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Protocols for the initial treatment of moderately severe juvenile dermatomyositis: results of a Children's Arthritis and Rheumatology Research Alliance Consensus Conference.

Publication ,  Journal Article
Huber, AM; Giannini, EH; Bowyer, SL; Kim, S; Lang, B; Lindsley, CB; Pachman, LM; Pilkington, C; Reed, AM; Rennebohm, RM; Rider, LG ...
Published in: Arthritis Care Res (Hoboken)
February 2010

OBJECTIVE: To use juvenile dermatomyositis (DM) survey data and expert opinion to develop a small number of consensus treatment protocols, which reflect current initial treatment of moderately severe juvenile DM. METHODS: A consensus meeting was held in Toronto, Ontario, Canada on December 1-2, 2007. Nominal group technique was used to achieve consensus on treatment protocols, which represented typical management of moderately severe juvenile DM. Consensus was also reached as to which patients these protocols would be applicable (inclusion and exclusion criteria), which initial investigations should be done prior to initiating one of these protocols, which data should be collected to evaluate these protocols, and the concomitant interventions required or recommended. RESULTS: Three protocols that described the first 2 months of treatment were developed. All protocols included corticosteroids and methotrexate. One protocol also included intravenous gamma globulin. Consensus was achieved for all issues that were addressed by conference participants, although there were some areas of controversy. CONCLUSION: Despite considerable variation in clinical practice, it is possible to achieve consensus on the initial treatment of juvenile DM. Once these protocols are extended beyond 2 months, these protocols will be available for clinical use. By using methods that account for differences between patients (confounding by indication), the comparative effectiveness of the protocols will be evaluated. In the future, the goal will be to identify the optimal treatment of moderately severe juvenile DM.

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Published In

Arthritis Care Res (Hoboken)

DOI

EISSN

2151-4658

Publication Date

February 2010

Volume

62

Issue

2

Start / End Page

219 / 225

Location

United States

Related Subject Headings

  • gamma-Globins
  • Severity of Illness Index
  • Methotrexate
  • Injections, Intravenous
  • Humans
  • Dermatomyositis
  • Clinical Protocols
  • Antirheumatic Agents
  • Adrenal Cortex Hormones
  • 4201 Allied health and rehabilitation science
 

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Huber, A. M., Giannini, E. H., Bowyer, S. L., Kim, S., Lang, B., Lindsley, C. B., … Feldman, B. M. (2010). Protocols for the initial treatment of moderately severe juvenile dermatomyositis: results of a Children's Arthritis and Rheumatology Research Alliance Consensus Conference. Arthritis Care Res (Hoboken), 62(2), 219–225. https://doi.org/10.1002/acr.20071
Huber, Adam M., Edward H. Giannini, Suzanne L. Bowyer, Susan Kim, Bianca Lang, Carol B. Lindsley, Lauren M. Pachman, et al. “Protocols for the initial treatment of moderately severe juvenile dermatomyositis: results of a Children's Arthritis and Rheumatology Research Alliance Consensus Conference.Arthritis Care Res (Hoboken) 62, no. 2 (February 2010): 219–25. https://doi.org/10.1002/acr.20071.
Huber AM, Giannini EH, Bowyer SL, Kim S, Lang B, Lindsley CB, et al. Protocols for the initial treatment of moderately severe juvenile dermatomyositis: results of a Children's Arthritis and Rheumatology Research Alliance Consensus Conference. Arthritis Care Res (Hoboken). 2010 Feb;62(2):219–25.
Huber, Adam M., et al. “Protocols for the initial treatment of moderately severe juvenile dermatomyositis: results of a Children's Arthritis and Rheumatology Research Alliance Consensus Conference.Arthritis Care Res (Hoboken), vol. 62, no. 2, Feb. 2010, pp. 219–25. Pubmed, doi:10.1002/acr.20071.
Huber AM, Giannini EH, Bowyer SL, Kim S, Lang B, Lindsley CB, Pachman LM, Pilkington C, Reed AM, Rennebohm RM, Rider LG, Wallace CA, Feldman BM. Protocols for the initial treatment of moderately severe juvenile dermatomyositis: results of a Children's Arthritis and Rheumatology Research Alliance Consensus Conference. Arthritis Care Res (Hoboken). 2010 Feb;62(2):219–225.
Journal cover image

Published In

Arthritis Care Res (Hoboken)

DOI

EISSN

2151-4658

Publication Date

February 2010

Volume

62

Issue

2

Start / End Page

219 / 225

Location

United States

Related Subject Headings

  • gamma-Globins
  • Severity of Illness Index
  • Methotrexate
  • Injections, Intravenous
  • Humans
  • Dermatomyositis
  • Clinical Protocols
  • Antirheumatic Agents
  • Adrenal Cortex Hormones
  • 4201 Allied health and rehabilitation science