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Noninvasive monitoring of muscle damage during reloading following limb disuse.

Publication ,  Journal Article
Frimel, TN; Walter, GA; Gibbs, JD; Gaidosh, GS; Vandenborne, K
Published in: Muscle Nerve
November 2005

Cast immobilization causes skeletal muscle disuse atrophy and an increased susceptibility to muscle damage. The objective of this study was to explore the utility of noninvasive magnetic resonance (MR) imaging to monitor muscle damage in the lower hindlimb muscles of the mouse during reloading following cast immobilization and to compare the findings in different muscles. The hindlimbs of C57BL6 mice were immobilized for 2 weeks in plantarflexion using a bilateral casting model. Following immobilization the mice were allowed to reambulate and muscle damage was monitored at different times. Cage-restricted reloading following cast immobilization induced a significant shift (P < 0.0001) in the transverse (T2) relaxation characteristics of the postural slow-twitch soleus muscle, but not in the neighboring gastrocnemius. Soleus T2 values peaked at 2 days of reloading. Muscle-specific changes in MR T2 relaxation properties correlated with uptake of Evans blue dye, a histological marker of muscle damage. This study demonstrates that T2 MR imaging can be implemented to monitor noninvasively and sequentially muscle-specific damage during reloading following limb disuse.

Duke Scholars

Published In

Muscle Nerve

DOI

ISSN

0148-639X

Publication Date

November 2005

Volume

32

Issue

5

Start / End Page

605 / 612

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Muscle, Skeletal
  • Mice, Inbred C57BL
  • Mice
  • Magnetic Resonance Imaging
  • Hindlimb Suspension
  • Hindlimb
  • Female
  • Animals
  • 11 Medical and Health Sciences
 

Citation

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Frimel, T. N., Walter, G. A., Gibbs, J. D., Gaidosh, G. S., & Vandenborne, K. (2005). Noninvasive monitoring of muscle damage during reloading following limb disuse. Muscle Nerve, 32(5), 605–612. https://doi.org/10.1002/mus.20398
Frimel, Tiffany N., Glenn A. Walter, John D. Gibbs, Gabriel S. Gaidosh, and Krista Vandenborne. “Noninvasive monitoring of muscle damage during reloading following limb disuse.Muscle Nerve 32, no. 5 (November 2005): 605–12. https://doi.org/10.1002/mus.20398.
Frimel TN, Walter GA, Gibbs JD, Gaidosh GS, Vandenborne K. Noninvasive monitoring of muscle damage during reloading following limb disuse. Muscle Nerve. 2005 Nov;32(5):605–12.
Frimel, Tiffany N., et al. “Noninvasive monitoring of muscle damage during reloading following limb disuse.Muscle Nerve, vol. 32, no. 5, Nov. 2005, pp. 605–12. Pubmed, doi:10.1002/mus.20398.
Frimel TN, Walter GA, Gibbs JD, Gaidosh GS, Vandenborne K. Noninvasive monitoring of muscle damage during reloading following limb disuse. Muscle Nerve. 2005 Nov;32(5):605–612.
Journal cover image

Published In

Muscle Nerve

DOI

ISSN

0148-639X

Publication Date

November 2005

Volume

32

Issue

5

Start / End Page

605 / 612

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Muscle, Skeletal
  • Mice, Inbred C57BL
  • Mice
  • Magnetic Resonance Imaging
  • Hindlimb Suspension
  • Hindlimb
  • Female
  • Animals
  • 11 Medical and Health Sciences