Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Boston University 2007
• 

  Previous Appointments & Affiliations

  • Associate Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2020
  • Assistant Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2017 - 2019
  • Medical Instructor in the Department of Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2014 - 2017
• Recognition
• 

  In the News

  • NOV 6, 2020

    School of Medicine

    Years in the Making: Duke Human Vaccine Institute Researchers Attack COVID-19

  • JAN 15, 2015

    Human Mode Of Responding To HIV Vaccine Is Conserved From Monkeys
• Research
• 

  Selected Grants

  • SOSIP-NP/mRNA combination for novel preventive and therapeutic HIV-1 vaccine regimens awarded by National Institutes of Health 2022 - 2027
  • Duke DARPA Pandemic Prevention Platform (P3) awarded by Defense Advanced Research Projects Agency 2017 - 2023
  • CIVICS Component A - Option 3 awarded by National Institutes of Health 2019 - 2023
  • SHIV/HIV Env-antibody coevolution as a molecular guide to V3 glycan targeted vaccine design awarded by University of Pennsylvania 2022 - 2023
  • Immunogen Design of HIV Sequential Envelopes Derived from SHIV-infected Macaques awarded by University of Pennsylvania 2017 - 2023
  • Natural killer cell regulation of the germinal center HIV neutralizing antibody response awarded by The Children's Mercy Hospital 2019 - 2022
  • Clinical and viral characteristics of maternal cytomegalovirus infection among seropositive pregnant women in the United States awarded by National Institutes of Health 2018 - 2022
  • Defining and Redirecting Influenza Immunity After Imprinting awarded by Boston Children's Hospital 2021 - 2022
  • Project 2: RNA vaccination in early life to induce potent and broad HIV Env-specific antibody responses awarded by Weill Cornell Medicine 2020 - 2022
  • Combined Hepatitis B and HIV-1 Envelope Infant Vaccination to Augment T cell Help through Enhanced Linked Recognition awarded by National Institutes of Health 2017 - 2022
  • Immunogen Design Strategies To Direct Hiv-1 Broadly Neutralizing Antibody Maturation By Probability-Based Targeting Of Critical Mutations awarded by National Institutes of Health 2019 - 2021
  • Project 2: RNA vaccination in early life to induce potent and broad HIV Env-specific antibody responses awarded by Weill Cornell Medicine 2020 - 2021
  • Validation of the ADAMANT Platform awarded by Ology Bioservices 2019 - 2020
  • Natural killer cell regulation of the germinal center HIV neutralizing antibody response awarded by The Children's Mercy Hospital 2019
  • Creation of a bnAbnectin awarded by ViiV Healthcare 2017 - 2019
  • Critical domains for HIV-1 entry through atypical coreceptor usage awarded by National Institutes of Health 2013 - 2016
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Saunders, Kevin O., Robert J. Edwards, Kedamawit Tilahun, Kartik Manne, Xiaozhi Lu, Derek W. Cain, Kevin Wiehe, et al. “Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection.” Sci Transl Med 14, no. 661 (September 7, 2022): eabo5598. https://doi.org/10.1126/scitranslmed.abo5598.
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    • Haynes, Barton F., Kevin Wiehe, Persephone Borrrow, Kevin O. Saunders, Bette Korber, Kshitij Wagh, Andrew J. McMichael, et al. “Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.” Nat Rev Immunol, August 12, 2022. https://doi.org/10.1038/s41577-022-00753-w.
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    • Stalls, Victoria, Jared Lindenberger, Sophie M-C Gobeil, Rory Henderson, Rob Parks, Maggie Barr, Margaret Deyton, et al. “Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike.” Cell Rep 39, no. 13 (June 28, 2022): 111009. https://doi.org/10.1016/j.celrep.2022.111009.
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    • Gobeil, Sophie M-C, Rory Henderson, Victoria Stalls, Katarzyna Janowska, Xiao Huang, Aaron May, Micah Speakman, et al. “Structural diversity of the SARS-CoV-2 Omicron spike.” Mol Cell 82, no. 11 (June 2, 2022): 2050-2068.e6. https://doi.org/10.1016/j.molcel.2022.03.028.
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    • Sacks, David, Kevin Wiehe, Lynn Morris, and Penny L. Moore. “Complementary Roles of Antibody Heavy and Light Chain Somatic Hypermutation in Conferring Breadth and Potency to the HIV-1-Specific CAP256-VRC26 bNAb Lineage.” J Virol 96, no. 10 (May 25, 2022): e0027022. https://doi.org/10.1128/jvi.00270-22.
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    • Gao, Nan, Yanxin Gai, Lina Meng, Chu Wang, Wei Wang, Xiaojun Li, Tiejun Gu, et al. “Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2.” Adv Sci (Weinh) 9, no. 15 (May 2022): e2200063. https://doi.org/10.1002/advs.202200063.
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    • Li, Dapeng, Simon Brackenridge, Lucy C. Walters, Olivia Swanson, Karl Harlos, Daniel Rozbesky, Derek W. Cain, et al. “Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.” Commun Biol 5, no. 1 (March 28, 2022): 271. https://doi.org/10.1038/s42003-022-03183-5.
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    • Mu, Zekun, Kevin Wiehe, Kevin O. Saunders, Rory Henderson, Derek W. Cain, Robert Parks, Diana Martik, et al. “mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice.” Cell Rep 38, no. 11 (March 15, 2022): 110514. https://doi.org/10.1016/j.celrep.2022.110514.
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    • Martinez, David R., Alexandra Schäfer, Sophie Gobeil, Dapeng Li, Gabriela De la Cruz, Robert Parks, Xiaozhi Lu, et al. “A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice.” Sci Transl Med 14, no. 629 (January 26, 2022): eabj7125. https://doi.org/10.1126/scitranslmed.abj7125.
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    • Williams, Wilton B., Kevin Wiehe, Kevin O. Saunders, and Barton F. Haynes. “Strategies for induction of HIV-1 envelope-reactive broadly neutralizing antibodies.” J Int Aids Soc 24 Suppl 7 (November 2021): e25831. https://doi.org/10.1002/jia2.25831.
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    • Macintyre, Andrew N., Matthew J. French, Brittany R. Sanders, Kristina J. Riebe, Ivo D. Shterev, Kevin Wiehe, Bhavna Hora, et al. “Long-Term Recovery of the Adaptive Immune System in Rhesus Macaques After Total Body Irradiation.” Adv Radiat Oncol 6, no. 5 (September 2021): 100677. https://doi.org/10.1016/j.adro.2021.100677.
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    • Swanson, Olivia, Brianna Rhodes, Avivah Wang, Shi-Mao Xia, Robert Parks, Haiyan Chen, Aja Sanzone, et al. “Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations.” Cell Rep 36, no. 7 (August 17, 2021): 109561. https://doi.org/10.1016/j.celrep.2021.109561.
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    • Gobeil, Sophie M-C, Katarzyna Janowska, Shana McDowell, Katayoun Mansouri, Robert Parks, Victoria Stalls, Megan F. Kopp, et al. “Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.” Science 373, no. 6555 (August 6, 2021). https://doi.org/10.1126/science.abi6226.
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    • Li, Dapeng, Robert J. Edwards, Kartik Manne, David R. Martinez, Alexandra Schäfer, S Munir Alam, Kevin Wiehe, et al. “In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.” Cell 184, no. 16 (August 5, 2021): 4203-4219.e32. https://doi.org/10.1016/j.cell.2021.06.021.
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    • Cai, Fangping, Wei-Hung Chen, Weimin Wu, Julia A. Jones, Misook Choe, Neelakshi Gohain, Xiaoying Shen, et al. “Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates.” Plos Pathog 17, no. 6 (June 2021): e1009624. https://doi.org/10.1371/journal.ppat.1009624.
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    • Saunders, Kevin O., Esther Lee, Robert Parks, David R. Martinez, Dapeng Li, Haiyan Chen, Robert J. Edwards, et al. “Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.” Nature 594, no. 7864 (June 2021): 553–59. https://doi.org/10.1038/s41586-021-03594-0.
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    • Williams, Wilton B., R Ryan Meyerhoff, R. J. Edwards, Hui Li, Kartik Manne, Nathan I. Nicely, Rory Henderson, et al. “Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.” Cell 184, no. 11 (May 27, 2021): 2955-2972.e25. https://doi.org/10.1016/j.cell.2021.04.042.
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    • Roark, Ryan S., Hui Li, Wilton B. Williams, Hema Chug, Rosemarie D. Mason, Jason Gorman, Shuyi Wang, et al. “Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.” Science 371, no. 6525 (January 8, 2021). https://doi.org/10.1126/science.abd2638.
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    • Berendam, Stella J., Papa K. Morgan-Asiedu, Riley J. Mangan, Shuk Hang Li, Holly Heimsath, Kan Luo, Alan D. Curtis, et al. “Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques.” Plos One 16, no. 12 (2021): e0256885. https://doi.org/10.1371/journal.pone.0256885.
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    • Pollara, Justin, Matthew Zirui Tay, R Whitney Edwards, Derrick Goodman, Andrew R. Crowley, Robert J. Edwards, David Easterhoff, et al. “Functional Homology for Antibody-Dependent Phagocytosis Across Humans and Rhesus Macaques.” Front Immunol 12 (2021): 678511. https://doi.org/10.3389/fimmu.2021.678511.
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    • Tolbert, William D., Dung N. Nguyen, Marina Tuyishime, Andrew R. Crowley, Yaozong Chen, Shalini Jha, Derrick Goodman, et al. “Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s.” Front Immunol 12 (2021): 787603. https://doi.org/10.3389/fimmu.2021.787603.
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    • McNamara, Hayley A., Azza H. Idris, Henry J. Sutton, Rachel Vistein, Barbara J. Flynn, Yeping Cai, Kevin Wiehe, et al. “Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response.” Cell Host Microbe 28, no. 4 (October 7, 2020): 572-585.e7. https://doi.org/10.1016/j.chom.2020.07.001.
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    • Sempowski, Gregory D., Kevin O. Saunders, Priyamvada Acharya, Kevin J. Wiehe, and Barton F. Haynes. “Pandemic Preparedness: Developing Vaccines and Therapeutic Antibodies For COVID-19.” Cell 181, no. 7 (June 25, 2020): 1458–63. https://doi.org/10.1016/j.cell.2020.05.041.
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    • Martinez, David R., Joshua J. Tu, Amit Kumar, Jesse F. Mangold, Riley J. Mangan, Ria Goswami, Elena E. Giorgi, et al. “Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants.” Mbio 11, no. 2 (March 10, 2020). https://doi.org/10.1128/mBio.00176-20.
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    • Bradley, Todd, Masayuki Kuraoka, Chen-Hao Yeh, Ming Tian, Huan Chen, Derek W. Cain, Xuejun Chen, et al. “Immune checkpoint modulation enhances HIV-1 antibody induction.” Nat Commun 11, no. 1 (February 19, 2020): 948. https://doi.org/10.1038/s41467-020-14670-w.
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    • Han, Qifeng, Todd Bradley, Wilton B. Williams, Derek W. Cain, David C. Montefiori, Kevin O. Saunders, Robert J. Parks, et al. “Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization.” Cell Rep 30, no. 5 (February 4, 2020): 1553-1569.e6. https://doi.org/10.1016/j.celrep.2019.12.091.
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    • Easterhoff, David, Justin Pollara, Kan Luo, William D. Tolbert, Brianna Young, Dieter Mielke, Shalini Jha, et al. “Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency.” J Virol 94, no. 4 (January 31, 2020). https://doi.org/10.1128/JVI.01120-19.
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    • Easterhoff, David, Justin Pollara, Kan Luo, Benjamin Janus, Neelakshi Gohain, LaTonya D. Williams, Matthew Zirui Tay, et al. “HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions.” Jci Insight 5, no. 2 (January 30, 2020). https://doi.org/10.1172/jci.insight.131437.
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    • Henderson, Rory, Maolin Lu, Ye Zhou, Zekun Mu, Robert Parks, Qifeng Han, Allen L. Hsu, et al. “Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements.” Nat Commun 11, no. 1 (January 24, 2020): 520. https://doi.org/10.1038/s41467-019-14196-w.
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    • Saunders, Kevin O., Kevin Wiehe, Ming Tian, Priyamvada Acharya, Todd Bradley, S Munir Alam, Eden P. Go, et al. “Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.” Science 366, no. 6470 (December 6, 2019). https://doi.org/10.1126/science.aay7199.
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    • LaBranche, Celia C., Rory Henderson, Allen Hsu, Shay Behrens, Xuejun Chen, Tongqing Zhou, Kevin Wiehe, et al. “Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.” Plos Pathog 15, no. 12 (December 2019): e1008200. https://doi.org/10.1371/journal.ppat.1008200.
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    • Sacks, David, Jinal N. Bhiman, Kevin Wiehe, Jason Gorman, Peter D. Kwong, Lynn Morris, and Penny L. Moore. “Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage.” Plos Pathog 15, no. 9 (September 2019): e1008005. https://doi.org/10.1371/journal.ppat.1008005.
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    • LaBranche, Celia C., Rory Henderson, Allen Hsu, Shay Behrens, Xuejun Chen, Tongqing Zhou, Kevin Wiehe, et al. “Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.” Plos Pathog 15, no. 9 (September 2019): e1008026. https://doi.org/10.1371/journal.ppat.1008026.
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    • Nyanhete, Tinashe E., Alyse L. Frisbee, Todd Bradley, William J. Faison, Elizabeth Robins, Tamika Payne, Stephanie A. Freel, et al. “HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.” Sci Rep 9, no. 1 (July 15, 2019): 10165. https://doi.org/10.1038/s41598-019-46462-8.
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    • Henderson, Rory, Brian E. Watts, Hieu N. Ergin, Kara Anasti, Robert Parks, Shi-Mao Xia, Ashley Trama, et al. “Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies.” Nat Commun 10, no. 1 (February 8, 2019): 654. https://doi.org/10.1038/s41467-019-08415-7.
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    • Tay, Matthew Zirui, Kevin Wiehe, and Justin Pollara. “Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses.” Front Immunol 10 (2019): 332. https://doi.org/10.3389/fimmu.2019.00332.
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    • Kisalu, Neville K., Azza H. Idris, Connor Weidle, Yevel Flores-Garcia, Barbara J. Flynn, Brandon K. Sack, Sean Murphy, et al. “Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.” Nat Med 25, no. 1 (January 2019): 188–89. https://doi.org/10.1038/s41591-018-0315-0.
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    • Bonsignori, Mattia, Eric Scott, Kevin Wiehe, David Easterhoff, S Munir Alam, Kwan-Ki Hwang, Melissa Cooper, et al. “Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier.” Immunity 49, no. 6 (December 18, 2018): 1162-1174.e8. https://doi.org/10.1016/j.immuni.2018.10.015.
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    • Eeden, Charmaine van, Constantinos Kurt Wibmer, Cathrine Scheepers, Simone I. Richardson, Molati Nonyane, Bronwen Lambson, Nonhlanhla N. Mkhize, et al. “V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity.” Cell Rep 25, no. 11 (December 11, 2018): 3123-3135.e6. https://doi.org/10.1016/j.celrep.2018.11.058.
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    • Wiehe, Kevin, Todd Bradley, R Ryan Meyerhoff, Connor Hart, Wilton B. Williams, David Easterhoff, William J. Faison, et al. “Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.” Cell Host Microbe 23, no. 6 (June 13, 2018): 759-765.e6. https://doi.org/10.1016/j.chom.2018.04.018.
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    • Kisalu, Neville K., Azza H. Idris, Connor Weidle, Yevel Flores-Garcia, Barbara J. Flynn, Brandon K. Sack, Sean Murphy, et al. “A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.” Nat Med 24, no. 4 (May 2018): 408–16. https://doi.org/10.1038/nm.4512.
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    • Fera, Daniela, Matthew S. Lee, Kevin Wiehe, R Ryan Meyerhoff, Alessandro Piai, Mattia Bonsignori, Baptiste Aussedat, et al. “HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope.” Nat Commun 9, no. 1 (March 16, 2018): 1111. https://doi.org/10.1038/s41467-018-03565-6.
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    • Blasi, Maria, Donatella Negri, Celia LaBranche, S Munir Alam, Erich J. Baker, Elizabeth C. Brunner, Morgan A. Gladden, et al. “IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells.” Commun Biol 1 (2018): 134. https://doi.org/10.1038/s42003-018-0131-6.
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    • Williams, Wilton B., Jinsong Zhang, Chuancang Jiang, Nathan I. Nicely, Daniela Fera, Kan Luo, M Anthony Moody, et al. “Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.” Nat Commun 8, no. 1 (November 23, 2017): 1732. https://doi.org/10.1038/s41467-017-01336-3.
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    • Han, Qifeng, Wilton B. Williams, Kevin O. Saunders, Kelly E. Seaton, Kevin J. Wiehe, Nathan Vandergrift, Tarra A. Von Holle, et al. “HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces gp41 Antibody Immunodominance in Rhesus Macaques.” J Virol 91, no. 21 (November 1, 2017). https://doi.org/10.1128/JVI.00923-17.
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    • Shen, Xiaoying, Willy M. Bogers, Nicole L. Yates, Guido Ferrari, Antu K. Dey, William T. Williams, Frederick H. Jaeger, et al. “Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques.” J Virol 91, no. 19 (October 1, 2017). https://doi.org/10.1128/JVI.00401-17.
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    • Meyerhoff, R Ryan, Richard M. Scearce, Damon F. Ogburn, Brad Lockwood, Joy Pickeral, Masa Kuraoka, Kara Anasti, et al. “HIV-1 Consensus Envelope-Induced Broadly Binding Antibodies.” Aids Res Hum Retroviruses 33, no. 8 (August 2017): 859–68. https://doi.org/10.1089/AID.2016.0294.
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    • Alam, S Munir, Baptiste Aussedat, Yusuf Vohra, R Ryan Meyerhoff, Evan M. Cale, William E. Walkowicz, Nathan A. Radakovich, et al. “Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.” Sci Transl Med 9, no. 381 (March 15, 2017). https://doi.org/10.1126/scitranslmed.aai7521.
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    • Bonsignori, Mattia, Edward F. Kreider, Daniela Fera, R Ryan Meyerhoff, Todd Bradley, Kevin Wiehe, S Munir Alam, et al. “Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.” Sci Transl Med 9, no. 381 (March 15, 2017). https://doi.org/10.1126/scitranslmed.aai7514.
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    • Saunders, Kevin O., Nathan I. Nicely, Kevin Wiehe, Mattia Bonsignori, R Ryan Meyerhoff, Robert Parks, William E. Walkowicz, et al. “Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates.” Cell Rep 18, no. 9 (February 28, 2017): 2175–88. https://doi.org/10.1016/j.celrep.2017.02.003.
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    • Easterhoff, David, M Anthony Moody, Daniela Fera, Hao Cheng, Margaret Ackerman, Kevin Wiehe, Kevin O. Saunders, et al. “Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.” Plos Pathog 13, no. 2 (February 2017): e1006182. https://doi.org/10.1371/journal.ppat.1006182.
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    • Wiehe, Kevin, Nathan I. Nicely, Bradley Lockwood, Masayuki Kuraoka, Kara Anasti, Sabrina Arora, Cindy M. Bowman, et al. “Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice.” J Immunol 198, no. 3 (February 1, 2017): 1047–55. https://doi.org/10.4049/jimmunol.1601640.
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    • Williams, LaTonya D., Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, et al. “Potent and broad HIV-neutralizing antibodies in memory B cells and plasma.” Sci Immunol 2, no. 7 (January 27, 2017). https://doi.org/10.1126/sciimmunol.aal2200.
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    • Kepler, Thomas B., and Kevin Wiehe. “Genetic and structural analyses of affinity maturation in the humoral response to HIV-1.” Immunol Rev 275, no. 1 (January 2017): 129–44. https://doi.org/10.1111/imr.12513.
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    • Luo, Kan, Hua-Xin Liao, Ruijun Zhang, David Easterhoff, Kevin Wiehe, Thaddeus C. Gurley, Lawrence C. Armand, et al. “Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques.” Jci Insight 1, no. 20 (December 8, 2016): e88522. https://doi.org/10.1172/jci.insight.88522.
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    • Zhang, Ruijun, Laurent Verkoczy, Kevin Wiehe, S. Munir Alam, Nathan I. Nicely, Sampa Santra, Todd Bradley, et al. “Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages.” Sci Transl Med 8, no. 336 (April 27, 2016): 336ra62. https://doi.org/10.1126/scitranslmed.aaf0618.
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    • Bonsignori, Mattia, Tongqing Zhou, Zizhang Sheng, Lei Chen, Feng Gao, M Gordon Joyce, Gabriel Ozorowski, et al. “Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.” Cell 165, no. 2 (April 7, 2016): 449–63. https://doi.org/10.1016/j.cell.2016.02.022.
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    • Jeffries, T. L., C. R. Sacha, J. Pollara, J. Himes, F. H. Jaeger, S. M. Dennison, E. McGuire, et al. “The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells.” Mucosal Immunol 9, no. 2 (March 2016): 414–27. https://doi.org/10.1038/mi.2015.70.
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    • Williams, Wilton B., Hua-Xin Liao, M Anthony Moody, Thomas B. Kepler, S Munir Alam, Feng Gao, Kevin Wiehe, et al. “HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies.” Science 349, no. 6249 (August 14, 2015): aab1253. https://doi.org/10.1126/science.aab1253.
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    • Nicely, Nathan I., Kevin Wiehe, Thomas B. Kepler, Frederick H. Jaeger, S Moses Dennison, Supachai Rerks-Ngarm, Sorachai Nitayaphan, et al. “Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee.” Ebiomedicine 2, no. 7 (July 2015): 713–22. https://doi.org/10.1016/j.ebiom.2015.06.016.
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    • Liu, Mengfei, Guang Yang, Kevin Wiehe, Nathan I. Nicely, Nathan A. Vandergrift, Wes Rountree, Mattia Bonsignori, et al. “Polyreactivity and autoreactivity among HIV-1 antibodies.” J Virol 89, no. 1 (January 2015): 784–98. https://doi.org/10.1128/JVI.02378-14.
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    • Wiehe, Kevin, David Easterhoff, Kan Luo, Nathan I. Nicely, Todd Bradley, Frederick H. Jaeger, S Moses Dennison, et al. “Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved.” Immunity 41, no. 6 (December 18, 2014): 909–18. https://doi.org/10.1016/j.immuni.2014.11.014.
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    • Trama, Ashley M., M Anthony Moody, S Munir Alam, Frederick H. Jaeger, Bradley Lockwood, Robert Parks, Krissey E. Lloyd, et al. “HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria.” Cell Host Microbe 16, no. 2 (August 13, 2014): 215–26. https://doi.org/10.1016/j.chom.2014.07.003.
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    • Pierce, Brian G., Kevin Wiehe, Howook Hwang, Bong-Hyun Kim, Thom Vreven, and Zhiping Weng. “ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers.” Bioinformatics 30, no. 12 (June 15, 2014): 1771–73. https://doi.org/10.1093/bioinformatics/btu097.
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    • Bonsignori, Mattia, Kevin Wiehe, Sebastian K. Grimm, Rebecca Lynch, Guang Yang, Daniel M. Kozink, Florence Perrin, et al. “An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.” J Clin Invest 124, no. 4 (April 2014): 1835–43. https://doi.org/10.1172/JCI73441.
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    • Hwang, Kwan-Ki, Ashley M. Trama, Daniel M. Kozink, Xi Chen, Kevin Wiehe, Abby J. Cooper, Shi-Mao Xia, et al. “IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria.” Plos One 9, no. 3 (2014): e90725. https://doi.org/10.1371/journal.pone.0090725.
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    • Song, Hongshuo, Bhavna Hora, Tanmoy Bhattacharya, Nilu Goonetilleke, Michael K. P. Liu, Kevin Wiehe, Hui Li, et al. “Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus.” Plos One 9, no. 7 (2014): e102734. https://doi.org/10.1371/journal.pone.0102734.
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    • Kepler, Thomas B., Supriya Munshaw, Kevin Wiehe, Ruijun Zhang, Jae-Sung Yu, Christopher W. Woods, Thomas N. Denny, et al. “Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation.” Front Immunol 5 (2014): 170. https://doi.org/10.3389/fimmu.2014.00170.
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    • Liao, Hua-Xin, Rebecca Lynch, Tongqing Zhou, Feng Gao, S Munir Alam, Scott D. Boyd, Andrew Z. Fire, et al. “Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.” Nature 496, no. 7446 (April 25, 2013): 469–76. https://doi.org/10.1038/nature12053.
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    • Liao, Hua-Xin, Mattia Bonsignori, S Munir Alam, Jason S. McLellan, Georgia D. Tomaras, M Anthony Moody, Daniel M. Kozink, et al. “Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2.” Immunity 38, no. 1 (January 24, 2013): 176–86. https://doi.org/10.1016/j.immuni.2012.11.011.
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    • Hwang, Howook, Thom Vreven, Troy W. Whitfield, Kevin Wiehe, and Zhiping Weng. “A machine learning approach for the prediction of protein surface loop flexibility.” Proteins 79, no. 8 (August 2011): 2467–74. https://doi.org/10.1002/prot.23070.
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    • Wiehe, K., T. B. Kepler, and S. C. Schmidler. “P19-50. Simulation of an MPER peptide samples epitope conformations of two broadly neutralizing antibodies.” Retrovirology 6, no. SUPPL. 3 (October 22, 2009). https://doi.org/10.1186/1742-4690-6-S3-P370.
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    • Wiehe, Kevin, Matthew W. Peterson, Brian Pierce, Julian Mintseris, and Zhiping Weng. “Protein-protein docking: overview and performance analysis.” Methods Mol Biol 413 (2008): 283–314. https://doi.org/10.1007/978-1-59745-574-9_11.
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    • Wiehe, Kevin, Brian Pierce, Wei Wei Tong, Howook Hwang, Julian Mintseris, and Zhiping Weng. “The performance of ZDOCK and ZRANK in rounds 6-11 of CAPRI.” Proteins 69, no. 4 (December 1, 2007): 719–25. https://doi.org/10.1002/prot.21747.
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    • Mintseris, Julian, Brian Pierce, Kevin Wiehe, Robert Anderson, Rong Chen, and Zhiping Weng. “Integrating statistical pair potentials into protein complex prediction.” Proteins 69, no. 3 (November 15, 2007): 511–20. https://doi.org/10.1002/prot.21502.
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    • Wiehe, Kevin, Brian Pierce, Julian Mintseris, Wei Wei Tong, Robert Anderson, Rong Chen, and Zhiping Weng. “ZDOCK and RDOCK performance in CAPRI rounds 3, 4, and 5.” Proteins 60, no. 2 (August 1, 2005): 207–13. https://doi.org/10.1002/prot.20559.
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    • Mintseris, Julian, Kevin Wiehe, Brian Pierce, Robert Anderson, Rong Chen, Joël Janin, and Zhiping Weng. “Protein-Protein Docking Benchmark 2.0: an update.” Proteins 60, no. 2 (August 1, 2005): 214–16. https://doi.org/10.1002/prot.20560.
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