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Malondialdehyde in exhaled breath condensate and urine as a biomarker of air pollution induced oxidative stress.

Publication ,  Journal Article
Gong, J; Zhu, T; Kipen, H; Wang, G; Hu, M; Ohman-Strickland, P; Lu, S-E; Zhang, L; Wang, Y; Zhu, P; Rich, DQ; Diehl, SR; Huang, W; Zhang, JJ
Published in: Journal of exposure science & environmental epidemiology
May 2013

Underlying mechanisms by which air pollutants adversely affect human health remain poorly understood. Oxidative stress has been considered as a potential mechanism that may promote lipid peroxidation by reactive oxygen species, leading to the formation of malondialdehyde (MDA) that is excreted in biofluids (e.g., urine and exhaled breath condensate (EBC)). A panel study was conducted to examine whether concentrations of MDA in EBC and urine were associated, respectively, with changes in air pollution levels brought by the Beijing Olympic air pollution control measures. EBC and urine samples from 125 healthy adults were collected twice in each of the pre-, during-, and post-Olympic periods. Period-specific means of MDA and changes in MDA levels associated with increases in 24-h average pollutant concentrations were estimated using linear mixed-effects models. From the pre- to the during-Olympic period, when concentrations of most pollutants decreased, EBC MDA and urinary MDA significantly decreased by 24% (P<0.0001) and 28% (P=0.0002), respectively. From the during-Olympic to the post-Olympic period, when concentrations of most pollutants increased, EBC MDA and urinary MDA increased by 28% (P=0.094) and 55% (P=0.046), respectively. Furthermore, the largest increases in EBC MDA associated with one interquartile range (IQR) increases in all pollutants but ozone ranged from 10% (95% CI: 2%, 18%) to 19% (95% CI: 14%, 25%). The largest increases in urinary MDA associated with IQR increases in pollutant concentration ranged from 9% (95%: 0.3%, 19%) to 15% (95% CI: 3%, 28%). These findings support the utility of EBC MDA as a biomarker of oxidative stress in the respiratory tract and urinary MDA as a biomarker of systemic oxidative stress in relation to air pollution exposure in healthy young adults. Both EBC and urine samples can be collected noninvasively in the general population.

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Published In

Journal of exposure science & environmental epidemiology

DOI

EISSN

1559-064X

ISSN

1559-0631

Publication Date

May 2013

Volume

23

Issue

3

Start / End Page

322 / 327

Related Subject Headings

  • Oxidative Stress
  • Malondialdehyde
  • Humans
  • Epidemiology
  • Breath Tests
  • Biomarkers
  • Air Pollutants
  • 4206 Public health
  • 4202 Epidemiology
  • 11 Medical and Health Sciences
 

Citation

APA
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ICMJE
MLA
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Gong, J., Zhu, T., Kipen, H., Wang, G., Hu, M., Ohman-Strickland, P., … Zhang, J. J. (2013). Malondialdehyde in exhaled breath condensate and urine as a biomarker of air pollution induced oxidative stress. Journal of Exposure Science & Environmental Epidemiology, 23(3), 322–327. https://doi.org/10.1038/jes.2012.127
Gong, Jicheng, Tong Zhu, Howard Kipen, Guangfa Wang, Min Hu, Pamela Ohman-Strickland, Shou-En Lu, et al. “Malondialdehyde in exhaled breath condensate and urine as a biomarker of air pollution induced oxidative stress.Journal of Exposure Science & Environmental Epidemiology 23, no. 3 (May 2013): 322–27. https://doi.org/10.1038/jes.2012.127.
Gong J, Zhu T, Kipen H, Wang G, Hu M, Ohman-Strickland P, et al. Malondialdehyde in exhaled breath condensate and urine as a biomarker of air pollution induced oxidative stress. Journal of exposure science & environmental epidemiology. 2013 May;23(3):322–7.
Gong, Jicheng, et al. “Malondialdehyde in exhaled breath condensate and urine as a biomarker of air pollution induced oxidative stress.Journal of Exposure Science & Environmental Epidemiology, vol. 23, no. 3, May 2013, pp. 322–27. Epmc, doi:10.1038/jes.2012.127.
Gong J, Zhu T, Kipen H, Wang G, Hu M, Ohman-Strickland P, Lu S-E, Zhang L, Wang Y, Zhu P, Rich DQ, Diehl SR, Huang W, Zhang JJ. Malondialdehyde in exhaled breath condensate and urine as a biomarker of air pollution induced oxidative stress. Journal of exposure science & environmental epidemiology. 2013 May;23(3):322–327.

Published In

Journal of exposure science & environmental epidemiology

DOI

EISSN

1559-064X

ISSN

1559-0631

Publication Date

May 2013

Volume

23

Issue

3

Start / End Page

322 / 327

Related Subject Headings

  • Oxidative Stress
  • Malondialdehyde
  • Humans
  • Epidemiology
  • Breath Tests
  • Biomarkers
  • Air Pollutants
  • 4206 Public health
  • 4202 Epidemiology
  • 11 Medical and Health Sciences