Distal acquired demyelinating symmetric neuropathy after vaccination.

Journal Article (Journal Article)

Neuropathy after vaccination is a rare event. Chronic immune-mediated polyneuropathy developing in the postvaccination period is distinctly unusual and not well described. Almost all such patients have been reported as having typical chronic inflammatory demyelinating polyneuropathy. Distal acquired demyelinating symmetric neuropathy, unlike classic chronic inflammatory demyelinating polyneuropathy, is characterized by distally predominant sensory symptoms with no or mild distal weakness. We describe the clinical, laboratory, and neurophysiological findings of 2 patients who developed distal acquired demyelinating symmetric neuropathy after vaccination. Immunomodulatory therapy led to clinical improvement in both cases. The literature is reviewed with attention to the clinical features of chronic immune-mediated neuropathies that follow vaccination.

Full Text

Duke Authors

Cited Authors

  • Gable, KL; Afshari, Z; Sufit, RL; Allen, JA

Published Date

  • March 2013

Published In

Volume / Issue

  • 14 / 3

Start / End Page

  • 117 - 122

PubMed ID

  • 23492464

Electronic International Standard Serial Number (EISSN)

  • 1537-1611

Digital Object Identifier (DOI)

  • 10.1097/CND.0b013e318285256b


  • eng

Conference Location

  • United States