Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo.
Publication
, Journal Article
Liu, Z; Wang, M; Alvarez, JV; Bonney, ME; Chen, C-C; D'Cruz, C; Pan, T-C; Tadesse, MG; Chodosh, LA
Published in: Genome Biol
2008
The ability to detect activation of signaling pathways based solely on gene expression data represents an important goal in biological research. We tested the sensitivity of singular value decomposition-based regression by focusing on functional interactions between the Ras and transforming growth factor beta signaling pathways. Our findings demonstrate that this approach is sufficiently sensitive to detect the secondary activation of endogenous signaling pathways as it occurs through crosstalk following ectopic activation of a primary pathway.
Duke Scholars
Published In
Genome Biol
DOI
EISSN
1474-760X
Publication Date
2008
Volume
9
Issue
12
Start / End Page
R180
Location
England
Related Subject Headings
- ras Proteins
- Transforming Growth Factor beta
- Signal Transduction
- Regression Analysis
- Mice, Transgenic
- Mice
- Mammary Neoplasms, Animal
- Mammary Glands, Animal
- Gene Expression Profiling
- Female
Citation
APA
Chicago
ICMJE
MLA
NLM
Liu, Z., Wang, M., Alvarez, J. V., Bonney, M. E., Chen, C.-C., D’Cruz, C., … Chodosh, L. A. (2008). Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo. Genome Biol, 9(12), R180. https://doi.org/10.1186/gb-2008-9-12-r180
Liu, Zhandong, Min Wang, James V. Alvarez, Megan E. Bonney, Chien-chung Chen, Celina D’Cruz, Tien-chi Pan, Mahlet G. Tadesse, and Lewis A. Chodosh. “Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo.” Genome Biol 9, no. 12 (2008): R180. https://doi.org/10.1186/gb-2008-9-12-r180.
Liu Z, Wang M, Alvarez JV, Bonney ME, Chen C-C, D’Cruz C, et al. Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo. Genome Biol. 2008;9(12):R180.
Liu, Zhandong, et al. “Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo.” Genome Biol, vol. 9, no. 12, 2008, p. R180. Pubmed, doi:10.1186/gb-2008-9-12-r180.
Liu Z, Wang M, Alvarez JV, Bonney ME, Chen C-C, D’Cruz C, Pan T-C, Tadesse MG, Chodosh LA. Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo. Genome Biol. 2008;9(12):R180.
Published In
Genome Biol
DOI
EISSN
1474-760X
Publication Date
2008
Volume
9
Issue
12
Start / End Page
R180
Location
England
Related Subject Headings
- ras Proteins
- Transforming Growth Factor beta
- Signal Transduction
- Regression Analysis
- Mice, Transgenic
- Mice
- Mammary Neoplasms, Animal
- Mammary Glands, Animal
- Gene Expression Profiling
- Female