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Practical murine hematopathology: a comparative review and implications for research.

Publication ,  Journal Article
O'Connell, KE; Mikkola, AM; Stepanek, AM; Vernet, A; Hall, CD; Sun, CC; Yildirim, E; Staropoli, JF; Lee, JT; Brown, DE
Published in: Comp Med
April 2015

Hematologic parameters are important markers of disease in human and veterinary medicine. Biomedical research has benefited from mouse models that recapitulate such disease, thus expanding knowledge of pathogenetic mechanisms and investigative therapies that translate across species. Mice in health have many notable hematologic differences from humans and other veterinary species, including smaller erythrocytes, higher percentage of circulating reticulocytes or polychromasia, lower peripheral blood neutrophil and higher peripheral blood and bone marrow lymphocyte percentages, variable leukocyte morphologies, physiologic splenic hematopoiesis and iron storage, and more numerous and shorter-lived erythrocytes and platelets. For accurate and complete hematologic analyses of disease and response to investigative therapeutic interventions, these differences and the unique features of murine hematopathology must be understood. Here we review murine hematology and hematopathology for practical application to translational investigation.

Duke Scholars

Published In

Comp Med

EISSN

2769-819X

Publication Date

April 2015

Volume

65

Issue

2

Start / End Page

96 / 113

Location

United States

Related Subject Headings

  • Veterinary Sciences
  • Translational Research, Biomedical
  • Pathology, Veterinary
  • Mice
  • Humans
  • Hematopoiesis
  • Hematology
  • Hematologic Diseases
  • Disease Models, Animal
  • Bone Marrow
 

Citation

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O’Connell, K. E., Mikkola, A. M., Stepanek, A. M., Vernet, A., Hall, C. D., Sun, C. C., … Brown, D. E. (2015). Practical murine hematopathology: a comparative review and implications for research. Comp Med, 65(2), 96–113.
O’Connell, Karyn E., Amy M. Mikkola, Aaron M. Stepanek, Andyna Vernet, Christopher D. Hall, Chia C. Sun, Eda Yildirim, John F. Staropoli, Jeannie T. Lee, and Diane E. Brown. “Practical murine hematopathology: a comparative review and implications for research.Comp Med 65, no. 2 (April 2015): 96–113.
O’Connell KE, Mikkola AM, Stepanek AM, Vernet A, Hall CD, Sun CC, et al. Practical murine hematopathology: a comparative review and implications for research. Comp Med. 2015 Apr;65(2):96–113.
O’Connell, Karyn E., et al. “Practical murine hematopathology: a comparative review and implications for research.Comp Med, vol. 65, no. 2, Apr. 2015, pp. 96–113.
O’Connell KE, Mikkola AM, Stepanek AM, Vernet A, Hall CD, Sun CC, Yildirim E, Staropoli JF, Lee JT, Brown DE. Practical murine hematopathology: a comparative review and implications for research. Comp Med. 2015 Apr;65(2):96–113.

Published In

Comp Med

EISSN

2769-819X

Publication Date

April 2015

Volume

65

Issue

2

Start / End Page

96 / 113

Location

United States

Related Subject Headings

  • Veterinary Sciences
  • Translational Research, Biomedical
  • Pathology, Veterinary
  • Mice
  • Humans
  • Hematopoiesis
  • Hematology
  • Hematologic Diseases
  • Disease Models, Animal
  • Bone Marrow