Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Boston University 2007
• 

  Duke Appointment History

  • Medical Instructor in the Department of Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2014 - 2017
• Recognition
• 

  In the News

  • JAN 15, 2015

    Human Mode Of Responding To HIV Vaccine Is Conserved From Monkeys
• Research
• 

  Selected Grants

  • Combined Hepatitis B and HIV-1 envelope vaccination to augment T cell help via linked recognition of unrelated antigens awarded by National Institutes of Health 2017 - 2020
  • Duke DARPA Pandemic Prevention Platform (P3) awarded by Defense Advanced Research Projects Agency 2017 - 2020
  • Defining and Redirecting Influenza Immunity After Imprinting awarded by Boston Children's Hospital 2017 - 2018
  • Collaboratory of AIDS Researchers for Eradication - Management and Operations awarded by University of North Carolina - Chapel Hill 2016 - 2018
  • Creation of a bnAbnectin awarded by ViiV Healthcare 2017 - 2018
  • Immunogen Design of HIV Sequential Envelopes Derived from SHIV-infected Macaques awarded by University of Pennsylvania 2017 - 2018
  • Critical domains for HIV-1 entry through atypical coreceptor usage awarded by National Institutes of Health 2013 - 2016
• Publications & Artistic Works
• 

  Selected Publications

  • Journal Articles

    • Fera, D, Lee, MS, Wiehe, K, Meyerhoff, RR, Piai, A, Bonsignori, M, Aussedat, B, Walkowicz, WE, Ton, T, Zhou, JO, Danishefsky, S, Haynes, BF, and Harrison, SC. "HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope." Nature communications 9, no. 1 (March 16, 2018): 1111-.  Full Text
    • Williams, WB, Zhang, J, Jiang, C, Nicely, NI, Fera, D, Luo, K, Moody, MA, Liao, H-X, Alam, SM, Kepler, TB, Ramesh, A, Wiehe, K, Holland, JA, Bradley, T, Vandergrift, N, Saunders, KO, Parks, R, Foulger, A, Xia, S-M, Bonsignori, M, Montefiori, DC, Louder, M, Eaton, A, Santra, S, Scearce, R, Sutherland, L, Newman, A, Bouton-Verville, H, Bowman, C, Bomze, H, Gao, F, Marshall, DJ, Whitesides, JF, Nie, X, Kelsoe, G, Reed, SG, Fox, CB, Clary, K, Koutsoukos, M, Franco, D, Mascola, JR, and Harrison, SC et al. "Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations." Nature communications 8, no. 1 (November 23, 2017): 1732-.  Full Text
    • Han, Q, Williams, WB, Saunders, KO, Seaton, KE, Wiehe, KJ, Vandergrift, N, Von Holle, TA, Trama, AM, Parks, RJ, Luo, K, Gurley, TC, Kepler, TB, Marshall, DJ, Montefiori, DC, Sutherland, LL, Alam, MS, Whitesides, JF, Bowman, CM, Permar, SR, Graham, BS, Mascola, JR, Seed, PC, Van Rompay, KKA, Tomaras, GD, Moody, MA, and Haynes, BF. "HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces gp41 Antibody Immunodominance in Rhesus Macaques." Journal of virology 91, no. 21 (November 2017).  Full Text
    • Shen, X, Bogers, WM, Yates, NL, Ferrari, G, Dey, AK, Williams, WT, Jaeger, FH, Wiehe, K, Sawant, S, Alam, SM, LaBranche, CC, Montefiori, DC, Martin, L, Srivastava, I, Heeney, J, Barnett, SW, and Tomaras, GD. "Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques." Journal of virology 91, no. 19 (October 2017).  Full Text
    • Meyerhoff, RR, Scearce, RM, Ogburn, DF, Lockwood, B, Pickeral, J, Kuraoka, M, Anasti, K, Eudailey, J, Eaton, A, Cooper, M, Wiehe, K, Montefiori, DC, Tomaras, G, Ferrari, G, Alam, SM, Liao, H-X, Korber, B, Gao, F, and Haynes, BF. "HIV-1 Consensus Envelope-Induced Broadly Binding Antibodies." AIDS research and human retroviruses 33, no. 8 (August 2017): 859-868.  Full Text
    • Alam, SM, Aussedat, B, Vohra, Y, Meyerhoff, RR, Cale, EM, Walkowicz, WE, Radakovich, NA, Anasti, K, Armand, L, Parks, R, Sutherland, L, Scearce, R, Joyce, MG, Pancera, M, Druz, A, Georgiev, IS, Von Holle, T, Eaton, A, Fox, C, Reed, SG, Louder, M, Bailer, RT, Morris, L, Abdool-Karim, SS, Cohen, M, Liao, H-X, Montefiori, DC, Park, PK, Fernández-Tejada, A, Wiehe, K, Santra, S, Kepler, TB, Saunders, KO, Sodroski, J, Kwong, PD, Mascola, JR, Bonsignori, M, Moody, MA, Danishefsky, S, and Haynes, BF. "Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide." Science translational medicine 9, no. 381 (March 2017).  Full Text
    • Bonsignori, M, Kreider, EF, Fera, D, Meyerhoff, RR, Bradley, T, Wiehe, K, Alam, SM, Aussedat, B, Walkowicz, WE, Hwang, K-K, Saunders, KO, Zhang, R, Gladden, MA, Monroe, A, Kumar, A, Xia, S-M, Cooper, M, Louder, MK, McKee, K, Bailer, RT, Pier, BW, Jette, CA, Kelsoe, G, Williams, WB, Morris, L, Kappes, J, Wagh, K, Kamanga, G, Cohen, MS, Hraber, PT, Montefiori, DC, Trama, A, Liao, H-X, Kepler, TB, Moody, MA, Gao, F, Danishefsky, SJ, Mascola, JR, Shaw, GM, Hahn, BH, Harrison, SC, and Korber, BT et al. "Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies." Science translational medicine 9, no. 381 (March 2017).  Full Text
    • Easterhoff, D, Moody, MA, Fera, D, Cheng, H, Ackerman, M, Wiehe, K, Saunders, KO, Pollara, J, Vandergrift, N, Parks, R, Kim, J, Michael, NL, O'Connell, RJ, Excler, J-L, Robb, ML, Vasan, S, Rerks-Ngarm, S, Kaewkungwal, J, Pitisuttithum, P, Nitayaphan, S, Sinangil, F, Tartaglia, J, Phogat, S, Kepler, TB, Alam, SM, Liao, H-X, Ferrari, G, Seaman, MS, Montefiori, DC, Tomaras, GD, Harrison, SC, and Haynes, BF. "Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial." PLoS pathogens 13, no. 2 (February 24, 2017): e1006182-.  Full Text
    • Saunders, KO, Nicely, NI, Wiehe, K, Bonsignori, M, Meyerhoff, RR, Parks, R, Walkowicz, WE, Aussedat, B, Wu, NR, Cai, F, Vohra, Y, Park, PK, Eaton, A, Go, EP, Sutherland, LL, Scearce, RM, Barouch, DH, Zhang, R, Von Holle, T, Overman, RG, Anasti, K, Sanders, RW, Moody, MA, Kepler, TB, Korber, B, Desaire, H, Santra, S, Letvin, NL, Nabel, GJ, Montefiori, DC, Tomaras, GD, Liao, H-X, Alam, SM, Danishefsky, SJ, and Haynes, BF. "Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates." Cell reports 18, no. 9 (February 2017): 2175-2188.  Full Text
    • Wiehe, K, Nicely, NI, Lockwood, B, Kuraoka, M, Anasti, K, Arora, S, Bowman, CM, Stolarchuk, C, Parks, R, Lloyd, KE, Xia, S-M, Duffy, R, Shen, X, Kyratsous, CA, Macdonald, LE, Murphy, AJ, Scearce, RM, Moody, MA, Alam, SM, Verkoczy, L, Tomaras, GD, Kelsoe, G, and Haynes, BF. "Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice." Journal of immunology (Baltimore, Md. : 1950) 198, no. 3 (February 2017): 1047-1055.  Full Text
    • Kepler, TB, and Wiehe, K. "Genetic and structural analyses of affinity maturation in the humoral response to HIV-1." Immunological reviews 275, no. 1 (January 2017): 129-144. (Review)  Full Text
    • Bonsignori, M, Zhou, T, Sheng, Z, Chen, L, Gao, F, Joyce, MG, Ozorowski, G, Chuang, G-Y, Schramm, CA, Wiehe, K, Alam, SM, Bradley, T, Gladden, MA, Hwang, K-K, Iyengar, S, Kumar, A, Lu, X, Luo, K, Mangiapani, MC, Parks, RJ, Song, H, Acharya, P, Bailer, RT, Cao, A, Druz, A, Georgiev, IS, Kwon, YD, Louder, MK, Zhang, B, Zheng, A, Hill, BJ, Kong, R, Soto, C, NISC Comparative Sequencing Program, , Mullikin, JC, Douek, DC, Montefiori, DC, Moody, MA, Shaw, GM, Hahn, BH, Kelsoe, G, and Hraber, PT et al. "Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody." Cell 165, no. 2 (April 2016): 449-463.  Full Text
    • Zhang, R, Verkoczy, L, Wiehe, K, Munir Alam, S, Nicely, NI, Santra, S, Bradley, T, Pemble, CW, Zhang, J, Gao, F, Montefiori, DC, Bouton-Verville, H, Kelsoe, G, Larimore, K, Greenberg, PD, Parks, R, Foulger, A, Peel, JN, Luo, K, Lu, X, Trama, AM, Vandergrift, N, Tomaras, GD, Kepler, TB, Moody, MA, Liao, H-X, and Haynes, BF. "Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages." Science translational medicine 8, no. 336 (April 2016): 336ra62-.  Full Text
    • Jeffries, TL, Sacha, CR, Pollara, J, Himes, J, Jaeger, FH, Dennison, SM, McGuire, E, Kunz, E, Eudailey, JA, Trama, AM, LaBranche, C, Fouda, GG, Wiehe, K, Montefiori, DC, Haynes, BF, Liao, H-X, Ferrari, G, Alam, SM, Moody, MA, and Permar, SR. "The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells." Mucosal immunology 9, no. 2 (March 2016): 414-427.  Full Text
    • Williams, WB, Liao, H-X, Moody, MA, Kepler, TB, Alam, SM, Gao, F, Wiehe, K, Trama, AM, Jones, K, Zhang, R, Song, H, Marshall, DJ, Whitesides, JF, Sawatzki, K, Hua, A, Liu, P, Tay, MZ, Seaton, KE, Shen, X, Foulger, A, Lloyd, KE, Parks, R, Pollara, J, Ferrari, G, Yu, J-S, Vandergrift, N, Montefiori, DC, Sobieszczyk, ME, Hammer, S, Karuna, S, Gilbert, P, Grove, D, Grunenberg, N, McElrath, MJ, Mascola, JR, Koup, RA, Corey, L, Nabel, GJ, Morgan, C, Churchyard, G, Maenza, J, Keefer, M, and Graham, BS et al. "HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies." Science (New York, N.Y.) 349, no. 6249 (August 2015): aab1253-.  Full Text
    • Nicely, NI, Wiehe, K, Kepler, TB, Jaeger, FH, Dennison, SM, Rerks-Ngarm, S, Nitayaphan, S, Pitisuttithum, P, Kaewkungwal, J, Robb, ML, O'Connell, RJ, Michael, NL, Kim, JH, Liao, H-X, Munir Alam, S, Hwang, K-K, Bonsignori, M, and Haynes, BF. "Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee." EBioMedicine 2, no. 7 (July 2015): 713-722.  Full Text
    • Liu, M, Yang, G, Wiehe, K, Nicely, NI, Vandergrift, NA, Rountree, W, Bonsignori, M, Alam, SM, Gao, J, Haynes, BF, and Kelsoe, G. "Polyreactivity and autoreactivity among HIV-1 antibodies." Journal of virology 89, no. 1 (January 2015): 784-798.  Full Text
    • Wiehe, K, Easterhoff, D, Luo, K, Nicely, NI, Bradley, T, Jaeger, FH, Dennison, SM, Zhang, R, Lloyd, KE, Stolarchuk, C, Parks, R, Sutherland, LL, Scearce, RM, Morris, L, Kaewkungwal, J, Nitayaphan, S, Pitisuttithum, P, Rerks-Ngarm, S, Sinangil, F, Phogat, S, Michael, NL, Kim, JH, Kelsoe, G, Montefiori, DC, Tomaras, GD, Bonsignori, M, Santra, S, Kepler, TB, Alam, SM, Moody, MA, Liao, H-X, and Haynes, BF. "Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved." Immunity 41, no. 6 (December 2014): 909-918.  Full Text
    • Trama, AM, Moody, MA, Alam, SM, Jaeger, FH, Lockwood, B, Parks, R, Lloyd, KE, Stolarchuk, C, Scearce, R, Foulger, A, Marshall, DJ, Whitesides, JF, Jeffries, TL, Wiehe, K, Morris, L, Lambson, B, Soderberg, K, Hwang, K-K, Tomaras, GD, Vandergrift, N, Jackson, KJL, Roskin, KM, Boyd, SD, Kepler, TB, Liao, H-X, and Haynes, BF. "HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria." Cell host & microbe 16, no. 2 (August 2014): 215-226.  Full Text  Open Access Copy
    • Pierce, BG, Wiehe, K, Hwang, H, Kim, B-H, Vreven, T, and Weng, Z. "ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers." Bioinformatics (Oxford, England) 30, no. 12 (June 2014): 1771-1773.  Full Text
    • Bonsignori, M, Wiehe, K, Grimm, SK, Lynch, R, Yang, G, Kozink, DM, Perrin, F, Cooper, AJ, Hwang, K-K, Chen, X, Liu, M, McKee, K, Parks, RJ, Eudailey, J, Wang, M, Clowse, M, Criscione-Schreiber, LG, Moody, MA, Ackerman, ME, Boyd, SD, Gao, F, Kelsoe, G, Verkoczy, L, Tomaras, GD, Liao, H-X, Kepler, TB, Montefiori, DC, Mascola, JR, and Haynes, BF. "An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1." The Journal of clinical investigation 124, no. 4 (April 2014): 1835-1843.  Full Text
    • Hwang, K-K, Trama, AM, Kozink, DM, Chen, X, Wiehe, K, Cooper, AJ, Xia, S-M, Wang, M, Marshall, DJ, Whitesides, J, Alam, M, Tomaras, GD, Allen, SL, Rai, KR, McKeating, J, Catera, R, Yan, X-J, Chu, CC, Kelsoe, G, Liao, H-X, Chiorazzi, N, and Haynes, BF. "IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria." PLoS ONE 9, no. 3 (January 2014): e90725-.  Full Text  Open Access Copy
    • Kepler, TB, Munshaw, S, Wiehe, K, Zhang, R, Yu, J-S, Woods, CW, Denny, TN, Tomaras, GD, Alam, SM, Moody, MA, Kelsoe, G, Liao, H-X, and Haynes, BF. "Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation." Frontiers in immunology 5 (January 2014): 170-.  Full Text  Open Access Copy
    • Song, H, Hora, B, Bhattacharya, T, Goonetilleke, N, Liu, MKP, Wiehe, K, Li, H, Iyer, SS, McMichael, AJ, Perelson, AS, and Gao, F. "Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus." PloS one 9, no. 7 (January 2014): e102734-.  Full Text
    • Liao, H-X, Lynch, R, Zhou, T, Gao, F, Alam, SM, Boyd, SD, Fire, AZ, Roskin, KM, Schramm, CA, Zhang, Z, Zhu, J, Shapiro, L, NISC Comparative Sequencing Program, , Mullikin, JC, Gnanakaran, S, Hraber, P, Wiehe, K, Kelsoe, G, Yang, G, Xia, S-M, Montefiori, DC, Parks, R, Lloyd, KE, Scearce, RM, Soderberg, KA, Cohen, M, Kamanga, G, Louder, MK, Tran, LM, Chen, Y, Cai, F, Chen, S, Moquin, S, Du, X, Joyce, MG, Srivatsan, S, Zhang, B, Zheng, A, Shaw, GM, Hahn, BH, Kepler, TB, Korber, BTM, and Kwong, PD et al. "Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus." Nature 496, no. 7446 (April 3, 2013): 469-476.  Full Text  Open Access Copy
    • Liao, H-X, Bonsignori, M, Alam, SM, McLellan, JS, Tomaras, GD, Moody, MA, Kozink, DM, Hwang, K-K, Chen, X, Tsao, C-Y, Liu, P, Lu, X, Parks, RJ, Montefiori, DC, Ferrari, G, Pollara, J, Rao, M, Peachman, KK, Santra, S, Letvin, NL, Karasavvas, N, Yang, Z-Y, Dai, K, Pancera, M, Gorman, J, Wiehe, K, Nicely, NI, Rerks-Ngarm, S, Nitayaphan, S, Kaewkungwal, J, Pitisuttithum, P, Tartaglia, J, Sinangil, F, Kim, JH, Michael, NL, Kepler, TB, Kwong, PD, Mascola, JR, Nabel, GJ, Pinter, A, and Zolla-Pazner, S et al. "Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2." Immunity 38, no. 1 (January 11, 2013): 176-186.  Full Text
    • Hwang, H, Vreven, T, Whitfield, TW, Wiehe, K, and Weng, Z. "A machine learning approach for the prediction of protein surface loop flexibility." Proteins 79, no. 8 (August 2011): 2467-2474.  Full Text
    • Wiehe, K, Kepler, T, and Schmidler, S. "P19-50. Simulation of an MPER peptide samples epitope conformations of two broadly neutralizing antibodies." Retrovirology 6, no. Suppl 3 (2009): P370-P370.  Full Text
    • Wiehe, K, Peterson, MW, Pierce, B, Mintseris, J, and Weng, Z. "Protein-protein docking: overview and performance analysis." Methods in molecular biology (Clifton, N.J.) 413 (January 2008): 283-314.  Full Text
    • Wiehe, K, Pierce, B, Tong, WW, Hwang, H, Mintseris, J, and Weng, Z. "The performance of ZDOCK and ZRANK in rounds 6-11 of CAPRI." Proteins 69, no. 4 (December 2007): 719-725.  Full Text
    • Mintseris, J, Pierce, B, Wiehe, K, Anderson, R, Chen, R, and Weng, Z. "Integrating statistical pair potentials into protein complex prediction." Proteins 69, no. 3 (November 2007): 511-520.  Full Text
    • Mintseris, J, Wiehe, K, Pierce, B, Anderson, R, Chen, R, Janin, J, and Weng, Z. "Protein-Protein Docking Benchmark 2.0: an update." Proteins 60, no. 2 (August 2005): 214-216.  Full Text
    • Wiehe, K, Pierce, B, Mintseris, J, Tong, WW, Anderson, R, Chen, R, and Weng, Z. "ZDOCK and RDOCK performance in CAPRI rounds 3, 4, and 5." Proteins 60, no. 2 (August 2005): 207-213.  Full Text

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