Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of London (UK) 1996
• 

  Duke Appointment History

  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2013 - 2017
• Research
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  Selected Grants

  • Sfrp2 induces in situ c-Kit cell differentiation into cardiomyocytes via Wnt11-Fzd5 mediated b-catenin inhibition awarded by National Institutes of Health 2018 - 2022
  • Novel strategy for Enhancing miRNA as a Therapeutic for Cardiac Regeneration awarded by National Institutes of Health 2016 - 2020
  • Enhancing cardiac reprogramming via TLR3 awarded by Rosenfeld Heart Foundation 2018 - 2019
  • Integrated Cellular and Tissue Engineering for Ischemic Heart Disease awarded by University of Alabama at Birmingham 2016 - 2019
  • Sfrp2 and Cardiac Progenitor Cells in Regenerative Response to Ischemic Injury awarded by National Institutes of Health 2005 - 2016
  • Gene Therapy for Long-Term Myocardial Protection awarded by National Institutes of Health 2003 - 2014
  • Genetically Altered Mesenchymal Stem Cell; Paracrine Effect on Neovascularization awarded by National Institutes of Health 2003 - 2014
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Hodgkinson, Conrad P., José A. Gomez, Syeda Samara Baksh, Alan Payne, Jeffrey Schmeckpeper, Richard E. Pratt, and Victor J. Dzau. “Insights from molecular signature of in vivo cardiac c-Kit(+) cells following cardiac injury and β-catenin inhibition..” Journal of Molecular and Cellular Cardiology 123 (October 2018): 64–74. https://doi.org/10.1016/j.yjmcc.2018.08.024.
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    • Hodgkinson, Conrad P., Richard E. Pratt, Imke Kirste, Sophie Dal-Pra, John P. Cooke, and Victor J. Dzau. “Cardiomyocyte Maturation Requires TLR3 Activated Nuclear Factor Kappa B..” Stem Cells (Dayton, Ohio) 36, no. 8 (August 2018): 1198–1209. https://doi.org/10.1002/stem.2833.
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    • Bareja, Akshay, Shubham Patel, Conrad P. Hodgkinson, Alan Payne, and Victor J. Dzau. “Understanding the mechanism of bias signaling of the insulin-like growth factor 1 receptor: Effects of LL37 and HASF..” Cellular Signalling 46 (June 2018): 113–19. https://doi.org/10.1016/j.cellsig.2018.02.013.
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    • Bareja, Akshay, Conrad P. Hodgkinson, Erik Soderblom, Greg Waitt, and Victor J. Dzau. “The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway..” J Biol Chem 293, no. 17 (April 27, 2018): 6449–59. https://doi.org/10.1074/jbc.RA118.002406.
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    • Dal-Pra, Sophie, Conrad P. Hodgkinson, Maria Mirotsou, Imke Kirste, and Victor J. Dzau. “Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo..” Circ Res 120, no. 9 (April 28, 2017): 1403–13. https://doi.org/10.1161/CIRCRESAHA.116.308741.
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    • Bareja, Akshay, Conrad P. Hodgkinson, Alan J. Payne, Richard E. Pratt, and Victor J. Dzau. “HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor..” Biochem J 474, no. 5 (February 20, 2017): 771–80. https://doi.org/10.1042/BCJ20160976.
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    • Li, Yanzhen, Sophie Dal-Pra, Maria Mirotsou, Tilanthi M. Jayawardena, Conrad P. Hodgkinson, Nenad Bursac, and Victor J. Dzau. “Tissue-engineered 3-dimensional (3D) microenvironment enhances the direct reprogramming of fibroblasts into cardiomyocytes by microRNAs..” Scientific Reports 6 (December 12, 2016). https://doi.org/10.1038/srep38815.
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    • Wang, Xiaowen, Conrad P. Hodgkinson, Kefeng Lu, Alan J. Payne, Richard E. Pratt, and Victor J. Dzau. “Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog..” Scientific Reports 6 (March 15, 2016). https://doi.org/10.1038/srep23017.
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    • Hodgkinson, Conrad P., Akshay Bareja, José A. Gomez, and Victor J. Dzau. “Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology..” Circ Res 118, no. 1 (January 8, 2016): 95–107. https://doi.org/10.1161/CIRCRESAHA.115.305373.
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    • Hodgkinson, Conrad P., Martin H. Kang, Sophie Dal-Pra, Maria Mirotsou, and Victor J. Dzau. “MicroRNAs and Cardiac Regeneration..” Circulation Research 116, no. 10 (May 2015): 1700–1711. https://doi.org/10.1161/CIRCRESAHA.116.304377.
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    • Hodgkinson, Conrad P., and Victor J. Dzau. “Conserved microRNA program as key to mammalian cardiac regeneration: insights from zebrafish..” Circulation Research 116, no. 7 (March 2015): 1109–11. https://doi.org/10.1161/circresaha.115.305852.
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    • Jayawardena, Tilanthi M., Elizabeth A. Finch, Lunan Zhang, Hengtao Zhang, Conrad P. Hodgkinson, Richard E. Pratt, Paul B. Rosenberg, Maria Mirotsou, and Victor J. Dzau. “MicroRNA induced cardiac reprogramming in vivo: evidence for mature cardiac myocytes and improved cardiac function..” Circ Res 116, no. 3 (January 30, 2015): 418–24. https://doi.org/10.1161/CIRCRESAHA.116.304510.
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    • Hodgkinson, C. P., J. A. Gomez, A. J. Payne, L. Zhang, X. Wang, S. Dal-Pra, R. E. Pratt, and V. J. Dzau. “Abi3bp regulates cardiac progenitor cell proliferation and differentiation.” Circulation Research 115, no. 12 (December 5, 2014): 1007–16. https://doi.org/10.1161/CIRCRESAHA.115.304216.
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    • Hodgkinson, Conrad P., Jose A. Gomez, Alan J. Payne, Lunan Zhang, Xiaowen Wang, Sophie Dal-Pra, Richard E. Pratt, and Victor J. Dzau. “Abi3bp regulates cardiac progenitor cell proliferation and differentiation..” Circ Res 115, no. 12 (December 5, 2014): 1007–16. https://doi.org/10.1161/CIRCRESAHA.115.304216.
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    • Jayawardena, T. M., E. A. Finch, L. Zhang, H. Zhang, C. P. Hodgkinson, R. E. Pratt, P. B. Rosenberg, M. Mirotsou, and V. J. Dzau. “MicroRNA induced cardiac reprogramming in vivo evidence for mature cardiac myocytes and improved cardiac function.” Circulation Research 116, no. 3 (October 28, 2014): 418–24. https://doi.org/10.1161/CIRCRESAHA.116.304510.
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    • Huang, Jing, Jian Guo, Farideh Beigi, Conrad P. Hodgkinson, Heberty T. Facundo, Zhiping Zhang, Jorge Espinoza-Derout, et al. “HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection..” Journal of Molecular and Cellular Cardiology 66 (January 2014): 157–64. https://doi.org/10.1016/j.yjmcc.2013.11.010.
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    • Hodgkinson, Conrad P., Vinogran Naidoo, Karl G. Patti, Jose A. Gomez, Jeffrey Schmeckpeper, Zhiping Zhang, Bryce Davis, Richard E. Pratt, Maria Mirotsou, and Victor J. Dzau. “Abi3bp is a multifunctional autocrine/paracrine factor that regulates mesenchymal stem cell biology..” Stem Cells 31, no. 8 (August 2013): 1669–82. https://doi.org/10.1002/stem.1416.
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    • Lin, Y. T., A. Verma, and C. P. Hodgkinson. “Toll-like receptors and human disease: Lessons from single nucleotide polymorphisms.” Current Genomics 13, no. 8 (December 3, 2012): 633–45. https://doi.org/10.2174/138920212803759712.
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    • Hodgkinson, Conrad P., and Shu Ye. “Toll-like receptors, their ligands, and atherosclerosis..” Thescientificworldjournal 11 (February 14, 2011): 437–53. https://doi.org/10.1100/tsw.2011.36.
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    • Hodgkinson, Conrad P., José A. Gomez, Maria Mirotsou, and Victor J. Dzau. “Genetic engineering of mesenchymal stem cells and its application in human disease therapy..” Hum Gene Ther 21, no. 11 (November 2010): 1513–26. https://doi.org/10.1089/hum.2010.165.
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    • Laxton, Ross C., Yanhua Hu, Johan Duchene, Feng Zhang, Zhongyi Zhang, Kit-Yi Leung, Qingzhong Xiao, et al. “A role of matrix metalloproteinase-8 in atherosclerosis..” Circulation Research 105, no. 9 (October 2009): 921–29. https://doi.org/10.1161/CIRCRESAHA.109.200279.
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    • Hodgkinson, Conrad P., Ross C. Laxton, Kunal Patel, and Shu Ye. “Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis..” Arteriosclerosis, Thrombosis, and Vascular Biology 28, no. 12 (December 2008): 2275–81. https://doi.org/10.1161/atvbaha.108.175992.
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    • Hodgkinson, Conrad P., and Shu Ye. “Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression..” Pharmacogenetics and Genomics 18, no. 9 (September 2008): 803–13. https://doi.org/10.1097/fpc.0b013e3283050aff.
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    • Hodgkinson, Conrad P., Kunal Patel, and Shu Ye. “Functional Toll-like receptor 4 mutations modulate the response to fibrinogen..” Thrombosis and Haemostasis 100, no. 2 (August 2008): 301–7.
    • Smithers, Natalie P., Conrad P. Hodgkinson, Matt Cuttle, and Graham J. Sale. “Insulin-triggered repositioning of munc18c on syntaxin-4 in GLUT4 signalling..” The Biochemical Journal 410, no. 2 (March 2008): 255–60. https://doi.org/10.1042/bj20070802.
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    • Smithers, Natalie P., Conrad P. Hodgkinson, Matt Cuttle, and Graham J. Sale. “80K-H acts as a signaling bridge in intact living cells between PKCzeta and the GLUT4 translocation regulator Munc18c..” Journal of Receptor and Signal Transduction Research 28, no. 6 (January 2008): 581–89. https://doi.org/10.1080/10799890802598571.
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    • Decock, Julie, Ji-Rong Long, Ross C. Laxton, Xiao-Ou Shu, Conrad Hodgkinson, Wouter Hendrickx, Eve G. Pearce, et al. “Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis..” Cancer Research 67, no. 21 (November 2007): 10214–21. https://doi.org/10.1158/0008-5472.can-07-1683.
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    • Kyriakou, Theodosios, David E. Pontefract, Enrique Viturro, Conrad P. Hodgkinson, Ross C. Laxton, Neda Bogari, George Cooper, et al. “Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients..” Human Molecular Genetics 16, no. 12 (June 2007): 1412–22. https://doi.org/10.1093/hmg/ddm091.
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    • Sale, Elizabeth M., Conrad P. Hodgkinson, Neil P. Jones, and Graham J. Sale. “A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase..” Biochemistry 45, no. 1 (January 2006): 213–23. https://doi.org/10.1021/bi050287i.
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    • Hodgkinson, C. P., A. Mander, and G. J. Sale. “Protein kinase-zeta interacts with munc18c: role in GLUT4 trafficking..” Diabetologia 48, no. 8 (August 2005): 1627–36. https://doi.org/10.1007/s00125-005-1819-y.
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    • Hodgkinson, Conrad P., Ann Mander, and Graham J. Sale. “Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking..” The Biochemical Journal 388, no. Pt 3 (June 2005): 785–93. https://doi.org/10.1042/BJ20041845.
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    • Mander, Ann, Conrad P. Hodgkinson, and Graham J. Sale. “Knock-down of LAR protein tyrosine phosphatase induces insulin resistance..” Febs Letters 579, no. 14 (June 2005): 3024–28. https://doi.org/10.1016/j.febslet.2005.04.057.
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    • Kyriakou, Theodosios, Conrad Hodgkinson, David E. Pontefract, Srikanth Iyengar, W Martin Howell, Yuk-ki Wong, Per Eriksson, and Shu Ye. “Genotypic effect of the -565C>T polymorphism in the ABCA1 gene promoter on ABCA1 expression and severity of atherosclerosis..” Arteriosclerosis, Thrombosis, and Vascular Biology 25, no. 2 (February 2005): 418–23. https://doi.org/10.1161/01.atv.0000149379.72018.20.
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    • Hodgkinson, Conrad P., and Shu Ye. “Microarray analysis of peroxisome proliferator-activated receptor-gamma induced changes in gene expression in macrophages..” Biochemical and Biophysical Research Communications 308, no. 3 (August 2003): 505–10. https://doi.org/10.1016/s0006-291x(03)01416-5.
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    • Hodgkinson, Conrad P., Elizabeth M. Sale, and Graham J. Sale. “Characterization of PDK2 activity against protein kinase B gamma..” Biochemistry 41, no. 32 (August 2002): 10351–59. https://doi.org/10.1021/bi026065r.
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    • Hodgkinson, Conrad P., and Graham J. Sale. “Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment..” Biochemistry 41, no. 2 (January 2002): 561–69. https://doi.org/10.1021/bi010719z.
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    • Hodgkinson, C. P., M. C. Wright, and A. J. Paine. “Fibronectin-mediated hepatocyte shape change reprograms cytochrome P450 2C11 gene expression via an integrin-signaled induction of ribonuclease activity..” Molecular Pharmacology 58, no. 5 (November 2000): 976–81. https://doi.org/10.1124/mol.58.5.976.
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    • Wang, X. J., C. P. Hodgkinson, M. C. Wright, and A. J. Paine. “Temperature-sensitive mRNA degradation is an early event in hepatocyte de-differentiation..” The Biochemical Journal 328 ( Pt 3) (December 1997): 937–44. https://doi.org/10.1042/bj3280937.
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