Overview
I am a pediatric oncologist with a specific interest in hereditary cancer syndromes and sarcoma. I am also director of the Duke Comprehensive Neurofibromatosis Clinic where I see children and adults with neurofibromatosis type I and II, in addition to schwannomatosis.
Current Appointments & Affiliations
Associate Professor of Pediatrics
·
2024 - Present
Pediatrics, Hematology-Oncology,
Pediatrics
Member of the Duke Cancer Institute
·
2018 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Population Pharmacokinetic and Pharmacodynamic Study of Palbociclib in Children and Young Adults with Recurrent, Progressive, or Refractory Brain Tumors.
Journal Article Pharmaceutics · November 28, 2024 Background/Objectives: Palbociclib, an oral CDK 4/6 inhibitor, was evaluated in a Pediatric Brain Tumor Consortium (PBTC) phase 1 (NCT02255461; PBTC-042) study to treat children and young adults with recurrent, progressive, or refractory brain tumors. The ... Full text Link to item CiteSuccessful Management of Cushing Syndrome From Ectopic ACTH Secretion in an Adolescent With Osilodrostat.
Journal Article JCEM Case Rep · July 2023 A previously healthy 11-year-old male was found to have a mass in the pancreatic head after several months of abdominal pain and jaundice. Pathology was consistent with a World Health Organization grade 2 pancreatic neuroendocrine tumor. He developed refra ... Full text Link to item CiteEye Swelling and Weight Loss in an 18-year-old Adolescent.
Journal Article Pediatr Rev · June 1, 2022 Full text Link to item CiteRecent Grants
Genome Editing for the Treatment of Neurofibromatosis Type I
ResearchCollaborator · Awarded by Gilbert Family Foundation · 2022 - 2026Phase I study of PD-0332991 for pediatric patiens with retinoblastoma protein (RB)-positive recurrent or refractory central nervous system (CNS) tumors.
Clinical TrialPrincipal Investigator · Awarded by Pfizer, Inc. · 2014 - 2026MAIN STUDY: Developing Evidence-Based Crieteria for Initiating Treatment fo NF1-OPG.
Clinical TrialPrincipal Investigator · Awarded by Children's Tumor Foundation · 2015 - 2025View All Grants
Education, Training & Certifications
University of Michigan, Ann Arbor ·
2006
MD./PhD.