David Sinclaire Van Mater

David Sinclaire Van Mater
Assistant Professor of Pediatrics

I am a pediatric oncologist with a specific interest in hereditary cancer syndromes and sarcoma. I also director of the Duke Comprehensive Neurofibromatosis Clinic where I see children and adults with neurofibromatosis type I and II, in addition to schwannomatosis.

Current Appointments & Affiliations

Assistant Professor of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2016
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2018

Contact Information

102382, Durham, NC 27710
Dept of Pediatrics, Box 2916, Durham, NC 27710
david.vanmater@duke.edu (919) 684-8111

Background
Education, Training, & Certifications
- Pediatric Hematology/Oncology Fellowship, Pediatrics, Duke University School of Medicine 2009 - 2013
- Pediatrics Internship and Residency, Pediatrics, University of Michigan at Ann Arbor 2006 - 2009
- MD./PhD., University of Michigan at Ann Arbor 2006
Duke Appointment History
- Medical Instructor in the Department of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2013 - 2016
Expertise
Subject Headings
Research
Selected Grants
- PBTC-042 (Phase 1 of PD-0332991) awarded by Pfizer, Inc. 2014 - 2019
- NF1-OPG awarded by Children's Tumor Foundation 2015 - 2019
- Visual Field Outcomes in Pediatric Patients with NF1-associated Optic Pathway Gliomas awarded by Boston Children's Hospital 2018 - 2019
- Expansion of the AYA Oncology Initiative at Duke University awarded by St. Baldrick's Foundation 2016 - 2018
- Dissecting the role of injury is sarcoma formation awarded by Sarcoma Alliance for Research Through Collaboration 2015 - 2017
- Dissecting the role of injury is sarcoma formation awarded by Sarcoma Alliance for Research Through Collaboration 2015 - 2017
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Bose, Shree, Joanna Robles, Chad M. McCall, Anand S. Lagoo, Daniel S. Wechsler, Gary R. Schooler, and David Van Mater. “Favorable response to nivolumab in a young adult patient with metastatic histiocytic sarcoma..” Pediatric Blood & Cancer 66, no. 1 (January 2019). https://doi.org/10.1002/pbc.27491.
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  - Van Mater, David, Eric Xu, Anupama Reddy, Leonor Añó, Mohit Sachdeva, Wesley Huang, Nerissa Williams, et al. “Injury promotes sarcoma development in a genetically and temporally restricted manner..” Jci Insight 3, no. 20 (October 18, 2018). https://doi.org/10.1172/jci.insight.123687.
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  - Narine, Kalindi Y., Christopher C. Oh, Herbert E. Fuchs, and David Van Mater. “Calvarial mass as a presenting feature of neurofibromatosis type 2 in a pediatric patient..” American Journal of Medical Genetics. Part A 176, no. 1 (January 2018): 246–47. https://doi.org/10.1002/ajmg.a.38505.
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  - Huang, Jianguo, Mark Chen, Melodi Javid Whitley, Hsuan-Cheng Kuo, Eric S. Xu, Andrea Walens, Yvonne M. Mowery, et al. “Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma..” Nature Communications 8 (July 10, 2017). https://doi.org/10.1038/ncomms15999.
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  - Sayour, Elias J., Talal Mousallem, David Van Mater, Endi Wang, Paul Martin, Rebecca H. Buckley, and Raymond C. Barfield. “Bone marrow transplantation for CVID-like humoral immune deficiency associated with red cell aplasia..” Pediatric Blood & Cancer 63, no. 10 (October 2016): 1856–59. https://doi.org/10.1002/pbc.26092.
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  - Van Mater, David, Leonor Añó, Jordan M. Blum, Micah T. Webster, WeiQiao Huang, Nerissa Williams, Yan Ma, Diana M. Cardona, Chen-Ming Fan, and David G. Kirsch. “Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway..” Cancer Research 75, no. 3 (February 2015): 605–14. https://doi.org/10.1158/0008-5472.CAN-14-2527.
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  - Dodd, Rebecca D., Leonor Añó, Jordan M. Blum, Zhizhong Li, David Van Mater, and David G. Kirsch. “Methods to generate genetically engineered mouse models of soft tissue sarcoma..” Methods in Molecular Biology (Clifton, N.J.) 1267 (January 2015): 283–95. https://doi.org/10.1007/978-1-4939-2297-0_13.
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  - Sachdeva, Mohit, Jeffrey K. Mito, Chang-Lung Lee, Minsi Zhang, Zhizhong Li, Rebecca D. Dodd, David Cason, et al. “MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes..” The Journal of Clinical Investigation 124, no. 10 (October 2014): 4305–19. https://doi.org/10.1172/JCI77116.
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  - Blum, Jordan M., Leonor Añó, Zhizhong Li, David Van Mater, Brian D. Bennett, Mohit Sachdeva, Irina Lagutina, et al. “Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells..” Cell Reports 5, no. 4 (November 14, 2013): 933–40. https://doi.org/10.1016/j.celrep.2013.10.020.
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  - Raizis, Anthony M., David Van Mater, Lauri A. Aaltonen, Dietmar Lohmann, Michelle S. Cheale, Vivienne M. Bickley, Peter M. George, Yaolin Zhou, and Philip M. Rosoff. “Trilateral retinoblastoma in a patient with Peutz-Jeghers syndrome..” American Journal of Medical Genetics. Part A 161A, no. 5 (May 2013): 1096–1100. https://doi.org/10.1002/ajmg.a.35748.
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  - Van Mater, David, Erik H. Knelson, Kathleen A. Kaiser-Rogers, and Michael B. Armstrong. “Neuroblastoma in a pediatric patient with a microduplication of 2p involving the MYCN locus..” American Journal of Medical Genetics. Part A 161A, no. 3 (March 2013): 605–10. https://doi.org/10.1002/ajmg.a.35766.
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  - Raizis, A. M., D. V. Mater, L. A. Aaltonen, D. Lohmann, M. S. Cheale, V. M. Bickley, P. M. George, Y. Zhou, and P. M. Rosoff. “Trilateral Retinoblastoma in a Patient With Peutz-Jeghers Syndrome.” American Journal of Medical Genetics, Part A 161, no. 5 (2013): 1096–1100. https://doi.org/10.1002/ajmg.a.35748.
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  - Mater, David Van, Barbara K. Goodman, Endi Wang, Ana M. Gaca, and Daniel S. Wechsler. “MLL duplication in a pediatric patient with B-cell lymphoblastic lymphoma..” Journal of Pediatric Hematology/Oncology 34, no. 3 (April 2012): e120–23. https://doi.org/10.1097/mph.0b013e3182273b57.
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  - Papalas, John A., David Van Mater, and Endi Wang. “Pyogenic variant of primary cutaneous anaplastic large-cell lymphoma: a lymphoproliferative disorder with a predilection for the immunocompromized and the young..” The American Journal of Dermatopathology 32, no. 8 (December 2010): 821–27. https://doi.org/10.1097/dad.0b013e3181d81dc3.
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  - Van Mater, David, Frank T. Kolligs, Andrzej A. Dlugosz, and Eric R. Fearon. “Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice..” Genes & Development 17, no. 10 (May 2003): 1219–24. https://doi.org/10.1101/gad.1076103.
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  - Kolligs, Frank T., Marvin T. Nieman, Ira Winer, Gang Hu, David Van Mater, Ying Feng, Ian M. Smith, et al. “ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation..” Cancer Cell 1, no. 2 (March 2002): 145–55. https://doi.org/10.1016/s1535-6108(02)00035-1.
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  - Piwien-Pilipuk, G., D. Van Mater, S. E. Ross, O. A. MacDougald, and J. Schwartz. “Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3..” The Journal of Biological Chemistry 276, no. 22 (June 2001): 19664–71. https://doi.org/10.1074/jbc.m010193200.
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  - Dance, G. S., P. Beemiller, Y. Yang, D. V. Mater, I. S. Mian, and H. C. Smith. “Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase..” Nucleic Acids Research 29, no. 8 (April 2001): 1772–80. https://doi.org/10.1093/nar/29.8.1772.
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  - Siddiqui, J. F., D. Van Mater, M. P. Sowden, and H. C. Smith. “Disproportionate relationship between APOBEC-1 expression and apolipoprotein B mRNA editing activity..” Experimental Cell Research 252, no. 1 (October 1999): 154–64. https://doi.org/10.1006/excr.1999.4598.
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  - Van Mater, D., M. P. Sowden, J. Cianci, J. D. Sparks, C. E. Sparks, N. Ballatori, and H. C. Smith. “Ethanol increases apolipoprotein B mRNA editing in rat primary hepatocytes and McArdle cells..” Biochemical and Biophysical Research Communications 252, no. 2 (November 1998): 334–39. https://doi.org/10.1006/bbrc.1998.9647.
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Education, Training, & Certifications

Duke Appointment History

Subject Headings

Selected Grants

Selected Publications

Academic Articles