Nasal effects of a mixture of volatile organic compounds and their ozone oxidation products.

Journal Article (Journal Article)


Our objective was to determine if low levels of a mixture of volatile organic compounds (VOCs) and their ozone (O3) oxidation products, similar to what might be found in "sick buildings," cause nasal irritation and inflammation under controlled exposure conditions.


Healthy, nonsmoking women (n=130) completed 2-hour controlled exposures to VOCs, VOCs and O3, and a masked air "MA" control in random order at least 1 week apart. VOCs and O3 concentrations were approximately 25 mg/m and approximately 40 ppb, respectively. Nasal symptoms were rated before, during, and after exposure. Nasal lavage fluid was analyzed for polymorphonuclear cells, total protein, interleukin-6, and interleukin-8.


We found no significant differences in symptoms or markers of nasal inflammation between exposure conditions.


Results suggest that VOCs and their oxidation products may not cause acute nasal effects at low concentrations.

Full Text

Duke Authors

Cited Authors

  • Laumbach, RJ; Fiedler, N; Gardner, CR; Laskin, DL; Fan, Z-H; Zhang, J; Weschler, CJ; Lioy, PJ; Devlin, RB; Ohman-Strickland, P; Kelly-McNeil, K; Kipen, HM

Published Date

  • November 2005

Published In

Volume / Issue

  • 47 / 11

Start / End Page

  • 1182 - 1189

PubMed ID

  • 16282880

Electronic International Standard Serial Number (EISSN)

  • 1536-5948

International Standard Serial Number (ISSN)

  • 1076-2752

Digital Object Identifier (DOI)

  • 10.1097/01.jom.0000183338.95778.f0


  • eng