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Immunogenetic risk and protective factors for juvenile dermatomyositis in Caucasians.

Publication ,  Journal Article
Mamyrova, G; O'Hanlon, TP; Monroe, JB; Carrick, DM; Malley, JD; Adams, S; Reed, AM; Shamim, EA; James-Newton, L; Miller, FW; Rider, LG ...
Published in: Arthritis Rheum
December 2006

OBJECTIVE: To define the relative importance (RI) of class II major histocompatibility complex (MHC) alleles and peptide binding motifs as risk or protective factors for juvenile dermatomyositis (DM), and to compare these with HLA associations in adult DM. METHODS: DRB1 and DQA1 typing was performed in 142 Caucasian patients with juvenile DM, and the results were compared with HLA typing data from 193 patients with adult DM and 797 race-matched controls. Random Forests classification and multiple logistic regression were used to assess the RI of the HLA associations. RESULTS: The HLA-DRB1*0301 allele was a primary risk factor (odds ratio [OR] 3.9), while DQA1*0301 (OR 2.8), DQA1*0501 (OR 2.1), and homozygosity for DQA1*0501 (OR 3.2) were additional risk factors for juvenile DM. These risk factors were not present in patients with adult DM without defined autoantibodies. DQA1 alleles *0201 (OR 0.37), *0101 (OR 0.38), and *0102 (OR 0.51) were identified as novel protective factors for juvenile DM, the latter 2 also being protective factors in adult DM. The peptide binding motif DRB1 (9)EYSTS(13) was a risk factor, and DQA1 motifs F(25), S(26), and (45)(V/A)W(R/K)(47) were protective. Random Forests classification analysis revealed that among the identified risk factors for juvenile DM, DRB1*0301 had a higher RI (100%) than DQA1*0301 (RI 57%), DQA1*0501 (RI 42%), or the peptide binding motifs. In a logistic regression model, DRB1*0301 and DQA1*0201 were the strongest risk and protective factors, respectively, for juvenile DM. CONCLUSION: DRB1*0301 is ranked higher in RI than DQA1*0501 as a risk factor for juvenile DM. DQA1*0301 is a newly identified HLA risk factor for juvenile DM, while 3 of the DQA1 alleles studied are newly identified protective factors for juvenile DM.

Duke Scholars

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

December 2006

Volume

54

Issue

12

Start / End Page

3979 / 3987

Location

United States

Related Subject Headings

  • White People
  • Risk Factors
  • Odds Ratio
  • Humans
  • Histocompatibility Testing
  • HLA-DRB1 Chains
  • HLA-DR Antigens
  • HLA-DQ alpha-Chains
  • HLA-DQ Antigens
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
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MLA
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Mamyrova, G., O’Hanlon, T. P., Monroe, J. B., Carrick, D. M., Malley, J. D., Adams, S., … Childhood Myositis Heterogeneity Collaborative Study Group, . (2006). Immunogenetic risk and protective factors for juvenile dermatomyositis in Caucasians. Arthritis Rheum, 54(12), 3979–3987. https://doi.org/10.1002/art.22216
Mamyrova, Gulnara, Terrance P. O’Hanlon, Jason B. Monroe, Danielle Mercatante Carrick, James D. Malley, Sharon Adams, Ann M. Reed, et al. “Immunogenetic risk and protective factors for juvenile dermatomyositis in Caucasians.Arthritis Rheum 54, no. 12 (December 2006): 3979–87. https://doi.org/10.1002/art.22216.
Mamyrova G, O’Hanlon TP, Monroe JB, Carrick DM, Malley JD, Adams S, et al. Immunogenetic risk and protective factors for juvenile dermatomyositis in Caucasians. Arthritis Rheum. 2006 Dec;54(12):3979–87.
Mamyrova, Gulnara, et al. “Immunogenetic risk and protective factors for juvenile dermatomyositis in Caucasians.Arthritis Rheum, vol. 54, no. 12, Dec. 2006, pp. 3979–87. Pubmed, doi:10.1002/art.22216.
Mamyrova G, O’Hanlon TP, Monroe JB, Carrick DM, Malley JD, Adams S, Reed AM, Shamim EA, James-Newton L, Miller FW, Rider LG, Childhood Myositis Heterogeneity Collaborative Study Group. Immunogenetic risk and protective factors for juvenile dermatomyositis in Caucasians. Arthritis Rheum. 2006 Dec;54(12):3979–3987.
Journal cover image

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

December 2006

Volume

54

Issue

12

Start / End Page

3979 / 3987

Location

United States

Related Subject Headings

  • White People
  • Risk Factors
  • Odds Ratio
  • Humans
  • Histocompatibility Testing
  • HLA-DRB1 Chains
  • HLA-DR Antigens
  • HLA-DQ alpha-Chains
  • HLA-DQ Antigens
  • Genetic Predisposition to Disease