A model of muscle atrophy using cast immobilization in mice.


Journal Article

We describe a new cast-immobilization protocol to induce muscle atrophy in the lower hindlimb muscles of mice. Bilateral cast immobilization for 2 weeks in a shortened position resulted in a significant loss of muscle size and strength in the soleus and extensor digitorum longus. The availability of a model of cast immobilization in mice may benefit future studies targeting genetic or cell therapy interventions of muscle atrophy in transgenic and mutant mice strains.

Full Text

Duke Authors

Cited Authors

  • Frimel, TN; Kapadia, F; Gaidosh, GS; Li, Y; Walter, GA; Vandenborne, K

Published Date

  • November 2005

Published In

Volume / Issue

  • 32 / 5

Start / End Page

  • 672 - 674

PubMed ID

  • 16025524

Pubmed Central ID

  • 16025524

International Standard Serial Number (ISSN)

  • 0148-639X

Digital Object Identifier (DOI)

  • 10.1002/mus.20399


  • eng

Conference Location

  • United States