Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging.

Journal Article (Journal Article)

We investigated whether individuals with impaired glucose tolerance (IGT) in midlife subsequently show regionally specific longitudinal changes in regional cerebral blood flow (rCBF) relative to those with normal glucose tolerance (NGT). Sixty-four cognitively normal participants in the neuroimaging substudy of the Baltimore Longitudinal Study of Aging underwent serial (15)O-water positron emission tomography scans (age at first scan, 69.6 ± 7.5 years) and oral glucose tolerance tests 12 years earlier (age at first oral glucose tolerance test, 57.2 ± 11.1 years). Using voxel-based analysis, we compared changes in rCBF over an 8-year period between 15 participants with IGT in midlife and 49 with NGT. Significant differences were observed in longitudinal change in rCBF between the IGT and NGT groups. The predominant pattern was greater rCBF decline in the IGT group in the frontal, parietal, and temporal cortices. Some brain regions in the frontal and temporal cortices also showed greater longitudinal increments in rCBF in the IGT group. Our findings suggest that IGT in midlife is associated with subsequent longitudinal changes in brain function during aging even in cognitively normal older individuals.

Full Text

Duke Authors

Cited Authors

  • Thambisetty, M; Beason-Held, LL; An, Y; Kraut, M; Metter, J; Egan, J; Ferrucci, L; O'Brien, R; Resnick, SM

Published Date

  • October 2013

Published In

Volume / Issue

  • 34 / 10

Start / End Page

  • 2271 - 2276

PubMed ID

  • 23608110

Pubmed Central ID

  • PMC4577027

Electronic International Standard Serial Number (EISSN)

  • 1558-1497

Digital Object Identifier (DOI)

  • 10.1016/j.neurobiolaging.2013.03.025


  • eng

Conference Location

  • United States