The inflammatory milieu in idiopathic inflammatory myositis.

Journal Article (Journal Article)

The idiopathic inflammatory myopathies (IIM) are systemic autoimmune diseases that have predominant mononuclear inflammatory cell infiltrates in the skeletal muscle. The cells that are typically involved in the pathogenesis of disease are B-lymphocytes, T-lymphocytes, macrophages, dendritic cells, and natural killer cells. However, in addition to these immune cells, cells of nonimmunologic origin, such as myocytes, may be directly involved in the immune response. The local milieu also consists of distinct cytokine and chemokine profiles considered related to type 1 interferon stimulation. Tumor necrosis factor and interleukin 1 are also prominent, proinflammatory cytokines involved in the evolution of IIM. Although the pathologic processes involved in IIM have yet to be fully elucidated, we understand the inflammatory milieu is a model of dynamic flux made of diverse cytokine and chemokine expressions leading to alterations in muscle fiber structure and function.

Full Text

Duke Authors

Cited Authors

  • Reed, AM; Ernste, F

Published Date

  • August 2009

Published In

Volume / Issue

  • 11 / 4

Start / End Page

  • 295 - 301

PubMed ID

  • 19691933

Electronic International Standard Serial Number (EISSN)

  • 1534-6307

Digital Object Identifier (DOI)

  • 10.1007/s11926-009-0041-1


  • eng

Conference Location

  • United States