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ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation.

Publication ,  Journal Article
Kolligs, FT; Nieman, MT; Winer, I; Hu, G; Van Mater, D; Feng, Y; Smith, IM; Wu, R; Zhai, Y; Cho, KR; Fearon, ER
Published in: Cancer Cell
March 2002

In many cancers, inactivation of the adenomatous polyposis coli (APC) or Axin tumor suppressor proteins or activating mutations in beta-catenin lead to elevated beta-catenin levels, enhanced binding of beta-catenin to T cell factor (TCF) proteins, and increased expression of TCF-regulated genes. We found that the gene for the basic helix-loop-helix transcription factor ITF-2 (immunoglobulin transcription factor-2) was activated in rat E1A-immortalized RK3E cells following neoplastic transformation by beta-catenin or ligand-induced activation of a beta-catenin-estrogen receptor fusion protein. Human cancers with beta-catenin regulatory defects had elevated ITF-2 expression, and ITF-2 was repressed by restoring wild-type APC function or inhibiting TCF activity. Of note, ITF-2 promoted neoplastic transformation of RK3E cells. We propose that ITF-2 is a TCF-regulated gene, which functions in concert with other TCF target genes to promote growth and/or survival of cancer cells with defects in beta-catenin regulation.

Duke Scholars

Published In

Cancer Cell

DOI

ISSN

1535-6108

Publication Date

March 2002

Volume

1

Issue

2

Start / End Page

145 / 155

Location

United States

Related Subject Headings

  • beta Catenin
  • Zebrafish Proteins
  • Wnt Proteins
  • Tumor Cells, Cultured
  • Transcription Factors
  • Transcription Factor 7-Like 2 Protein
  • Transcription Factor 4
  • Trans-Activators
  • TCF Transcription Factors
  • Signal Transduction
 

Citation

APA
Chicago
ICMJE
MLA
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Kolligs, F. T., Nieman, M. T., Winer, I., Hu, G., Van Mater, D., Feng, Y., … Fearon, E. R. (2002). ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation. Cancer Cell, 1(2), 145–155. https://doi.org/10.1016/s1535-6108(02)00035-1
Kolligs, Frank T., Marvin T. Nieman, Ira Winer, Gang Hu, David Van Mater, Ying Feng, Ian M. Smith, et al. “ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation.Cancer Cell 1, no. 2 (March 2002): 145–55. https://doi.org/10.1016/s1535-6108(02)00035-1.
Kolligs FT, Nieman MT, Winer I, Hu G, Van Mater D, Feng Y, et al. ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation. Cancer Cell. 2002 Mar;1(2):145–55.
Kolligs, Frank T., et al. “ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation.Cancer Cell, vol. 1, no. 2, Mar. 2002, pp. 145–55. Pubmed, doi:10.1016/s1535-6108(02)00035-1.
Kolligs FT, Nieman MT, Winer I, Hu G, Van Mater D, Feng Y, Smith IM, Wu R, Zhai Y, Cho KR, Fearon ER. ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation. Cancer Cell. 2002 Mar;1(2):145–155.
Journal cover image

Published In

Cancer Cell

DOI

ISSN

1535-6108

Publication Date

March 2002

Volume

1

Issue

2

Start / End Page

145 / 155

Location

United States

Related Subject Headings

  • beta Catenin
  • Zebrafish Proteins
  • Wnt Proteins
  • Tumor Cells, Cultured
  • Transcription Factors
  • Transcription Factor 7-Like 2 Protein
  • Transcription Factor 4
  • Trans-Activators
  • TCF Transcription Factors
  • Signal Transduction