Karissa Lorraine Gable
Associate Professor of Neurology
Current Appointments & Affiliations
- Associate Professor of Neurology, Neurology, Neuromuscular Disease, Neurology 2021
Contact Information
- DUMC 3909, Durham, NC 27710
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(919) 668-3786
- Background
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Education, Training, & Certifications
- Partners Neuromuscular Fellowship, Brigham And Women's Hospital, Massachusetts General Hospital 2013 - 2014
- Neurology Residency, Neurology, Northwestern Memorial Hospital 2010 - 2013
- Internal Medicine Residency, Medicine, The University of Chicago 2009 - 2010
- M.D., University of North Carolina - Chapel Hill 2009
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Previous Appointments & Affiliations
- Assistant Professor of Neurology, Neurology, Neuromuscular Disease, Neurology 2014 - 2020
- Research
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Selected Grants
- Open-label Extension of the ARGX-113-1802 Trial to Investigate the Long-term Safety, Tolerability, and Efficacy of Efgartigimod PH20 SC in Patients with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) awarded by Argenx BVBA 2021 - 2024
- Inflammatory Neuropathy Consortium data Base (INCBase): A prospective international CIDP registry awarded by University of Minnesota 2022 - 2024
- Open Label Extension study of Rozanolixizumab in CIDP awarded by UCB Biopharma SPRL 2020 - 2022
- A Phase 2 Trial to Investigate the Efficacy, Safety, and Tolerability of Efgartigimod PH20 SC in Adult Patients with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) (ADHERE) awarded by Argenex BVBA 2020 - 2022
- Electrical Impedance Myography and Muscle Ultrasound: Longitudinal Measures in Pompe Disease awarded by Genzyme Corporation 2016 - 2021
- MultiCenter, Randomized, Double-Blind study of Rozanolixizumab in Subjects with Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) awarded by UCB Biopharma SPRL 2020 - 2021
- Pathogenic Th17 cell pathology in CIDP awarded by GBS/CIDP Foundation International 2019 - 2021
- Mechanisms of Immune Dysregulation in Chronic Inflammatory Demyelinating Polyneuropathy awarded by AANEM Foundation for Research & Education 2019 - 2020
- Exploratory Study of BioMarkers Predicting Response to Immunosuppressives in Myasthenia Gravis awarded by Duke Clinical Research Institute 2015 - 2020
- Role of CD4 T Cell subsets as drivers of MG Diseases -EPM 6568 awarded by Myasthenia Gravis Foundation 2018 - 2019
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External Relationships
- AANEM
- Adelphi Values
- Adivo Associates
- Beacon consulting group
- Cowen and Company
- Guidepoint
- KeyQuest Health
- MarketPlus
- Medscape ( WebMD HLTH Corp.)
- Pharmacy Times Continuing Education
- REACH Institute
- TECHSPERT
- Triangle Insights Group
- Ultragenyx
- argenx US, Inc
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Gable, Karissa L., Stojan Peric, Michael W. Lutz, Ivo Bozovic, Milutin Petrovic, Aleksandar Stojanov, Ivana Basta, and Jeffrey A. Allen. “A longitudinal evaluation of fatigue in chronic inflammatory demyelinating polyneuropathy.” Brain Behav 12, no. 8 (August 2022): e2712. https://doi.org/10.1002/brb3.2712.Full Text Link to Item
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London, Zachary N., Karissa L. Gable, Ragav Govindarajan, Amanda C. Guidon, Kelly G. Gwathmey, Michael K. Hehir, Matthew Imperioli, et al. “The neuromuscular fellowship portal and match.” Muscle Nerve 65, no. 6 (June 2022): 640–45. https://doi.org/10.1002/mus.27525.Full Text Link to Item
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Rumsey, John W., Case Lorance, Max Jackson, Trevor Sasserath, Christopher W. McAleer, Christopher J. Long, Arindom Goswami, et al. “Classical Complement Pathway Inhibition in a "Human-On-A-Chip" Model of Autoimmune Demyelinating Neuropathies.” Adv Ther (Weinh) 5, no. 6 (June 2022). https://doi.org/10.1002/adtp.202200030.Full Text Link to Item
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Massey, Janice M., and Karissa L. Gable. “Neuromuscular Disorders and Pregnancy.” Continuum (Minneap Minn) 28, no. 1 (February 1, 2022): 55–71. https://doi.org/10.1212/CON.0000000000001069.Full Text Link to Item
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Gable, Karissa L., and Jeffrey A. Allen. “Could posturography be a useful outcome measure for chronic inflammatory demyelinating polyneuropathy?” Muscle Nerve 65, no. 1 (January 2022): 7–9. https://doi.org/10.1002/mus.27438.Full Text Link to Item
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Gable, Karissa L., and Lisa D. Hobson-Webb. “What is the significance of gender difference in myasthenia gravis?” Muscle Nerve 64, no. 5 (November 2021): 515–16. https://doi.org/10.1002/mus.27397.Full Text Link to Item
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Gable, Karissa L., and Lisa D. Hobson-Webb. “The axonal Z-score: Can electrodiagnostic testing find a new role in chronic inflammatory demyelinating polyneuropathy?” Clin Neurophysiol 132, no. 4 (April 2021): 998–99. https://doi.org/10.1016/j.clinph.2021.02.001.Full Text Link to Item
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Guptill, Jeffrey T., Richard Barfield, Cliburn Chan, Melissa A. Russo, Doug Emmett, Shruti Raja, Janice M. Massey, et al. “Reduced plasmablast frequency is associated with seronegative myasthenia gravis.” Muscle Nerve 63, no. 4 (April 2021): 577–85. https://doi.org/10.1002/mus.27140.Full Text Link to Item
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Li, Yingkai, C Douglas Emmett, Marjan Cobbaert, Donald B. Sanders, Vern C. Juel, Lisa D. Hobson-Webb, Janice M. Massey, et al. “Knowledge and perceptions of the COVID-19 pandemic among patients with myasthenia gravis.” Muscle Nerve 63, no. 3 (March 2021): 357–64. https://doi.org/10.1002/mus.27130.Full Text Link to Item
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Wainger, Brian J., Eric A. Macklin, Steve Vucic, Courtney E. McIlduff, Sabrina Paganoni, Nicholas J. Maragakis, Richard Bedlack, et al. “Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.” Jama Neurol 78, no. 2 (February 1, 2021): 186–96. https://doi.org/10.1001/jamaneurol.2020.4300.Full Text Link to Item
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Gable, Karissa L., Hrayr Attarian, and Jeffrey A. Allen. “Fatigue in chronic inflammatory demyelinating polyneuropathy.” Muscle Nerve 62, no. 6 (December 2020): 673–80. https://doi.org/10.1002/mus.27038.Full Text Link to Item
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Yi, John S., Melissa A. Russo, Shruti Raja, Janice M. Massey, Vern C. Juel, Jay Shin, Lisa D. Hobson-Webb, Karissa Gable, and Jeffrey T. Guptill. “Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis.” Exp Neurol 325 (March 2020): 113146. https://doi.org/10.1016/j.expneurol.2019.113146.Full Text Link to Item
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Gable, Karissa L., and Jeffrey T. Guptill. “Antagonism of the Neonatal Fc Receptor as an Emerging Treatment for Myasthenia Gravis.” Front Immunol 10 (2019): 3052. https://doi.org/10.3389/fimmu.2019.03052.Full Text Link to Item
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Safdieh, Joseph E., Adam D. Quick, Pearce J. Korb, Diego Torres-Russotto, Karissa L. Gable, Maggie Rock, Carolyn Cahill, Madhu Soni, and Madhu American Academy of Neurology Consortium of Neurology Clerkship Directors 2017 Neurology Clerkship Director Survey Workgroup. “A dozen years of evolution of neurology clerkships in the United States: Looking up.” Neurology 91, no. 15 (October 9, 2018): e1440–47. https://doi.org/10.1212/WNL.0000000000006170.Full Text Link to Item
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Gwathmey, Kelly G., Reza Sadjadi, William B. Horton, Mark R. Conaway, Carolina Barnett-Tapia, Vera Bril, James W. Russell, et al. “Validation of a simple disease-specific, quality-of-life measure for diabetic polyneuropathy: CAPPRI.” Neurology 90, no. 23 (June 5, 2018): e2034–41. https://doi.org/10.1212/WNL.0000000000005643.Full Text Link to Item
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Schaik, Ivo N. van, Orell Mielke, and Orell PATH study group. “Intravenous versus subcutaneous immunoglobulin - Authors' reply.” Lancet Neurol 17, no. 5 (May 2018): 393–94. https://doi.org/10.1016/S1474-4422(18)30109-1.Full Text Link to Item
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Schaik, Ivo N. van, Vera Bril, Nan van Geloven, Hans-Peter Hartung, Richard A. Lewis, Gen Sobue, John-Philip Lawo, et al. “Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial.” Lancet Neurol 17, no. 1 (January 2018): 35–46. https://doi.org/10.1016/S1474-4422(17)30378-2.Full Text Link to Item
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Yi, John S., Melissa A. Russo, Janice M. Massey, Vern Juel, Lisa D. Hobson-Webb, Karissa Gable, Shruti M. Raja, Kristina Balderson, Kent J. Weinhold, and Jeffrey T. Guptill. “B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity.” Front Neurol 8 (2017): 34. https://doi.org/10.3389/fneur.2017.00034.Full Text Open Access Copy Link to Item
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Burns, Ted M., Reza Sadjadi, Kimiaki Utsugisawa, Kelly G. Gwathmey, Amruta Joshi, Sarah Jones, Vera Bril, et al. “International clinimetric evaluation of the MG-QOL15, resulting in slight revision and subsequent validation of the MG-QOL15r.” Muscle Nerve 54, no. 6 (December 2016): 1015–22. https://doi.org/10.1002/mus.25198.Full Text Link to Item
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Billakota, Santoshi, Carolina Dejesus-Acosta, Karissa Gable, E Wayne Massey, and Lisa D. Hobson-Webb. “Ultrasound in EMG-Guided Biopsies: A Prospective, Randomized Pilot Trial.” Muscle Nerve 54, no. 4 (October 2016): 786–88. https://doi.org/10.1002/mus.25201.Full Text Link to Item
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Gwathmey, Kelly G., Mark R. Conaway, Reza Sadjadi, Amruta Joshi, Carolina Barnett, Vera Bril, Eduardo Ng, et al. “Construction and validation of the chronic acquired polyneuropathy patient-reported index (CAP-PRI): A disease-specific, health-related quality-of-life instrument.” Muscle Nerve 54, no. 1 (June 2016): 9–17. https://doi.org/10.1002/mus.24985.Full Text Link to Item
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Burns, Ted M., Gordon A. Smith, Jeffrey A. Allen, Anthony A. Amato, W David Arnold, Richard Barohn, Michael Benatar, et al. “Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine.” Muscle Nerve 53, no. 2 (February 2016): 165–68. https://doi.org/10.1002/mus.25009.Full Text Link to Item
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Gable, Karissa L., and Janice M. Massey. “Presynaptic Disorders: Lambert-Eaton Myasthenic Syndrome and Botulism.” Semin Neurol 35, no. 4 (August 2015): 340–46. https://doi.org/10.1055/s-0035-1558976.Full Text Link to Item
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Gable, Karissa L., Zahra Afshari, Robert L. Sufit, and Jeffrey A. Allen. “Distal acquired demyelinating symmetric neuropathy after vaccination.” J Clin Neuromuscul Dis 14, no. 3 (March 2013): 117–22. https://doi.org/10.1097/CND.0b013e318285256b.Full Text Link to Item
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Cox, E. T., L. H. Brennaman, K. L. Gable, R. M. Hamer, L. A. Glantz, A. -. S. Lamantia, J. A. Lieberman, J. H. Gilmore, P. F. Maness, and L. F. Jarskog. “Developmental regulation of neural cell adhesion molecule in human prefrontal cortex.” Neuroscience 162, no. 1 (August 4, 2009): 96–105. https://doi.org/10.1016/j.neuroscience.2009.04.037.Full Text Link to Item
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Meyer, Gary E., Louis Chesler, Dandan Liu, Karissa Gable, Betty A. Maddux, David D. Goldenberg, Jack F. Youngren, et al. “Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.” J Cell Biochem 102, no. 6 (December 15, 2007): 1529–41. https://doi.org/10.1002/jcb.21373.Full Text Link to Item
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Jarskog, L Fredrik, John H. Gilmore, Leisa A. Glantz, Karissa L. Gable, Thomas T. German, Ruth I. Tong, and Jeffrey A. Lieberman. “Caspase-3 activation in rat frontal cortex following treatment with typical and atypical antipsychotics.” Neuropsychopharmacology 32, no. 1 (January 2007): 95–102. https://doi.org/10.1038/sj.npp.1301074.Full Text Link to Item
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Gable, Karissa L., Betty A. Maddux, Cristina Penaranda, Marianna Zavodovskaya, Michael J. Campbell, Margaret Lobo, Louise Robinson, et al. “Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth.” Mol Cancer Ther 5, no. 4 (April 2006): 1079–86. https://doi.org/10.1158/1535-7163.MCT-05-0397.Full Text Link to Item
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Youngren, Jack F., Karissa Gable, Cristina Penaranda, Betty A. Maddux, Marianna Zavodovskaya, Margaret Lobo, Michael Campbell, John Kerner, and Ira D. Goldfine. “Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.” Breast Cancer Res Treat 94, no. 1 (November 2005): 37–46. https://doi.org/10.1007/s10549-005-6939-z.Full Text Link to Item
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- Teaching & Mentoring
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Recent Courses
- NEURO 205C: Neurology 2023
- NEURO 206C: Primary Care Leadership Track (PCLT)-Neurology 2023
- NEURO 209C: Longitudinal Integrated Curriculum - Neurology 2023
- NEURO 402C: Neurology Clerkship 2023
- NEURO 403C: Clinical Neurology Subspecialties 2023
- NEURO 404C: Consultative Neurology 2023
- NEURO 205C: Neurology 2022
- NEURO 206C: Primary Care Leadership Track (PCLT)-Neurology 2022
- NEURO 209C: Longitudinal Integrated Curriculum - Neurology 2022
- NEURO 402C: Neurology Clerkship 2022
- NEURO 403C: Clinical Neurology Subspecialties 2022
- NEURO 404C: Consultative Neurology 2022
- NEURO 205C: Neurology 2021
- NEURO 206C: Primary Care Leadership Track (PCLT)-Neurology 2021
- NEURO 209C: Longitudinal Integrated Curriculum - Neurology 2021
- NEURO 402C: Neurology Clerkship 2021
- NEURO 403C: Clinical Neurology Subspecialties 2021
- NEURO 404C: Consultative Neurology 2021
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