Practical murine hematopathology: a comparative review and implications for research.

Published

Journal Article (Review)

Hematologic parameters are important markers of disease in human and veterinary medicine. Biomedical research has benefited from mouse models that recapitulate such disease, thus expanding knowledge of pathogenetic mechanisms and investigative therapies that translate across species. Mice in health have many notable hematologic differences from humans and other veterinary species, including smaller erythrocytes, higher percentage of circulating reticulocytes or polychromasia, lower peripheral blood neutrophil and higher peripheral blood and bone marrow lymphocyte percentages, variable leukocyte morphologies, physiologic splenic hematopoiesis and iron storage, and more numerous and shorter-lived erythrocytes and platelets. For accurate and complete hematologic analyses of disease and response to investigative therapeutic interventions, these differences and the unique features of murine hematopathology must be understood. Here we review murine hematology and hematopathology for practical application to translational investigation.

Full Text

Duke Authors

Cited Authors

  • O'Connell, KE; Mikkola, AM; Stepanek, AM; Vernet, A; Hall, CD; Sun, CC; Yildirim, E; Staropoli, JF; Lee, JT; Brown, DE

Published Date

  • April 2015

Published In

Volume / Issue

  • 65 / 2

Start / End Page

  • 96 - 113

PubMed ID

  • 25926395

Pubmed Central ID

  • 25926395

International Standard Serial Number (ISSN)

  • 1532-0820

Language

  • eng

Conference Location

  • United States