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Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.

Publication ,  Journal Article
Guan, X; Zhao, H; Niu, J; Tan, D; Ajani, JA; Wei, Q
Published in: J Exp Clin Cancer Res
June 30, 2009

BACKGROUND: Some TGFB1 and VEGF polymorphisms are believed to be functional. Given that these genes are involved in tumor growth and progression including angiogenesis, dissemination, and invasiveness, we hypothesized that these polymorphisms would be associated with survival in patients with gastric cancer. METHODS: We genotyped TGFB1 -509 C>T, +1869 T>C, and +915 G>C and VEGF -1498T>C, -634G>C, and +936C>T in 167 patients with gastric cancer. Using the Kaplan and Meier method, log-rank tests, and Cox proportional hazard models, we evaluated associations among TGFB1 and VEGF variants with overall, 1-year, and 2-year survival rates. RESULTS: Although there were no significant differences in overall survival rates among all polymorphisms tested, patients with TGFB1+915CG and CC genotypes had a poorer 2-year survival (adjusted hazard ratio (HR), 3.06; 95% confidence interval (CI), 1.09-8.62; P = 0.034) than patients with the GG genotype had. In addition, patients heterozygous for VEGF -634CG also had a poorer 1-year survival (adjusted HR, 2.08; 95% CI, 1.03-4.22; P = 0.042) than patients with the -634GG genotype. CONCLUSION: Our study suggested that TGFB1+915CG/CC and VEGF -634CG genotypes may be associated with short-term survival in gastric cancer patients. However, larger studies are needed to verify these findings.

Duke Scholars

Published In

J Exp Clin Cancer Res

DOI

EISSN

1756-9966

Publication Date

June 30, 2009

Volume

28

Issue

1

Start / End Page

94

Location

England

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Transforming Growth Factor beta1
  • Survival Rate
  • Stomach Neoplasms
  • Prospective Studies
  • Proportional Hazards Models
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
 

Citation

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Guan, X., Zhao, H., Niu, J., Tan, D., Ajani, J. A., & Wei, Q. (2009). Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer. J Exp Clin Cancer Res, 28(1), 94. https://doi.org/10.1186/1756-9966-28-94
Guan, Xiaoxiang, Hui Zhao, Jiangong Niu, Dongfeng Tan, Jaffer A. Ajani, and Qingyi Wei. “Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.J Exp Clin Cancer Res 28, no. 1 (June 30, 2009): 94. https://doi.org/10.1186/1756-9966-28-94.
Guan X, Zhao H, Niu J, Tan D, Ajani JA, Wei Q. Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer. J Exp Clin Cancer Res. 2009 Jun 30;28(1):94.
Guan, Xiaoxiang, et al. “Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.J Exp Clin Cancer Res, vol. 28, no. 1, June 2009, p. 94. Pubmed, doi:10.1186/1756-9966-28-94.
Guan X, Zhao H, Niu J, Tan D, Ajani JA, Wei Q. Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer. J Exp Clin Cancer Res. 2009 Jun 30;28(1):94.

Published In

J Exp Clin Cancer Res

DOI

EISSN

1756-9966

Publication Date

June 30, 2009

Volume

28

Issue

1

Start / End Page

94

Location

England

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Transforming Growth Factor beta1
  • Survival Rate
  • Stomach Neoplasms
  • Prospective Studies
  • Proportional Hazards Models
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male