Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo.
Publication
, Journal Article
Liu, Z; Wang, M; Alvarez, JV; Bonney, ME; Chen, C-C; D'Cruz, C; Pan, T-C; Tadesse, MG; Chodosh, LA
Published in: Genome biology
January 2008
The ability to detect activation of signaling pathways based solely on gene expression data represents an important goal in biological research. We tested the sensitivity of singular value decomposition-based regression by focusing on functional interactions between the Ras and transforming growth factor beta signaling pathways. Our findings demonstrate that this approach is sufficiently sensitive to detect the secondary activation of endogenous signaling pathways as it occurs through crosstalk following ectopic activation of a primary pathway.
Duke Scholars
Published In
Genome biology
DOI
EISSN
1474-760X
ISSN
1474-7596
Publication Date
January 2008
Volume
9
Issue
12
Start / End Page
R180
Related Subject Headings
- ras Proteins
- Transforming Growth Factor beta
- Signal Transduction
- Regression Analysis
- Mice, Transgenic
- Mice
- Mammary Neoplasms, Animal
- Mammary Glands, Animal
- Gene Expression Profiling
- Female
Citation
APA
Chicago
ICMJE
MLA
NLM
Liu, Z., Wang, M., Alvarez, J. V., Bonney, M. E., Chen, C.-C., D’Cruz, C., … Chodosh, L. A. (2008). Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo. Genome Biology, 9(12), R180. https://doi.org/10.1186/gb-2008-9-12-r180
Liu, Zhandong, Min Wang, James V. Alvarez, Megan E. Bonney, Chien-chung Chen, Celina D’Cruz, Tien-chi Pan, Mahlet G. Tadesse, and Lewis A. Chodosh. “Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo.” Genome Biology 9, no. 12 (January 2008): R180. https://doi.org/10.1186/gb-2008-9-12-r180.
Liu Z, Wang M, Alvarez JV, Bonney ME, Chen C-C, D’Cruz C, et al. Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo. Genome biology. 2008 Jan;9(12):R180.
Liu, Zhandong, et al. “Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo.” Genome Biology, vol. 9, no. 12, Jan. 2008, p. R180. Epmc, doi:10.1186/gb-2008-9-12-r180.
Liu Z, Wang M, Alvarez JV, Bonney ME, Chen C-C, D’Cruz C, Pan T-C, Tadesse MG, Chodosh LA. Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo. Genome biology. 2008 Jan;9(12):R180.
Published In
Genome biology
DOI
EISSN
1474-760X
ISSN
1474-7596
Publication Date
January 2008
Volume
9
Issue
12
Start / End Page
R180
Related Subject Headings
- ras Proteins
- Transforming Growth Factor beta
- Signal Transduction
- Regression Analysis
- Mice, Transgenic
- Mice
- Mammary Neoplasms, Animal
- Mammary Glands, Animal
- Gene Expression Profiling
- Female