Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Partners Neuromuscular Fellowship, Brigham And Women's Hospital, Massachusetts General Hospital 2013 - 2014
  • Neurology Residency, Neurology, Northwestern Memorial Hospital 2010 - 2013
  • Internal Medicine Residency, Medicine, The University of Chicago 2009 - 2010
  • M.D., University of North Carolina at Chapel Hill 2009
• Research
• 

  Selected Grants

  • Mechanisms of Immune Dysregulation in Chronic Inflammatory Demyelinating Polyneuropathy 2019 - 2020
  • Electrical Impedance Myography and Muscle Ultrasound: Longitudinal Measures in Pompe Disease 2016 - 2020
  • Pathogenic Th17 cell pathology in CIDP 2019 - 2020
  • Exploratory Study of BioMarkers Predicting Response to Immunosuppressives in Myasthenia Gravis awarded by Duke Clinical Research Institute 2015 - 2019
  • Role of CD4 T Cell subsets as drivers of MG Diseases -EPM 6568 2018
• 

  External Relationships

  • Akcea
  • Stealth Biotherapeutics
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Yi, John S., Melissa A. Russo, Shruti Raja, Janice M. Massey, Vern C. Juel, Jay Shin, Lisa D. Hobson-Webb, Karissa Gable, and Jeffrey T. Guptill. “Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis.” Exp Neurol 325 (March 2020): 113146. https://doi.org/10.1016/j.expneurol.2019.113146.
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    • Safdieh, Joseph E., Adam D. Quick, Pearce J. Korb, Diego Torres-Russotto, Karissa L. Gable, Maggie Rock, Carolyn Cahill, Madhu Soni, and Madhu American Academy of Neurology Consortium of Neurology Clerkship Directors 2017 Neurology Clerkship Director Survey Workgroup. “A dozen years of evolution of neurology clerkships in the United States: Looking up.” Neurology 91, no. 15 (October 9, 2018): e1440–47. https://doi.org/10.1212/WNL.0000000000006170.
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    • Gwathmey, Kelly G., Reza Sadjadi, William B. Horton, Mark R. Conaway, Carolina Barnett-Tapia, Vera Bril, James W. Russell, et al. “Validation of a simple disease-specific, quality-of-life measure for diabetic polyneuropathy: CAPPRI.” Neurology 90, no. 23 (June 5, 2018): e2034–41. https://doi.org/10.1212/WNL.0000000000005643.
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    • Schaik, Ivo N. van, Orell Mielke, and Orell PATH study group. “Intravenous versus subcutaneous immunoglobulin - Authors' reply.” Lancet Neurol 17, no. 5 (May 2018): 393–94. https://doi.org/10.1016/S1474-4422(18)30109-1.
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    • Schaik, Ivo N. van, Vera Bril, Nan van Geloven, Hans-Peter Hartung, Richard A. Lewis, Gen Sobue, John-Philip Lawo, et al. “Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial.” Lancet Neurol 17, no. 1 (January 2018): 35–46. https://doi.org/10.1016/S1474-4422(17)30378-2.
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    • Yi, John S., Melissa A. Russo, Janice M. Massey, Vern Juel, Lisa D. Hobson-Webb, Karissa Gable, Shruti M. Raja, Kristina Balderson, Kent J. Weinhold, and Jeffrey T. Guptill. “B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity.” Front Neurol 8 (2017): 34. https://doi.org/10.3389/fneur.2017.00034.
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    • Burns, Ted M., Reza Sadjadi, Kimiaki Utsugisawa, Kelly G. Gwathmey, Amruta Joshi, Sarah Jones, Vera Bril, et al. “International clinimetric evaluation of the MG-QOL15, resulting in slight revision and subsequent validation of the MG-QOL15r.” Muscle Nerve 54, no. 6 (December 2016): 1015–22. https://doi.org/10.1002/mus.25198.
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    • Billakota, Santoshi, Carolina Dejesus-Acosta, Karissa Gable, E Wayne Massey, and Lisa D. Hobson-Webb. “Ultrasound in EMG-Guided Biopsies: A Prospective, Randomized Pilot Trial.” Muscle Nerve 54, no. 4 (October 2016): 786–88. https://doi.org/10.1002/mus.25201.
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    • Gwathmey, Kelly G., Mark R. Conaway, Reza Sadjadi, Amruta Joshi, Carolina Barnett, Vera Bril, Eduardo Ng, et al. “Construction and validation of the chronic acquired polyneuropathy patient-reported index (CAP-PRI): A disease-specific, health-related quality-of-life instrument.” Muscle Nerve 54, no. 1 (June 2016): 9–17. https://doi.org/10.1002/mus.24985.
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    • Burns, Ted M., Gordon A. Smith, Jeffrey A. Allen, Anthony A. Amato, W David Arnold, Richard Barohn, Michael Benatar, et al. “Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine.” Muscle Nerve 53, no. 2 (February 2016): 165–68. https://doi.org/10.1002/mus.25009.
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    • Gable, Karissa L., and Janice M. Massey. “Presynaptic Disorders: Lambert-Eaton Myasthenic Syndrome and Botulism.” Semin Neurol 35, no. 4 (August 2015): 340–46. https://doi.org/10.1055/s-0035-1558976.
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    • Gable, Karissa L., Zahra Afshari, Robert L. Sufit, and Jeffrey A. Allen. “Distal acquired demyelinating symmetric neuropathy after vaccination.” J Clin Neuromuscul Dis 14, no. 3 (March 2013): 117–22. https://doi.org/10.1097/CND.0b013e318285256b.
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    • Cox, E. T., L. H. Brennaman, K. L. Gable, R. M. Hamer, L. A. Glantz, A. -. S. Lamantia, J. A. Lieberman, J. H. Gilmore, P. F. Maness, and L. F. Jarskog. “Developmental regulation of neural cell adhesion molecule in human prefrontal cortex.” Neuroscience 162, no. 1 (August 4, 2009): 96–105. https://doi.org/10.1016/j.neuroscience.2009.04.037.
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    • Meyer, Gary E., Louis Chesler, Dandan Liu, Karissa Gable, Betty A. Maddux, David D. Goldenberg, Jack F. Youngren, et al. “Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.” J Cell Biochem 102, no. 6 (December 15, 2007): 1529–41. https://doi.org/10.1002/jcb.21373.
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    • Jarskog, L Fredrik, John H. Gilmore, Leisa A. Glantz, Karissa L. Gable, Thomas T. German, Ruth I. Tong, and Jeffrey A. Lieberman. “Caspase-3 activation in rat frontal cortex following treatment with typical and atypical antipsychotics.” Neuropsychopharmacology 32, no. 1 (January 2007): 95–102. https://doi.org/10.1038/sj.npp.1301074.
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    • Gable, Karissa L., Betty A. Maddux, Cristina Penaranda, Marianna Zavodovskaya, Michael J. Campbell, Margaret Lobo, Louise Robinson, et al. “Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth.” Mol Cancer Ther 5, no. 4 (April 2006): 1079–86. https://doi.org/10.1158/1535-7163.MCT-05-0397.
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    • Youngren, Jack F., Karissa Gable, Cristina Penaranda, Betty A. Maddux, Marianna Zavodovskaya, Margaret Lobo, Michael Campbell, John Kerner, and Ira D. Goldfine. “Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.” Breast Cancer Res Treat 94, no. 1 (November 2005): 37–46. https://doi.org/10.1007/s10549-005-6939-z.
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• Teaching & Mentoring
• 

  Recent Courses

  • NEURO 209C: Longitudinal Integrated Curriculum - Neurology 2020
  • NEURO 401C: Neurology Sub-Internship 2020
  • NEURO 404C: Consultative Neurology 2019
  • NEURO 205C: Neurology 2018

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