Scholars@Duke
Ann Marie Reed

Ann Marie Reed

Samuel L. Katz Distinguished Professor of Pediatrics
Pediatrics
ann.reed@duke.edu
2301 Erwin Road, Box 3352, Durham, NC 27710
Not Shown, Not Shown, NC 27710

Selected Publications

A protocol for scoping reviews on the role of whole-body and dedicated body-part magnetic resonance imaging for assessment of adult and juvenile idiopathic inflammatory myopathies.

Journal Article Rheumatol Int · November 2024 Currently, standardized magnetic resonance imaging (MRI) scoring systems and protocols for assessment of idiopathic inflammatory myopathies (IIMs) in children and adults are lacking. Therefore, we will perform a scoping review of the literature to collate ... Full text Link to item Cite

Atherosclerosis Progression in the APPLE Trial Can Be Predicted in Young People With Juvenile-Onset Systemic Lupus Erythematosus Using a Novel Lipid Metabolomic Signature.

Journal Article Arthritis Rheumatol · March 2024 OBJECTIVE: Patients with juvenile-onset systemic lupus erythematosus (JSLE) have increased atherosclerosis risk. This study investigated novel atherosclerosis progression biomarkers in the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) ... Full text Link to item Cite

Juvenile Dermatomyositis

Chapter · January 1, 2024 Full text Cite

Performance of the 2016 ACR-EULAR myositis response criteria in juvenile dermatomyositis therapeutic trials and consensus profiles.

Journal Article Rheumatology (Oxford) · November 2, 2023 OBJECTIVES: The 2016 ACR-EULAR Response Criteria for JDM was developed as a composite measure with differential weights of six core set measures (CSMs) to calculate a Total Improvement Score (TIS). We assessed the contribution of each CSM, representation o ... Full text Link to item Cite

Health Equity Implications of Missing Data Among Youths With Childhood-Onset Systemic Lupus Erythematosus: A Proof-of-Concept Study in the Childhood Arthritis and Rheumatology Research Alliance Registry.

Journal Article Arthritis Care Res (Hoboken) · November 2023 OBJECTIVE: Health disparities in childhood-onset systemic lupus erythematosus (SLE) disproportionately impact marginalized populations. Socioeconomically patterned missing data can magnify existing health inequities by supporting inferences that may misrep ... Full text Link to item Cite

The evolving model of pediatric research.

Journal Article Pediatr Res · August 2023 Full text Link to item Cite

Changes in Confidence, Feelings, and Perceived Necessity Concerning COVID-19 Booster.

Journal Article Vaccines (Basel) · July 15, 2023 The COVID-19 booster first became available to all adults in the U.S. in November 2021 and a bivalent version in September 2022, but a large population remains booster-hesitant; only 17% of Americans have obtained the updated vaccine as of June 2023. We co ... Full text Link to item Cite

Childhood-Onset Lupus Nephritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: Short-Term Kidney Status and Variation in Care.

Journal Article Arthritis Care Res (Hoboken) · July 2023 OBJECTIVE: The goal was to characterize short-term kidney status and describe variation in early care utilization in a multicenter cohort of patients with childhood-onset systemic lupus erythematosus (cSLE) and nephritis. METHODS: We analyzed previously co ... Full text Link to item Cite

Identification of Novel Associations and Localization of Signals in Idiopathic Inflammatory Myopathies Using Genome-Wide Imputation.

Journal Article Arthritis & rheumatology (Hoboken, N.J.) · June 2023 ObjectiveThe idiopathic inflammatory myopathies (IIMs) are heterogeneous diseases thought to be initiated by immune activation in genetically predisposed individuals. We imputed variants from the ImmunoChip array using a large reference panel to f ... Full text Cite

Trajectories of disease activity in patients with JIA in the Childhood Arthritis and Rheumatology Research Alliance Registry.

Journal Article Rheumatology (Oxford) · February 1, 2023 OBJECTIVE: To describe 2-year trajectories of the clinical Juvenile Arthritis Disease Activity Score, 10 joints (cJADAS10) and associated baseline characteristics in patients with JIA. METHODS: JIA patients in the Childhood Arthritis and Rheumatology Resea ... Full text Link to item Cite

Anti–Valosin-Containing Protein (VCP/p97) Autoantibodies in Inclusion Body Myositis and Other Inflammatory Myopathies

Journal Article ACR Open Rheumatology · January 1, 2023 Objective: The rationale for this study was based on reports that valosin-containing protein (VCP) mutations are found in hereditary inclusion body myositis (IBM) and VCP was detected in rimmed vacuoles of sporadic IBM (sIBM) muscle biopsies. Autoantibodie ... Full text Cite

Juvenile Dermatomyositis

Chapter · January 1, 2023 • Juvenile dermatomyositis (JDM) is the most common idiopathic inflammatory myopathy (IIM) of childhood. Although JDM shares some risk factors, clinical and laboratory features with its adult counterpart, a number of features distinguish JDM from adult DM. ... Full text Cite

Gene Expression Profiles of Treatment Response and Non-Response in Children With Juvenile Dermatomyositis.

Journal Article ACR Open Rheumatol · August 2022 OBJECTIVE: The study objective was to identify differences in gene expression between treatment responders (TRs) and treatment non-responders (TNRs) diagnosed with juvenile dermatomyositis (JDM). METHODS: Gene expression analyses were performed using whole ... Full text Link to item Cite

Association with HLA-DRβ1 position 37 distinguishes juvenile dermatomyositis from adult-onset myositis.

Journal Article Hum Mol Genet · July 21, 2022 Juvenile dermatomyositis (JDM) is a rare, severe autoimmune disease and the most common idiopathic inflammatory myopathy of children. JDM and adult-onset dermatomyositis (DM) have similar clinical, biological and serological features, although these featur ... Full text Link to item Cite

Baseline characteristics of children with juvenile dermatomyositis enrolled in the first year of the new Childhood Arthritis and Rheumatology Research Alliance registry.

Journal Article Pediatr Rheumatol Online J · July 19, 2022 BACKGROUND: To report baseline characteristics, patient reported outcomes and treatment of children with Juvenile Dermatomyositis (JDM) in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. METHODS: Children newly diagnosed with J ... Full text Link to item Cite

Academic Careers in Advocacy: Aligning Institutional Values Through Use of an Advocacy Portfolio.

Journal Article Pediatrics · July 1, 2022 Academic children's hospitals must embrace advocacy as a central component of their missions to discover new knowledge and improve the health of the communities and patients they serve. To do so, they must ensure faculty have both the tools and the opportu ... Full text Link to item Cite

Metabolomics analysis identifies a lipidomic profile in treatment-naïve juvenile dermatomyositis patients vs healthy control subjects.

Journal Article Rheumatology (Oxford) · April 11, 2022 OBJECTIVES: To perform an exploratory study to identify a JDM serum metabolic profile that differs from healthy controls (HCs) and responds to immunosuppressive treatment. METHODS: Blood was collected from 9 HCs and 10 patients diagnosed with probable (n = ... Full text Link to item Cite

Social determinants of health influence disease activity and functional disability in Polyarticular Juvenile Idiopathic Arthritis.

Journal Article Pediatr Rheumatol Online J · March 7, 2022 BACKGROUND: Social determinants of health (SDH) greatly influence outcomes during the first year of treatment in rheumatoid arthritis, a disease similar to polyarticular juvenile idiopathic arthritis (pJIA). We investigated the correlation of community pov ... Full text Link to item Cite

Down Syndrome-Associated Arthritis Cohort in the New Childhood Arthritis and Rheumatology Research Alliance Registry: Clinical Characteristics, Treatment, and Outcomes.

Conference Arthritis Care Res (Hoboken) · December 2021 OBJECTIVE: Down syndrome-associated arthritis (DA) is underrecognized, and current therapies used for juvenile idiopathic arthritis (JIA) appear to be poorly tolerated and less effective in patients with DA. The objective of this study was to characterize ... Full text Link to item Cite

Impact of the Season of Birth on the Development of Juvenile Idiopathic Arthritis in the United States: A Nationwide Registry-based Study.

Journal Article J Rheumatol · December 2021 OBJECTIVE: Autoimmune disorders result from the interplay of genetic and environmental factors. Many autoimmune disorders are associated with specific seasons of birth, implicating a role for environmental determinants in their etiopathology. We investigat ... Full text Link to item Cite

Improved Disease Course Associated With Early Initiation of Biologics in Polyarticular Juvenile Idiopathic Arthritis: Trajectory Analysis of a Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans Study.

Journal Article Arthritis Rheumatol · October 2021 OBJECTIVE: To investigate the effects of early introduction of biologic disease-modifying antirheumatic drugs (bDMARDs) on the disease course in untreated polyarticular juvenile idiopathic arthritis (JIA). METHODS: We analyzed data on patients with polyart ... Full text Link to item Cite

Optimizing the Start Time of Biologics in Polyarticular Juvenile Idiopathic Arthritis: A Comparative Effectiveness Study of Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans.

Journal Article Arthritis Rheumatol · October 2021 OBJECTIVE: The optimal time to start biologics in polyarticular juvenile idiopathic arthritis (JIA) remains uncertain. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed 3 consensus treatment plans (CTPs) for untreated polyarticul ... Full text Link to item Cite

Patterns of etanercept use in juvenile idiopathic arthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry.

Journal Article Pediatr Rheumatol Online J · August 21, 2021 BACKGROUND: We aimed to characterize etanercept (ETN) use in juvenile idiopathic arthritis (JIA) patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. METHODS: The CARRA Registry is a convenience cohort of patien ... Full text Link to item Cite

Community poverty level influences time to first pediatric rheumatology appointment in Polyarticular Juvenile Idiopathic Arthritis.

Journal Article Pediatr Rheumatol Online J · August 14, 2021 BACKGROUND: The impact of social determinants of health on children with polyarticular juvenile idiopathic arthritis (pJIA) is poorly understood. Prompt initiation of treatment for pJIA is important to prevent disease morbidity; however, a potential barrie ... Full text Link to item Cite

Biologic Switching Among Nonsystemic Juvenile Idiopathic Arthritis Patients: A Cohort Study in the Childhood Arthritis and Rheumatology Research Alliance Registry.

Journal Article J Rheumatol · August 2021 OBJECTIVE: Biologic medications have significantly improved disease control and outcomes of patients with juvenile idiopathic arthritis (JIA). Current treatment recommendations suggest escalating therapy, including changing biologics if needed, when inacti ... Full text Link to item Cite

Juvenile Spondyloarthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: High Biologic Use, Low Prevalence of HLA-B27, and Equal Sex Representation in Sacroiliitis.

Journal Article Arthritis Care Res (Hoboken) · July 2021 OBJECTIVE: To describe characteristics of children with enthesitis-related arthritis (ERA) and juvenile psoriatic arthritis (PsA) who were enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry. METHODS: All children with E ... Full text Link to item Cite

Inflammatory Bowel Disease in Children With Systemic Juvenile Idiopathic Arthritis.

Journal Article J Rheumatol · April 2021 OBJECTIVE: The incidence of inflammatory bowel disease (IBD) in juvenile idiopathic arthritis (JIA) is higher than in the general pediatric population. However, reports of IBD in the systemic JIA (sJIA) subtype are limited. We sought to characterize sJIA p ... Full text Link to item Cite

Pilot Study of the Juvenile Dermatomyositis Consensus Treatment Plans: A CARRA Registry Study.

Journal Article J Rheumatol · January 1, 2021 OBJECTIVES: To determine the feasibility of comparing the Childhood Arthritis and Rheumatology ResearchAlliance (CARRA) consensus treatment plans (CTP) in treating moderate new-onset juvenile dermatomyositis (JDM) using the CARRA registry, and to establish ... Full text Link to item Cite

A Clinically and Biologically Based Subclassification of the Idiopathic Inflammatory Myopathies Using Machine Learning.

Journal Article ACR Open Rheumatol · March 2020 OBJECTIVE: Published predictive models of disease outcomes in idiopathic inflammatory myopathies (IIMs) are sparse and of limited accuracy due to disease heterogeneity. Computational methods may address this heterogeneity by partitioning patients based on ... Full text Link to item Cite

Juvenile dermatomyositis: advances in clinical presentation, myositis-specific antibodies and treatment.

Journal Article World J Pediatr · February 2020 BACKGROUND: Juvenile dermatomyositis (JDM) is a chronic autoimmune disease characteristic by inflammation of small vessels within the skin, muscle and vital organs. But the clinical features and treatment of JDM have not been fully clarified. DATA SOURCES: ... Full text Link to item Cite

Patient and physician discordance of global disease assessment in juvenile dermatomyositis: findings from the Childhood Arthritis & Rheumatology Research Alliance Legacy Registry.

Journal Article Pediatr Rheumatol Online J · January 15, 2020 BACKGROUND: Global disease activity scores (gVAS) capture patient or family (PF) and physician (MD) assessments of disease. This study sought to measure discordance between PF and MD global activity scores in juvenile dermatomyositis (JDM), and determine f ... Full text Link to item Cite

Association of Short-Term Ultraviolet Radiation Exposure and Disease Severity in Juvenile Dermatomyositis: Results From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry.

Journal Article Arthritis Care Res (Hoboken) · December 2019 OBJECTIVE: Ultraviolet (UV) radiation is considered to be an important environmental factor in the clinical course of children with juvenile dermatomyositis (DM). We aimed to evaluate the association between UV radiation and severe disease outcomes in juve ... Full text Link to item Cite

Pain, functional disability, and their Association in Juvenile Fibromyalgia Compared to other pediatric rheumatic diseases.

Journal Article Pediatr Rheumatol Online J · November 6, 2019 BACKGROUND: Severe pain and impairments in functioning are commonly reported for youth with juvenile fibromyalgia. The prevalence and impact of pain in other diseases commonly managed in pediatric rheumatology comparatively have been rarely systematically ... Full text Link to item Cite

Cultivating Research Skills During Clinical Training to Promote Pediatric-Scientist Development.

Journal Article Pediatrics · August 2019 Physician-scientists represent a critical component of the biomedical and health research workforce. However, the proportion of physicians who spend a significant amount of effort on scientific research has declined over the past 40 years. This trend has b ... Full text Open Access Link to item Cite

Management Considerations: Juvenile Dermatomyositis

Chapter · July 25, 2019 This comprehensive book serves as a guide in the day-to-day management of patients with idiopathic inflammatory myopathies (IIM), with a particular emphasis on adult dermatomyositis (DM), polymyositis (PM), juvenile dermatomyositis, ... ... Cite

Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups.

Journal Article Ann Rheum Dis · July 2019 OBJECTIVES: Idiopathic inflammatory myopathies (IIM) are a spectrum of rare autoimmune diseases characterised clinically by muscle weakness and heterogeneous systemic organ involvement. The strongest genetic risk is within the major histocompatibility comp ... Full text Link to item Cite

Interferon Chemokine Score and Other Cytokine Measures Track With Changes in Disease Activity in Patients With Juvenile and Adult Dermatomyositis.

Conference ACR Open Rheumatol · April 2019 OBJECTIVE: Our aim was to identify cytokines and chemokines in patients with adult dermatomyositis (DM) and juvenile dermatomyositis (JDM) that predict changes in disease activity. METHODS: Multiplexed immunoassays (Meso Scale Discovery) enabled simultaneo ... Full text Link to item Cite

Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry.

Journal Article ACR Open Rheumatol · April 2019 OBJECTIVE: Localized scleroderma (LS) is a chronic inflammatory and fibrosing skin disorder. We present baseline data on the juvenile LS (jLS) cohort from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry, a multicenter obs ... Full text Link to item Cite

A Path to Prediction of Outcomes in Juvenile Idiopathic Inflammatory Myopathy.

Journal Article Front Immunol · 2019 Humans have an innate desire to observe and subsequently dissect an event into component pieces in an effort to better characterize the event. We then examine these pieces individually and in combinations using this information to determine the outcome of ... Full text Link to item Cite

Clinical Characteristics and Factors Associated With Disability and Impaired Quality of Life in Children With Juvenile Systemic Sclerosis: Results From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry.

Journal Article Arthritis Care Res (Hoboken) · December 2018 OBJECTIVE: To investigate clinical manifestations of juvenile systemic sclerosis (SSc; scleroderma), including disease characteristics and patient quality of life, using the multinational Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legac ... Full text Link to item Cite

T-cell transcriptomics from peripheral blood highlights differences between polymyositis and dermatomyositis patients.

Journal Article Arthritis Res Ther · August 29, 2018 BACKGROUND: Polymyositis (PM) and dermatomyositis (DM) are two distinct subgroups of idiopathic inflammatory myopathies, a chronic inflammatory disorder clinically characterized by muscle weakness and inflammatory cell infiltrates in muscle tissue. In PM, ... Full text Link to item Cite

Brief Report: The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis.

Journal Article Arthritis Rheumatol · June 2018 OBJECTIVE: Juvenile idiopathic arthritis (JIA) comprises 7 heterogeneous categories of chronic childhood arthritides. Approximately 5% of children with JIA have rheumatoid factor (RF)-positive arthritis, which phenotypically resembles adult rheumatoid arth ... Full text Open Access Link to item Cite

Update on outcome assessment in myositis.

Journal Article Nat Rev Rheumatol · May 2018 The adult and juvenile myositis syndromes, commonly referred to collectively as idiopathic inflammatory myopathies (IIMs), are systemic autoimmune diseases with the hallmarks of muscle weakness and inflammation. Validated, well-standardized measures to ass ... Full text Link to item Cite

Predictors of changes in disease activity among children with juvenile dermatomyositis enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry.

Journal Article Clin Rheumatol · April 2018 Determinants of changes in disease activity among patients with juvenile dermatomyositis (JDM) are unknown. Our objective was to develop predictive models to predict changes in disease activity using the CARRA Legacy Registry. The CARRA Legacy Registry inc ... Full text Link to item Cite

Adiposity in Juvenile Psoriatic Arthritis.

Journal Article J Rheumatol · March 2018 OBJECTIVE: Adult patients with psoriatic arthritis are at increased risk for obesity and metabolic syndrome, but data regarding adiposity in children with juvenile psoriatic arthritis (JPsA) are limited. Our study assessed adiposity in children with JPsA i ... Full text Link to item Cite

Delays to Care in Pediatric Lupus Patients: Data From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry.

Journal Article Arthritis Care Res (Hoboken) · March 2018 OBJECTIVE: Prompt treatment for lupus is important to prevent morbidity. A potential barrier to early treatment of pediatric lupus is delayed presentation to a pediatric rheumatologist. To better understand factors contributing to delayed presentation amon ... Full text Link to item Cite

Development of a consensus core dataset in juvenile dermatomyositis for clinical use to inform research.

Journal Article Ann Rheum Dis · February 2018 OBJECTIVES: This study aimed to develop consensus on an internationally agreed dataset for juvenile dermatomyositis (JDM), designed for clinical use, to enhance collaborative research and allow integration of data between centres. METHODS: A prototype data ... Full text Link to item Cite

2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups.

Journal Article Ann Rheum Dis · December 2017 OBJECTIVE: To develop and validate new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM) and their major subgroups. METHODS: Candidate variables were assembled from published criteria and expert opinion using consensus ... Full text Link to item Cite

2017 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups.

Journal Article Arthritis Rheumatol · December 2017 OBJECTIVE: To develop and validate new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM) and their major subgroups. METHODS: Candidate variables were assembled from published criteria and expert opinion using consensus ... Full text Link to item Cite

2016 ACR-EULAR adult dermatomyositis and polymyositis and juvenile dermatomyositis response criteria-methodological aspects.

Journal Article Rheumatology (Oxford) · November 1, 2017 OBJECTIVE: The objective was to describe the methodology used to develop new response criteria for adult DM/PM and JDM. METHODS: Patient profiles from prospective natural history data and clinical trials were rated by myositis specialists to develop consen ... Full text Link to item Cite

Plasma CXCL4 As a Biomarker in Juvenile Systemic Sclerosis

Conference ARTHRITIS & RHEUMATOLOGY · October 1, 2017 Link to item Cite

Rilonacept maintains long-term inflammatory remission in patients with deficiency of the IL-1 receptor antagonist.

Journal Article JCI Insight · August 17, 2017 BACKGROUND: Deficiency of IL-1 receptor antagonist (DIRA) is a rare autoinflammatory disease that presents with life-threatening systemic inflammation, aseptic multifocal osteomyelitis, and pustulosis responsive to IL-1-blocking treatment. This study was p ... Full text Link to item Cite

2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.

Journal Article Arthritis Rheumatol · May 2017 OBJECTIVE: To develop response criteria for juvenile dermatomyositis (DM). METHODS: We analyzed the performance of 312 definitions that used core set measures from either the International Myositis Assessment and Clinical Studies Group (IMACS) or the Paedi ... Full text Link to item Cite

2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.

Journal Article Ann Rheum Dis · May 2017 To develop response criteria for juvenile dermatomyositis (DM). We analysed the performance of 312 definitions that used core set measures from either the International Myositis Assessment and Clinical Studies Group (IMACS) or the Paediatric Rheumatology I ... Full text Link to item Cite

2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.

Journal Article Arthritis Rheumatol · May 2017 OBJECTIVE: To develop response criteria for adult dermatomyositis (DM) and polymyositis (PM). METHODS: Expert surveys, logistic regression, and conjoint analysis were used to develop 287 definitions using core set measures. Myositis experts rated greater i ... Full text Link to item Cite

Race, Income, and Disease Outcomes in Juvenile Dermatomyositis.

Journal Article J Pediatr · May 2017 OBJECTIVE: To determine the relationships among race, income, and disease outcomes in children with juvenile dermatomyositis (JDM). STUDY DESIGN: Data from 438 subjects with JDM enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) ... Full text Link to item Cite

Pilot study comparing the Childhood Arthritis & Rheumatology Research Alliance (CARRA) systemic Juvenile Idiopathic Arthritis Consensus Treatment Plans.

Journal Article Pediatr Rheumatol Online J · April 11, 2017 OBJECTIVES: To assess the feasibility of studying the comparative effectiveness of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus treatment plans (CTPs) for systemic Juvenile Idiopathic Arthritis (JIA) using an observational r ... Full text Link to item Cite

Cutaneous improvement in refractory adult and juvenile dermatomyositis after treatment with rituximab.

Journal Article Rheumatology (Oxford) · February 2017 OBJECTIVE: The aim was to assess the efficacy of rituximab for the cutaneous manifestations of adult DM and JDM. METHODS: Patients with refractory adult DM (n = 72) and JDM (n = 48) were treated with rituximab in a randomized placebo-phase-controlled trial ... Full text Link to item Cite

Gene Expression Profiling in Blood and Affected Muscle Tissues Reveals Differential Activation Pathways in Patients with New-onset Juvenile and Adult Dermatomyositis.

Journal Article J Rheumatol · January 2017 OBJECTIVE: To identify shared and differential molecular pathways in blood and affected muscle between adult dermatomyositis (DM) and juvenile DM, and their association with clinical disease activity measures. METHODS: Gene expression of transcription fact ... Full text Link to item Cite

Childhood Arthritis and Rheumatology Research Alliance Consensus Clinical Treatment Plans for Juvenile Dermatomyositis with Persistent Skin Rash.

Journal Article J Rheumatol · January 2017 OBJECTIVE: Juvenile dermatomyositis (JDM) is the most common form of idiopathic inflammatory myopathy in children. While outcomes are generally thought to be good, persistence of skin rash is a common problem. The goal of this study was to describe the dev ... Full text Link to item Cite

EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups: a methodology report.

Journal Article RMD Open · 2017 OBJECTIVE: To describe the methodology used to develop new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIMs) and their major subgroups. METHODS: An international, multidisciplinary group of myositis experts produced a ... Full text Link to item Cite

Brief Report: HLA-DRB1, DQA1, and DQB1 in Juvenile-Onset Systemic Sclerosis.

Journal Article Arthritis Rheumatol · November 2016 OBJECTIVE: Systemic sclerosis (SSc) is a rare disease that is particularly uncommon in children. Specific HLA alleles have been associated with SSc in adults. This study was undertaken to investigate HLA class II alleles in juvenile-onset SSc. METHODS: DRB ... Full text Link to item Cite

Comparing Presenting Clinical Features in 48 Children With Microscopic Polyangiitis to 183 Children Who Have Granulomatosis With Polyangiitis (Wegener's): An ARChiVe Cohort Study.

Journal Article Arthritis Rheumatol · October 2016 OBJECTIVE: To uniquely classify children with microscopic polyangiitis (MPA), to describe their demographic characteristics, presenting clinical features, and initial treatments in comparison to patients with granulomatosis with polyangiitis (Wegener's) (G ... Full text Link to item Cite

The Systemic Juvenile Idiopathic Arthritis Cohort of the Childhood Arthritis and Rheumatology Research Alliance Registry: 2010-2013.

Journal Article J Rheumatol · September 2016 OBJECTIVE: We aimed to identify the (1) demographic/clinical characteristics, (2) medication usage trends, (3) variables associated with worse disease activity, and (4) characteristics of patients with persistent chronic arthritis in the Childhood Arthriti ... Full text Link to item Cite

Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.

Journal Article Ann Rheum Dis · August 2016 OBJECTIVES: The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes and interstitial lung disease. We genotyped 2566 IIM cases ... Full text Link to item Cite

Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies.

Journal Article Arthritis Res Ther · July 7, 2016 BACKGROUND: The idiopathic inflammatory myopathies (IIM) are autoimmune diseases characterised by acquired proximal muscle weakness, inflammatory cell infiltrates in muscle and myositis-specific/associated autoantibodies. It is unclear which pathways are i ... Full text Link to item Cite

Juvenile idiopathic arthritis and future risk for cardiovascular disease: a multicenter study.

Journal Article Scand J Rheumatol · July 2016 OBJECTIVES: To evaluate the frequency of cardiovascular disease (CVD) and CVD risk factor development in adult patients previously diagnosed with juvenile idiopathic arthritis (JIA). METHOD: A cohort study was conducted utilizing patients at two academic i ... Full text Link to item Cite

Autoantibody levels in myositis patients correlate with clinical response during B cell depletion with rituximab.

Journal Article Rheumatology (Oxford) · June 2016 OBJECTIVES: To determine the longitudinal trends in serum levels of four myositis-associated autoantibodies: anti-Jo-1, -transcription intermediary factor 1 γ (TIF1-γ), -signal recognition particle (SRP) and -Mi-2, after B cell depletion with rituximab, an ... Full text Link to item Cite

Familial autoimmunity in the Childhood Arthritis and Rheumatology Research Alliance registry.

Journal Article Pediatr Rheumatol Online J · March 10, 2016 BACKGROUND: Clinically distinct autoimmune phenotypes share genetic susceptibility factors. We investigated the prevalence of familial autoimmunity among subjects with juvenile idiopathic arthritis (JIA), childhood systemic lupus erythematosus (cSLE) and j ... Full text Link to item Cite

Outcome of Whole Exome Sequencing for Diagnostic Odyssey Cases of an Individualized Medicine Clinic: The Mayo Clinic Experience.

Journal Article Mayo Clin Proc · March 2016 OBJECTIVE: To describe the experience and outcome of performing whole-exome sequencing (WES) for resolution of patients on a diagnostic odyssey in the first 18 months of an individualized medicine clinic (IMC). PATIENTS AND METHODS: The IMC offered WES to ... Full text Link to item Cite

Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls.

Journal Article J Rheumatol · December 2015 OBJECTIVE: Autoantibodies to the dense fine speckled 70 kDa antigen (DFS70) are reported to be more common in individuals who do not have an antinuclear antibody (ANA)-associated rheumatic disease (AARD) than in patients with AARD. The frequency of anti-DF ... Full text Link to item Cite

Immunological biomarkers in dermatomyositis.

Journal Article Curr Rheumatol Rep · November 2015 Dermatomyositis (DM) is a chronic acquired disorder that affects primarily the muscle and skin. The pathogenesis of DM, as well as methods for monitoring disease activity and predicting response to therapy, are subjects of active research. Studies looking ... Full text Link to item Cite

Dermatologic Features of ADA2 Deficiency in Cutaneous Polyarteritis Nodosa.

Journal Article JAMA Dermatol · November 2015 IMPORTANCE: Mutations in the CERC1 gene associated with deficiency in the ADA2 protein (DADA2) have been implicated in the pathogenesis of cutaneous polyarteritis nodosa (cPAN) and early-onset vasculopathy. DADA2 is not only limited to cPAN and vasculopath ... Full text Link to item Cite

Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.

Journal Article Genes Immun · October 2015 Autoimmune muscle diseases (myositis) comprise a group of complex phenotypes influenced by genetic and environmental factors. To identify genetic risk factors in patients of European ancestry, we conducted a genome-wide association study (GWAS) of the majo ... Full text Link to item Cite

Biologic predictors of clinical improvement in rituximab-treated refractory myositis.

Journal Article BMC Musculoskelet Disord · September 17, 2015 BACKGROUND: To examine the longitudinal utility of a biomarker signature in conjunction with myositis autoantibodies (autoAbs) as predictors of disease improvement in refractory myositis patients treated with rituximab. METHODS: In the RIM Trial, all subje ... Full text Link to item Cite

Adipokine gene expression in peripheral blood of adult and juvenile dermatomyositis patients and their relation to clinical parameters and disease activity measures.

Journal Article J Inflamm (Lond) · 2015 OBJECTIVE: Recently adipokines have been implicated in the regulation of immune and inflammatory responses in autoimmune disease. To investigate the role of adipokines in adult and pediatric patients with newly diagnosed dermatomyositis (DM), we analyzed p ... Full text Link to item Cite

Interferon-regulated chemokine score associated with improvement in disease activity in refractory myositis patients treated with rituximab.

Journal Article Clin Exp Rheumatol · 2015 OBJECTIVES: The purpose of this study was to investigate whether serum interferon (IFN)-regulated chemokine and distinct cytokine response profiles are associated with clinical improvement in patients with refractory inflammatory myopathy treated with ritu ... Link to item Cite

Recent advances in juvenile idiopathic inflammatory myopathies.

Journal Article Curr Opin Rheumatol · November 2014 PURPOSE OF REVIEW: Ongoing research continues to advance our understanding of the juvenile idiopathic inflammatory myopathies (JIIMs). We review the recent contributions from the published literature about the classification, pathogenesis, assessment, and ... Full text Link to item Cite

Clinical characteristics of children with juvenile dermatomyositis: the Childhood Arthritis and Rheumatology Research Alliance Registry.

Journal Article Arthritis Care Res (Hoboken) · March 2014 OBJECTIVE: To investigate aspects of juvenile dermatomyositis (DM), including disease characteristics and treatment, through a national multicenter registry. METHODS: Subjects meeting the modified Bohan and Peter criteria for definite juvenile DM were anal ... Full text Link to item Cite

Predictors of clinical improvement in rituximab-treated refractory adult and juvenile dermatomyositis and adult polymyositis.

Journal Article Arthritis Rheumatol · March 2014 OBJECTIVE: To identify the clinical and laboratory predictors of clinical improvement in a cohort of myositis patients treated with rituximab. METHODS: We analyzed data for 195 patients with myositis (75 with adult polymyositis [PM], 72 with adult dermatom ... Full text Link to item Cite

Secondary analysis of APPLE study suggests atorvastatin may reduce atherosclerosis progression in pubertal lupus patients with higher C reactive protein.

Journal Article Ann Rheum Dis · March 2014 OBJECTIVE: Participants in the Atherosclerosis Prevention in Paediatric Lupus Erythematosus (APPLE) trial were randomised to placebo or atorvastatin for 36 months. The primary endpoint, reduced carotid intima medial thickness (CIMT) progression, was not me ... Full text Link to item Cite

Vitamin D status is a determinant of atorvastatin effect on carotid intima medial thickening progression rate in children with lupus: an Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) substudy.

Journal Article Lupus Sci Med · 2014 OBJECTIVE: Epidemiological associations suggest that vitamin D status may play a role in inflammation and progression of atherosclerosis. Using frozen serum, carotid intima medial thickness (CIMT) measurements and other existing data from the Atheroscleros ... Full text Link to item Cite

Progress and prognosis in juvenile dermatomyositis

Journal Article International Journal of Clinical Rheumatology · January 1, 2014 With the advent of corticosteroids as a treatment option for autoimmune disease in the early 1960s, the course of juvenile dermatomyositis was altered from one of high mortality to one with various degrees of morbidity. Prior to treatment with corticostero ... Full text Cite

Updates on morphea: Role of vascular injury and advances in treatment

Journal Article Autoimmune Diseases · December 16, 2013 Morphea and systemic sclerosis are fibrosing disorders of the skin that share common inflammatory and immunologic pathways that are responsible for the vascular changes, increased collagen production, and extracellular matrix proliferation seen in both con ... Full text Cite

Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders.

Journal Article Arthritis Rheum · December 2013 OBJECTIVE: To identify new genetic associations with juvenile and adult dermatomyositis (DM). METHODS: We performed a genome-wide association study (GWAS) of adult and juvenile DM patients of European ancestry (n = 1,178) and controls (n = 4,724). To asses ... Full text Link to item Cite

Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis.

Journal Article Arthritis Rheum · August 2013 OBJECTIVE: CD8+ T cells lacking CD28 were originally reported to be a characteristic feature of juvenile idiopathic arthritis (JIA), but the relevance of these unusual cells to this disease remains to be elucidated. Because of recent evidence that loss of ... Full text Link to item Cite

Longitudinal peripheral blood lymphocyte subsets correlate with decreased disease activity in juvenile dermatomyositis.

Journal Article J Rheumatol · July 2013 OBJECTIVE: To determine the clinical characteristics and subsets of peripheral blood lymphocytes (PBL), which correlate with decreased disease activity in patients with juvenile dermatomyositis (JDM). METHODS: Peripheral blood mononuclear cells from 24 pat ... Full text Link to item Cite

Susceptibility to childhood-onset rheumatoid arthritis: investigation of a weighted genetic risk score that integrates cumulative effects of variants at five genetic loci.

Journal Article Arthritis Rheum · June 2013 OBJECTIVE: Children with childhood-onset rheumatoid arthritis (RA) include those with rheumatoid factor or anti-citrullinated protein antibody-positive juvenile idiopathic arthritis. To test the hypothesis that adult-onset RA-associated variants are also a ... Full text Link to item Cite

The PRINTO criteria for clinically inactive disease in juvenile dermatomyositis.

Journal Article Ann Rheum Dis · May 2013 OBJECTIVES: To develop data-driven criteria for clinically inactive disease on and off therapy for juvenile dermatomyositis (JDM). METHODS: The Paediatric Rheumatology International Trials Organisation (PRINTO) database contains 275 patients with active JD ... Full text Link to item Cite

MRI guided wire localization muscle biopsy in a child with juvenile dermatomyositis

Journal Article Pediatric Rheumatology · April 8, 2013 A novel technique for preoperative MRI guided wire localization for targeted surgical excisional biopsy of muscle is described in a pediatric patient with juvenile dermatomyositis (JDM). This technique allows for preoperative localization of abnormalities ... Full text Cite

BAFF expression correlates with idiopathic inflammatory myopathy disease activity measures and autoantibodies.

Journal Article J Rheumatol · March 2013 OBJECTIVE: To investigate B cell survival cytokine messenger RNA (mRNA) levels as biomarkers of idiopathic inflammatory myopathies (IIM). METHODS: We measured and compared mRNA levels of B cell survival cytokines by quantitative real-time polymerase chain ... Full text Link to item Cite

Rituximab in the treatment of refractory adult and juvenile dermatomyositis and adult polymyositis: a randomized, placebo-phase trial.

Journal Article Arthritis Rheum · February 2013 OBJECTIVE: To assess the safety and efficacy of rituximab in a randomized, double-blind, placebo-phase trial in adult and pediatric myositis patients. METHODS: Adults with refractory polymyositis (PM) and adults and children with refractory dermatomyositis ... Full text Link to item Cite

Cardiac transplantation in a pediatric patient with systemic sclerosis.

Journal Article Congenit Heart Dis · 2013 INTRODUCTION: Diffuse cutaneous systemic sclerosis (SSc) is rare in children, but has a poor prognosis when cardiomyopathy is present. METHODS: We reviewed the case of a 14-year-old female with progressive skin thickening/tightness and dyspnea on exertion ... Full text Link to item Cite

Idiopathic inflammatory myopathies: Current trends in pathogenesis, clinical features, and up-to-date treatment recommendations

Journal Article Mayo Clinic Proceedings · January 1, 2013 Recently, there have been important advances in the understanding of the pathophysiologic features, assessment, and management of patients with a newly diagnosed idiopathic inflammatory myopathy (IIM). Myositis-specific autoantibodies have been identified ... Full text Cite

Changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis are sensitive biomarkers of disease course.

Journal Article Arthritis Rheum · December 2012 OBJECTIVE: Muscle enzyme levels are insensitive markers of disease activity in juvenile and adult dermatomyositis (DM), especially during the active treatment phase. To improve our ability to monitor DM disease activity longitudinally, especially in the pr ... Full text Link to item Cite

Update: biomarkers for idiopathic inflammatory myopathies.

Journal Article Curr Opin Rheumatol · November 2012 PURPOSE OF REVIEW: Establishing diagnoses and distinguishing active disease from chronic injury remain significant clinical challenges in idiopathic inflammatory myopathies (IIM). Recent 'discovery' approaches utilizing novel genomic and proteomic techniqu ... Full text Link to item Cite

The Myositis Activities Profile -- initial validation for assessment of polymyositis/dermatomyositis in the USA.

Journal Article J Rheumatol · November 2012 OBJECTIVE: To evaluate some measurement properties of the Myositis Activities Profile (MAP) in adult patients with polymyositis (PM) and dermatomyositis (DM) in the United States. METHODS: To assess content validity, patients with PM/DM rated difficulty an ... Full text Link to item Cite

Consensus treatments for moderate juvenile dermatomyositis: beyond the first two months. Results of the second Childhood Arthritis and Rheumatology Research Alliance consensus conference.

Journal Article Arthritis Care Res (Hoboken) · April 2012 OBJECTIVE: To use consensus methods and the considerable expertise contained within the Childhood Arthritis and Rheumatology Research Alliance (CARRA) organization to extend the 3 previously developed treatment plans for moderate juvenile dermatomyositis ( ... Full text Link to item Cite

Hierarchy of risk of childhood-onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared epitope.

Journal Article Arthritis Rheum · March 2012 OBJECTIVE: Associations between shared epitope (SE)-encoding HLA-DRB1 alleles and rheumatoid arthritis (RA) are well established. However, only a limited number of studies have investigated these alleles in patients with childhood-onset RA, which is define ... Full text Link to item Cite

Maternal microchimerism in Hirschsprung's disease.

Journal Article Am J Perinatol · February 2012 Hirschsprung's disease (HD) presents with severe constipation due to absent ganglion cells in the distal rectum. We sought to determine whether maternal chimeric cells are present in aganglionic bowel. We hypothesize that chimeric cells are part of the unf ... Full text Link to item Cite

Coronary artery thickening with mucosal lesions in Henoch-Schönlein purpura.

Journal Article Pediatr Dermatol · 2012 Henoch-Schönlein purpura (HSP) is the most common vasculitis of childhood. It is usually self-limiting and is characterized by an immune complex-mediated vasculitis associated with IgA deposition. We present an unusual case of HSP with mucosal lesions and ... Full text Link to item Cite

Pediatric rheumatology: A color handbook

Book · January 1, 2012 Physicians caring for children with rheumatic disease need a varied and highly developed set of clinical skills, including general pediatrics, immunology, musculoskeletal medicine and the management of chronic diseases. With these requirements in mind, the ... Full text Cite

Use of atorvastatin in systemic lupus erythematosus in children and adolescents.

Journal Article Arthritis Rheum · January 2012 OBJECTIVE: Statins reduce atherosclerosis and cardiovascular morbidity in the general population, but their efficacy and safety in children and adolescents with systemic lupus erythematosus (SLE) are unknown. This study was undertaken to determine the 3-ye ... Full text Link to item Cite

The first reported case of compound heterozygous IL1RN mutations causing deficiency of the interleukin-1 receptor antagonist.

Journal Article Arthritis Rheum · December 2011 Interleukin-1 receptor antagonist (IL-1Ra) deficiency is a rare autoinflammatory disease involving neonatal onset of pustulosis, periostitis, and sterile osteomyelitis. We report the case of a 2-week-old male who presented with a swollen, erythematous left ... Full text Link to item Cite

Pregnancy and rheumatoid arthritis: insights into the immunology of fetal tolerance and control of autoimmunity.

Journal Article Curr Rheumatol Rep · October 2011 It has long been recognized that symptoms and signs of rheumatoid arthritis (RA) frequently improve spontaneously during pregnancy, only to flare postpartum. Although the mechanisms behind this phenomenon remain poorly understood, there is growing interest ... Full text Link to item Cite

Clinical features, pathogenesis and treatment of juvenile and adult dermatomyositis.

Journal Article Nat Rev Rheumatol · September 27, 2011 Juvenile and adult dermatomyositis (DM) have multiple commonalities, yet display differing prevalence of features, outcomes and comorbidities. In general, compared with the disease in adults, children with DM have more vasculopathy and a greater likelihood ... Full text Link to item Cite

Evaluation of muscles affected by myositis using magnetic resonance elastography.

Journal Article Muscle Nerve · April 2011 INTRODUCTION: Idiopathic inflammatory myopathies (IIMs, or myositis) represent a group of autoimmune diseases that result in decreased muscle strength and/or endurance. Non-invasive tools to assess muscle may improve our understanding of the clinical and f ... Full text Link to item Cite

Type I interferon pathway in adult and juvenile dermatomyositis.

Journal Article Arthritis Res Ther · 2011 Gene expression profiling and protein studies of the type I interferon pathway have revealed important insights into the disease process in adult and juvenile dermatomyositis. The most prominent and consistent feature has been a characteristic whole blood ... Full text Link to item Cite

The Paediatric Rheumatology International Trials Organisation provisional criteria for the evaluation of response to therapy in juvenile dermatomyositis.

Journal Article Arthritis Care Res (Hoboken) · November 2010 OBJECTIVE: To develop a provisional definition for the evaluation of response to therapy in juvenile dermatomyositis (DM) based on the Paediatric Rheumatology International Trials Organisation juvenile DM core set of variables. METHODS: Thirty-seven experi ... Full text Link to item Cite

Laboratory markers of cardiovascular risk in pediatric SLE: the APPLE baseline cohort.

Journal Article Lupus · October 2010 As part of the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) Trial, a prospective multicenter cohort of 221 children and adolescents with systemic lupus erythematosus (SLE) (mean age 15.7 years, 83% female) underwent baseline measurem ... Full text Link to item Cite

Treatment approaches to juvenile dermatomyositis (JDM) across North America: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) JDM Treatment Survey.

Journal Article J Rheumatol · September 2010 OBJECTIVE: There are a number of different approaches to the initial treatment of juvenile dermatomyositis (JDM). We assessed the therapeutic approaches of North American pediatric rheumatologists to inform future studies of therapy in JDM. METHODS: A surv ... Full text Link to item Cite

Reply

Journal Article Arthritis and Rheumatism · July 1, 2010 Full text Cite

Immunopathogenesis of juvenile dermatomyositis.

Journal Article Muscle Nerve · May 2010 There is increasing evidence for involvement of the mechanisms of the innate immune system in the pathogenesis of idiopathic inflammatory myopathies (IIMs), especially in the adult and juvenile forms of dermatomyositis. Juvenile dermatomyositis (JDM) is th ... Full text Link to item Cite

Protocols for the initial treatment of moderately severe juvenile dermatomyositis: results of a Children's Arthritis and Rheumatology Research Alliance Consensus Conference.

Journal Article Arthritis Care Res (Hoboken) · February 2010 OBJECTIVE: To use juvenile dermatomyositis (DM) survey data and expert opinion to develop a small number of consensus treatment protocols, which reflect current initial treatment of moderately severe juvenile DM. METHODS: A consensus meeting was held in To ... Full text Link to item Cite

Juvenile dermatomyositis

Journal Article · December 1, 2009 Children with inflammatory myopathies have clinical and laboratory features, as well as risk factors and outcomes that overlap with their adult counterparts. However, a number of important differences exist between pediatric and adult disease. Juvenile der ... Full text Cite

Damage extent and predictors in adult and juvenile dermatomyositis and polymyositis as determined with the myositis damage index.

Journal Article Arthritis Rheum · November 2009 OBJECTIVE: We undertook this study to validate the Myositis Damage Index (MDI) in juvenile and adult myositis, to describe the degree and types of damage and to develop predictors of damage. METHODS: Retrospective MDI evaluations and prospective assessment ... Full text Link to item Cite

Interleukin-6 and type I interferon-regulated genes and chemokines mark disease activity in dermatomyositis.

Journal Article Arthritis Rheum · November 2009 OBJECTIVE: Up-regulation of whole blood type I interferon (IFN)-driven transcripts and chemokines has been described in a number of autoimmune diseases. An IFN gene expression "signature" is a candidate biomarker in patients with dermatomyositis (DM). This ... Full text Link to item Cite

Classification, presentation, and initial treatment of Wegener's granulomatosis in childhood.

Journal Article Arthritis Rheum · November 2009 OBJECTIVE: To compare the criteria for Wegener's granulomatosis (WG) of the American College of Rheumatology (ACR) with those of the European League Against Rheumatism/Pediatric Rheumatology European Society (EULAR/PRES) in a cohort of children with WG and ... Full text Link to item Cite

Biomarkers in rheumatologic disease: a review.

Journal Article Minn Med · September 2009 Rheumatologic disorders are in many ways heterogeneous diseases.They have an array of clinical manifestations, involve multiple organs, produce unpredictable flares, and have widely varying clinical outcomes. Diagnosing rheumatologic diseases and predictin ... Link to item Cite

Atypical presentation of Henoch-Schönlein purpura.

Journal Article Pediatr Emerg Care · August 2009 Henoch-Schönlein purpura (HSP) is the most common form of vasculitis found in the pediatric population. The most common presenting complaint for children with HSP is a purpuric rash on the lower extremities. Many other organ systems beyond the skin can be ... Full text Link to item Cite

The inflammatory milieu in idiopathic inflammatory myositis.

Journal Article Curr Rheumatol Rep · August 2009 The idiopathic inflammatory myopathies (IIM) are systemic autoimmune diseases that have predominant mononuclear inflammatory cell infiltrates in the skeletal muscle. The cells that are typically involved in the pathogenesis of disease are B-lymphocytes, T- ... Full text Link to item Cite

Health-related quality of life in children and adolescents with juvenile localized scleroderma.

Journal Article Rheumatology (Oxford) · June 2009 OBJECTIVES: To examine the health-related quality of life (HRQOL) of children with juvenile localized scleroderma (JLS) and to compare them with patients with atopic dermatitis (AD) and healthy controls. METHODS: The cohorts were identified through a diagn ... Full text Link to item Cite

Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort.

Journal Article Arthritis Rheum · May 2009 OBJECTIVE: To evaluate risk factors for subclinical atherosclerosis in a population of patients with pediatric systemic lupus erythematosus (SLE). METHODS: In a prospective multicenter study, a cohort of 221 patients underwent baseline measurements of caro ... Full text Link to item Cite

Extranodal lymphoid microstructures in inflamed muscle and disease severity of new-onset juvenile dermatomyositis.

Journal Article Arthritis Rheum · April 2009 OBJECTIVE: Juvenile dermatomyositis (DM) is an autoimmune disease of childhood characterized by lesions in skin and muscle that are populated by plasmacytoid dendritic cells (PDCs) and lymphocyte infiltrates. We undertook this study to examine the cellular ... Full text Link to item Cite

Rituximab for successful management of probable pediatric catastrophic antiphospholipid syndrome.

Journal Article Pediatr Blood Cancer · April 2009 Catastrophic antiphospholipid syndrome (CAPS) is a life-threatening condition characterized by small-vessel thrombi and a rapid onset of multiorgan system failure associated with systemic inflammatory response syndrome. Current treatment options include an ... Full text Link to item Cite

The inflammatory milieu cells and cytokines

Journal Article · January 1, 2009 Idiopathic inflammatory myopathies (IIMs) are characterized by mononuclear inflammatory cell infiltrates in skeletal muscle with associated weakness and fatigue, although often the severity of inflammation does not correlate with clinical severity. Inflamm ... Full text Cite

Dendritic cells and the immunopathogenesis of idiopathic inflammatory myopathies.

Journal Article Curr Opin Rheumatol · November 2008 PURPOSE OF REVIEW: Mechanisms driving the autoimmune process in idiopathic inflammatory myopathies (IIMs) have not been unraveled, despite extensive studies. In recent times, it has become apparent that heterogeneous populations of dendritic cells have spe ... Full text Link to item Cite

Juvenile dermatomyositis and other idiopathic inflammatory myopathies of childhood.

Journal Article Lancet · June 28, 2008 Juvenile dermatomyositis, the most common inflammatory myopathy of childhood, is a rare systemic autoimmune vasculopathy that is characterised by weakness in proximal muscles and pathognomonic skin rashes. The length of time before the initiation of treatm ... Full text Link to item Cite

Epidemiology of sporadic inclusion body myositis and polymyositis in Olmsted County, Minnesota.

Journal Article J Rheumatol · March 2008 OBJECTIVE: To determine the incidence and prevalence of sporadic inclusion body myositis (sIBM) and polymyositis (PM) in a population-based study. METHODS: Charts of patients with myositis in Olmsted County, Minnesota, USA, from 1981 to 2000 were reviewed. ... Link to item Cite

Preliminary validation and clinical meaning of the Cutaneous Assessment Tool in juvenile dermatomyositis.

Journal Article Arthritis Rheum · February 15, 2008 OBJECTIVE: To provide preliminary validation of the Cutaneous Assessment Tool (CAT), a new tool to assess cutaneous manifestations of juvenile dermatomyositis (DM), and to explore the clinical meaning of CAT scores. METHODS: Children with juvenile DM (n = ... Full text Link to item Cite

The Cutaneous Assessment Tool: development and reliability in juvenile idiopathic inflammatory myopathy.

Journal Article Rheumatology (Oxford) · October 2007 OBJECTIVES: Clinical care and therapeutic trials in idiopathic inflammatory myopathies (IIM) require accurate and consistent assessment of cutaneous involvement. The Cutaneous Assessment Tool (CAT) was designed to measure skin activity and damage in IIM. W ... Full text Link to item Cite

Pathogenesis of myositis in children.

Journal Article Curr Opin Rheumatol · September 2007 PURPOSE OF REVIEW: There is increasing evidence for involvement of innate immune mechanisms in the pathogenesis of idiopathic inflammatory myopathies. This review focuses on recent advances in understanding these mechanisms in juvenile dermatomyositis, the ... Full text Link to item Cite

Involvement of dendritic cells in autoimmune diseases in children

Journal Article Pediatric Rheumatology · July 11, 2007 Dendritic cells (DCs) are professional antigen-presenting cells that are specialized in the uptake of antigens and their transport from peripheral tissues to the lymphoid organs. Over the last decades, the properties of DCs have been intensely studied and ... Full text Cite

Plasmacytoid dendritic cells in inflamed muscle of patients with juvenile dermatomyositis.

Journal Article Arthritis Rheum · May 2007 OBJECTIVE: To examine whether dendritic cells (DCs) are constituents of muscle inflammation in juvenile dermatomyositis (DM). METHODS: The types, numbers, and activation state of DC subsets in inflamed muscle tissue from patients with juvenile DM and in no ... Full text Link to item Cite

Immunophenotyping of chimeric cells in localized scleroderma.

Journal Article Rheumatology (Oxford) · March 2007 OBJECTIVE: Localized scleroderma causes thickening of the skin due to excessive collagen deposition. This condition has clinical and histopathological similarities to chronic graft-vs-host disease. We wanted to identify whether chimeric cells are present i ... Full text Link to item Cite

Spondyloarthropathy presenting at a young age: case report and review.

Journal Article Skeletal Radiol · February 2007 The diagnosis of juvenile spondyloarthritis (JSA) is rarely entertained in young children who present with back and leg pain. We present a case of a 6-year-old male who presented with a 3-year history of severe back and leg pain and a positive Gower's sign ... Full text Link to item Cite

An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity.

Journal Article Mol Med · 2007 Recent studies have shown increased expression of interferon (IFN)-regulated genes in the peripheral blood cells of patients with systemic lupus erythematosus. A similar interferon signature has been observed in affected muscle tissue from patients with de ... Full text Link to item Cite

Immunogenetic risk and protective factors for juvenile dermatomyositis in Caucasians.

Journal Article Arthritis Rheum · December 2006 OBJECTIVE: To define the relative importance (RI) of class II major histocompatibility complex (MHC) alleles and peptide binding motifs as risk or protective factors for juvenile dermatomyositis (DM), and to compare these with HLA associations in adult DM. ... Full text Link to item Cite

HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies.

Journal Article Arthritis Rheum · November 2006 OBJECTIVE: To investigate possible associations of HLA polymorphisms with idiopathic inflammatory myopathy (IIM) in African Americans, and to compare this with HLA associations in European American IIM patients with IIM. METHODS: Molecular genetic analyses ... Full text Link to item Cite

Acute graft-versus-host disease after liver transplantation diagnosed by fluorescent in situ hybridization testing of skin biopsy specimens.

Journal Article J Am Acad Dermatol · October 2006 Acute graft-versus-host disease after orthotopic liver transplantation is an underrecognized entity with a guarded prognosis. We describe a patient who underwent orthotopic liver transplantation with an HLA-matched donor liver. She had an uneventful recove ... Full text Link to item Cite

Enzyme elevation in patients with juvenile dermatomyositis and steroid myopathy.

Journal Article J Rheumatol · July 2006 OBJECTIVE: Steroid myopathy can occur in patients with juvenile dermatomyositis (JDM) receiving chronic steroid therapy. We report an elevation of serum muscle enzymes, normal strength by manual muscle testing (MMT), and electromyographic (EMG) findings of ... Link to item Cite

A boy with fever and whorl keratopathy.

Journal Article J Rheumatol · June 2006 Link to item Cite

Gene expression profiling in human autoimmunity.

Journal Article Immunol Rev · April 2006 Human autoimmune diseases are well suited for the application of gene expression profiling. Sampling of blood cells and target tissues has already revealed many important pathways contributing to this spectrum of disorders, and many commonalities are emerg ... Full text Link to item Cite

Maternal-Fetal Aspects of Autoimmune Disease

Journal Article Handbook of Systemic Autoimmune Diseases · December 1, 2005 Full text Cite

Update in juvenile rheumatoid arthritis.

Journal Article Arthritis Rheum · October 15, 2005 Full text Link to item Cite

Cysteine-tailed class I-binding peptides bind to CpG adjuvant and enhance primary CTL responses.

Journal Article J Immunol · September 15, 2005 Immunostimulatory CpG motifs in synthetic oligonucleotides can be effective adjuvants for the priming of CTLs. We first observed that a single male-specific peptide (KCSRNRQYL) (HY2) was more efficient than another male-specific peptide (WMHHNMDLI) (HY1) a ... Full text Link to item Cite

Antiphospholipid syndrome with catastrophic bleeding and recurrent ischemic strokes as initial presentation of systemic lupus erythematosus.

Journal Article J Pediatr Hematol Oncol · July 2005 Bleeding is a rare manifestation of lupus anticoagulant-antiphospholipid syndrome unless associated with coagulation factor deficiency, thrombocytopenia, or intrinsic vascular defect. The authors report the clinical and laboratory findings in a 16-year-old ... Full text Link to item Cite

History of infection before the onset of juvenile dermatomyositis: results from the National Institute of Arthritis and Musculoskeletal and Skin Diseases Research Registry.

Journal Article Arthritis Rheum · April 15, 2005 OBJECTIVE: To obtain data concerning a history of infection occurring in the 3 months before recognition of the typical weakness and rash associated with juvenile dermatomyositis (JDM). METHODS: Parents or caretakers of children within 6 months of JDM diag ... Full text Link to item Cite

Recent advances in juvenile dermatomyositis.

Journal Article Curr Rheumatol Rep · April 2005 This paper reviews the knowledge we continue to gain in the areas of pathogenesis, evaluation of disease activity, and interventional strategies with regards to idiopathic inflammatory myositis. Potential new diagnostic criteria incorporate the use of magn ... Full text Link to item Cite

Radiographic progression in children with polyarticular juvenile rheumatoid arthritis: a pilot study.

Journal Article Ann Rheum Dis · March 2005 OBJECTIVE: To assess disease progression on hand/wrist x rays from children with polyarticular juvenile rheumatoid arthritis. METHODS: Initial and subsequent films of 13 white children (10 girls) were read blind by a paediatric radiologist for the presence ... Full text Link to item Cite

International consensus on preliminary definitions of improvement in adult and juvenile myositis.

Journal Article Arthritis Rheum · July 2004 OBJECTIVE: To use a core set of outcome measures to develop preliminary definitions of improvement for adult and juvenile myositis as composite end points for therapeutic trials. METHODS: Twenty-nine experts in the assessment of myositis achieved consensus ... Full text Link to item Cite

Normal scores for nine maneuvers of the Childhood Myositis Assessment Scale.

Journal Article Arthritis Rheum · June 15, 2004 OBJECTIVE: To document and evaluate the scores that normal, healthy children achieve when performing 9 maneuvers of the Childhood Myositis Assessment Scale (CMAS). METHODS: A total of 303 healthy children, 4-9 years of age, were scored as they performed 9 ... Full text Link to item Cite

Cushing's syndrome after intra-articular and intradermal administration of triamcinolone acetonide in three pediatric patients.

Journal Article Pediatrics · June 2004 BACKGROUND: Intra-articular and intradermal steroids are often used for their antiinflammatory effect. There is limited experience with intra-articular and intralesional administration of corticosteroids in the pediatric age group. DESIGN/METHODS: We perfo ... Full text Link to item Cite

Validation and clinical significance of the Childhood Myositis Assessment Scale for assessment of muscle function in the juvenile idiopathic inflammatory myopathies.

Journal Article Arthritis Rheum · May 2004 OBJECTIVE: To examine the measurement characteristics of the Childhood Myositis Assessment Scale (CMAS) in children with juvenile idiopathic inflammatory myopathy (juvenile IIM), and to obtain preliminary data on the clinical significance of CMAS scores. M ... Full text Link to item Cite

Does HLA-dependent chimerism underlie the pathogenesis of juvenile dermatomyositis?

Journal Article J Immunol · April 15, 2004 Juvenile dermatomyositis (JDM) is a multisystem autoimmune disease that at times resembles chronic graft-vs-host disease. This led us to suggest that nonself cells may play a role in the disease process. In this study we examined the relationship between H ... Full text Link to item Cite

International consensus outcome measures for patients with idiopathic inflammatory myopathies. Development and initial validation of myositis activity and damage indices in patients with adult onset disease.

Journal Article Rheumatology (Oxford) · January 2004 OBJECTIVE: To devise new tools to assess activity and damage in patients with idiopathic myopathies (IIM). METHODS: An international multidisciplinary consensus effort to standardize the conduct and reporting of the myositis clinical trials has been establ ... Full text Link to item Cite

Chimerism in myositis.

Journal Article Curr Rheumatol Rep · December 2003 Bidirectional cell trafficking occurs between a mother and fetus during pregnancy. The trafficking is associated with the persistence of non-self cells. Persistence of these cells has been demonstrated after birth for many years in the child and mother. Ch ... Full text Link to item Cite

Microchimerism in children with rheumatic disorders: what does it mean?

Journal Article Curr Rheumatol Rep · December 2003 Bidirectional cell trafficking occurs between a mother and fetus during pregnancy. This trafficking is associated with the persistence of non-self cells and is termed chimerism or, because of the low levels of non-self cells, microchimerism. Persistence of ... Full text Link to item Cite

Preliminary core sets of measures for disease activity and damage assessment in juvenile systemic lupus erythematosus and juvenile dermatomyositis.

Journal Article Rheumatology (Oxford) · December 2003 OBJECTIVE: To identify preliminary core sets of outcome variables for disease activity and damage assessment in juvenile systemic lupus erythematosus (JSLE) and juvenile dermatomyositis (JDM). METHODS: Two questionnaire surveys were mailed to 267 physician ... Full text Link to item Cite

Genetic and environmental risk factors for idiopathic inflammatory myopathies.

Journal Article Rheum Dis Clin North Am · November 2002 Although the studies discussed are beginning to reveal a number of genetic and possible environmental risk factors for myositis, further investigations are needed to fully understand and classify these syndromes. The difficulties in this process include sm ... Full text Link to item Cite

Frequency of abnormal hand and wrist radiographs at time of diagnosis of polyarticular juvenile rheumatoid arthritis.

Journal Article J Rheumatol · October 2002 OBJECTIVE: To determine the frequency of radiographic abnormalities in hand/wrist radiographs of children with newly diagnosed polyarticular juvenile rheumatoid arthritis (polyJRA) because radiographs of small joints are an important tool in assessing outc ... Link to item Cite

Juvenile dermatomyositis: recognition and treatment.

Journal Article Paediatr Drugs · 2002 Juvenile dermatomyositis (JDM) is a multisystem disease characterized by acute and chronic lymphocytic inflammation of the skeletal muscle and skin. The disease is marked early in its course by the presence of a vasculopathy or vasculitis, and later by the ... Full text Link to item Cite

Myositis in children.

Journal Article Curr Opin Rheumatol · September 2001 Idiopathic inflammatory myositis in children includes multiple disease entities, but is primarily made up of juvenile dermatomyositis and, to a lesser degree, juvenile polymyositis. Much new information has been published in the last few years about these ... Full text Link to item Cite

Juvenile arthritis and autoimmunity to type II collagen.

Journal Article Arthritis Rheum · August 2001 OBJECTIVE: Joint inflammation in juvenile rheumatoid arthritis (JRA) is sometimes associated with an autoimmune response to type II collagen (CII), a cartilage-specific protein. To test the hypothesis that down-regulation of autoimmunity to CII can be acco ... Full text Link to item Cite

Validation of the Childhood Health Assessment Questionnaire in the juvenile idiopathic myopathies. Juvenile Dermatomyositis Disease Activity Collaborative Study Group.

Journal Article J Rheumatol · May 2001 OBJECTIVE: To examine the validity of the Childhood Health Assessment Questionnaire (CHAQ) in patients with juvenile idiopathic inflammatory myopathy (IIM). METHODS: One hundred fifteen patients were enrolled in a multicenter collaborative study, during wh ... Link to item Cite

Chimerism in children with juvenile dermatomyositis.

Journal Article Lancet · December 23, 2000 Juvenile dermatomyositis is a disease with similarities to chronic graft-versus-host disease. To identify whether chimerism is present in juvenile dermatomyositis, we investigated the families of 15 children with the disorder. Chimerism was identified by P ... Full text Link to item Cite

Immunogenetic associations in childhood dermatomyositis.

Journal Article Curr Rheumatol Rep · June 2000 Childhood dermatomyositis is a multisystem autoimmune disease characterized by acute and chronic inflammatory infiltrate and vasculitis seen primarily in skin and muscle. The disease occurs in genetically susceptible individuals with a yet undescribed envi ... Full text Link to item Cite

Autoantibodies to DEK oncoprotein in human inflammatory disease.

Journal Article Arthritis Rheum · January 2000 OBJECTIVE: To evaluate the specificity of anti-DEK antibodies for juvenile rheumatoid arthritis (JRA). METHODS: Anti-DEK autoantibodies were measured by enzyme-linked immunosorbent assay (ELISA) using affinity-purified his6-DEK fusion protein. Sera from 63 ... Full text Link to item Cite

Familial dermatomyositis.

Journal Article J Rheumatol · December 1999 Susceptibility, response to therapy, prognosis, and natural history of connective tissue diseases are variably linked to histocompatibility antigens (HLA), although the precise role that such genes play is still not clear. In juvenile dermatomyositis (JDMS ... Link to item Cite

Prevention of leg length discrepancy in young children with pauciarticular juvenile rheumatoid arthritis by treatment with intraarticular steroids.

Journal Article Arthritis Rheum · November 1999 OBJECTIVE: To determine if intraarticular (i.a.) injection of triamcinolone hexacetonide (steroids) used early in the course of pauciarticular juvenile rheumatoid arthritis (pauci JRA) is associated with less leg length discrepancy (LLD) or thigh circumfer ... Full text Link to item Cite

Development of validated disease activity and damage indices for the juvenile idiopathic inflammatory myopathies. II. The Childhood Myositis Assessment Scale (CMAS): a quantitative tool for the evaluation of muscle function. The Juvenile Dermatomyositis Disease Activity Collaborative Study Group.

Journal Article Arthritis Rheum · October 1999 OBJECTIVE: To develop, validate, and determine the measurement characteristics of a quantitative tool for assessing the severity of muscle involvement in children with idiopathic inflammatory myopathies. METHODS: The Childhood Myositis Assessment Scale (CM ... Full text Link to item Cite

Analysis of HLA-DM polymorphism in juvenile dermatomyositis (JDM) patients.

Journal Article Hum Immunol · March 1999 Annually approximately 1:200,000 young children and adolescents are affected by juvenile dermatomyositis (JDM). Genetic factors are thought to contribute to the etiology. Since the discovery of the human leukocyte antigen class II associated DM molecule mu ... Full text Link to item Cite

Panniculitis in juvenile dermatomyositis.

Journal Article Pediatr Dermatol · 1999 Panniculitis is a rarely reported clinical finding in dermatomyositis. We present a 14-year-old African American boy with a 4-year history of dermatomyositis referred for evaluation of tender, indurated plaques and nodules on the trunk and proximal extremi ... Full text Link to item Cite

Geographic clustering of juvenile dermatomyositis (JDM) subjects.

Journal Article ARTHRITIS AND RHEUMATISM · September 1, 1998 Link to item Cite

Immunogenetic studies in families of children with juvenile dermatomyositis.

Journal Article J Rheumatol · May 1998 OBJECTIVE: We reported an association between juvenile dermatomyositis (JDMS) and the HLA-DQA1*0501 allele. The purpose of this study was to determine whether there is evidence for linkage between JDMS and the DQA1*0501 allele in JDMS families. METHODS: Th ... Link to item Cite

Diminished class II-associated Ii peptide binding to the juvenile dermatomyositis HLA-DQ alpha 1*0501/DQ beta 1*0301 molecule.

Journal Article J Immunol · December 15, 1997 HLA class II molecules bind and present peptide Ags to T cells, binding specific sets of peptides due to polymorphism in the peptide binding groove. Class II proteins associate with the invariant chain (Ii chain) and its derived class II-associated Ii pept ... Link to item Cite

Development of validated disease activity and damage indices for the juvenile idiopathic inflammatory myopathies: I. Physician, parent, and patient global assessments. Juvenile Dermatomyositis Disease Activity Collaborative Study Group.

Journal Article Arthritis Rheum · November 1997 OBJECTIVE: To determine the reliability, content validity, and responsiveness of physician global assessments of disease activity and damage in the juvenile idiopathic inflammatory myopathies (IIM), and to investigate concordance among physician, parent, a ... Full text Link to item Cite

Seldom recognized cutaneous manifestations of juvenile dermatomyositis (JDMS).

Journal Article ARTHRITIS AND RHEUMATISM · September 1, 1996 Link to item Cite

The 8.5-kb PstI allele of the stress protein gene, Hsp70-2: an independent risk factor for systemic lupus erythematosus in African Americans?

Journal Article Hum Immunol · January 1996 SLE is dramatically more prevalent in persons of African descent than in other populations. Several genes in the class III region of the MHC have been considered as potential susceptibility loci for this disorder, but the primary association(s) remains unk ... Full text Link to item Cite

Association of the HLA-DQA1*0501 allele in multiple racial groups with juvenile dermatomyositis.

Journal Article Hum Immunol · November 1995 We wanted to determine if HLA-DQA1*0501 is as strongly associated with JDMS in Hispanic and African Americans as it is Caucasians. Using DNA sequencing and oligonucleotide typing, the DNA of 70 JDMS subjects was studied. The HLA-DQA1 allelle DQA1*0501 was ... Full text Link to item Cite

Breast feeding and the development of juvenile rheumatoid arthritis.

Journal Article J Rheumatol · June 1995 OBJECTIVE: To determine if children with juvenile rheumatoid arthritis (JRA) are less likely to have been breast fed than controls. METHODS: Case-control study of data obtained from a survey of mothers 54 children with JRA and 79 playmates regarding breast ... Link to item Cite

FDDI information management system for centralizing interactive, computerized multimedia clinical experiences in pediatric rheumatology/Immunology.

Journal Article Medinfo · 1995 This paper describes the design, authoring, and development of interactive, computerized, multimedia clinical simulations in pediatric rheumatology/immunology and related musculoskeletal diseases, the development and implementation of a high speed informat ... Link to item Cite

BREAST-FEEDING AND THE DEVELOPMENT OF JUVENILE RHEUMATOID-ARTHRITIS

Journal Article ARTHRITIS AND RHEUMATISM · September 1, 1993 Link to item Cite

Repair of osteopenia in children with juvenile rheumatoid arthritis.

Journal Article J Pediatr · May 1993 To test the hypothesis that the presence of osteopenia in juvenile rheumatoid arthritis is directly correlated with clinical disease activity and therefore reversible, we prospectively studied cortical bone mineral density (BMD) serially in 27 children. Tw ... Full text Link to item Cite

Molecular genetic studies of major histocompatibility complex genes in children with juvenile dermatomyositis: increased risk associated with HLA-DQA1 *0501.

Journal Article Hum Immunol · December 1991 Juvenile dermatomyositis (JDMS) is an inflammatory disease associated with HLA-DR3. We therefore undertook molecular genetic studies of HLA region genes to determine whether HLA-DR3 itself confers susceptibility to JDMS or whether susceptibility is conferr ... Full text Link to item Cite

Abnormalities in serum osteocalcin values in children with chronic rheumatic diseases.

Journal Article J Pediatr · April 1990 We studied bone mineral metabolism prospectively in 113 children with chronic rheumatic diseases (juvenile arthritis, systemic lupus erythematosus, and juvenile dermatomyositis) to determine the relationship of serum levels of osteocalcin to rheumatic dise ... Full text Link to item Cite

Lyme disease in children and adolescents.

Journal Article Compr Ther · January 1989 Link to item Cite