Richard J O'Brien | Scholars@Duke

Richard J O'Brien
Disque D. Deane University Distinguished Professor of Neurology

Current Appointments & Affiliations

Disque D. Deane University Distinguished Professor of Neurology, Neurology, Clinical Science Departments 2015
Professor of Neurology, Neurology, Clinical Science Departments 2014
Chair, Department of Neurology, Neurology, Clinical Science Departments 2014
Professor of Neurobiology, Neurobiology, Basic Science Departments 2014

Contact Information

richard.obrien@duke.edu

Background
Education, Training, & Certifications
- MD./PhD., Harvard Medical School 1985
Previous Appointments & Affiliations
- Instructor, Temporary in the Department of Neurology, Neurology, Clinical Science Departments 2014
Recognition
In the News
- SEP 12, 2021 Duke Health News
  
  Duke/UNC Awarded Grant to Establish Joint Alzheimer’s Disease Research Center
- DEC 6, 2019 School of Medicine
  
  Why Can't I Remember What I Ate for Lunch?
Awards & Honors
- Clinical Scientist Awards in Translational Research. Burroughs Wellcome Fund. 2005
Research
Selected Grants
- Common mechanistic biomarkers of vascular and neuro-degeneration awarded by National Institutes of Health 2023 - 2027
- NINDS Research Education Programs for Residents and Fellows in Neurosurgery awarded by National Institutes of Health 2009 - 2025
- Duke Creating ADRD Researchers for the Next Generation - Stimulating Access to Research in Residency Program (CARiNG-StARR)" awarded by National Institutes of Health 2020 - 2024
- Brain networks in mouse models of aging awarded by National Institutes of Health 2019 - 2024
- Effects of Healthy Aging and Mild Cognitive Impairment on Memory Representations awarded by National Institutes of Health 2021 - 2024
- Healthy Skeletal Muscle, Healthy Brain: Are Kynurenine Metabolites the Link? awarded by National Institutes of Health 2020 - 2023
- Developing Biomarkers for Traumatic Brain Injury and Alzheimer's Disease via Acoustic Exosome Separation Devices awarded by United States Army Medical Research Acquisition Activity 2018 - 2021
- Sponsored research agreement: UCI awarded by University of California - Irvine 2020 - 2021
- Sponsored research agreement: UCI (DLAR) awarded by University of California - Irvine 2020 - 2021
- Sponsored research agreement: UCI (Macopson) awarded by University of California - Irvine 2020 - 2021
- Efficacy of Nido Drug Compound BF3 in an animal model of SBMA awarded by Nido Biosciences, Inc. 2020 - 2021
External Relationships
- UCB Pharmaceuticals and its CRO Icon plc
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Mahajan, Uma V., Vijay R. Varma, Michael E. Griswold, Chad T. Blackshear, Yang An, Anup M. Oommen, Sudhir Varma, et al. “Correction: Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study.” Plos Med 17, no. 10 (October 2020): e1003439. https://doi.org/10.1371/journal.pmed.1003439.
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  - Anderson, Robert J., Christopher M. Long, Evan D. Calabrese, Scott H. Robertson, G Allan Johnson, Gary P. Cofer, Richard J. O’Brien, and Alexandra Badea. “Optimizing Diffusion Imaging Protocols for Structural Connectomics in Mouse Models of Neurological Conditions.” Front Phys 8 (April 2020). https://doi.org/10.3389/fphy.2020.00088.
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  - Mahajan, Uma V., Vijay R. Varma, Michael E. Griswold, Chad T. Blackshear, Yang An, Anup M. Oommen, Sudhir Varma, et al. “Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study.” Plos Med 17, no. 1 (January 2020): e1003012. https://doi.org/10.1371/journal.pmed.1003012.
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  - Hubbard, Robert, Jason Dunthorn, Richard J. O’Brien, Dan Tasch, Uri Tasch, and Steven R. Zeiler. “Evaluating Skilled Prehension in Mice Using an Auto-Trainer.” J Vis Exp, no. 151 (September 12, 2019). https://doi.org/10.3791/59784.
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  - Bell, W Robert, Yang An, Yusuke Kageyama, Collin English, Gay L. Rudow, Olga Pletnikova, Madhav Thambisetty, et al. “Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease.” Alzheimers Dement 15, no. 1 (January 2019): 8–16. https://doi.org/10.1016/j.jalz.2018.07.215.
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  - Snowden, Stuart G., Amera A. Ebshiana, Abdul Hye, Olga Pletnikova, Richard O’Brien, An Yang, Juan Troncoso, Cristina Legido-Quigley, and Madhav Thambisetty. “Neurotransmitter Imbalance in the Brain and Alzheimer's Disease Pathology.” J Alzheimers Dis 72, no. 1 (2019): 35–43. https://doi.org/10.3233/JAD-190577.
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  - Li, Kan, Richard O’Brien, Michael Lutz, Sheng Luo, and Sheng Alzheimer’s Disease Neuroimaging Initiative. “A prognostic model of Alzheimer's disease relying on multiple longitudinal measures and time-to-event data.” Alzheimers Dement 14, no. 5 (May 2018): 644–51. https://doi.org/10.1016/j.jalz.2017.11.004.
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  - An, Yang, Vijay R. Varma, Sudhir Varma, Ramon Casanova, Eric Dammer, Olga Pletnikova, Chee W. Chia, et al. “Evidence for brain glucose dysregulation in Alzheimer's disease.” Alzheimers Dement 14, no. 3 (March 2018): 318–29. https://doi.org/10.1016/j.jalz.2017.09.011.
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  - Witoelar, Aree, Iris E. Jansen, Yunpeng Wang, Rahul S. Desikan, J Raphael Gibbs, Cornelis Blauwendraat, Wesley K. Thompson, et al. “Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.” Jama Neurol 74, no. 7 (July 1, 2017): 780–92. https://doi.org/10.1001/jamaneurol.2017.0469.
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  - Chapuis, Julien, Amandine Flaig, Benjamin Grenier-Boley, Fanny Eysert, Virginie Pottiez, Gaspard Deloison, Alexandre Vandeputte, et al. “Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.” Acta Neuropathol 133, no. 6 (June 2017): 955–66. https://doi.org/10.1007/s00401-016-1652-z.
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  - Ennis, Gilda E., Yang An, Susan M. Resnick, Luigi Ferrucci, Richard J. O’Brien, and Scott D. Moffat. “Long-term cortisol measures predict Alzheimer disease risk.” Neurology 88, no. 4 (January 24, 2017): 371–78. https://doi.org/10.1212/WNL.0000000000003537.
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  - Varma, V. R., S. Varma, Y. An, T. J. Hohman, S. Seddighi, R. Casanova, A. Beri, et al. “Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway.” Mol Psychiatry 22, no. 1 (January 2017): 13–23. https://doi.org/10.1038/mp.2016.206.
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  - Zeiler, Steven R., Robert Hubbard, Ellen M. Gibson, Tony Zheng, Kwan Ng, Richard O’Brien, and John W. Krakauer. “Paradoxical Motor Recovery From a First Stroke After Induction of a Second Stroke: Reopening a Postischemic Sensitive Period.” Neurorehabil Neural Repair 30, no. 8 (September 2016): 794–800. https://doi.org/10.1177/1545968315624783.
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  - Chuang, Y. -. F., Y. An, M. Bilgel, D. F. Wong, J. C. Troncoso, R. J. O’Brien, J. C. Breitner, L. Ferruci, S. M. Resnick, and M. Thambisetty. “Midlife adiposity predicts earlier onset of Alzheimer's dementia, neuropathology and presymptomatic cerebral amyloid accumulation.” Mol Psychiatry 21, no. 7 (July 2016): 910–15. https://doi.org/10.1038/mp.2015.129.
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  - Soldan, Anja, Corinne Pettigrew, Qing Cai, Mei-Cheng Wang, Abhay R. Moghekar, Richard J. O’Brien, Ola A. Selnes, Marilyn S. Albert, and Marilyn S. BIOCARD Research Team. “Hypothetical Preclinical Alzheimer Disease Groups and Longitudinal Cognitive Change.” Jama Neurol 73, no. 6 (June 1, 2016): 698–705. https://doi.org/10.1001/jamaneurol.2016.0194.
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  - Pettigrew, Corinne, Anja Soldan, Abhay Moghekar, Mei-Cheng Wang, Alden L. Gross, Richard O’Brien, and Marilyn Albert. “Relationship between cerebrospinal fluid biomarkers of Alzheimer's disease and cognition in cognitively normal older adults.” Neuropsychologia 78 (November 2015): 63–72. https://doi.org/10.1016/j.neuropsychologia.2015.09.024.
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  - Peters, Marjolein J., Roby Joehanes, Luke C. Pilling, Claudia Schurmann, Karen N. Conneely, Joseph Powell, Eva Reinmaa, et al. “The transcriptional landscape of age in human peripheral blood.” Nat Commun 6 (October 22, 2015): 8570. https://doi.org/10.1038/ncomms9570.
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  - Ng, Kwan L., Ellen M. Gibson, Robert Hubbard, Juemin Yang, Brian Caffo, Richard J. O’Brien, John W. Krakauer, and Steven R. Zeiler. “Fluoxetine Maintains a State of Heightened Responsiveness to Motor Training Early After Stroke in a Mouse Model.” Stroke 46, no. 10 (October 2015): 2951–60. https://doi.org/10.1161/STROKEAHA.115.010471.
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  - Resnick, Susan M., Murat Bilgel, Abhay Moghekar, Yang An, Qing Cai, Mei-Cheng Wang, Madhav Thambisetty, et al. “Changes in Aβ biomarkers and associations with APOE genotype in 2 longitudinal cohorts.” Neurobiol Aging 36, no. 8 (August 2015): 2333–39. https://doi.org/10.1016/j.neurobiolaging.2015.04.001.
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  - Soldan, Anja, Corinne Pettigrew, Yi Lu, Mei-Cheng Wang, Ola Selnes, Marilyn Albert, Timothy Brown, et al. “Relationship of medial temporal lobe atrophy, APOE genotype, and cognitive reserve in preclinical Alzheimer's disease.” Hum Brain Mapp 36, no. 7 (July 2015): 2826–41. https://doi.org/10.1002/hbm.22810.
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  - Miller, M. I., J. T. Ratnanather, D. J. Tward, T. Brown, D. S. Lee, M. Ketcha, K. Mori, et al. “Network neurodegeneration in Alzheimer's disease via MRI based shape diffeomorphometry and high-field atlasing.” Frontiers in Bioengineering and Biotechnology 3, no. MAY (January 1, 2015). https://doi.org/10.3389/fbioe.2015.00054.
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  - Iacono, Diego, Susan M. Resnick, Richard O’Brien, Alan B. Zonderman, Yang An, Olga Pletnikova, Gay Rudow, Barbara Crain, and Juan C. Troncoso. “Mild cognitive impairment and asymptomatic Alzheimer disease subjects: equivalent β-amyloid and tau loads with divergent cognitive outcomes.” J Neuropathol Exp Neurol 73, no. 4 (April 2014): 295–304. https://doi.org/10.1097/NEN.0000000000000052.
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  - Terracciano, Antonio, Angelina R. Sutin, Yang An, Richard J. O’Brien, Luigi Ferrucci, Alan B. Zonderman, and Susan M. Resnick. “Personality and risk of Alzheimer's disease: new data and meta-analysis.” Alzheimers Dement 10, no. 2 (March 2014): 179–86. https://doi.org/10.1016/j.jalz.2013.03.002.
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  - Semba, Richard D., Abhay R. Moghekar, Jason Hu, Kai Sun, Randi Turner, Luigi Ferrucci, and Richard O’Brien. “Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease.” Neurosci Lett 558 (January 13, 2014): 37–40. https://doi.org/10.1016/j.neulet.2013.10.058.
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  - Soldan, Anja, Corinne Pettigrew, Shanshan Li, Mei-Cheng Wang, Abhay Moghekar, Ola A. Selnes, Marilyn Albert, Richard O’Brien, and Richard BIOCARD Research Team. “Relationship of cognitive reserve and cerebrospinal fluid biomarkers to the emergence of clinical symptoms in preclinical Alzheimer's disease.” Neurobiol Aging 34, no. 12 (December 2013): 2827–34. https://doi.org/10.1016/j.neurobiolaging.2013.06.017.
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  - Beason-Held, Lori L., Joshua O. Goh, Yang An, Michael A. Kraut, Richard J. O’Brien, Luigi Ferrucci, and Susan M. Resnick. “Changes in brain function occur years before the onset of cognitive impairment.” J Neurosci 33, no. 46 (November 13, 2013): 18008–14. https://doi.org/10.1523/JNEUROSCI.1402-13.2013.
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  - Moghekar, Abhay, Shanshan Li, Yi Lu, Ming Li, Mei-Cheng Wang, Marilyn Albert, Richard O’Brien, and Richard BIOCARD Research Team. “CSF biomarker changes precede symptom onset of mild cognitive impairment.” Neurology 81, no. 20 (November 12, 2013): 1753–58. https://doi.org/10.1212/01.wnl.0000435558.98447.17.
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  - Miller, M. I., L. Younes, J. T. Ratnanather, T. Brown, H. Trinh, E. Postell, D. S. Lee, et al. “The diffeomorphometry of temporal lobe structures in preclinical Alzheimer's disease.” Neuroimage: Clinical 3 (October 31, 2013): 352–60. https://doi.org/10.1016/j.nicl.2013.09.001.
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  - Thambisetty, Madhav, Lori L. Beason-Held, Yang An, Michael Kraut, Jeffrey Metter, Josephine Egan, Luigi Ferrucci, Richard O’Brien, and Susan M. Resnick. “Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging.” Neurobiol Aging 34, no. 10 (October 2013): 2271–76. https://doi.org/10.1016/j.neurobiolaging.2013.03.025.
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  - Thambisetty, Madhav, E. Jeffrey Metter, An Yang, Hillary Dolan, Christopher Marano, Alan B. Zonderman, Juan C. Troncoso, et al. “Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of Aging.” Jama Neurol 70, no. 9 (September 1, 2013): 1167–72. https://doi.org/10.1001/jamaneurol.2013.284.
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  - Stewart, S. E., D. Yu, J. M. Scharf, B. M. Neale, J. A. Fagerness, C. A. Mathews, P. D. Arnold, et al. “Genome-wide association study of obsessive-compulsive disorder.” Mol Psychiatry 18, no. 7 (July 2013): 788–98. https://doi.org/10.1038/mp.2012.85.
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  - Liu, Xiaoqian, Zhicheng Jin, Richard O’Brien, Joan Bathon, Harry C. Dietz, Eric Grote, and Jennifer E. Van Eyk. “Constrained selected reaction monitoring: quantification of selected post-translational modifications and protein isoforms.” Methods 61, no. 3 (June 15, 2013): 304–12. https://doi.org/10.1016/j.ymeth.2013.03.006.
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  - Beydoun, May A., Hind A. Beydoun, Jay S. Kaufman, Yang An, Susan M. Resnick, Richard O’Brien, Luigi Ferrucci, and Alan B. Zonderman. “Apolipoprotein E ε4 allele interacts with sex and cognitive status to influence all-cause and cause-specific mortality in U.S. older adults.” J Am Geriatr Soc 61, no. 4 (April 2013): 525–34. https://doi.org/10.1111/jgs.12156.
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  - Terracciano, Antonio, Diego Iacono, Richard J. O’Brien, Juan C. Troncoso, Yang An, Angelina R. Sutin, Luigi Ferrucci, Alan B. Zonderman, and Susan M. Resnick. “Personality and resilience to Alzheimer's disease neuropathology: a prospective autopsy study.” Neurobiol Aging 34, no. 4 (April 2013): 1045–50. https://doi.org/10.1016/j.neurobiolaging.2012.08.008.
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  - Zeiler, Steven R., Ellen M. Gibson, Robert E. Hoesch, Ming Y. Li, Paul F. Worley, Richard J. O’Brien, and John W. Krakauer. “Medial premotor cortex shows a reduction in inhibitory markers and mediates recovery in a mouse model of focal stroke.” Stroke 44, no. 2 (February 2013): 483–89. https://doi.org/10.1161/STROKEAHA.112.676940.
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  - Pettigrew, Corinne, Anja Soldan, Shanshan Li, Yi Lu, Mei-Cheng Wang, Ola A. Selnes, Abhay Moghekar, Richard O’Brien, Marilyn Albert, and Marilyn The Biocard Research Team. “Relationship of cognitive reserve and APOE status to the emergence of clinical symptoms in preclinical Alzheimer's disease.” Cogn Neurosci 4, no. 3–4 (2013): 136–42. https://doi.org/10.1080/17588928.2013.831820.
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  - Wendell, Carrington R., Shari R. Waldstein, Luigi Ferrucci, Richard J. O’Brien, James B. Strait, and Alan B. Zonderman. “Carotid atherosclerosis and prospective risk of dementia.” Stroke 43, no. 12 (December 2012): 3319–24. https://doi.org/10.1161/STROKEAHA.112.672527.
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  - Driscoll, Ira, Juan C. Troncoso, Gay Rudow, Jitka Sojkova, Olga Pletnikova, Yun Zhou, Michael A. Kraut, et al. “Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques.” Acta Neuropathol 124, no. 6 (December 2012): 823–31. https://doi.org/10.1007/s00401-012-1025-1.
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  - Moghekar, Abhay, Michael Kraut, Wendy Elkins, Juan Troncoso, Alan B. Zonderman, Susan M. Resnick, and Richard J. O’Brien. “Cerebral white matter disease is associated with Alzheimer pathology in a prospective cohort.” Alzheimers Dement 8, no. 5 Suppl (October 2012): S71–77. https://doi.org/10.1016/j.jalz.2012.04.006.
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  - Hernandez, Dena G., Mike A. Nalls, Matthew Moore, Sean Chong, Allissa Dillman, Daniah Trabzuni, J Raphael Gibbs, et al. “Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain.” Neurobiol Dis 47, no. 1 (July 2012): 20–28. https://doi.org/10.1016/j.nbd.2012.03.020.
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  - Codispoti, Kari-Elise T., Lori L. Beason-Held, Michael A. Kraut, Richard J. O’Brien, Gay Rudow, Olga Pletnikova, Barbara Crain, Juan C. Troncoso, and Susan M. Resnick. “Longitudinal brain activity changes in asymptomatic Alzheimer disease.” Brain Behav 2, no. 3 (May 2012): 221–30. https://doi.org/10.1002/brb3.47.
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  - Beydoun, May A., Adel Boueiz, Marwan S. Abougergi, Melissa H. Kitner-Triolo, Hind A. Beydoun, Susan M. Resnick, Richard O’Brien, and Alan B. Zonderman. “Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline.” Neurobiol Aging 33, no. 4 (April 2012): 720-731.e4. https://doi.org/10.1016/j.neurobiolaging.2010.05.017.
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  - Moghekar, Abhay, Joshua Goh, Ming Li, Marilyn Albert, and Richard J. O’Brien. “Cerebrospinal fluid Aβ and tau level fluctuation in an older clinical cohort.” Arch Neurol 69, no. 2 (February 2012): 246–50. https://doi.org/10.1001/archneurol.2011.732.
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  - Moghekar, Abhay, and Richard J. O’Brien. “Con: Alzheimer's disease and circadian dysfunction: chicken or egg?” Alzheimers Res Ther 4, no. 4 (2012): 26. https://doi.org/10.1186/alzrt129.
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  - Mattsson, Niklas, Ulf Andreasson, Staffan Persson, Hiroyuki Arai, Sat Dev Batish, Sergio Bernardini, Luisella Bocchio-Chiavetto, et al. “The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.” Alzheimers Dement 7, no. 4 (July 2011): 386-395.e6. https://doi.org/10.1016/j.jalz.2011.05.2243.
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  - OBrien, R. J. “Vascular dementia: atherosclerosis, cognition and Alzheimer's disease.” Curr Alzheimer Res 8, no. 4 (June 2011): 341–44. https://doi.org/10.2174/156720511795745267.
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  - Moghekar, Abhay, Sneha Rao, Ming Li, Dawn Ruben, Andrew Mammen, Xiaopei Tang, and Richard J. O’Brien. “Large quantities of Abeta peptide are constitutively released during amyloid precursor protein metabolism in vivo and in vitro.” J Biol Chem 286, no. 18 (May 6, 2011): 15989–97. https://doi.org/10.1074/jbc.M110.191262.
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  - Lin, Frank R., E Jeffrey Metter, Richard J. O’Brien, Susan M. Resnick, Alan B. Zonderman, and Luigi Ferrucci. “Hearing loss and incident dementia.” Arch Neurol 68, no. 2 (February 2011): 214–20. https://doi.org/10.1001/archneurol.2010.362.
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  - Sojkova, Jitka, Ira Driscoll, Diego Iacono, Yun Zhou, Kari-Elise Codispoti, Michael A. Kraut, Luigi Ferrucci, et al. “In vivo fibrillar beta-amyloid detected using [11C]PiB positron emission tomography and neuropathologic assessment in older adults.” Arch Neurol 68, no. 2 (February 2011): 232–40. https://doi.org/10.1001/archneurol.2010.357.
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  - Okonkwo, Ozioma C., Michelle M. Mielke, H Randall Griffith, Abhay R. Moghekar, Richard J. O’Brien, Leslie M. Shaw, John Q. Trojanowski, Marilyn S. Albert, and Marilyn S. Alzheimer’s Disease Neuroimaging Initiative. “Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairment.” Arch Neurol 68, no. 1 (January 2011): 113–19. https://doi.org/10.1001/archneurol.2010.334.
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  - O’Brien, Richard J., and Philip C. Wong. “Amyloid precursor protein processing and Alzheimer's disease.” Annu Rev Neurosci 34 (2011): 185–204. https://doi.org/10.1146/annurev-neuro-061010-113613.
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  - Dolan, David, Juan Troncoso, Susan M. Resnick, Barbara J. Crain, Alan B. Zonderman, and Richard J. O’Brien. “Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of Ageing.” Brain 133, no. Pt 8 (August 2010): 2225–31. https://doi.org/10.1093/brain/awq141.
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  - Dolan, Hillary, Barbara Crain, Juan Troncoso, Susan M. Resnick, Alan B. Zonderman, and Richard J. Obrien. “Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of Aging cohort.” Ann Neurol 68, no. 2 (August 2010): 231–40. https://doi.org/10.1002/ana.22055.
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  - O’Brien, Richard J., Susan M. Resnick, Alan B. Zonderman, Luigi Ferrucci, Barbara J. Crain, Olga Pletnikova, Gay Rudow, et al. “Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA).” J Alzheimers Dis 18, no. 3 (2009): 665–75. https://doi.org/10.3233/JAD-2009-1179.
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  - Beydoun, May A., April Lhotsky, Youfa Wang, Gloria Dal Forno, Yang An, E Jeffrey Metter, Luigi Ferrucci, Richard O’Brien, and Alan B. Zonderman. “Association of adiposity status and changes in early to mid-adulthood with incidence of Alzheimer's disease.” Am J Epidemiol 168, no. 10 (November 15, 2008): 1179–89. https://doi.org/10.1093/aje/kwn229.
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  - Troncoso, Juan C., Alan B. Zonderman, Susan M. Resnick, Barbara Crain, Olga Pletnikova, and Richard J. O’Brien. “Effect of infarcts on dementia in the Baltimore longitudinal study of aging.” Ann Neurol 64, no. 2 (August 2008): 168–76. https://doi.org/10.1002/ana.21413.
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  - Iacono, Diego, Richard O’Brien, Susan M. Resnick, Alan B. Zonderman, Olga Pletnikova, Gay Rudow, Yang An, Mark J. West, Barbara Crain, and Juan C. Troncoso. “Neuronal hypertrophy in asymptomatic Alzheimer disease.” J Neuropathol Exp Neurol 67, no. 6 (June 2008): 578–89. https://doi.org/10.1097/NEN.0b013e3181772794.
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  - Rudow, Gay, Richard O’Brien, Alena V. Savonenko, Susan M. Resnick, Alan B. Zonderman, Olga Pletnikova, Laura Marsh, et al. “Morphometry of the human substantia nigra in ageing and Parkinson's disease.” Acta Neuropathol 115, no. 4 (April 2008): 461–70. https://doi.org/10.1007/s00401-008-0352-8.
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  - Riudavets, Miguel Angel, Diego Iacono, Susan M. Resnick, Richard O’Brien, Alan B. Zonderman, Lee J. Martin, Gay Rudow, Olga Pletnikova, and Juan C. Troncoso. “Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons.” Neurobiol Aging 28, no. 10 (October 2007): 1484–92. https://doi.org/10.1016/j.neurobiolaging.2007.05.005.
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  - O’Brien, R. “Reply from the authors [4].” Neurology 68, no. 20 (May 1, 2007): 1749. https://doi.org/10.1212/01.wnl.0000266745.86958.ce.
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  - Rosen, Kenneth M., Abhay Moghekar, and Richard J. O’Brien. “Activity dependent localization of synaptic NMDA receptors in spinal neurons.” Mol Cell Neurosci 34, no. 4 (April 2007): 578–91. https://doi.org/10.1016/j.mcn.2006.12.008.
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  - Morgan, Melissa D., Michelle M. Mielke, Richard O’Brien, Juan C. Troncoso, Alan B. Zonderman, and Constantine G. Lyketsos. “Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA).” Alzheimer Dis Assoc Disord 21, no. 3 (2007): 199–204. https://doi.org/10.1097/WAD.0b013e3181461932.
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  - Driscoll, Ira, Susan M. Resnick, Juan C. Troncoso, Yang An, Richard O’Brien, and Alan B. Zonderman. “Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly.” Ann Neurol 60, no. 6 (December 2006): 688–95. https://doi.org/10.1002/ana.21031.
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  - Gamaldo, A., A. Moghekar, S. Kilada, S. M. Resnick, A. B. Zonderman, and R. O’Brien. “Effect of a clinical stroke on the risk of dementia in a prospective cohort.” Neurology 67, no. 8 (October 24, 2006): 1363–69. https://doi.org/10.1212/01.wnl.0000240285.89067.3f.
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  - Mikolaenko, Irina, Olga Pletnikova, Claudia H. Kawas, Richard O’Brien, Susan M. Resnick, Barbara Crain, and Juan C. Troncoso. “Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA).” J Neuropathol Exp Neurol 64, no. 2 (February 2005): 156–62. https://doi.org/10.1093/jnen/64.2.156.
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  - Kilada, Sandy, Alyssa Gamaldo, Elizabeth A. Grant, Abhay Moghekar, John C. Morris, and Richard J. O’Brien. “Brief screening tests for the diagnosis of dementia: comparison with the mini-mental state exam.” Alzheimer Dis Assoc Disord 19, no. 1 (2005): 8–16. https://doi.org/10.1097/01.wad.0000155381.01350.bf.
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  - Mi, Ruifa, Gek-Ming Sia, Kenneth Rosen, Xiaopei Tang, Abhay Moghekar, John L. Black, Maureen McEnery, Richard L. Huganir, and Richard J. O’Brien. “AMPA receptor-dependent clustering of synaptic NMDA receptors is mediated by Stargazin and NR2A/B in spinal neurons and hippocampal interneurons.” Neuron 44, no. 2 (October 14, 2004): 335–49. https://doi.org/10.1016/j.neuron.2004.09.029.
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  - Hossain, Mir Ahamed, Juliet C. Russell, Richard O’Brien, and John Laterra. “Neuronal pentraxin 1: a novel mediator of hypoxic-ischemic injury in neonatal brain.” J Neurosci 24, no. 17 (April 28, 2004): 4187–96. https://doi.org/10.1523/JNEUROSCI.0347-04.2004.
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  - Schlickum, Stephanie, Abhay Moghekar, Jeremy C. Simpson, Cordula Steglich, Richard J. O’Brien, Andreas Winterpacht, and Sabine U. Endele. “LETM1, a gene deleted in Wolf-Hirschhorn syndrome, encodes an evolutionarily conserved mitochondrial protein.” Genomics 83, no. 2 (February 2004): 254–61. https://doi.org/10.1016/j.ygeno.2003.08.013.
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  - Xu, Desheng, Carsten Hopf, Radhika Reddy, Richard W. Cho, Liping Guo, Anthony Lanahan, Ronald S. Petralia, Robert J. Wenthold, Richard J. O’Brien, and Paul Worley. “Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity.” Neuron 39, no. 3 (July 31, 2003): 513–28. https://doi.org/10.1016/s0896-6273(03)00463-x.
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  - Mi, Ruifa, Xiaopei Tang, Ralph Sutter, Desheng Xu, Paul Worley, and Richard J. O’Brien. “Differing mechanisms for glutamate receptor aggregation on dendritic spines and shafts in cultured hippocampal neurons.” J Neurosci 22, no. 17 (September 1, 2002): 7606–16. https://doi.org/10.1523/JNEUROSCI.22-17-07606.2002.
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  - O’Brien, Richard, Desheng Xu, Ruifa Mi, Xiaopei Tang, Carsten Hopf, and Paul Worley. “Synaptically targeted narp plays an essential role in the aggregation of AMPA receptors at excitatory synapses in cultured spinal neurons.” J Neurosci 22, no. 11 (June 1, 2002): 4487–98. https://doi.org/10.1523/JNEUROSCI.22-11-04487.2002.
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  - Chaudhry, V., D. R. Cornblath, J. W. Griffin, R. O’Brien, and D. B. Drachman. “Mycophenolate mofetil: a safe and promising immunosuppressant in neuromuscular diseases.” Neurology 56, no. 1 (January 9, 2001): 94–96. https://doi.org/10.1212/wnl.56.1.94.
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  - O’Brien, R. J., D. Xu, R. S. Petralia, O. Steward, R. L. Huganir, and P. Worley. “Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp.” Neuron 23, no. 2 (June 1999): 309–23. https://doi.org/10.1016/s0896-6273(00)80782-5.
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  - Chaudhry, V., A. M. Corse, R. O’Brian, D. R. Cornblath, A. S. Klein, and P. J. Thuluvath. “Autonomic and peripheral (sensorimotor) neuropathy in chronic liver disease: a clinical and electrophysiologic study.” Hepatology 29, no. 6 (June 1999): 1698–1703. https://doi.org/10.1002/hep.510290630.
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  - Bar-Peled, O., R. J. O’Brien, J. H. Morrison, and J. D. Rothstein. “Cultured motor neurons possess calcium-permeable AMPA/kainate receptors.” Neuroreport 10, no. 4 (March 17, 1999): 855–59. https://doi.org/10.1097/00001756-199903170-00034.
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  - Liao, D., X. Zhang, R. O’Brien, M. D. Ehlers, and R. L. Huganir. “Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons.” Nat Neurosci 2, no. 1 (January 1999): 37–43. https://doi.org/10.1038/4540.
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  - O’Brien, R. J., S. Kamboj, M. D. Ehlers, K. R. Rosen, G. D. Fischbach, and R. L. Huganir. “Activity-dependent modulation of synaptic AMPA receptor accumulation.” Neuron 21, no. 5 (November 1998): 1067–78. https://doi.org/10.1016/s0896-6273(00)80624-8.
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  - O’Brien, R. J., L. F. Lau, and R. L. Huganir. “Molecular mechanisms of glutamate receptor clustering at excitatory synapses.” Curr Opin Neurobiol 8, no. 3 (June 1998): 364–69. https://doi.org/10.1016/s0959-4388(98)80062-7.
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  - Ehlers, M. D., E. T. Fung, R. J. O’Brien, and R. L. Huganir. “Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments.” J Neurosci 18, no. 2 (January 15, 1998): 720–30. https://doi.org/10.1523/JNEUROSCI.18-02-00720.1998.
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  - Mammen, A. L., R. L. Huganir, and R. J. O’Brien. “Redistribution and stabilization of cell surface glutamate receptors during synapse formation.” J Neurosci 17, no. 19 (October 1, 1997): 7351–58. https://doi.org/10.1523/JNEUROSCI.17-19-07351.1997.
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  - O’Brien, R. J., A. L. Mammen, S. Blackshaw, M. D. Ehlers, J. D. Rothstein, and R. L. Huganir. “The development of excitatory synapses in cultured spinal neurons.” J Neurosci 17, no. 19 (October 1, 1997): 7339–50. https://doi.org/10.1523/JNEUROSCI.17-19-07339.1997.
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  - Dong, H., R. J. O’Brien, E. T. Fung, A. A. Lanahan, P. F. Worley, and R. L. Huganir. “GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors.” Nature 386, no. 6622 (March 20, 1997): 279–84. https://doi.org/10.1038/386279a0.
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  - Brakeman, P. R., A. A. Lanahan, R. O’Brien, K. Roche, C. A. Barnes, R. L. Huganir, and P. F. Worley. “Homer: a protein that selectively binds metabotropic glutamate receptors.” Nature 386, no. 6622 (March 20, 1997): 284–88. https://doi.org/10.1038/386284a0.
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  - Roche, K. W., R. J. O’Brien, A. L. Mammen, J. Bernhardt, and R. L. Huganir. “Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit.” Neuron 16, no. 6 (June 1996): 1179–88. https://doi.org/10.1016/s0896-6273(00)80144-0.
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  - O’Brien, R. J., and G. D. Fischbach. “Isolation of embryonic chick motoneurons and their survival in vitro.” J Neurosci 6, no. 11 (November 1986): 3265–74. https://doi.org/10.1523/JNEUROSCI.06-11-03265.1986.
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  - O’Brien, R. J., and G. D. Fischbach. “Excitatory synaptic transmission between interneurons and motoneurons in chick spinal cord cell cultures.” J Neurosci 6, no. 11 (November 1986): 3284–89. https://doi.org/10.1523/JNEUROSCI.06-11-03284.1986.
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  - O’Brien, R. J., and G. D. Fischbach. “Modulation of embryonic chick motoneuron glutamate sensitivity by interneurons and agonists.” J Neurosci 6, no. 11 (November 1986): 3290–96. https://doi.org/10.1523/JNEUROSCI.06-11-03290.1986.
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  - O’Brien, R. J., and G. D. Fischbach. “Characterization of excitatory amino acid receptors expressed by embryonic chick motoneurons in vitro.” J Neurosci 6, no. 11 (November 1986): 3275–83. https://doi.org/10.1523/JNEUROSCI.06-11-03275.1986.
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  - O’Brien, R. J., J. A. Fox, M. G. Kopczynski, and B. M. Babior. “The mechanism of action of ethanolamine ammonia-lyase, an adenosylcobalamin-dependent enzyme. Evidence that the hydrogen transfer mechanism involves a second intermediate hydrogen carrier in addition to the cofactor.” J Biol Chem 260, no. 30 (December 25, 1985): 16131–36.
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  - Role, L. W., V. R. Matossian, R. J. O’Brien, and G. D. Fischbach. “On the mechanism of acetylcholine receptor accumulation at newly formed synapses on chick myotubes.” J Neurosci 5, no. 8 (August 1985): 2197–2204. https://doi.org/10.1523/JNEUROSCI.05-08-02197.1985.
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  - Mann, J., R. O’Brien, M. K. Hostetter, C. A. Alper, F. S. Rosen, and B. M. Babior. “The third component of complement: covalent attachment of a radioactive sugar to the labile binding site of C3 via the alternative pathway.” J Immunol 126, no. 6 (June 1981): 2370–72.
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- Book Sections
  - Berkeley, J. L., and R. J. O’Brien. “Neurodegenerative and Movement Disorders.” In Cerebrospinal Fluid in Clinical Practice, 115–19, 2009. https://doi.org/10.1016/B978-141602908-3.50017-0.
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