Conrad Phillip Hodgkinson

Conrad Phillip Hodgkinson
Assistant Professor in Medicine

Current Appointments & Affiliations

Assistant Professor in Medicine, Medicine, Cardiology, Medicine 2017

Contact Information

GSRB II Room 4035, Box 3178, Durham, NC 27710
conrad.hodgkinson@duke.edu (919) 681-3828

Background
Education, Training, & Certifications
- Ph.D., University of London (UK) 1996
Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2013 - 2017
Research
Selected Grants
- Sfrp2 induces in situ c-Kit cell differentiation into cardiomyocytes via Wnt11-Fzd5 mediated b-catenin inhibition awarded by National Institutes of Health 2018 - 2022
- Novel strategy for Enhancing miRNA as a Therapeutic for Cardiac Regeneration awarded by National Institutes of Health 2016 - 2020
- Enhancing cardiac reprogramming via TLR3 awarded by Rosenfeld Heart Foundation 2018 - 2019
- Integrated Cellular and Tissue Engineering for Ischemic Heart Disease awarded by University of Alabama at Birmingham 2016 - 2019
- Sfrp2 and Cardiac Progenitor Cells in Regenerative Response to Ischemic Injury awarded by National Institutes of Health 2005 - 2016
- Gene Therapy for Long-Term Myocardial Protection awarded by National Institutes of Health 2003 - 2014
- Genetically Altered Mesenchymal Stem Cell; Paracrine Effect on Neovascularization awarded by National Institutes of Health 2003 - 2014
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Hodgkinson, CP, Gomez, JA, Baksh, SS, Payne, A, Schmeckpeper, J, Pratt, RE, and Dzau, VJ. "Insights from molecular signature of in vivo cardiac c-Kit(+) cells following cardiac injury and β-catenin inhibition." Journal of Molecular and Cellular Cardiology 123 (October 2018): 64-74. Full Text
  - Hodgkinson, CP, Pratt, RE, Kirste, I, Dal-Pra, S, Cooke, JP, and Dzau, VJ. "Cardiomyocyte Maturation Requires TLR3 Activated Nuclear Factor Kappa B." Stem Cells (Dayton, Ohio) 36, no. 8 (August 2018): 1198-1209. Full Text
  - Bareja, A, Patel, S, Hodgkinson, CP, Payne, A, and Dzau, VJ. "Understanding the mechanism of bias signaling of the insulin-like growth factor 1 receptor: Effects of LL37 and HASF." Cellular Signalling 46 (June 2018): 113-119. Full Text
  - Bareja, A, Hodgkinson, CP, Soderblom, E, Waitt, G, and Dzau, VJ. "The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway." The Journal of Biological Chemistry 293, no. 17 (April 2018): 6449-6459. Full Text
  - Dal-Pra, S, Hodgkinson, CP, Mirotsou, M, Kirste, I, and Dzau, VJ. "Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo." Circulation research 120, no. 9 (April 2017): 1403-1413. Full Text
  - Bareja, A, Hodgkinson, CP, Payne, AJ, Pratt, RE, and Dzau, VJ. "HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor." Biochemical Journal 474, no. 5 (February 2017): 771-780. Full Text
  - Li, Y, Dal-Pra, S, Mirotsou, M, Jayawardena, TM, Hodgkinson, CP, Bursac, N, and Dzau, VJ. "Tissue-engineered 3-dimensional (3D) microenvironment enhances the direct reprogramming of fibroblasts into cardiomyocytes by microRNAs." Scientific Reports 6 (December 12, 2016): 38815-null. Full Text
  - Wang, X, Hodgkinson, CP, Lu, K, Payne, AJ, Pratt, RE, and Dzau, VJ. "Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog." Scientific reports 6 (March 15, 2016): 23017-. Full Text
  - Hodgkinson, CP, Bareja, A, Gomez, JA, and Dzau, VJ. "Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology." Circulation Research 118, no. 1 (January 2016): 95-107. (Review) Full Text
  - Hodgkinson, CP, Kang, MH, Dal-Pra, S, Mirotsou, M, and Dzau, VJ. "MicroRNAs and Cardiac Regeneration." Circulation Research 116, no. 10 (May 2015): 1700-1711. (Review) Full Text
  - Hodgkinson, CP, and Dzau, VJ. "Conserved microRNA program as key to mammalian cardiac regeneration: insights from zebrafish." Circulation research 116, no. 7 (March 2015): 1109-1111. Full Text
  - Jayawardena, TM, Finch, EA, Zhang, L, Zhang, H, Hodgkinson, CP, Pratt, RE, Rosenberg, PB, Mirotsou, M, and Dzau, VJ. "MicroRNA induced cardiac reprogramming in vivo: evidence for mature cardiac myocytes and improved cardiac function." Circulation Research 116, no. 3 (January 2015): 418-424. Full Text
  - Hodgkinson, CP, Gomez, JA, Payne, AJ, Zhang, L, Wang, X, Dal-Pra, S, Pratt, RE, and Dzau, VJ. "Abi3bp regulates cardiac progenitor cell proliferation and differentiation." Circulation Research 115, no. 12 (December 2014): 1007-1016. Full Text
  - Jayawardena, TM, Finch, EA, Zhang, L, Zhang, H, Hodgkinson, CP, Pratt, RE, Rosenberg, PB, Mirotsou, M, and Dzau, VJ. "MicroRNA induced cardiac reprogramming in vivo evidence for mature cardiac myocytes and improved cardiac function." Circulation Research 116, no. 3 (October 28, 2014): 418-424. Full Text
  - Hodgkinson, CP, Gomez, JA, Payne, AJ, Zhang, L, Wang, X, Dal-Pra, S, Pratt, RE, and Dzau, VJ. "Abi3bp regulates cardiac progenitor cell proliferation and differentiation." Circulation Research 115, no. 12 (January 1, 2014): 1007-1016.
  - Huang, J, Guo, J, Beigi, F, Hodgkinson, CP, Facundo, HT, Zhang, Z, Espinoza-Derout, J, Zhou, X, Pratt, RE, Mirotsou, M, and Dzau, VJ. "HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection." J Mol Cell Cardiol 66 (January 2014): 157-164. Full Text Link to Item
  - Hodgkinson, CP, Naidoo, V, Patti, KG, Gomez, JA, Schmeckpeper, J, Zhang, Z, Davis, B, Pratt, RE, Mirotsou, M, and Dzau, VJ. "Abi3bp is a multifunctional autocrine/paracrine factor that regulates mesenchymal stem cell biology." Stem Cells (Dayton, Ohio) 31, no. 8 (August 2013): 1669-1682. Full Text
  - Lin, Y-T, Verma, A, and P. Hodgkinson, C. "Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms." Current Genomics 13, no. 8 (October 1, 2012): 633-645. Full Text
  - Hodgkinson, CP, and Ye, S. "Toll-like receptors, their ligands, and atherosclerosis." Thescientificworldjournal 11 (February 14, 2011): 437-453. (Review) Full Text
  - Hodgkinson, CP, Gomez, JA, Mirotsou, M, and Dzau, VJ. "Genetic engineering of mesenchymal stem cells and its application in human disease therapy." Human Gene Therapy 21, no. 11 (November 2010): 1513-1526. (Review) Full Text Open Access Copy
  - Laxton, RC, Hu, Y, Duchene, J, Zhang, F, Zhang, Z, Leung, K-Y, Xiao, Q, Scotland, RS, Hodgkinson, CP, Smith, K, Willeit, J, López-Otín, C, Simpson, IA, Kiechl, S, Ahluwalia, A, Xu, Q, and Ye, S. "A role of matrix metalloproteinase-8 in atherosclerosis." Circulation Research 105, no. 9 (October 2009): 921-929. Full Text
  - Hodgkinson, CP, Laxton, RC, Patel, K, and Ye, S. "Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis." Arteriosclerosis, Thrombosis, and Vascular Biology 28, no. 12 (December 2008): 2275-2281. Full Text
  - Hodgkinson, CP, and Ye, S. "Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression." Pharmacogenetics and genomics 18, no. 9 (September 2008): 803-813. Full Text
  - Hodgkinson, CP, Patel, K, and Ye, S. "Functional Toll-like receptor 4 mutations modulate the response to fibrinogen." Thrombosis and Haemostasis 100, no. 2 (August 2008): 301-307.
  - Smithers, NP, Hodgkinson, CP, Cuttle, M, and Sale, GJ. "Insulin-triggered repositioning of munc18c on syntaxin-4 in GLUT4 signalling." The Biochemical Journal 410, no. 2 (March 2008): 255-260. Full Text
  - Smithers, NP, Hodgkinson, CP, Cuttle, M, and Sale, GJ. "80K-H acts as a signaling bridge in intact living cells between PKCzeta and the GLUT4 translocation regulator Munc18c." Journal of receptor and signal transduction research 28, no. 6 (January 2008): 581-589. Full Text
  - Decock, J, Long, J-R, Laxton, RC, Shu, X-O, Hodgkinson, C, Hendrickx, W, Pearce, EG, Gao, Y-T, Pereira, AC, Paridaens, R, Zheng, W, and Ye, S. "Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis." Cancer research 67, no. 21 (November 2007): 10214-10221. Full Text
  - Kyriakou, T, Pontefract, DE, Viturro, E, Hodgkinson, CP, Laxton, RC, Bogari, N, Cooper, G, Davies, M, Giblett, J, Day, INM, Simpson, IA, Albrecht, C, and Ye, S. "Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients." Human Molecular Genetics 16, no. 12 (June 2007): 1412-1422. Full Text
  - Sale, EM, Hodgkinson, CP, Jones, NP, and Sale, GJ. "A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase." Biochemistry 45, no. 1 (January 2006): 213-223. Full Text
  - Hodgkinson, CP, Mander, A, and Sale, GJ. "Protein kinase-zeta interacts with munc18c: role in GLUT4 trafficking." Diabetologia 48, no. 8 (August 2005): 1627-1636. Full Text
  - Hodgkinson, CP, Mander, A, and Sale, GJ. "Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking." The Biochemical Journal 388, no. Pt 3 (June 2005): 785-793. Full Text
  - Mander, A, Hodgkinson, CP, and Sale, GJ. "Knock-down of LAR protein tyrosine phosphatase induces insulin resistance." FEBS letters 579, no. 14 (June 2005): 3024-3028. Full Text
  - Kyriakou, T, Hodgkinson, C, Pontefract, DE, Iyengar, S, Howell, WM, Wong, Y-K, Eriksson, P, and Ye, S. "Genotypic effect of the -565C>T polymorphism in the ABCA1 gene promoter on ABCA1 expression and severity of atherosclerosis." Arteriosclerosis, thrombosis, and vascular biology 25, no. 2 (February 2005): 418-423. Full Text
  - Hodgkinson, CP, and Ye, S. "Microarray analysis of peroxisome proliferator-activated receptor-gamma induced changes in gene expression in macrophages." Biochemical and biophysical research communications 308, no. 3 (August 2003): 505-510. Full Text
  - Hodgkinson, CP, Sale, EM, and Sale, GJ. "Characterization of PDK2 activity against protein kinase B gamma." Biochemistry 41, no. 32 (August 2002): 10351-10359. Full Text
  - Hodgkinson, CP, and Sale, GJ. "Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment." Biochemistry 41, no. 2 (January 2002): 561-569. Full Text
  - Hodgkinson, CP, Wright, MC, and Paine, AJ. "Fibronectin-mediated hepatocyte shape change reprograms cytochrome P450 2C11 gene expression via an integrin-signaled induction of ribonuclease activity." Molecular Pharmacology 58, no. 5 (November 2000): 976-981. Full Text
  - Wang, XJ, Hodgkinson, CP, Wright, MC, and Paine, AJ. "Temperature-sensitive mRNA degradation is an early event in hepatocyte de-differentiation." The Biochemical journal 328 ( Pt 3) (December 1997): 937-944. Full Text
Teaching & Mentoring
Recent Courses
- PHARM 394: Research Independent Study 2016

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Recent Courses