The performance of ZDOCK and ZRANK in rounds 6-11 of CAPRI.
Journal Article (Journal Article)
We present an evaluation of our protein-protein docking approach using the ZDOCK and ZRANK algorithms, in combination with structural clustering and filtering, utilizing biological data in Rounds 6-11 of the CAPRI docking experiment. We achieved at least one prediction of acceptable accuracy for five of six targets submitted. In addition, two targets resulted in medium-accuracy predictions. In the new scoring portion of the CAPRI exercise, we were able to attain at least one acceptable prediction for the three targets submitted and achieved three medium-accuracy predictions for Target 26. Scoring was performed using ZRANK, a new algorithm for reranking initial-stage docking predictions using a weighted energy function and no structural refinement. Here we outline a practical and successful docking strategy, given limited prior biological knowledge of the complex to be predicted.
Full Text
Duke Authors
Cited Authors
- Wiehe, K; Pierce, B; Tong, WW; Hwang, H; Mintseris, J; Weng, Z
Published Date
- December 1, 2007
Published In
Volume / Issue
- 69 / 4
Start / End Page
- 719 - 725
PubMed ID
- 17803212
Electronic International Standard Serial Number (EISSN)
- 1097-0134
Digital Object Identifier (DOI)
- 10.1002/prot.21747
Language
- eng
Conference Location
- United States