Current Appointments & Affiliations
Associate Professor in Medicine
·
2023 - Present
Medicine, Cardiology,
Medicine
Associate Professor of Pathology
·
2023 - Present
Pathology,
Clinical Science Departments
Recent Publications
Hemoglobin inhibits fibroblast-to-cardiomyocyte reprogramming via TLR2/TLR4-dependent chromatin compaction
Journal Article Molecular Therapy Nucleic Acids · June 16, 2026 Fibroblast-to-cardiomyocyte reprogramming is influenced by signals present in the injured heart. However, the nature of those signals is unclear. The efficacy of fibroblast-to-cardiomyocyte reprogramming was found to be negatively impacted by extracts deri ... Full text CiteNucleosome repositioning in cardiac reprogramming.
Journal Article PLoS One · 2025 Early events in the reprogramming of fibroblasts to cardiac muscle cells are unclear. While various histone undergo modification and re-positioning, and these correlate with the activity of certain genes, it is unknown if these events are causal or happen ... Full text Link to item CiteThe impact of aging on cardiac repair and regeneration.
Journal Article J Biol Chem · September 2024 In contrast to neonates and lower organisms, the adult mammalian heart lacks any capacity to regenerate following injury. The vast majority of our understanding of cardiac regeneration is based on research in young animals. Research in aged individuals is ... Full text Link to item CiteRecent Grants
Novel approaches for cardiac reprogramming: Exosome delivery of reprogramming miRNAs and repressor targeting siRNAs
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2029CTX340 AGT In vivo Gene Editing Collaboration
ResearchPrincipal Investigator · Awarded by CRISPR Therapeutics · 2025 - 2026Enhancing cardiac reprogramming via TLR3
ResearchPrincipal Investigator · Awarded by Rosenfeld Heart Foundation · 2018 - 2024View All Grants
Education
University of London (United Kingdom) ·
1996
Ph.D.