Karissa Lorraine Gable | Scholars@Duke

Karissa Lorraine Gable
Associate Professor of Neurology

Current Appointments & Affiliations

Associate Professor of Neurology, Neurology, Neuromuscular Disease, Neurology 2021

Contact Information

DUMC 3909, Durham, NC 27710
(919) 668-3786

Background
Education, Training, & Certifications
- Partners Neuromuscular Fellowship, Brigham And Women's Hospital, Massachusetts General Hospital 2013 - 2014
- Neurology Residency, Neurology, Northwestern Memorial Hospital 2010 - 2013
- Internal Medicine Residency, Medicine, The University of Chicago 2009 - 2010
- M.D., University of North Carolina - Chapel Hill 2009
Previous Appointments & Affiliations
- Associate Professor of Neurology, Neurology, Neuromuscular Disease, Neurology 2021 - 2022
- Assistant Professor of Neurology, Neurology, Neuromuscular Disease, Neurology 2019 - 2020
- Assistant Professor of Neurology, Neurology, Neuromuscular Disease, Neurology 2018 - 2020
- Assistant Professor of Neurology, Neurology, Neuromuscular Disease, Neurology 2017 - 2019
- Assistant Professor of Neurology, Neurology, Neuromuscular Disease, Neurology 2016 - 2018
- Assistant Professor of Neurology, Neurology, Neuromuscular Disease, Neurology 2015 - 2017
- Assistant Professor of Neurology, Neurology, Neuromuscular Disease, Neurology 2014 - 2016
- Assistant Professor of Neurology, Neurology, Neuromuscular Disease, Neurology 2014 - 2015
Research
Selected Grants
- Open-label Extension of the ARGX-113-1802 Trial to Investigate the Long-term Safety, Tolerability, and Efficacy of Efgartigimod PH20 SC in Patients with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) awarded by Argenx BVBA 2021 - 2024
- MultiCenter, Randomized, Double-Blind study of Rozanolixizumab in Subjects with Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) awarded by UCB Biopharma SPRL 2020 - 2023
- Open Label Extension study of Rozanolixizumab in CIDP awarded by UCB Biopharma SPRL 2020 - 2022
- A Phase 2 Trial to Investigate the Efficacy, Safety, and Tolerability of Efgartigimod PH20 SC in Adult Patients with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) (ADHERE) awarded by Argenex BVBA 2020 - 2022
- Electrical Impedance Myography and Muscle Ultrasound: Longitudinal Measures in Pompe Disease awarded by Genzyme Corporation 2016 - 2021
- Pathogenic Th17 cell pathology in CIDP awarded by GBS/CIDP Foundation International 2019 - 2021
- Mechanisms of Immune Dysregulation in Chronic Inflammatory Demyelinating Polyneuropathy awarded by AANEM Foundation for Research & Education 2019 - 2020
- Exploratory Study of BioMarkers Predicting Response to Immunosuppressives in Myasthenia Gravis awarded by Duke Clinical Research Institute 2015 - 2020
- Role of CD4 T Cell subsets as drivers of MG Diseases -EPM 6568 awarded by Myasthenia Gravis Foundation 2018 - 2019
External Relationships
- Apellis Pharmaceuticals
- Continuum review article for AAN
- Medscape ( WebMD HLTH Corp.)
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Gable, Karissa L., Stojan Peric, Michael W. Lutz, Ivo Bozovic, Milutin Petrovic, Aleksandar Stojanov, Ivana Basta, and Jeffrey A. Allen. “A longitudinal evaluation of fatigue in chronic inflammatory demyelinating polyneuropathy.” Brain Behav 12, no. 8 (August 2022): e2712. https://doi.org/10.1002/brb3.2712.
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  - London, Zachary N., Karissa L. Gable, Ragav Govindarajan, Amanda C. Guidon, Kelly G. Gwathmey, Michael K. Hehir, Matthew Imperioli, et al. “The neuromuscular fellowship portal and match.” Muscle Nerve 65, no. 6 (June 2022): 640–45. https://doi.org/10.1002/mus.27525.
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  - Rumsey, J. W., C. Lorance, M. Jackson, T. Sasserath, C. W. McAleer, C. J. Long, A. Goswami, et al. “Classical Complement Pathway Inhibition in a “Human-On-A-Chip” Model of Autoimmune Demyelinating Neuropathies.” Advanced Therapeutics 5, no. 6 (June 1, 2022). https://doi.org/10.1002/adtp.202200030.
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  - Massey, Janice M., and Karissa L. Gable. “Neuromuscular Disorders and Pregnancy.” Continuum (Minneap Minn) 28, no. 1 (February 1, 2022): 55–71. https://doi.org/10.1212/CON.0000000000001069.
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  - Gable, Karissa L., and Jeffrey A. Allen. “Could posturography be a useful outcome measure for chronic inflammatory demyelinating polyneuropathy?” Muscle Nerve 65, no. 1 (January 2022): 7–9. https://doi.org/10.1002/mus.27438.
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  - Gable, Karissa L., and Lisa D. Hobson-Webb. “What is the significance of gender difference in myasthenia gravis?” Muscle Nerve 64, no. 5 (November 2021): 515–16. https://doi.org/10.1002/mus.27397.
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  - Gable, Karissa L., and Lisa D. Hobson-Webb. “The axonal Z-score: Can electrodiagnostic testing find a new role in chronic inflammatory demyelinating polyneuropathy?” Clin Neurophysiol 132, no. 4 (April 2021): 998–99. https://doi.org/10.1016/j.clinph.2021.02.001.
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  - Guptill, Jeffrey T., Richard Barfield, Cliburn Chan, Melissa A. Russo, Doug Emmett, Shruti Raja, Janice M. Massey, et al. “Reduced plasmablast frequency is associated with seronegative myasthenia gravis.” Muscle Nerve 63, no. 4 (April 2021): 577–85. https://doi.org/10.1002/mus.27140.
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  - Li, Yingkai, C Douglas Emmett, Marjan Cobbaert, Donald B. Sanders, Vern C. Juel, Lisa D. Hobson-Webb, Janice M. Massey, et al. “Knowledge and perceptions of the COVID-19 pandemic among patients with myasthenia gravis.” Muscle Nerve 63, no. 3 (March 2021): 357–64. https://doi.org/10.1002/mus.27130.
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  - Wainger, Brian J., Eric A. Macklin, Steve Vucic, Courtney E. McIlduff, Sabrina Paganoni, Nicholas J. Maragakis, Richard Bedlack, et al. “Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.” Jama Neurol 78, no. 2 (February 1, 2021): 186–96. https://doi.org/10.1001/jamaneurol.2020.4300.
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  - Gable, Karissa L., Hrayr Attarian, and Jeffrey A. Allen. “Fatigue in chronic inflammatory demyelinating polyneuropathy.” Muscle Nerve 62, no. 6 (December 2020): 673–80. https://doi.org/10.1002/mus.27038.
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  - Yi, John S., Melissa A. Russo, Shruti Raja, Janice M. Massey, Vern C. Juel, Jay Shin, Lisa D. Hobson-Webb, Karissa Gable, and Jeffrey T. Guptill. “Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis.” Exp Neurol 325 (March 2020): 113146. https://doi.org/10.1016/j.expneurol.2019.113146.
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  - Gable, Karissa L., and Jeffrey T. Guptill. “Antagonism of the Neonatal Fc Receptor as an Emerging Treatment for Myasthenia Gravis.” Front Immunol 10 (2019): 3052. https://doi.org/10.3389/fimmu.2019.03052.
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  - Safdieh, Joseph E., Adam D. Quick, Pearce J. Korb, Diego Torres-Russotto, Karissa L. Gable, Maggie Rock, Carolyn Cahill, Madhu Soni, and Madhu American Academy of Neurology Consortium of Neurology Clerkship Directors 2017 Neurology Clerkship Director Survey Workgroup. “A dozen years of evolution of neurology clerkships in the United States: Looking up.” Neurology 91, no. 15 (October 9, 2018): e1440–47. https://doi.org/10.1212/WNL.0000000000006170.
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  - Gwathmey, Kelly G., Reza Sadjadi, William B. Horton, Mark R. Conaway, Carolina Barnett-Tapia, Vera Bril, James W. Russell, et al. “Validation of a simple disease-specific, quality-of-life measure for diabetic polyneuropathy: CAPPRI.” Neurology 90, no. 23 (June 5, 2018): e2034–41. https://doi.org/10.1212/WNL.0000000000005643.
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  - Schaik, Ivo N. van, Orell Mielke, and Orell PATH study group. “Intravenous versus subcutaneous immunoglobulin - Authors' reply.” Lancet Neurol 17, no. 5 (May 2018): 393–94. https://doi.org/10.1016/S1474-4422(18)30109-1.
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  - Schaik, Ivo N. van, Vera Bril, Nan van Geloven, Hans-Peter Hartung, Richard A. Lewis, Gen Sobue, John-Philip Lawo, et al. “Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial.” Lancet Neurol 17, no. 1 (January 2018): 35–46. https://doi.org/10.1016/S1474-4422(17)30378-2.
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  - Yi, John S., Melissa A. Russo, Janice M. Massey, Vern Juel, Lisa D. Hobson-Webb, Karissa Gable, Shruti M. Raja, Kristina Balderson, Kent J. Weinhold, and Jeffrey T. Guptill. “B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity.” Front Neurol 8 (2017): 34. https://doi.org/10.3389/fneur.2017.00034.
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  - Burns, Ted M., Reza Sadjadi, Kimiaki Utsugisawa, Kelly G. Gwathmey, Amruta Joshi, Sarah Jones, Vera Bril, et al. “International clinimetric evaluation of the MG-QOL15, resulting in slight revision and subsequent validation of the MG-QOL15r.” Muscle Nerve 54, no. 6 (December 2016): 1015–22. https://doi.org/10.1002/mus.25198.
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  - Billakota, Santoshi, Carolina Dejesus-Acosta, Karissa Gable, E Wayne Massey, and Lisa D. Hobson-Webb. “Ultrasound in EMG-Guided Biopsies: A Prospective, Randomized Pilot Trial.” Muscle Nerve 54, no. 4 (October 2016): 786–88. https://doi.org/10.1002/mus.25201.
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  - Gwathmey, Kelly G., Mark R. Conaway, Reza Sadjadi, Amruta Joshi, Carolina Barnett, Vera Bril, Eduardo Ng, et al. “Construction and validation of the chronic acquired polyneuropathy patient-reported index (CAP-PRI): A disease-specific, health-related quality-of-life instrument.” Muscle Nerve 54, no. 1 (June 2016): 9–17. https://doi.org/10.1002/mus.24985.
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  - Burns, Ted M., Gordon A. Smith, Jeffrey A. Allen, Anthony A. Amato, W David Arnold, Richard Barohn, Michael Benatar, et al. “Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine.” Muscle Nerve 53, no. 2 (February 2016): 165–68. https://doi.org/10.1002/mus.25009.
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  - Gable, Karissa L., and Janice M. Massey. “Presynaptic Disorders: Lambert-Eaton Myasthenic Syndrome and Botulism.” Semin Neurol 35, no. 4 (August 2015): 340–46. https://doi.org/10.1055/s-0035-1558976.
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  - Gable, Karissa L., Zahra Afshari, Robert L. Sufit, and Jeffrey A. Allen. “Distal acquired demyelinating symmetric neuropathy after vaccination.” J Clin Neuromuscul Dis 14, no. 3 (March 2013): 117–22. https://doi.org/10.1097/CND.0b013e318285256b.
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  - Cox, E. T., L. H. Brennaman, K. L. Gable, R. M. Hamer, L. A. Glantz, A. -. S. Lamantia, J. A. Lieberman, J. H. Gilmore, P. F. Maness, and L. F. Jarskog. “Developmental regulation of neural cell adhesion molecule in human prefrontal cortex.” Neuroscience 162, no. 1 (August 4, 2009): 96–105. https://doi.org/10.1016/j.neuroscience.2009.04.037.
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  - Meyer, Gary E., Louis Chesler, Dandan Liu, Karissa Gable, Betty A. Maddux, David D. Goldenberg, Jack F. Youngren, et al. “Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.” J Cell Biochem 102, no. 6 (December 15, 2007): 1529–41. https://doi.org/10.1002/jcb.21373.
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  - Jarskog, L Fredrik, John H. Gilmore, Leisa A. Glantz, Karissa L. Gable, Thomas T. German, Ruth I. Tong, and Jeffrey A. Lieberman. “Caspase-3 activation in rat frontal cortex following treatment with typical and atypical antipsychotics.” Neuropsychopharmacology 32, no. 1 (January 2007): 95–102. https://doi.org/10.1038/sj.npp.1301074.
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  - Gable, Karissa L., Betty A. Maddux, Cristina Penaranda, Marianna Zavodovskaya, Michael J. Campbell, Margaret Lobo, Louise Robinson, et al. “Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth.” Mol Cancer Ther 5, no. 4 (April 2006): 1079–86. https://doi.org/10.1158/1535-7163.MCT-05-0397.
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  - Youngren, Jack F., Karissa Gable, Cristina Penaranda, Betty A. Maddux, Marianna Zavodovskaya, Margaret Lobo, Michael Campbell, John Kerner, and Ira D. Goldfine. “Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.” Breast Cancer Res Treat 94, no. 1 (November 2005): 37–46. https://doi.org/10.1007/s10549-005-6939-z.
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Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Previous Appointments & Affiliations

Selected Grants

External Relationships

Selected Publications

Academic Articles

Recent Courses