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Antiphospholipid antibodies in pediatric lupus nephritis.

Publication ,  Journal Article
Massengill, SF; Hedrick, C; Ayoub, EM; Sleasman, JW; Kao, KJ
Published in: Am J Kidney Dis
March 1997

Antiphospholipid antibodies (aPL) of various isotypes are known to occur in systemic lupus erythematosus (SLE), but the significance of this finding in the pediatric population remains unclear. Our aim was to determine whether children with lupus nephritis have an increased risk of thrombosis and whether antiphosphatidylserine (APS) or antiphosphatidylinositol (API) antibodies were predictive of thrombotic complications. Thirty-six children (27 girls/9 boys; 44% black) with SLE nephritis (WHO II, 1; WHO III, 7; WHO IV, 21; WHO V, 7) were evaluated for antiphosphatidylserine, antiphosphatidylinositol, and anticardiolipin immunoglobulin (Ig) G and IgM isotypes, using a modified solid-phase enzyme-linked immunoassay (ELISA). Twenty-four patients (67%) had at least one positive aPL. Longitudinal data on 26 patients showed fluctuations in the degree of positivity. Eight patients experienced thrombotic complications, with equal distribution between arterial and venous events. Other clinical manifestations included thrombocytopenia in seven patients (19%), hemolytic anemia (44%), lupus anticoagulant (6%) and false-positive Venereal Disease Research Laboratory (VDRL) test results (11%). Comparisons between those with and without a thrombotic event showed no detectable difference in the incidence of aPL positivity between the two groups. We conclude that neither APS, API, nor anticardiolipin (ACL) activity was predictive of thrombotic complications in our subset of patients with lupus nephritis.

Duke Scholars

Published In

Am J Kidney Dis

DOI

ISSN

0272-6386

Publication Date

March 1997

Volume

29

Issue

3

Start / End Page

355 / 361

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Thrombosis
  • Prospective Studies
  • Prognosis
  • Phosphatidylserines
  • Phosphatidylinositols
  • Male
  • Lupus Nephritis
  • Infant
  • Incidence
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Massengill, S. F., Hedrick, C., Ayoub, E. M., Sleasman, J. W., & Kao, K. J. (1997). Antiphospholipid antibodies in pediatric lupus nephritis. Am J Kidney Dis, 29(3), 355–361. https://doi.org/10.1016/s0272-6386(97)90195-5
Massengill, S. F., C. Hedrick, E. M. Ayoub, J. W. Sleasman, and K. J. Kao. “Antiphospholipid antibodies in pediatric lupus nephritis.Am J Kidney Dis 29, no. 3 (March 1997): 355–61. https://doi.org/10.1016/s0272-6386(97)90195-5.
Massengill SF, Hedrick C, Ayoub EM, Sleasman JW, Kao KJ. Antiphospholipid antibodies in pediatric lupus nephritis. Am J Kidney Dis. 1997 Mar;29(3):355–61.
Massengill, S. F., et al. “Antiphospholipid antibodies in pediatric lupus nephritis.Am J Kidney Dis, vol. 29, no. 3, Mar. 1997, pp. 355–61. Pubmed, doi:10.1016/s0272-6386(97)90195-5.
Massengill SF, Hedrick C, Ayoub EM, Sleasman JW, Kao KJ. Antiphospholipid antibodies in pediatric lupus nephritis. Am J Kidney Dis. 1997 Mar;29(3):355–361.
Journal cover image

Published In

Am J Kidney Dis

DOI

ISSN

0272-6386

Publication Date

March 1997

Volume

29

Issue

3

Start / End Page

355 / 361

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Thrombosis
  • Prospective Studies
  • Prognosis
  • Phosphatidylserines
  • Phosphatidylinositols
  • Male
  • Lupus Nephritis
  • Infant
  • Incidence