Kevin J Wiehe | Scholars@Duke

Kevin J Wiehe
Associate Professor in Medicine

Current Appointments & Affiliations

Associate Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2020
Associate Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2020
Member of the Duke Human Vaccine Institute, Duke Human Vaccine Institute, Institutes and Centers 2014

Contact Information

106 Research Dr, MSRBII Box 103020, Durham, NC 27710
(919) 684-2320

Background
Education, Training, & Certifications
- Ph.D., Boston University 2007
Duke Appointment History
- Assistant Professor in Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2017 - 2019
- Medical Instructor in the Department of Medicine, Medicine, Duke Human Vaccine Institute, Medicine 2014 - 2017
Recognition
In the News
- JAN 15, 2015
  
  Human Mode Of Responding To HIV Vaccine Is Conserved From Monkeys
Research
Selected Grants
- Induction of protective antibodies for HIV vaccine development awarded by National Institutes of Health 2019 - 2026
- Defining and Redirecting Influenza Immunity After Imprinting 2011 - 2022
- CIVICS Component A awarded by National Institutes of Health 2019 - 2020
- Clinical and viral characteristics of maternal cytomegalovirus infection among seropositive pregnant women in the United States awarded by National Institutes of Health 2018 - 2020
- Combined Hepatitis B and HIV-1 envelope vaccination to augment T cell help via linked recognition of unrelated antigens awarded by National Institutes of Health 2017 - 2020
- Immunogen Design Strategies To Direct Hiv-1 Broadly Neutralizing Antibody Maturation By Probability-Based Targeting Of Critical Mutations awarded by National Institutes of Health 2019 - 2020
- Validation of the ADAMANT Platform 2019 - 2020
- Collaboratory of AIDS Researchers for Eradication - Management and Operations awarded by University of North Carolina - Chapel Hill 2016 - 2020
- Duke DARPA Pandemic Prevention Platform (P3) awarded by Defense Advanced Research Projects Agency 2017 - 2020
- Immunogen Design of HIV Sequential Envelopes Derived from SHIV-infected Macaques awarded by University of Pennsylvania 2017 - 2020
- Natural killer cell regulation of the germinal center HIV neutralizing antibody response 2019
- Creation of a bnAbnectin 2017 - 2019
- Critical domains for HIV-1 entry through atypical coreceptor usage awarded by National Institutes of Health 2013 - 2016
External Relationships
- Viiv (GlaxoSmithKline)
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Saunders, Kevin O., Kevin Wiehe, Ming Tian, Priyamvada Acharya, Todd Bradley, S Munir Alam, Eden P. Go, et al. “Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.” Science 366, no. 6470 (December 6, 2019). https://doi.org/10.1126/science.aay7199.
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  - LaBranche, Celia C., Rory Henderson, Allen Hsu, Shay Behrens, Xuejun Chen, Tongqing Zhou, Kevin Wiehe, et al. “Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.” Plos Pathog 15, no. 12 (December 2019): e1008200. https://doi.org/10.1371/journal.ppat.1008200.
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  - LaBranche, Celia C., Rory Henderson, Allen Hsu, Shay Behrens, Xuejun Chen, Tongqing Zhou, Kevin Wiehe, et al. “Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.” Plos Pathog 15, no. 9 (September 2019): e1008026. https://doi.org/10.1371/journal.ppat.1008026.
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  - Sacks, David, Jinal N. Bhiman, Kevin Wiehe, Jason Gorman, Peter D. Kwong, Lynn Morris, and Penny L. Moore. “Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage.” Plos Pathog 15, no. 9 (September 2019): e1008005. https://doi.org/10.1371/journal.ppat.1008005.
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  - Nyanhete, Tinashe E., Alyse L. Frisbee, Todd Bradley, William J. Faison, Elizabeth Robins, Tamika Payne, Stephanie A. Freel, et al. “HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers.” Sci Rep 9, no. 1 (July 15, 2019): 10165. https://doi.org/10.1038/s41598-019-46462-8.
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  - Henderson, Rory, Brian E. Watts, Hieu N. Ergin, Kara Anasti, Robert Parks, Shi-Mao Xia, Ashley Trama, et al. “Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies.” Nat Commun 10, no. 1 (February 8, 2019): 654. https://doi.org/10.1038/s41467-019-08415-7.
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  - Kisalu, Neville K., Azza H. Idris, Connor Weidle, Yevel Flores-Garcia, Barbara J. Flynn, Brandon K. Sack, Sean Murphy, et al. “Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.” Nat Med 25, no. 1 (January 2019): 188–89. https://doi.org/10.1038/s41591-018-0315-0.
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  - Tay, Matthew Zirui, Kevin Wiehe, and Justin Pollara. “Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses.” Front Immunol 10 (2019): 332. https://doi.org/10.3389/fimmu.2019.00332.
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  - Bonsignori, Mattia, Eric Scott, Kevin Wiehe, David Easterhoff, S Munir Alam, Kwan-Ki Hwang, Melissa Cooper, et al. “Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier.” Immunity 49, no. 6 (December 18, 2018): 1162-1174.e8. https://doi.org/10.1016/j.immuni.2018.10.015.
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  - Eeden, Charmaine van, Constantinos Kurt Wibmer, Cathrine Scheepers, Simone I. Richardson, Molati Nonyane, Bronwen Lambson, Nonhlanhla N. Mkhize, et al. “V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity.” Cell Rep 25, no. 11 (December 11, 2018): 3123-3135.e6. https://doi.org/10.1016/j.celrep.2018.11.058.
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  - Wiehe, Kevin, Todd Bradley, R Ryan Meyerhoff, Connor Hart, Wilton B. Williams, David Easterhoff, William J. Faison, et al. “Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.” Cell Host Microbe 23, no. 6 (June 13, 2018): 759-765.e6. https://doi.org/10.1016/j.chom.2018.04.018.
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  - Kisalu, Neville K., Azza H. Idris, Connor Weidle, Yevel Flores-Garcia, Barbara J. Flynn, Brandon K. Sack, Sean Murphy, et al. “A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.” Nat Med 24, no. 4 (May 2018): 408–16. https://doi.org/10.1038/nm.4512.
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  - Fera, Daniela, Matthew S. Lee, Kevin Wiehe, R Ryan Meyerhoff, Alessandro Piai, Mattia Bonsignori, Baptiste Aussedat, et al. “HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope.” Nat Commun 9, no. 1 (March 16, 2018): 1111. https://doi.org/10.1038/s41467-018-03565-6.
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  - Blasi, Maria, Donatella Negri, Celia LaBranche, S Munir Alam, Erich J. Baker, Elizabeth C. Brunner, Morgan A. Gladden, et al. “IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells.” Commun Biol 1 (2018): 134. https://doi.org/10.1038/s42003-018-0131-6.
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  - Williams, Wilton B., Jinsong Zhang, Chuancang Jiang, Nathan I. Nicely, Daniela Fera, Kan Luo, M Anthony Moody, et al. “Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.” Nat Commun 8, no. 1 (November 23, 2017): 1732. https://doi.org/10.1038/s41467-017-01336-3.
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  - Han, Qifeng, Wilton B. Williams, Kevin O. Saunders, Kelly E. Seaton, Kevin J. Wiehe, Nathan Vandergrift, Tarra A. Von Holle, et al. “HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces gp41 Antibody Immunodominance in Rhesus Macaques.” J Virol 91, no. 21 (November 1, 2017). https://doi.org/10.1128/JVI.00923-17.
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  - Shen, Xiaoying, Willy M. Bogers, Nicole L. Yates, Guido Ferrari, Antu K. Dey, William T. Williams, Frederick H. Jaeger, et al. “Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques.” J Virol 91, no. 19 (October 1, 2017). https://doi.org/10.1128/JVI.00401-17.
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  - Meyerhoff, R Ryan, Richard M. Scearce, Damon F. Ogburn, Brad Lockwood, Joy Pickeral, Masa Kuraoka, Kara Anasti, et al. “HIV-1 Consensus Envelope-Induced Broadly Binding Antibodies.” Aids Res Hum Retroviruses 33, no. 8 (August 2017): 859–68. https://doi.org/10.1089/AID.2016.0294.
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  - Alam, S Munir, Baptiste Aussedat, Yusuf Vohra, R Ryan Meyerhoff, Evan M. Cale, William E. Walkowicz, Nathan A. Radakovich, et al. “Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.” Sci Transl Med 9, no. 381 (March 15, 2017). https://doi.org/10.1126/scitranslmed.aai7521.
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  - Bonsignori, Mattia, Edward F. Kreider, Daniela Fera, R Ryan Meyerhoff, Todd Bradley, Kevin Wiehe, S Munir Alam, et al. “Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.” Sci Transl Med 9, no. 381 (March 15, 2017). https://doi.org/10.1126/scitranslmed.aai7514.
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  - Saunders, Kevin O., Nathan I. Nicely, Kevin Wiehe, Mattia Bonsignori, R Ryan Meyerhoff, Robert Parks, William E. Walkowicz, et al. “Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates.” Cell Rep 18, no. 9 (February 28, 2017): 2175–88. https://doi.org/10.1016/j.celrep.2017.02.003.
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  - Easterhoff, David, M Anthony Moody, Daniela Fera, Hao Cheng, Margaret Ackerman, Kevin Wiehe, Kevin O. Saunders, et al. “Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.” Plos Pathog 13, no. 2 (February 2017): e1006182. https://doi.org/10.1371/journal.ppat.1006182.
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  - Wiehe, Kevin, Nathan I. Nicely, Bradley Lockwood, Masayuki Kuraoka, Kara Anasti, Sabrina Arora, Cindy M. Bowman, et al. “Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice.” J Immunol 198, no. 3 (February 1, 2017): 1047–55. https://doi.org/10.4049/jimmunol.1601640.
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  - Williams, LaTonya D., Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, et al. “Potent and broad HIV-neutralizing antibodies in memory B cells and plasma.” Sci Immunol 2, no. 7 (January 27, 2017). https://doi.org/10.1126/sciimmunol.aal2200.
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  - Kepler, Thomas B., and Kevin Wiehe. “Genetic and structural analyses of affinity maturation in the humoral response to HIV-1.” Immunol Rev 275, no. 1 (January 2017): 129–44. https://doi.org/10.1111/imr.12513.
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  - Luo, Kan, Hua-Xin Liao, Ruijun Zhang, David Easterhoff, Kevin Wiehe, Thaddeus C. Gurley, Lawrence C. Armand, et al. “Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques.” Jci Insight 1, no. 20 (December 8, 2016): e88522. https://doi.org/10.1172/jci.insight.88522.
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  - Zhang, Ruijun, Laurent Verkoczy, Kevin Wiehe, S. Munir Alam, Nathan I. Nicely, Sampa Santra, Todd Bradley, et al. “Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages.” Sci Transl Med 8, no. 336 (April 27, 2016): 336ra62. https://doi.org/10.1126/scitranslmed.aaf0618.
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  - Bonsignori, Mattia, Tongqing Zhou, Zizhang Sheng, Lei Chen, Feng Gao, M Gordon Joyce, Gabriel Ozorowski, et al. “Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.” Cell 165, no. 2 (April 7, 2016): 449–63. https://doi.org/10.1016/j.cell.2016.02.022.
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  - Jeffries, T. L., C. R. Sacha, J. Pollara, J. Himes, F. H. Jaeger, S. M. Dennison, E. McGuire, et al. “The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells.” Mucosal Immunol 9, no. 2 (March 2016): 414–27. https://doi.org/10.1038/mi.2015.70.
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  - Williams, Wilton B., Hua-Xin Liao, M Anthony Moody, Thomas B. Kepler, S Munir Alam, Feng Gao, Kevin Wiehe, et al. “HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies.” Science 349, no. 6249 (August 14, 2015): aab1253. https://doi.org/10.1126/science.aab1253.
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  - Nicely, Nathan I., Kevin Wiehe, Thomas B. Kepler, Frederick H. Jaeger, S Moses Dennison, Supachai Rerks-Ngarm, Sorachai Nitayaphan, et al. “Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee.” Ebiomedicine 2, no. 7 (July 2015): 713–22. https://doi.org/10.1016/j.ebiom.2015.06.016.
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  - Liu, Mengfei, Guang Yang, Kevin Wiehe, Nathan I. Nicely, Nathan A. Vandergrift, Wes Rountree, Mattia Bonsignori, et al. “Polyreactivity and autoreactivity among HIV-1 antibodies.” J Virol 89, no. 1 (January 2015): 784–98. https://doi.org/10.1128/JVI.02378-14.
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  - Wiehe, Kevin, David Easterhoff, Kan Luo, Nathan I. Nicely, Todd Bradley, Frederick H. Jaeger, S Moses Dennison, et al. “Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved.” Immunity 41, no. 6 (December 18, 2014): 909–18. https://doi.org/10.1016/j.immuni.2014.11.014.
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  - Trama, Ashley M., M Anthony Moody, S Munir Alam, Frederick H. Jaeger, Bradley Lockwood, Robert Parks, Krissey E. Lloyd, et al. “HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria.” Cell Host Microbe 16, no. 2 (August 13, 2014): 215–26. https://doi.org/10.1016/j.chom.2014.07.003.
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  - Pierce, Brian G., Kevin Wiehe, Howook Hwang, Bong-Hyun Kim, Thom Vreven, and Zhiping Weng. “ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers.” Bioinformatics 30, no. 12 (June 15, 2014): 1771–73. https://doi.org/10.1093/bioinformatics/btu097.
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  - Bonsignori, Mattia, Kevin Wiehe, Sebastian K. Grimm, Rebecca Lynch, Guang Yang, Daniel M. Kozink, Florence Perrin, et al. “An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.” J Clin Invest 124, no. 4 (April 2014): 1835–43. https://doi.org/10.1172/JCI73441.
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  - Hwang, Kwan-Ki, Ashley M. Trama, Daniel M. Kozink, Xi Chen, Kevin Wiehe, Abby J. Cooper, Shi-Mao Xia, et al. “IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria.” Plos One 9, no. 3 (2014): e90725. https://doi.org/10.1371/journal.pone.0090725.
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  - Kepler, Thomas B., Supriya Munshaw, Kevin Wiehe, Ruijun Zhang, Jae-Sung Yu, Christopher W. Woods, Thomas N. Denny, et al. “Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation.” Front Immunol 5 (2014): 170. https://doi.org/10.3389/fimmu.2014.00170.
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  - Song, Hongshuo, Bhavna Hora, Tanmoy Bhattacharya, Nilu Goonetilleke, Michael K. P. Liu, Kevin Wiehe, Hui Li, et al. “Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus.” Plos One 9, no. 7 (2014): e102734. https://doi.org/10.1371/journal.pone.0102734.
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  - Liao, Hua-Xin, Rebecca Lynch, Tongqing Zhou, Feng Gao, S Munir Alam, Scott D. Boyd, Andrew Z. Fire, et al. “Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.” Nature 496, no. 7446 (April 25, 2013): 469–76. https://doi.org/10.1038/nature12053.
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  - Liao, Hua-Xin, Mattia Bonsignori, S Munir Alam, Jason S. McLellan, Georgia D. Tomaras, M Anthony Moody, Daniel M. Kozink, et al. “Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2.” Immunity 38, no. 1 (January 24, 2013): 176–86. https://doi.org/10.1016/j.immuni.2012.11.011.
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  - Hwang, Howook, Thom Vreven, Troy W. Whitfield, Kevin Wiehe, and Zhiping Weng. “A machine learning approach for the prediction of protein surface loop flexibility.” Proteins 79, no. 8 (August 2011): 2467–74. https://doi.org/10.1002/prot.23070.
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  - Wiehe, K., T. B. Kepler, and S. C. Schmidler. “P19-50. Simulation of an MPER peptide samples epitope conformations of two broadly neutralizing antibodies.” Retrovirology 6, no. SUPPL. 3 (October 22, 2009). https://doi.org/10.1186/1742-4690-6-S3-P370.
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  - Wiehe, Kevin, Matthew W. Peterson, Brian Pierce, Julian Mintseris, and Zhiping Weng. “Protein-protein docking: overview and performance analysis.” Methods Mol Biol 413 (2008): 283–314. https://doi.org/10.1007/978-1-59745-574-9_11.
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  - Wiehe, Kevin, Brian Pierce, Wei Wei Tong, Howook Hwang, Julian Mintseris, and Zhiping Weng. “The performance of ZDOCK and ZRANK in rounds 6-11 of CAPRI.” Proteins 69, no. 4 (December 1, 2007): 719–25. https://doi.org/10.1002/prot.21747.
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  - Mintseris, Julian, Brian Pierce, Kevin Wiehe, Robert Anderson, Rong Chen, and Zhiping Weng. “Integrating statistical pair potentials into protein complex prediction.” Proteins 69, no. 3 (November 15, 2007): 511–20. https://doi.org/10.1002/prot.21502.
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  - Mintseris, Julian, Kevin Wiehe, Brian Pierce, Robert Anderson, Rong Chen, Joël Janin, and Zhiping Weng. “Protein-Protein Docking Benchmark 2.0: an update.” Proteins 60, no. 2 (August 1, 2005): 214–16. https://doi.org/10.1002/prot.20560.
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  - Wiehe, Kevin, Brian Pierce, Julian Mintseris, Wei Wei Tong, Robert Anderson, Rong Chen, and Zhiping Weng. “ZDOCK and RDOCK performance in CAPRI rounds 3, 4, and 5.” Proteins 60, no. 2 (August 1, 2005): 207–13. https://doi.org/10.1002/prot.20559.
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Education, Training, & Certifications

Duke Appointment History

In the News

Selected Grants

External Relationships

Selected Publications

Academic Articles