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Low K+ promotes NF-kappaB/DNA binding in neuronal apoptosis induced by K+ loss.

Publication ,  Journal Article
Tao, Y; Yan, D; Yang, Q; Zeng, R; Wang, Y
Published in: Mol Cell Biol
February 2006

Low intracellular K+ concentration ([K+]i) promotes apoptosis and blocking K+ loss prevents apoptosis, but the mechanism of action of low [K+]i remains unclear. Here, we show that low [K+]i increases NF-kappaB transcriptional activity by enhancing its binding to the promoter of target genes without affecting its activation and nuclear translocation in cortical neurons deprived of serum. Low K+ concentration promotes NF-kappaB/DNA binding through direct effects on the interaction of NF-kappaB dimers with DNA. Up-regulation of proapoptotic protein Bcl-XS and neuronal apoptosis induced by serum deprivation are blocked by inhibition and/or down-regulation of NF-kappaB and by prevention of K+ loss. Thus, a direct action of K+ on NF-kappaB/DNA binding regulates gene transcription related to neuronal apoptosis.

Duke Scholars

Published In

Mol Cell Biol

DOI

ISSN

0270-7306

Publication Date

February 2006

Volume

26

Issue

3

Start / End Page

1038 / 1050

Location

United States

Related Subject Headings

  • bcl-X Protein
  • Up-Regulation
  • Transcription, Genetic
  • Rats
  • Promoter Regions, Genetic
  • Potassium
  • Neurons
  • NF-kappa B
  • Gene Expression Regulation
  • Down-Regulation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tao, Y., Yan, D., Yang, Q., Zeng, R., & Wang, Y. (2006). Low K+ promotes NF-kappaB/DNA binding in neuronal apoptosis induced by K+ loss. Mol Cell Biol, 26(3), 1038–1050. https://doi.org/10.1128/MCB.26.3.1038-1050.2006
Tao, Yanmei, Dong Yan, Qiaoyun Yang, Rui Zeng, and Yizheng Wang. “Low K+ promotes NF-kappaB/DNA binding in neuronal apoptosis induced by K+ loss.Mol Cell Biol 26, no. 3 (February 2006): 1038–50. https://doi.org/10.1128/MCB.26.3.1038-1050.2006.
Tao Y, Yan D, Yang Q, Zeng R, Wang Y. Low K+ promotes NF-kappaB/DNA binding in neuronal apoptosis induced by K+ loss. Mol Cell Biol. 2006 Feb;26(3):1038–50.
Tao, Yanmei, et al. “Low K+ promotes NF-kappaB/DNA binding in neuronal apoptosis induced by K+ loss.Mol Cell Biol, vol. 26, no. 3, Feb. 2006, pp. 1038–50. Pubmed, doi:10.1128/MCB.26.3.1038-1050.2006.
Tao Y, Yan D, Yang Q, Zeng R, Wang Y. Low K+ promotes NF-kappaB/DNA binding in neuronal apoptosis induced by K+ loss. Mol Cell Biol. 2006 Feb;26(3):1038–1050.

Published In

Mol Cell Biol

DOI

ISSN

0270-7306

Publication Date

February 2006

Volume

26

Issue

3

Start / End Page

1038 / 1050

Location

United States

Related Subject Headings

  • bcl-X Protein
  • Up-Regulation
  • Transcription, Genetic
  • Rats
  • Promoter Regions, Genetic
  • Potassium
  • Neurons
  • NF-kappa B
  • Gene Expression Regulation
  • Down-Regulation