Regulation of hepatic innate immunity by hepatitis C virus.


Journal Article (Review)

Hepatitis C virus (HCV) is a global public health problem involving chronic infection of the liver, which can cause liver disease and is linked with liver cancer. Viral innate immune evasion strategies and human genetic determinants underlie the transition of acute HCV infection to viral persistence and the support of chronic infection. Host genetic factors, such as sequence polymorphisms in IFNL3, a gene in the host interferon system, can influence both the outcome of the infection and the response to antiviral therapy. Recent insights into how HCV regulates innate immune signaling within the liver reveal a complex interaction of patient genetic background with viral and host factors of innate immune triggering and control that imparts the outcome of HCV infection and immunity.

Full Text

Duke Authors

Cited Authors

  • Horner, SM; Gale, M

Published Date

  • July 2013

Published In

Volume / Issue

  • 19 / 7

Start / End Page

  • 879 - 888

PubMed ID

  • 23836238

Pubmed Central ID

  • 23836238

Electronic International Standard Serial Number (EISSN)

  • 1546-170X

Digital Object Identifier (DOI)

  • 10.1038/nm.3253


  • eng

Conference Location

  • United States