Overview
I have spent my career caring for children with autoimmune disorders and immune dysfunction. I have focused my work caring for children with juvenile dermatomyositis and auto inflammatory disorders. I have overseen a research program for 24 years studying the genetics and cause of human autoimmune disease, focused on dermatomyositis in children and adults. The long-term goal of my research team is to develop new biomarkers of diseases to identify those predisposed to develop disease, as well as monitor disease activity and response to treatment. My team makes extensive use of genomics, gene expression, protein expression and immunohistochemical techniques to study the inflammatory and non-inflammatory aspects of dermatomyositis diseases. Other autoimmune disease processes, including systemic lupus and vasculitis, have been focused on as well.
Current Appointments & Affiliations
Samuel L. Katz Distinguished Professor of Pediatrics
·
2018 - Present
Pediatrics,
Clinical Science Departments
Professor of Pediatrics
·
2014 - Present
Pediatrics,
Clinical Science Departments
Chair, Department of Pediatrics
·
2014 - Present
Pediatrics,
Clinical Science Departments
Core Faculty in Innovation & Entrepreneurship
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2021 - Present
Duke Innovation & Entrepreneurship,
University Initiatives & Academic Support Units
Recent Publications
Genetic Architecture of Idiopathic Inflammatory Myopathies From Meta-Analyses.
Journal Article Arthritis Rheumatol · December 16, 2024 OBJECTIVE: Idiopathic inflammatory myopathies (IIMs, myositis) are rare systemic autoimmune disorders that lead to muscle inflammation, weakness, and extramuscular manifestations, with a strong genetic component influencing disease development and progress ... Full text Link to item CiteA protocol for scoping reviews on the role of whole-body and dedicated body-part magnetic resonance imaging for assessment of adult and juvenile idiopathic inflammatory myopathies.
Journal Article Rheumatol Int · November 2024 Currently, standardized magnetic resonance imaging (MRI) scoring systems and protocols for assessment of idiopathic inflammatory myopathies (IIMs) in children and adults are lacking. Therefore, we will perform a scoping review of the literature to collate ... Full text Link to item CiteAtherosclerosis Progression in the APPLE Trial Can Be Predicted in Young People With Juvenile-Onset Systemic Lupus Erythematosus Using a Novel Lipid Metabolomic Signature.
Journal Article Arthritis Rheumatol · March 2024 OBJECTIVE: Patients with juvenile-onset systemic lupus erythematosus (JSLE) have increased atherosclerosis risk. This study investigated novel atherosclerosis progression biomarkers in the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) ... Full text Link to item CiteRecent Grants
Using Bioengineered Human Muscle to Develop Treatments for Juvenile Dermatomyositis
ResearchCollaborator · Awarded by Hartwell Foundation · 2025 - 2028An Invitation to Support the Division of Pediatric Gastroenterology, Hepatology & Nutrition
ResearchInvestigator · Awarded by Mario Family Foundation · 2022 - 2026Duke Center for Advancement of Child Health (CAtCH).
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2021 - 2026View All Grants
Education, Training & Certifications
Medical College of Ohio ·
1984
M.D.