Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.

Journal Article (Journal Article)

BACKGROUND: Some TGFB1 and VEGF polymorphisms are believed to be functional. Given that these genes are involved in tumor growth and progression including angiogenesis, dissemination, and invasiveness, we hypothesized that these polymorphisms would be associated with survival in patients with gastric cancer. METHODS: We genotyped TGFB1 -509 C>T, +1869 T>C, and +915 G>C and VEGF -1498T>C, -634G>C, and +936C>T in 167 patients with gastric cancer. Using the Kaplan and Meier method, log-rank tests, and Cox proportional hazard models, we evaluated associations among TGFB1 and VEGF variants with overall, 1-year, and 2-year survival rates. RESULTS: Although there were no significant differences in overall survival rates among all polymorphisms tested, patients with TGFB1+915CG and CC genotypes had a poorer 2-year survival (adjusted hazard ratio (HR), 3.06; 95% confidence interval (CI), 1.09-8.62; P = 0.034) than patients with the GG genotype had. In addition, patients heterozygous for VEGF -634CG also had a poorer 1-year survival (adjusted HR, 2.08; 95% CI, 1.03-4.22; P = 0.042) than patients with the -634GG genotype. CONCLUSION: Our study suggested that TGFB1+915CG/CC and VEGF -634CG genotypes may be associated with short-term survival in gastric cancer patients. However, larger studies are needed to verify these findings.

Full Text

Duke Authors

Cited Authors

  • Guan, X; Zhao, H; Niu, J; Tan, D; Ajani, JA; Wei, Q

Published Date

  • June 30, 2009

Published In

Volume / Issue

  • 28 / 1

Start / End Page

  • 94 -

PubMed ID

  • 19566948

Pubmed Central ID

  • PMC2717936

Electronic International Standard Serial Number (EISSN)

  • 1756-9966

Digital Object Identifier (DOI)

  • 10.1186/1756-9966-28-94


  • eng

Conference Location

  • England