David Sinclaire Van Mater

David Sinclaire Van Mater
Assistant Professor of Pediatrics

I am a pediatric oncologist with a specific interest in hereditary cancer syndromes and sarcoma. I am co-director of the Duke Comprehensive Neurofibromatosis Clinic where I see children and adults with neurofibromatosis type I and II, in addition to schwannomatosis. From a research standpoint, I use mouse models of sarcoma to better understand the complex relationship between genetic mutations and the microenvironment in tumor formation.

Current Appointments & Affiliations

Assistant Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2016

Contact Information

102382, Durham, NC 27710
Dept Of Pediatrics, Box 2916, Durham, NC 27710
david.vanmater@duke.edu (919) 684-8111

Background
Education, Training, & Certifications
- Pediatric Hematology/Oncology Fellowship, Pediatrics, Duke University School of Medicine 2009 - 2013
- Pediatrics Internship and Residency, Pediatrics, University of Michigan at Ann Arbor 2006 - 2009
- MD./PhD., University of Michigan at Ann Arbor 2006
Duke Appointment History
- Medical Instructor in the Department of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2013 - 2016
Research
Selected Grants
- Targeting Tumor Initiating Cell in Undifferentiated Pleomorphic Sarcoma awarded by National Institutes of Health 2015 - 2019
- NF1-OPG awarded by Children's Tumor Foundation 2015 - 2019
- Expansion of the AYA Oncology Initiative at Duke University awarded by St. Baldrick's Foundation 2016 - 2018
- PBTC-042 (Phase 1 of PD-0332991) awarded by Pfizer, Inc. 2014 - 2018
- Dissecting the role of injury is sarcoma formation awarded by Sarcoma Alliance for Research Through Collaboration 2015 - 2017
- Dissecting the role of injury is sarcoma formation awarded by Sarcoma Alliance for Research Through Collaboration 2015 - 2017
Publications & Artistic Works
Selected Publications
- Journal Articles
  - Narine, KY, Oh, CC, Fuchs, HE, and Van Mater, D. "Calvarial mass as a presenting feature of neurofibromatosis type 2 in a pediatric patient." American journal of medical genetics. Part A 176, no. 1 (January 2018): 246-247. Full Text
  - Huang, J, Chen, M, Whitley, MJ, Kuo, H-C, Xu, ES, Walens, A, Mowery, YM, Van Mater, D, Eward, WC, Cardona, DM, Luo, L, Ma, Y, Lopez, OM, Nelson, CE, Robinson-Hamm, JN, Reddy, A, Dave, SS, Gersbach, CA, Dodd, RD, and Kirsch, DG. "Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma." Nature communications 8 (July 10, 2017): 15999-. Full Text
  - Sayour, EJ, Mousallem, T, Van Mater, D, Wang, E, Martin, P, Buckley, RH, and Barfield, RC. "Bone marrow transplantation for CVID-like humoral immune deficiency associated with red cell aplasia." Pediatric blood & cancer 63, no. 10 (October 2016): 1856-1859. Full Text
  - Van Mater, D, Añó, L, Blum, JM, Webster, MT, Huang, W, Williams, N, Ma, Y, Cardona, DM, Fan, C-M, and Kirsch, DG. "Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway." Cancer research 75, no. 3 (February 2015): 605-614. Full Text
  - Dodd, RD, Añó, L, Blum, JM, Li, Z, Van Mater, D, and Kirsch, DG. "Methods to generate genetically engineered mouse models of soft tissue sarcoma." Methods in molecular biology (Clifton, N.J.) 1267 (January 2015): 283-295. Full Text
  - Sachdeva, M, Mito, JK, Lee, C-L, Zhang, M, Li, Z, Dodd, RD, Cason, D, Luo, L, Ma, Y, Van Mater, D, Gladdy, R, Lev, DC, Cardona, DM, and Kirsch, DG. "MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes." The Journal of clinical investigation 124, no. 10 (October 2014): 4305-4319. Full Text
  - Blum, JM, Añó, L, Li, Z, Van Mater, D, Bennett, BD, Sachdeva, M, Lagutina, I, Zhang, M, Mito, JK, Dodd, LG, Cardona, DM, Dodd, RD, Williams, N, Ma, Y, Lepper, C, Linardic, CM, Mukherjee, S, Grosveld, GC, Fan, C-M, and Kirsch, DG. "Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells." Cell Rep 5, no. 4 (November 27, 2013): 933-940. Full Text Link to Item
  - Raizis, AM, Van Mater, D, Aaltonen, LA, Lohmann, D, Cheale, MS, Bickley, VM, George, PM, Zhou, Y, and Rosoff, PM. "Trilateral retinoblastoma in a patient with Peutz-Jeghers syndrome." Am J Med Genet A 161A, no. 5 (May 2013): 1096-1100. Full Text Link to Item
  - Van Mater, D, Knelson, EH, Kaiser-Rogers, KA, and Armstrong, MB. "Neuroblastoma in a pediatric patient with a microduplication of 2p involving the MYCN locus." Am J Med Genet A 161A, no. 3 (March 2013): 605-610. Full Text Link to Item
  - Raizis, AM, Mater, DV, Aaltonen, LA, Lohmann, D, Cheale, MS, Bickley, VM, George, PM, Zhou, Y, and Rosoff, PM. "Trilateral Retinoblastoma in a Patient With Peutz-Jeghers Syndrome." American Journal of Medical Genetics, Part A 161, no. 5 (2013): 1096-1100. Full Text
  - Mater, DV, Goodman, BK, Wang, E, Gaca, AM, and Wechsler, DS. "MLL duplication in a pediatric patient with B-cell lymphoblastic lymphoma." J Pediatr Hematol Oncol 34, no. 3 (April 2012): e120-e123. Full Text Link to Item
  - Papalas, JA, Van Mater, D, and Wang, E. "Pyogenic variant of primary cutaneous anaplastic large-cell lymphoma: a lymphoproliferative disorder with a predilection for the immunocompromized and the young." The American Journal of dermatopathology 32, no. 8 (December 2010): 821-827. (Review) Full Text
  - Van Mater, D, Kolligs, FT, Dlugosz, AA, and Fearon, ER. "Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice." Genes & development 17, no. 10 (May 2003): 1219-1224. Full Text
  - Kolligs, FT, Nieman, MT, Winer, I, Hu, G, Van Mater, D, Feng, Y, Smith, IM, Wu, R, Zhai, Y, Cho, KR, and Fearon, ER. "ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation." Cancer cell 1, no. 2 (March 2002): 145-155. Full Text
  - Piwien-Pilipuk, G, Van Mater, D, Ross, SE, MacDougald, OA, and Schwartz, J. "Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3." The Journal of biological chemistry 276, no. 22 (June 2001): 19664-19671. Full Text
  - Dance, GS, Beemiller, P, Yang, Y, Mater, DV, Mian, IS, and Smith, HC. "Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase." Nucleic acids research 29, no. 8 (April 2001): 1772-1780. Full Text
  - Siddiqui, JF, Van Mater, D, Sowden, MP, and Smith, HC. "Disproportionate relationship between APOBEC-1 expression and apolipoprotein B mRNA editing activity." Experimental cell research 252, no. 1 (October 1999): 154-164. Full Text
  - Van Mater, D, Sowden, MP, Cianci, J, Sparks, JD, Sparks, CE, Ballatori, N, and Smith, HC. "Ethanol increases apolipoprotein B mRNA editing in rat primary hepatocytes and McArdle cells." Biochemical and biophysical research communications 252, no. 2 (November 1998): 334-339. Full Text

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Journal Articles