David Sinclaire Van Mater

David Sinclaire Van Mater
Assistant Professor of Pediatrics

I am a pediatric oncologist with a specific interest in hereditary cancer syndromes and sarcoma. I also director of the Duke Comprehensive Neurofibromatosis Clinic where I see children and adults with neurofibromatosis type I and II, in addition to schwannomatosis.

Current Appointments & Affiliations

Assistant Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2016
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2018

Contact Information

102382, Durham, NC 27710
Dept of Pediatrics, Box 2916, Durham, NC 27710
david.vanmater@duke.edu (919) 684-8111

Background
Education, Training, & Certifications
- Pediatric Hematology/Oncology Fellowship, Pediatrics, Duke University School of Medicine 2009 - 2013
- Pediatrics Internship and Residency, Pediatrics, University of Michigan, Ann Arbor 2006 - 2009
- MD./PhD., University of Michigan, Ann Arbor 2006
Duke Appointment History
- Medical Instructor in the Department of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2013 - 2016
Expertise
Subject Headings
Research
Selected Grants
- A phase 2b trial of the MEK 1/2 inhibitor (MEKi) PD-0325901 in adult and pediatric patient with neurofibromatosis type 1 (NF1)-associated inoperable plexiform neurofibromas (PNs) that are causing significant morbidity awarded by SpringWorks Therapeutics 2020 - 2024
- Phase I study of PD-0332991 for pediatric patiens with retinoblastoma protein (RB)-positive recurrent or refractory central nervous system (CNS) tumors. awarded by Pfizer, Inc. 2014 - 2021
- Targeting epigenetic dysregulation in pediatric cancer awarded by Dana-Farber Cancer Institute 2019 - 2020
- MAIN STUDY: Developing Evidence-Based Crieteria for Initiating Treatment fo NF1-OPG. awarded by Children's Tumor Foundation 2015 - 2020
- Visual Field Outcomes in Pediatric Patients with NF1-associated Optic Pathway Gliomas awarded by Boston Children's Hospital 2018 - 2019
- Expansion of the AYA Oncology Initiative at Duke University awarded by St. Baldrick's Foundation 2016 - 2018
- Dissecting the role of injury is sarcoma formation awarded by Sarcoma Alliance for Research Through Collaboration 2015 - 2017
- Dissecting the role of injury is sarcoma formation awarded by Sarcoma Alliance for Research Through Collaboration 2015 - 2017
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Robles, Joanna, Vahakn S. Keskinyan, Matthew Thompson, Joseph T. Davis, and David Van Mater. “Combination therapy with sorafenib and celecoxib for pediatric patients with desmoid tumor.” Pediatr Hematol Oncol 37, no. 5 (August 2020): 445–49. https://doi.org/10.1080/08880018.2020.1735591.
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  - Lee, Chang-Lung, Yvonne M. Mowery, Andrea R. Daniel, Dadong Zhang, Alexander B. Sibley, Joe R. Delaney, Amy J. Wisdom, et al. “Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma.” Jci Insight 4, no. 13 (July 11, 2019). https://doi.org/10.1172/jci.insight.128698.
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  - Bose, Shree, Joanna Robles, Chad M. McCall, Anand S. Lagoo, Daniel S. Wechsler, Gary R. Schooler, and David Van Mater. “Favorable response to nivolumab in a young adult patient with metastatic histiocytic sarcoma.” Pediatr Blood Cancer 66, no. 1 (January 2019): e27491. https://doi.org/10.1002/pbc.27491.
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  - Lee, Sulgi, Madhuri Kambhampati, M Isabel Almira-Suarez, Cheng-Ying Ho, Eshini Panditharatna, Seth I. Berger, Joyce Turner, et al. “Somatic Mosaicism of IDH1 R132H Predisposes to Anaplastic Astrocytoma: A Case of Two Siblings.” Front Oncol 9 (2019): 1507. https://doi.org/10.3389/fonc.2019.01507.
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  - Van Mater, David, and Lars Wagner. “Management of recurrent Ewing sarcoma: challenges and approaches.” Onco Targets Ther 12 (2019): 2279–88. https://doi.org/10.2147/OTT.S170585.
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  - Van Mater, David, Eric Xu, Anupama Reddy, Leonor Añó, Mohit Sachdeva, Wesley Huang, Nerissa Williams, et al. “Injury promotes sarcoma development in a genetically and temporally restricted manner.” Jci Insight 3, no. 20 (October 18, 2018). https://doi.org/10.1172/jci.insight.123687.
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  - Narine, Kalindi Y., Christopher C. Oh, Herbert E. Fuchs, and David Van Mater. “Calvarial mass as a presenting feature of neurofibromatosis type 2 in a pediatric patient.” Am J Med Genet A 176, no. 1 (January 2018): 246–47. https://doi.org/10.1002/ajmg.a.38505.
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  - Huang, Jianguo, Mark Chen, Melodi Javid Whitley, Hsuan-Cheng Kuo, Eric S. Xu, Andrea Walens, Yvonne M. Mowery, et al. “Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma.” Nat Commun 8 (July 10, 2017): 15999. https://doi.org/10.1038/ncomms15999.
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  - Sayour, Elias J., Talal Mousallem, David Van Mater, Endi Wang, Paul Martin, Rebecca H. Buckley, and Raymond C. Barfield. “Bone marrow transplantation for CVID-like humoral immune deficiency associated with red cell aplasia.” Pediatr Blood Cancer 63, no. 10 (October 2016): 1856–59. https://doi.org/10.1002/pbc.26092.
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  - Van Mater, David, Leonor Añó, Jordan M. Blum, Micah T. Webster, WeiQiao Huang, Nerissa Williams, Yan Ma, Diana M. Cardona, Chen-Ming Fan, and David G. Kirsch. “Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway.” Cancer Res 75, no. 3 (February 1, 2015): 605–14. https://doi.org/10.1158/0008-5472.CAN-14-2527.
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  - Dodd, Rebecca D., Leonor Añó, Jordan M. Blum, Zhizhong Li, David Van Mater, and David G. Kirsch. “Methods to generate genetically engineered mouse models of soft tissue sarcoma.” Methods Mol Biol 1267 (2015): 283–95. https://doi.org/10.1007/978-1-4939-2297-0_13.
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  - Sachdeva, Mohit, Jeffrey K. Mito, Chang-Lung Lee, Minsi Zhang, Zhizhong Li, Rebecca D. Dodd, David Cason, et al. “MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes.” J Clin Invest 124, no. 10 (October 2014): 4305–19. https://doi.org/10.1172/JCI77116.
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  - Blum, Jordan M., Leonor Añó, Zhizhong Li, David Van Mater, Brian D. Bennett, Mohit Sachdeva, Irina Lagutina, et al. “Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells.” Cell Rep 5, no. 4 (November 27, 2013): 933–40. https://doi.org/10.1016/j.celrep.2013.10.020.
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  - Raizis, Anthony M., David Van Mater, Lauri A. Aaltonen, Dietmar Lohmann, Michelle S. Cheale, Vivienne M. Bickley, Peter M. George, Yaolin Zhou, and Philip M. Rosoff. “Trilateral retinoblastoma in a patient with Peutz-Jeghers syndrome.” Am J Med Genet A 161A, no. 5 (May 2013): 1096–1100. https://doi.org/10.1002/ajmg.a.35748.
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  - Van Mater, David, Erik H. Knelson, Kathleen A. Kaiser-Rogers, and Michael B. Armstrong. “Neuroblastoma in a pediatric patient with a microduplication of 2p involving the MYCN locus.” Am J Med Genet A 161A, no. 3 (March 2013): 605–10. https://doi.org/10.1002/ajmg.a.35766.
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  - Mater, David Van, Barbara K. Goodman, Endi Wang, Ana M. Gaca, and Daniel S. Wechsler. “MLL duplication in a pediatric patient with B-cell lymphoblastic lymphoma.” J Pediatr Hematol Oncol 34, no. 3 (April 2012): e120–23. https://doi.org/10.1097/MPH.0b013e3182273b57.
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  - Papalas, John A., David Van Mater, and Endi Wang. “Pyogenic variant of primary cutaneous anaplastic large-cell lymphoma: a lymphoproliferative disorder with a predilection for the immunocompromized and the young.” Am J Dermatopathol 32, no. 8 (December 2010): 821–27. https://doi.org/10.1097/DAD.0b013e3181d81dc3.
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  - Van Mater, David, Frank T. Kolligs, Andrzej A. Dlugosz, and Eric R. Fearon. “Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice.” Genes Dev 17, no. 10 (May 15, 2003): 1219–24. https://doi.org/10.1101/gad.1076103.
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  - Kolligs, Frank T., Marvin T. Nieman, Ira Winer, Gang Hu, David Van Mater, Ying Feng, Ian M. Smith, et al. “ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation.” Cancer Cell 1, no. 2 (March 2002): 145–55. https://doi.org/10.1016/s1535-6108(02)00035-1.
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  - Piwien-Pilipuk, G., D. Van Mater, S. E. Ross, O. A. MacDougald, and J. Schwartz. “Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3.” J Biol Chem 276, no. 22 (June 1, 2001): 19664–71. https://doi.org/10.1074/jbc.M010193200.
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  - Dance, G. S., P. Beemiller, Y. Yang, D. V. Mater, I. S. Mian, and H. C. Smith. “Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase.” Nucleic Acids Res 29, no. 8 (April 15, 2001): 1772–80. https://doi.org/10.1093/nar/29.8.1772.
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  - Siddiqui, J. F., D. Van Mater, M. P. Sowden, and H. C. Smith. “Disproportionate relationship between APOBEC-1 expression and apolipoprotein B mRNA editing activity.” Exp Cell Res 252, no. 1 (October 10, 1999): 154–64. https://doi.org/10.1006/excr.1999.4598.
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  - Van Mater, D., M. P. Sowden, J. Cianci, J. D. Sparks, C. E. Sparks, N. Ballatori, and H. C. Smith. “Ethanol increases apolipoprotein B mRNA editing in rat primary hepatocytes and McArdle cells.” Biochem Biophys Res Commun 252, no. 2 (November 18, 1998): 334–39. https://doi.org/10.1006/bbrc.1998.9647.
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Education, Training, & Certifications

Duke Appointment History

Subject Headings

Selected Grants

Selected Publications

Academic Articles