The performance of ZDOCK and ZRANK in rounds 6-11 of CAPRI.

Published

Journal Article

We present an evaluation of our protein-protein docking approach using the ZDOCK and ZRANK algorithms, in combination with structural clustering and filtering, utilizing biological data in Rounds 6-11 of the CAPRI docking experiment. We achieved at least one prediction of acceptable accuracy for five of six targets submitted. In addition, two targets resulted in medium-accuracy predictions. In the new scoring portion of the CAPRI exercise, we were able to attain at least one acceptable prediction for the three targets submitted and achieved three medium-accuracy predictions for Target 26. Scoring was performed using ZRANK, a new algorithm for reranking initial-stage docking predictions using a weighted energy function and no structural refinement. Here we outline a practical and successful docking strategy, given limited prior biological knowledge of the complex to be predicted.

Full Text

Duke Authors

Cited Authors

  • Wiehe, K; Pierce, B; Tong, WW; Hwang, H; Mintseris, J; Weng, Z

Published Date

  • December 1, 2007

Published In

Volume / Issue

  • 69 / 4

Start / End Page

  • 719 - 725

PubMed ID

  • 17803212

Pubmed Central ID

  • 17803212

Electronic International Standard Serial Number (EISSN)

  • 1097-0134

Digital Object Identifier (DOI)

  • 10.1002/prot.21747

Language

  • eng

Conference Location

  • United States