Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • MD./PhD., Harvard Medical School 1985
• 

  Duke Appointment History

  • Instructor, Temporary in the Department of Neurology, Neurology, Clinical Science Departments 2014
• Recognition
• 

  Awards & Honors

  • Clinical Scientist Awards in Translational Research. Burroughs Wellcome Fund. 2005
• Research
• 

  Selected Grants

  • Bilateral Brain Dynamics Supporting Cognition in Normal Aging and Dementia awarded by National Institutes of Health 2017 - 2021
  • Behavioral and Physiology in Aging awarded by National Institutes of Health 2015 - 2020
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Berkeley, JL, and O'Brien, RJ. "Neurodegenerative and Movement Disorders." In Cerebrospinal Fluid in Clinical Practice, 115-119. December 1, 2009.  Full Text

  • Journal Articles

    • Li, K, O'Brien, R, Lutz, M, Luo, S, and Alzheimer's Disease Neuroimaging Initiative, . "A prognostic model of Alzheimer's disease relying on multiple longitudinal measures and time-to-event data." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 14, no. 5 (May 2018): 644-651.  Full Text
    • An, Y, Varma, VR, Varma, S, Casanova, R, Dammer, E, Pletnikova, O, Chia, CW, Egan, JM, Ferrucci, L, Troncoso, J, Levey, AI, Lah, J, Seyfried, NT, Legido-Quigley, C, O'Brien, R, and Thambisetty, M. "Evidence for brain glucose dysregulation in Alzheimer's disease." Alzheimer's & Dementia (October 2017).  Full Text
    • Witoelar, A, Jansen, IE, Wang, Y, Desikan, RS, Gibbs, JR, Blauwendraat, C, Thompson, WK, Hernandez, DG, Djurovic, S, Schork, AJ, Bettella, F, Ellinghaus, D, Franke, A, Lie, BA, McEvoy, LK, Karlsen, TH, Lesage, S, Morris, HR, Brice, A, Wood, NW, Heutink, P, Hardy, J, Singleton, AB, Dale, AM, Gasser, T, Andreassen, OA, Sharma, M, International Parkinson’s Disease Genomics Consortium (IPDGC), North American Brain Expression Consortium (NABEC), and and United Kingdom Brain Expression Consortium (UKBEC) Investigators, . "Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases." Jama Neurology 74, no. 7 (July 2017): 780-792.  Full Text
    • Chapuis, J, Flaig, A, Grenier-Boley, B, Eysert, F, Pottiez, V, Deloison, G, Vandeputte, A, Ayral, A-M, Mendes, T, Desai, S, Goate, AM, Kauwe, JSK, Leroux, F, Herledan, A, Demiautte, F, Bauer, C, Checler, F, Petersen, RC, Blennow, K, Zetterberg, H, Minthon, L, Van Deerlin, VM, Lee, VM-Y, Shaw, LM, Trojanowski, JQ, Albert, M, Moghekar, A, O'Brien, R, Peskind, ER, Malmanche, N, Schellenberg, GD, Dourlen, P, Song, O-R, Cruchaga, C, Amouyel, P, Deprez, B, Brodin, P, Lambert, J-C, ADGC, and Alzheimer’s Disease Neuroimaging Initiative, . "Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism." Acta Neuropathologica 133, no. 6 (June 2017): 955-966.  Full Text
    • Ennis, GE, An, Y, Resnick, SM, Ferrucci, L, O'Brien, RJ, and Moffat, SD. "Long-term cortisol measures predict Alzheimer disease risk." Neurology 88, no. 4 (January 2017): 371-378.  Full Text
    • Varma, VR, Varma, S, An, Y, Hohman, TJ, Seddighi, S, Casanova, R, Beri, A, Dammer, EB, Seyfried, NT, Pletnikova, O, Moghekar, A, Wilson, MR, Lah, JJ, O'Brien, RJ, Levey, AI, Troncoso, JC, Albert, MS, and Thambisetty, M. "Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway." Molecular Psychiatry 22, no. 1 (January 2017): 13-23.  Full Text
    • Zeiler, SR, Hubbard, R, Gibson, EM, Zheng, T, Ng, K, O'Brien, R, and Krakauer, JW. "Paradoxical Motor Recovery From a First Stroke After Induction of a Second Stroke: Reopening a Postischemic Sensitive Period." Neurorehabilitation and Neural Repair 30, no. 8 (September 2016): 794-800.  Full Text
    • Chuang, Y-F, An, Y, Bilgel, M, Wong, DF, Troncoso, JC, O'Brien, RJ, Breitner, JC, Ferruci, L, Resnick, SM, and Thambisetty, M. "Midlife adiposity predicts earlier onset of Alzheimer's dementia, neuropathology and presymptomatic cerebral amyloid accumulation." Molecular psychiatry 21, no. 7 (July 2016): 910-915.  Full Text
    • Soldan, A, Pettigrew, C, Cai, Q, Wang, M-C, Moghekar, AR, O'Brien, RJ, Selnes, OA, Albert, MS, and BIOCARD Research Team, . "Hypothetical Preclinical Alzheimer Disease Groups and Longitudinal Cognitive Change." Jama Neurology 73, no. 6 (June 2016): 698-705.  Full Text
    • Pettigrew, C, Soldan, A, Moghekar, A, Wang, M-C, Gross, AL, O'Brien, R, and Albert, M. "Relationship between cerebrospinal fluid biomarkers of Alzheimer's disease and cognition in cognitively normal older adults." Neuropsychologia 78 (November 2015): 63-72.  Full Text
    • Peters, MJ, Joehanes, R, Pilling, LC, Schurmann, C, Conneely, KN, Powell, J, Reinmaa, E, Sutphin, GL, Zhernakova, A, Schramm, K, Wilson, YA, Kobes, S, Tukiainen, T, NABEC/UKBEC Consortium, , Ramos, YF, Göring, HHH, Fornage, M, Liu, Y, Gharib, SA, Stranger, BE, De Jager, PL, Aviv, A, Levy, D, Murabito, JM, Munson, PJ, Huan, T, Hofman, A, Uitterlinden, AG, Rivadeneira, F, van Rooij, J, Stolk, L, Broer, L, Verbiest, MMPJ, Jhamai, M, Arp, P, Metspalu, A, Tserel, L, Milani, L, and Samani, NJ et al. "The transcriptional landscape of age in human peripheral blood." Nature communications 6 (October 22, 2015): 8570-.  Full Text
    • Ng, KL, Gibson, EM, Hubbard, R, Yang, J, Caffo, B, O'Brien, RJ, Krakauer, JW, and Zeiler, SR. "Fluoxetine Maintains a State of Heightened Responsiveness to Motor Training Early After Stroke in a Mouse Model." Stroke 46, no. 10 (October 2015): 2951-2960.  Full Text
    • Resnick, SM, Bilgel, M, Moghekar, A, An, Y, Cai, Q, Wang, M-C, Thambisetty, M, Prince, JL, Zhou, Y, Soldan, A, Wong, DF, O'Brien, RJ, Ferrucci, L, and Albert, MS. "Changes in Aβ biomarkers and associations with APOE genotype in 2 longitudinal cohorts." Neurobiology of aging 36, no. 8 (August 2015): 2333-2339.  Full Text
    • Soldan, A, Pettigrew, C, Lu, Y, Wang, M-C, Selnes, O, Albert, M, Brown, T, Ratnanather, JT, Younes, L, Miller, MI, and BIOCARD Research Team, . "Relationship of medial temporal lobe atrophy, APOE genotype, and cognitive reserve in preclinical Alzheimer's disease." Human Brain Mapping 36, no. 7 (July 2015): 2826-2841.  Full Text
    • Miller, MI, Ratnanather, JT, Tward, DJ, Brown, T, Lee, DS, Ketcha, M, Mori, K, Wang, M-C, Mori, S, Albert, MS, and Younes, L. "Network Neurodegeneration in Alzheimer’s Disease via MRI Based Shape Diffeomorphometry and High-Field Atlasing." Frontiers in Bioengineering and Biotechnology 3 (May 15, 2015).  Full Text
    • Iacono, D, Resnick, SM, O'Brien, R, Zonderman, AB, An, Y, Pletnikova, O, Rudow, G, Crain, B, and Troncoso, JC. "Mild cognitive impairment and asymptomatic Alzheimer disease subjects: equivalent β-amyloid and tau loads with divergent cognitive outcomes." Journal of neuropathology and experimental neurology 73, no. 4 (April 2014): 295-304.  Full Text
    • Terracciano, A, Sutin, AR, An, Y, O'Brien, RJ, Ferrucci, L, Zonderman, AB, and Resnick, SM. "Personality and risk of Alzheimer's disease: new data and meta-analysis." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 10, no. 2 (March 2014): 179-186.  Full Text
    • Semba, RD, Moghekar, AR, Hu, J, Sun, K, Turner, R, Ferrucci, L, and O'Brien, R. "Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease." Neuroscience letters 558 (January 2014): 37-40.  Full Text
    • Soldan, A, Pettigrew, C, Li, S, Wang, M-C, Moghekar, A, Selnes, OA, Albert, M, O'Brien, R, and BIOCARD Research Team, . "Relationship of cognitive reserve and cerebrospinal fluid biomarkers to the emergence of clinical symptoms in preclinical Alzheimer's disease." Neurobiology of aging 34, no. 12 (December 2013): 2827-2834.  Full Text
    • Beason-Held, LL, Goh, JO, An, Y, Kraut, MA, O'Brien, RJ, Ferrucci, L, and Resnick, SM. "Changes in brain function occur years before the onset of cognitive impairment." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 33, no. 46 (November 2013): 18008-18014.  Full Text
    • Moghekar, A, Li, S, Lu, Y, Li, M, Wang, M-C, Albert, M, O'Brien, R, and BIOCARD Research Team, . "CSF biomarker changes precede symptom onset of mild cognitive impairment." Neurology 81, no. 20 (November 2013): 1753-1758.  Full Text
    • Thambisetty, M, Beason-Held, LL, An, Y, Kraut, M, Metter, J, Egan, J, Ferrucci, L, O'Brien, R, and Resnick, SM. "Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging." Neurobiology of aging 34, no. 10 (October 2013): 2271-2276.  Full Text
    • Pettigrew, C, Soldan, A, Li, S, Lu, Y, Wang, M-C, Selnes, OA, Moghekar, A, O'Brien, R, Albert, M, and The Biocard Research Team, . "Relationship of cognitive reserve and APOE status to the emergence of clinical symptoms in preclinical Alzheimer's disease." Cognitive neuroscience 4, no. 3-4 (September 2013): 136-142.  Full Text
    • Thambisetty, M, Jeffrey Metter, E, Yang, A, Dolan, H, Marano, C, Zonderman, AB, Troncoso, JC, Zhou, Y, Wong, DF, Ferrucci, L, Egan, J, Resnick, SM, and O'Brien, RJ. "Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of Aging." Jama Neurology 70, no. 9 (September 2013): 1167-1172.  Full Text
    • Stewart, SE, Yu, D, Scharf, JM, Neale, BM, Fagerness, JA, Mathews, CA, Arnold, PD, Evans, PD, Gamazon, ER, Davis, LK, Osiecki, L, McGrath, L, Haddad, S, Crane, J, Hezel, D, Illman, C, Mayerfeld, C, Konkashbaev, A, Liu, C, Pluzhnikov, A, Tikhomirov, A, Edlund, CK, Rauch, SL, Moessner, R, Falkai, P, Maier, W, Ruhrmann, S, Grabe, H-J, Lennertz, L, Wagner, M, Bellodi, L, Cavallini, MC, Richter, MA, Cook, EH, Kennedy, JL, Rosenberg, D, Stein, DJ, Hemmings, SMJ, Lochner, C, Azzam, A, Chavira, DA, Fournier, E, Garrido, H, Sheppard, B, Umaña, P, Murphy, DL, Wendland, JR, Veenstra-VanderWeele, J, Denys, D, Blom, R, Deforce, D, Van Nieuwerburgh, F, Westenberg, HGM, Walitza, S, Egberts, K, Renner, T, Miguel, EC, Cappi, C, Hounie, AG, Conceição do Rosário, M, Sampaio, AS, Vallada, H, Nicolini, H, Lanzagorta, N, Camarena, B, Delorme, R, Leboyer, M, Pato, CN, Pato, MT, Voyiaziakis, E, Heutink, P, Cath, DC, Posthuma, D, Smit, JH, Samuels, J, Bienvenu, OJ, Cullen, B, Fyer, AJ, Grados, MA, Greenberg, BD, McCracken, JT, Riddle, MA, Wang, Y, Coric, V, Leckman, JF, Bloch, M, Pittenger, C, Eapen, V, Black, DW, Ophoff, RA, Strengman, E, Cusi, D, Turiel, M, Frau, F, Macciardi, F, Gibbs, JR, Cookson, MR, Singleton, A, North American Brain Expression Consortium, , Hardy, J, UK Brain Expression Database, , Crenshaw, AT, Parkin, MA, Mirel, DB, Conti, DV, Purcell, S, Nestadt, G, Hanna, GL, Jenike, MA, Knowles, JA, Cox, N, and Pauls, DL. "Genome-wide association study of obsessive-compulsive disorder." Molecular Psychiatry 18, no. 7 (July 2013): 788-798.  Full Text
    • Liu, X, Jin, Z, O'Brien, R, Bathon, J, Dietz, HC, Grote, E, and Van Eyk, JE. "Constrained selected reaction monitoring: quantification of selected post-translational modifications and protein isoforms." Methods (San Diego, Calif.) 61, no. 3 (June 2013): 304-312.  Full Text
    • Beydoun, MA, Beydoun, HA, Kaufman, JS, An, Y, Resnick, SM, O'Brien, R, Ferrucci, L, and Zonderman, AB. "Apolipoprotein E ε4 allele interacts with sex and cognitive status to influence all-cause and cause-specific mortality in U.S. older adults." Journal of the American Geriatrics Society 61, no. 4 (April 2013): 525-534.  Full Text
    • Terracciano, A, Iacono, D, O'Brien, RJ, Troncoso, JC, An, Y, Sutin, AR, Ferrucci, L, Zonderman, AB, and Resnick, SM. "Personality and resilience to Alzheimer's disease neuropathology: a prospective autopsy study." Neurobiology of aging 34, no. 4 (April 2013): 1045-1050.  Full Text
    • Zeiler, SR, Gibson, EM, Hoesch, RE, Li, MY, Worley, PF, O'Brien, RJ, and Krakauer, JW. "Medial premotor cortex shows a reduction in inhibitory markers and mediates recovery in a mouse model of focal stroke." Stroke 44, no. 2 (February 2013): 483-489.  Full Text
    • Miller, MI, Younes, L, Ratnanather, JT, Brown, T, Trinh, H, Postell, E, Lee, DS, Wang, M-C, Mori, S, O'Brien, R, and Albert, M. "The diffeomorphometry of temporal lobe structures in preclinical Alzheimer's disease." NeuroImage: Clinical 3 (2013): 352-360.  Full Text
    • Driscoll, I, Troncoso, JC, Rudow, G, Sojkova, J, Pletnikova, O, Zhou, Y, Kraut, MA, Ferrucci, L, Mathis, CA, Klunk, WE, O'Brien, RJ, Davatzikos, C, Wong, DF, and Resnick, SM. "Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques." Acta Neuropathologica 124, no. 6 (December 2012): 823-831.  Full Text
    • Wendell, CR, Waldstein, SR, Ferrucci, L, O'Brien, RJ, Strait, JB, and Zonderman, AB. "Carotid atherosclerosis and prospective risk of dementia." Stroke 43, no. 12 (December 2012): 3319-3324.  Full Text
    • Moghekar, A, Kraut, M, Elkins, W, Troncoso, J, Zonderman, AB, Resnick, SM, and O'Brien, RJ. "Cerebral white matter disease is associated with Alzheimer pathology in a prospective cohort." Alzheimer's & dementia : the journal of the Alzheimer's Association 8, no. 5 Suppl (October 2012): S71-S77.  Full Text
    • Hernandez, DG, Nalls, MA, Moore, M, Chong, S, Dillman, A, Trabzuni, D, Gibbs, JR, Ryten, M, Arepalli, S, Weale, ME, Zonderman, AB, Troncoso, J, O'Brien, R, Walker, R, Smith, C, Bandinelli, S, Traynor, BJ, Hardy, J, Singleton, AB, and Cookson, MR. "Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain." Neurobiology of disease 47, no. 1 (July 2012): 20-28.  Full Text
    • Codispoti, K-ET, Beason-Held, LL, Kraut, MA, O'Brien, RJ, Rudow, G, Pletnikova, O, Crain, B, Troncoso, JC, and Resnick, SM. "Longitudinal brain activity changes in asymptomatic Alzheimer disease." Brain and behavior 2, no. 3 (May 2012): 221-230.  Full Text
    • Beydoun, MA, Boueiz, A, Abougergi, MS, Kitner-Triolo, MH, Beydoun, HA, Resnick, SM, O'Brien, R, and Zonderman, AB. "Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline." Neurobiology of aging 33, no. 4 (April 2012): 720-731.e4.  Full Text
    • Moghekar, A, Goh, J, Li, M, Albert, M, and O'Brien, RJ. "Cerebrospinal fluid Aβ and tau level fluctuation in an older clinical cohort." Archives of neurology 69, no. 2 (February 2012): 246-250.  Full Text
    • Moghekar, A, and O'Brien, RJ. "Con: Alzheimer's disease and circadian dysfunction: chicken or egg?." Alzheimer's research & therapy 4, no. 4 (January 2012): 26-.  Full Text
    • Mattsson, N, Andreasson, U, Persson, S, Arai, H, Batish, SD, Bernardini, S, Bocchio-Chiavetto, L, Blankenstein, MA, Carrillo, MC, Chalbot, S, Coart, E, Chiasserini, D, Cutler, N, Dahlfors, G, Duller, S, Fagan, AM, Forlenza, O, Frisoni, GB, Galasko, D, Galimberti, D, Hampel, H, Handberg, A, Heneka, MT, Herskovits, AZ, Herukka, S-K, Holtzman, DM, Humpel, C, Hyman, BT, Iqbal, K, Jucker, M, Kaeser, SA, Kaiser, E, Kapaki, E, Kidd, D, Klivenyi, P, Knudsen, CS, Kummer, MP, Lui, J, Lladó, A, Lewczuk, P, Li, Q-X, Martins, R, Masters, C, McAuliffe, J, Mercken, M, Moghekar, A, Molinuevo, JL, Montine, TJ, Nowatzke, W, O'Brien, R, Otto, M, Paraskevas, GP, Parnetti, L, Petersen, RC, Prvulovic, D, de Reus, HPM, Rissman, RA, Scarpini, E, Stefani, A, Soininen, H, Schröder, J, Shaw, LM, Skinningsrud, A, Skrogstad, B, Spreer, A, Talib, L, Teunissen, C, Trojanowski, JQ, Tumani, H, Umek, RM, Van Broeck, B, Vanderstichele, H, Vecsei, L, Verbeek, MM, Windisch, M, Zhang, J, Zetterberg, H, and Blennow, K. "The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers." Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association 7, no. 4 (July 2011): 386-395.e6.  Full Text
    • OBrien, RJ. "Vascular dementia: atherosclerosis, cognition and Alzheimer's disease." Current Alzheimer research 8, no. 4 (June 2011): 341-344. (Review)  Full Text
    • Moghekar, A, Rao, S, Li, M, Ruben, D, Mammen, A, Tang, X, and O'Brien, RJ. "Large quantities of Abeta peptide are constitutively released during amyloid precursor protein metabolism in vivo and in vitro." The Journal of Biological Chemistry 286, no. 18 (May 2011): 15989-15997.  Full Text
    • Lin, FR, Metter, EJ, O'Brien, RJ, Resnick, SM, Zonderman, AB, and Ferrucci, L. "Hearing loss and incident dementia." Archives of Neurology 68, no. 2 (February 2011): 214-220.  Full Text
    • Sojkova, J, Driscoll, I, Iacono, D, Zhou, Y, Codispoti, K-E, Kraut, MA, Ferrucci, L, Pletnikova, O, Mathis, CA, Klunk, WE, O'Brien, RJ, Wong, DF, Troncoso, JC, and Resnick, SM. "In vivo fibrillar beta-amyloid detected using [11C]PiB positron emission tomography and neuropathologic assessment in older adults." Archives of Neurology 68, no. 2 (February 2011): 232-240.  Full Text
    • O'Brien, RJ, and Wong, PC. "Amyloid precursor protein processing and Alzheimer's disease." Annual Review of Neuroscience 34 (January 2011): 185-204. (Review)  Full Text
    • Okonkwo, OC, Mielke, MM, Griffith, HR, Moghekar, AR, O'Brien, RJ, Shaw, LM, Trojanowski, JQ, Albert, MS, and Alzheimer's Disease Neuroimaging Initiative, . "Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairment." Archives of Neurology 68, no. 1 (January 2011): 113-119.  Full Text
    • Dolan, D, Troncoso, J, Resnick, SM, Crain, BJ, Zonderman, AB, and O'Brien, RJ. "Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of Ageing." Brain : a journal of neurology 133, no. Pt 8 (August 2010): 2225-2231.  Full Text
    • Dolan, H, Crain, B, Troncoso, J, Resnick, SM, Zonderman, AB, and Obrien, RJ. "Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of Aging cohort." Annals of neurology 68, no. 2 (August 2010): 231-240.  Full Text
    • O'Brien, RJ, Resnick, SM, Zonderman, AB, Ferrucci, L, Crain, BJ, Pletnikova, O, Rudow, G, Iacono, D, Riudavets, MA, Driscoll, I, Price, DL, Martin, LJ, and Troncoso, JC. "Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA)." Journal of Alzheimer'S Disease : Jad 18, no. 3 (January 2009): 665-675.  Full Text
    • Beydoun, MA, Lhotsky, A, Wang, Y, Dal Forno, G, An, Y, Metter, EJ, Ferrucci, L, O'Brien, R, and Zonderman, AB. "Association of adiposity status and changes in early to mid-adulthood with incidence of Alzheimer's disease." American journal of epidemiology 168, no. 10 (November 2008): 1179-1189.  Full Text
    • Troncoso, JC, Zonderman, AB, Resnick, SM, Crain, B, Pletnikova, O, and O'Brien, RJ. "Effect of infarcts on dementia in the Baltimore longitudinal study of aging." Annals of Neurology 64, no. 2 (August 2008): 168-176.  Full Text
    • Iacono, D, O'Brien, R, Resnick, SM, Zonderman, AB, Pletnikova, O, Rudow, G, An, Y, West, MJ, Crain, B, and Troncoso, JC. "Neuronal hypertrophy in asymptomatic Alzheimer disease." Journal of neuropathology and experimental neurology 67, no. 6 (June 2008): 578-589.  Full Text
    • Rudow, G, O'Brien, R, Savonenko, AV, Resnick, SM, Zonderman, AB, Pletnikova, O, Marsh, L, Dawson, TM, Crain, BJ, West, MJ, and Troncoso, JC. "Morphometry of the human substantia nigra in ageing and Parkinson's disease." Acta neuropathologica 115, no. 4 (April 2008): 461-470.  Full Text
    • Riudavets, MA, Iacono, D, Resnick, SM, O'Brien, R, Zonderman, AB, Martin, LJ, Rudow, G, Pletnikova, O, and Troncoso, JC. "Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons." Neurobiology of aging 28, no. 10 (October 2007): 1484-1492.  Full Text
    • Morgan, MD, Mielke, MM, O'Brien, R, Troncoso, JC, Zonderman, AB, and Lyketsos, CG. "Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA)." Alzheimer disease and associated disorders 21, no. 3 (July 2007): 199-204.  Full Text
    • Noble, JM, Hauser, WA, Silver, JM, and Harvey, PD. "EFFECTS OF RIVASTIGMINE ON COGNITIVE FUNCTION IN PATIENTS WITH TRAUMATIC BRAIN INJURY." Neurology 68, no. 20 (May 15, 2007): 1749-1750.  Full Text
    • Rosen, KM, Moghekar, A, and O'Brien, RJ. "Activity dependent localization of synaptic NMDA receptors in spinal neurons." Molecular and Cellular Neurosciences 34, no. 4 (April 2007): 578-591.  Full Text
    • Driscoll, I, Resnick, SM, Troncoso, JC, An, Y, O'Brien, R, and Zonderman, AB. "Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly." Annals of neurology 60, no. 6 (December 2006): 688-695.  Full Text
    • Gamaldo, A, Moghekar, A, Kilada, S, Resnick, SM, Zonderman, AB, and O'Brien, R. "Effect of a clinical stroke on the risk of dementia in a prospective cohort." Neurology 67, no. 8 (October 2006): 1363-1369.  Full Text
    • Mikolaenko, I, Pletnikova, O, Kawas, CH, O'Brien, R, Resnick, SM, Crain, B, and Troncoso, JC. "Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA)." Journal of neuropathology and experimental neurology 64, no. 2 (February 2005): 156-162.  Full Text
    • Kilada, S, Gamaldo, A, Grant, EA, Moghekar, A, Morris, JC, and O'Brien, RJ. "Brief screening tests for the diagnosis of dementia: comparison with the mini-mental state exam." Alzheimer disease and associated disorders 19, no. 1 (January 2005): 8-16.  Full Text
    • Mi, R, Sia, G-M, Rosen, K, Tang, X, Moghekar, A, Black, JL, McEnery, M, Huganir, RL, and O'Brien, RJ. "AMPA receptor-dependent clustering of synaptic NMDA receptors is mediated by Stargazin and NR2A/B in spinal neurons and hippocampal interneurons." Neuron 44, no. 2 (October 2004): 335-349.  Full Text
    • Hossain, MA, Russell, JC, O'Brien, R, and Laterra, J. "Neuronal pentraxin 1: a novel mediator of hypoxic-ischemic injury in neonatal brain." The Journal of neuroscience : the official journal of the Society for Neuroscience 24, no. 17 (April 2004): 4187-4196.  Full Text
    • Schlickum, S, Moghekar, A, Simpson, JC, Steglich, C, O'Brien, RJ, Winterpacht, A, and Endele, SU. "LETM1, a gene deleted in Wolf-Hirschhorn syndrome, encodes an evolutionarily conserved mitochondrial protein." Genomics 83, no. 2 (February 2004): 254-261.  Full Text
    • Xu, D, Hopf, C, Reddy, R, Cho, RW, Guo, L, Lanahan, A, Petralia, RS, Wenthold, RJ, O'Brien, RJ, and Worley, P. "Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity." Neuron 39, no. 3 (July 2003): 513-528.  Full Text
    • Mi, R, Tang, X, Sutter, R, Xu, D, Worley, P, and O'Brien, RJ. "Differing mechanisms for glutamate receptor aggregation on dendritic spines and shafts in cultured hippocampal neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience 22, no. 17 (September 2002): 7606-7616.
    • O'Brien, R, Xu, D, Mi, R, Tang, X, Hopf, C, and Worley, P. "Synaptically targeted narp plays an essential role in the aggregation of AMPA receptors at excitatory synapses in cultured spinal neurons." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 22, no. 11 (June 2002): 4487-4498.  Full Text
    • Chaudhry, V, Cornblath, DR, Griffin, JW, O'Brien, R, and Drachman, DB. "Mycophenolate mofetil: a safe and promising immunosuppressant in neuromuscular diseases." Neurology 56, no. 1 (January 2001): 94-96.  Full Text
    • Chaudhry, V, Corse, AM, O'Brian, R, Cornblath, DR, Klein, AS, and Thuluvath, PJ. "Autonomic and peripheral (sensorimotor) neuropathy in chronic liver disease: a clinical and electrophysiologic study." Hepatology (Baltimore, Md.) 29, no. 6 (June 1999): 1698-1703.  Full Text
    • O'Brien, RJ, Xu, D, Petralia, RS, Steward, O, Huganir, RL, and Worley, P. "Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp." Neuron 23, no. 2 (June 1999): 309-323.  Full Text
    • Bar-Peled, O, O'Brien, RJ, Morrison, JH, and Rothstein, JD. "Cultured motor neurons possess calcium-permeable AMPA/kainate receptors." Neuroreport 10, no. 4 (March 1999): 855-859.  Full Text
    • Liao, D, Zhang, X, O'Brien, R, Ehlers, MD, and Huganir, RL. "Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons." Nature neuroscience 2, no. 1 (January 1999): 37-43.  Full Text
    • O'Brien, RJ, Kamboj, S, Ehlers, MD, Rosen, KR, Fischbach, GD, and Huganir, RL. "Activity-dependent modulation of synaptic AMPA receptor accumulation." Neuron 21, no. 5 (November 1998): 1067-1078.  Full Text
    • O'Brien, RJ, Lau, LF, and Huganir, RL. "Molecular mechanisms of glutamate receptor clustering at excitatory synapses." Current opinion in neurobiology 8, no. 3 (June 1998): 364-369. (Review)  Full Text
    • Ehlers, MD, Fung, ET, O'Brien, RJ, and Huganir, RL. "Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments." The Journal of neuroscience : the official journal of the Society for Neuroscience 18, no. 2 (January 1998): 720-730.
    • Mammen, AL, Huganir, RL, and O'Brien, RJ. "Redistribution and stabilization of cell surface glutamate receptors during synapse formation." The Journal of neuroscience : the official journal of the Society for Neuroscience 17, no. 19 (October 1997): 7351-7358.
    • O'Brien, RJ, Mammen, AL, Blackshaw, S, Ehlers, MD, Rothstein, JD, and Huganir, RL. "The development of excitatory synapses in cultured spinal neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience 17, no. 19 (October 1997): 7339-7350.
    • Brakeman, PR, Lanahan, AA, O'Brien, R, Roche, K, Barnes, CA, Huganir, RL, and Worley, PF. "Homer: a protein that selectively binds metabotropic glutamate receptors." Nature 386, no. 6622 (March 1997): 284-288.  Full Text
    • Dong, H, O'Brien, RJ, Fung, ET, Lanahan, AA, Worley, PF, and Huganir, RL. "GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors." Nature 386, no. 6622 (March 1997): 279-284.  Full Text
    • Roche, KW, O'Brien, RJ, Mammen, AL, Bernhardt, J, and Huganir, RL. "Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit." Neuron 16, no. 6 (June 1996): 1179-1188.  Full Text
    • O'Brien, RJ, and Fischbach, GD. "Isolation of embryonic chick motoneurons and their survival in vitro." The Journal of neuroscience : the official journal of the Society for Neuroscience 6, no. 11 (November 1986): 3265-3274.
    • O'Brien, RJ, and Fischbach, GD. "Excitatory synaptic transmission between interneurons and motoneurons in chick spinal cord cell cultures." The Journal of neuroscience : the official journal of the Society for Neuroscience 6, no. 11 (November 1986): 3284-3289.
    • O'Brien, RJ, and Fischbach, GD. "Modulation of embryonic chick motoneuron glutamate sensitivity by interneurons and agonists." The Journal of neuroscience : the official journal of the Society for Neuroscience 6, no. 11 (November 1986): 3290-3296.
    • O'Brien, RJ, and Fischbach, GD. "Characterization of excitatory amino acid receptors expressed by embryonic chick motoneurons in vitro." The Journal of neuroscience : the official journal of the Society for Neuroscience 6, no. 11 (November 1986): 3275-3283.
    • O'Brien, RJ, Fox, JA, Kopczynski, MG, and Babior, BM. "The mechanism of action of ethanolamine ammonia-lyase, an adenosylcobalamin-dependent enzyme. Evidence that the hydrogen transfer mechanism involves a second intermediate hydrogen carrier in addition to the cofactor." The Journal of biological chemistry 260, no. 30 (December 1985): 16131-16136.
    • Role, LW, Matossian, VR, O'Brien, RJ, and Fischbach, GD. "On the mechanism of acetylcholine receptor accumulation at newly formed synapses on chick myotubes." The Journal of neuroscience : the official journal of the Society for Neuroscience 5, no. 8 (August 1985): 2197-2204.
    • Mann, J, O'Brien, R, Hostetter, MK, Alper, CA, Rosen, FS, and Babior, BM. "The third component of complement: covalent attachment of a radioactive sugar to the labile binding site of C3 via the alternative pathway." Journal of immunology (Baltimore, Md. : 1950) 126, no. 6 (June 1981): 2370-2372.

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.