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Richard J O'Brien

Disque D. Deane University Distinguished Professor of Neurology
Neurology
DUMC Box 27900, Durham, NC 27710
227 Bryan Research Building, Durham, NC 27710

Current Appointments & Affiliations


Disque D. Deane University Distinguished Professor of Neurology · 2015 - Present Neurology, Clinical Science Departments
Professor of Neurology · 2014 - Present Neurology, Clinical Science Departments
Chair, Department of Neurology · 2014 - Present Neurology, Clinical Science Departments
Professor of Neurobiology · 2014 - Present Neurobiology, Basic Science Departments
Professor in Neurosurgery · 2024 - Present Neurosurgery, Neurosurgery

In the News


Published September 12, 2021
Duke/UNC Awarded Grant to Establish Joint Alzheimer’s Disease Research Center
Published December 6, 2019
Why Can't I Remember What I Ate for Lunch?

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Recent Publications


Evaluating the Duke Iterative Cognitive Examination Against the Montreal Cognitive Assessment: Validity and Clinical Utility.

Journal Article Neurol Clin Pract · June 2026 BACKGROUND AND OBJECTIVES: Rapid and valid cognitive screening tools are a mainstay of clinical practice in the assessment of mild cognitive impairment and dementia. Although there are several available tools, there is concern for reduced sensitivity over ... Full text Link to item Cite

Diffusion weighted imaging abnormalities and cerebral ischemia in a cohort of patients on lecanemab.

Journal Article Alzheimers Dement · April 2026 INTRODUCTION: We evaluate the frequency of diffusion weighted imaging abnormalities consistent with stroke in patients on lecanemab, focusing on the association between amyloid-related imaging abnormalities (ARIAs) and stroke incidence. METHODS: For this r ... Full text Link to item Cite

Biomarkers.

Journal Article Alzheimers Dement · December 2025 BACKGROUND: Psychosocial factors, including mood function and residential status (urban vs. rural), have been suggested to affect the risk of Alzheimer's Disease and Related Dementias (ADRD). Few studies, however, have attempted to examine the associations ... Full text Link to item Cite
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Recent Grants


Common mechanistic biomarkers of vascular and neuro-degeneration

ResearchCollaborating Investigator · Awarded by National Institute on Aging · 2023 - 2027

Duke Creating ADRD Researchers for the Next Generation - Stimulating Access to Research in Residency Program (CARiNG-StARR)"

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2026

NINDS Research Education Programs for Residents and Fellows in Neurosurgery

Inst. Training Prgm or CMEMentor · Awarded by National Institute of Neurological Disorders and Stroke · 2009 - 2025

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Education


Harvard Medical School · 1985 MD./PhD.