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Nasal effects of a mixture of volatile organic compounds and their ozone oxidation products.

Publication ,  Journal Article
Laumbach, RJ; Fiedler, N; Gardner, CR; Laskin, DL; Fan, Z-H; Zhang, J; Weschler, CJ; Lioy, PJ; Devlin, RB; Ohman-Strickland, P; Kelly-McNeil, K ...
Published in: Journal of occupational and environmental medicine
November 2005

Our objective was to determine if low levels of a mixture of volatile organic compounds (VOCs) and their ozone (O3) oxidation products, similar to what might be found in "sick buildings," cause nasal irritation and inflammation under controlled exposure conditions.Healthy, nonsmoking women (n=130) completed 2-hour controlled exposures to VOCs, VOCs and O3, and a masked air "MA" control in random order at least 1 week apart. VOCs and O3 concentrations were approximately 25 mg/m and approximately 40 ppb, respectively. Nasal symptoms were rated before, during, and after exposure. Nasal lavage fluid was analyzed for polymorphonuclear cells, total protein, interleukin-6, and interleukin-8.We found no significant differences in symptoms or markers of nasal inflammation between exposure conditions.Results suggest that VOCs and their oxidation products may not cause acute nasal effects at low concentrations.

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Published In

Journal of occupational and environmental medicine

DOI

EISSN

1536-5948

ISSN

1076-2752

Publication Date

November 2005

Volume

47

Issue

11

Start / End Page

1182 / 1189

Related Subject Headings

  • Volatilization
  • Ozone
  • Oxidants, Photochemical
  • Organic Chemicals
  • Odds Ratio
  • Nasal Mucosa
  • Nasal Lavage Fluid
  • Humans
  • Female
  • Environmental & Occupational Health
 

Citation

APA
Chicago
ICMJE
MLA
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Laumbach, R. J., Fiedler, N., Gardner, C. R., Laskin, D. L., Fan, Z.-H., Zhang, J., … Kipen, H. M. (2005). Nasal effects of a mixture of volatile organic compounds and their ozone oxidation products. Journal of Occupational and Environmental Medicine, 47(11), 1182–1189. https://doi.org/10.1097/01.jom.0000183338.95778.f0
Laumbach, Robert J., Nancy Fiedler, Carol R. Gardner, Debra L. Laskin, Zhi-Hua Fan, Junfeng Zhang, Charles J. Weschler, et al. “Nasal effects of a mixture of volatile organic compounds and their ozone oxidation products.Journal of Occupational and Environmental Medicine 47, no. 11 (November 2005): 1182–89. https://doi.org/10.1097/01.jom.0000183338.95778.f0.
Laumbach RJ, Fiedler N, Gardner CR, Laskin DL, Fan Z-H, Zhang J, et al. Nasal effects of a mixture of volatile organic compounds and their ozone oxidation products. Journal of occupational and environmental medicine. 2005 Nov;47(11):1182–9.
Laumbach, Robert J., et al. “Nasal effects of a mixture of volatile organic compounds and their ozone oxidation products.Journal of Occupational and Environmental Medicine, vol. 47, no. 11, Nov. 2005, pp. 1182–89. Epmc, doi:10.1097/01.jom.0000183338.95778.f0.
Laumbach RJ, Fiedler N, Gardner CR, Laskin DL, Fan Z-H, Zhang J, Weschler CJ, Lioy PJ, Devlin RB, Ohman-Strickland P, Kelly-McNeil K, Kipen HM. Nasal effects of a mixture of volatile organic compounds and their ozone oxidation products. Journal of occupational and environmental medicine. 2005 Nov;47(11):1182–1189.

Published In

Journal of occupational and environmental medicine

DOI

EISSN

1536-5948

ISSN

1076-2752

Publication Date

November 2005

Volume

47

Issue

11

Start / End Page

1182 / 1189

Related Subject Headings

  • Volatilization
  • Ozone
  • Oxidants, Photochemical
  • Organic Chemicals
  • Odds Ratio
  • Nasal Mucosa
  • Nasal Lavage Fluid
  • Humans
  • Female
  • Environmental & Occupational Health