzau. “Abi3bp regulates cardiac progenitor cell proliferation and differentiation.” Circ Res 115, no. 12 (December 5, 2014): 1007–16. https://doi.org/10.1161/CIRCRESAHA.115.304216.
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    • Huang, Jing, Jian Guo, Farideh Beigi, Conrad P. Hodgkinson, Heberty T. Facundo, Zhiping Zhang, Jorge Espinoza-Derout, et al. “HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection.” J Mol Cell Cardiol 66 (January 2014): 157–64. https://doi.org/10.1016/j.yjmcc.2013.11.010.
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    • Hodgkinson, Conrad P., Vinogran Naidoo, Karl G. Patti, Jose A. Gomez, Jeffrey Schmeckpeper, Zhiping Zhang, Bryce Davis, Richard E. Pratt, Maria Mirotsou, and Victor J. Dzau. “Abi3bp is a multifunctional autocrine/paracrine factor that regulates mesenchymal stem cell biology.” Stem Cells 31, no. 8 (August 2013): 1669–82. https://doi.org/10.1002/stem.1416.
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    • Lin, Y. T., A. Verma, and C. P. Hodgkinson. “Toll-like receptors and human disease: Lessons from single nucleotide polymorphisms.” Current Genomics 13, no. 8 (December 3, 2012): 633–45. https://doi.org/10.2174/138920212803759712.
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    • Hodgkinson, Conrad P., and Shu Ye. “Toll-like receptors, their ligands, and atherosclerosis.” Scientificworldjournal 11 (February 14, 2011): 437–53. https://doi.org/10.1100/tsw.2011.36.
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    • Hodgkinson, Conrad P., José A. Gomez, Maria Mirotsou, and Victor J. Dzau. “Genetic engineering of mesenchymal stem cells and its application in human disease therapy.” Hum Gene Ther 21, no. 11 (November 2010): 1513–26. https://doi.org/10.1089/hum.2010.165.
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    • Laxton, Ross C., Yanhua Hu, Johan Duchene, Feng Zhang, Zhongyi Zhang, Kit-Yi Leung, Qingzhong Xiao, et al. “A role of matrix metalloproteinase-8 in atherosclerosis.” Circ Res 105, no. 9 (October 23, 2009): 921–29. https://doi.org/10.1161/CIRCRESAHA.109.200279.
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    • Hodgkinson, Conrad P., Ross C. Laxton, Kunal Patel, and Shu Ye. “Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis.” Arterioscler Thromb Vasc Biol 28, no. 12 (December 2008): 2275–81. https://doi.org/10.1161/ATVBAHA.108.175992.
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    • Hodgkinson, Conrad P., and Shu Ye. “Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression.” Pharmacogenet Genomics 18, no. 9 (September 2008): 803–13. https://doi.org/10.1097/FPC.0b013e3283050aff.
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    • Hodgkinson, Conrad P., Kunal Patel, and Shu Ye. “Functional Toll-like receptor 4 mutations modulate the response to fibrinogen.” Thromb Haemost 100, no. 2 (August 2008): 301–7.
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    • Smithers, Natalie P., Conrad P. Hodgkinson, Matt Cuttle, and Graham J. Sale. “Insulin-triggered repositioning of munc18c on syntaxin-4 in GLUT4 signalling.” Biochem J 410, no. 2 (March 1, 2008): 255–60. https://doi.org/10.1042/BJ20070802.
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    • Smithers, Natalie P., Conrad P. Hodgkinson, Matt Cuttle, and Graham J. Sale. “80K-H acts as a signaling bridge in intact living cells between PKCzeta and the GLUT4 translocation regulator Munc18c.” J Recept Signal Transduct Res 28, no. 6 (2008): 581–89. https://doi.org/10.1080/10799890802598571.
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    • Decock, Julie, Ji-Rong Long, Ross C. Laxton, Xiao-Ou Shu, Conrad Hodgkinson, Wouter Hendrickx, Eve G. Pearce, et al. “Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis.” Cancer Res 67, no. 21 (November 1, 2007): 10214–21. https://doi.org/10.1158/0008-5472.CAN-07-1683.
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    • Kyriakou, Theodosios, David E. Pontefract, Enrique Viturro, Conrad P. Hodgkinson, Ross C. Laxton, Neda Bogari, George Cooper, et al. “Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients.” Hum Mol Genet 16, no. 12 (June 15, 2007): 1412–22. https://doi.org/10.1093/hmg/ddm091.
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    • Sale, Elizabeth M., Conrad P. Hodgkinson, Neil P. Jones, and Graham J. Sale. “A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase.” Biochemistry 45, no. 1 (January 10, 2006): 213–23. https://doi.org/10.1021/bi050287i.
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    • Hodgkinson, C. P., A. Mander, and G. J. Sale. “Protein kinase-zeta interacts with munc18c: role in GLUT4 trafficking.” Diabetologia 48, no. 8 (August 2005): 1627–36. https://doi.org/10.1007/s00125-005-1819-y.
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    • Hodgkinson, Conrad P., Ann Mander, and Graham J. Sale. “Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking.” Biochem J 388, no. Pt 3 (June 15, 2005): 785–93. https://doi.org/10.1042/BJ20041845.
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    • Mander, Ann, Conrad P. Hodgkinson, and Graham J. Sale. “Knock-down of LAR protein tyrosine phosphatase induces insulin resistance.” Febs Lett 579, no. 14 (June 6, 2005): 3024–28. https://doi.org/10.1016/j.febslet.2005.04.057.
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    • Kyriakou, Theodosios, Conrad Hodgkinson, David E. Pontefract, Srikanth Iyengar, W Martin Howell, Yuk-ki Wong, Per Eriksson, and Shu Ye. “Genotypic effect of the -565C>T polymorphism in the ABCA1 gene promoter on ABCA1 expression and severity of atherosclerosis.” Arterioscler Thromb Vasc Biol 25, no. 2 (February 2005): 418–23. https://doi.org/10.1161/01.ATV.0000149379.72018.20.
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    • Hodgkinson, Conrad P., and Shu Ye. “Microarray analysis of peroxisome proliferator-activated receptor-gamma induced changes in gene expression in macrophages.” Biochem Biophys Res Commun 308, no. 3 (August 29, 2003): 505–10. https://doi.org/10.1016/s0006-291x(03)01416-5.
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    • Hodgkinson, Conrad P., Elizabeth M. Sale, and Graham J. Sale. “Characterization of PDK2 activity against protein kinase B gamma.” Biochemistry 41, no. 32 (August 13, 2002): 10351–59. https://doi.org/10.1021/bi026065r.
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    • Hodgkinson, Conrad P., and Graham J. Sale. “Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment.” Biochemistry 41, no. 2 (January 15, 2002): 561–69. https://doi.org/10.1021/bi010719z.
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    • Hodgkinson, C. P., M. C. Wright, and A. J. Paine. “Fibronectin-mediated hepatocyte shape change reprograms cytochrome P450 2C11 gene expression via an integrin-signaled induction of ribonuclease activity.” Mol Pharmacol 58, no. 5 (November 2000): 976–81. https://doi.org/10.1124/mol.58.5.976.
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    • Wang, X. J., C. P. Hodgkinson, M. C. Wright, and A. J. Paine. “Temperature-sensitive mRNA degradation is an early event in hepatocyte de-differentiation.” Biochem J 328 ( Pt 3) (December 15, 1997): 937–44. https://doi.org/10.1042/bj3280937.
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  • Book Sections

    • Hodgkinson, C. P., J. A. Gomez, A. Bareja, and V. J. Dzau. “Role of Paracrine Mechanisms.” In Stem Cell and Gene Therapy for Cardiovascular Disease, 39–48, 2015. https://doi.org/10.1016/B978-0-12-801888-0.00004-7.
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